Reproductive biology最新文献_第8页

The paternal clock: Uncovering the consequences of advanced paternal age on sperm DNA fragmentation 父亲的时钟揭示高龄父亲对精子 DNA 断裂的影响

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-08-23 DOI: 10.1016/j.repbio.2024.100931

Eva Kadoch , Jonas Benguigui , Mélanie Chow-Shi-Yée , Artak Tadevosyan , François Bissonnette , Simon Phillips , Armand Zini , Isaac-Jacques Kadoch

{"title":"The paternal clock: Uncovering the consequences of advanced paternal age on sperm DNA fragmentation","authors":"Eva Kadoch , Jonas Benguigui , Mélanie Chow-Shi-Yée , Artak Tadevosyan , François Bissonnette , Simon Phillips , Armand Zini , Isaac-Jacques Kadoch","doi":"10.1016/j.repbio.2024.100931","DOIUrl":"10.1016/j.repbio.2024.100931","url":null,"abstract":"<div><p>The objective of the study was to investigate the relationship between advanced paternal age and sperm DNA fragmentation (SDF) levels, specifically identifying the age at which a significant increase in SDF occurs. This is a retrospective cohort study involving 4250 consecutive semen samples from patients presenting for infertility evaluation. Patients were stratified into seven age groups: < 26 (n = 36; 0.8 %), 26–30 (n = 500; 11.8 %), 31–35 (n = 1269; 29.9 %), 36–40 (n = 1268; 29.8 %), 41–45 (n = 732; 17.2 %), 46–50 (n = 304; 7.2 %), > 50 (n = 141; 3.3 %). The main outcome measures included comparing mean SDF levels throughout different age groups and assessing the prevalence of normal, intermediate, and high SDF among the age groups. A positive correlation was observed between paternal age and SDF (r = 0.17, p < 0.001). SDF remained relatively constant until the age of 35 but increased significantly beyond age 35. Mean SDF levels in the older age groups (36–40, 41–45, 46–50, and >50 years) were significantly higher than in the younger age groups (<26, 26–30, and 31–35 years) (p < 0.001). The prevalence of normal SDF was highest among the younger age groups, whereas the prevalence of high SDF was highest among the older age groups. Interestingly, the prevalence of intermediate SDF was relatively constant throughout the age groups (ranging between 29.8 % to 37.2 %). The increase in SDF after the age of 35 highlights the importance of considering male age in infertility evaluations. Assessing SDF in men over the age of 35 is crucial in couples seeking to conceive.</p></div>","PeriodicalId":21018,"journal":{"name":"Reproductive biology","volume":"24 4","pages":"Article 100931"},"PeriodicalIF":2.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of resveratrol on spermatogenesis in breeding boars and the proteomic analysis for testes 白藜芦醇对种公猪精子发生的影响及睾丸蛋白质组分析

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-08-21 DOI: 10.1016/j.repbio.2024.100930

Shuang Guo , Chaoying Liu , Ye Wang , Fujia Chen , Jinjin Zhu , Siqiang Li , Enzhong Li

{"title":"Effect of resveratrol on spermatogenesis in breeding boars and the proteomic analysis for testes","authors":"Shuang Guo , Chaoying Liu , Ye Wang , Fujia Chen , Jinjin Zhu , Siqiang Li , Enzhong Li","doi":"10.1016/j.repbio.2024.100930","DOIUrl":"10.1016/j.repbio.2024.100930","url":null,"abstract":"<div><p>Effect of resveratrol (RSV) on spermatogenesis and the mechanism of resveratrol in promoting spermatogenesis of breeding boars was explored by feeding sexually mature Duroc boars with normal diet and 20 mg/kg resveratrol diet for 14 days to the control group and experimental group, respectively. Semen volume, sperm density, motility, viability and abnormality rate were analyzed on day 0, 7, and 14. Blood samples were collected, and levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) in serum were analyzed. On day 14, the testis tissue was collected for antioxidant and proteomics analysis etc. The semen volume, sperm density, motility, and viability of the experimental group and the contents of serum FSH, LH, T and plasma SOD activity were significantly higher than those in the control group. However, the serum IL-6, TNF-α and plasma MDA were remarkably lower in experimental group. The above results showed that resveratrol can simulate spermatogenesis in breeding boars. Proteomic results demonstrated that three differentially expressed proteins (DEPs) were up-regulated and 12 DEPs were down-regulated; ODF1, calmodulin, Cabs1, and Hp were involved in spermatogenesis; and the main enriched metabolic pathway is steroid hormone synthesis pathway. Therefore, the improvement in sperm quality by resveratrol may be achieved by regulating the changes in outer dense fiber 1, calmodulin, spermatid specific 1, and haptoglobin expression and steroid synthesis pathway.</p></div>","PeriodicalId":21018,"journal":{"name":"Reproductive biology","volume":"24 4","pages":"Article 100930"},"PeriodicalIF":2.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

X-chromosome inactivation pattern and telomere length in recurrent pregnancy loss 复发性妊娠失败中的 X 染色体失活模式和端粒长度

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-08-21 DOI: 10.1016/j.repbio.2024.100933

Diane Vaz , Sara Vasconcelos , Carla Caniçais , Beatriz Costa , Carla Ramalho , Joana Marques , Sofia Dória

{"title":"X-chromosome inactivation pattern and telomere length in recurrent pregnancy loss","authors":"Diane Vaz , Sara Vasconcelos , Carla Caniçais , Beatriz Costa , Carla Ramalho , Joana Marques , Sofia Dória","doi":"10.1016/j.repbio.2024.100933","DOIUrl":"10.1016/j.repbio.2024.100933","url":null,"abstract":"<div><p>Recurrent pregnancy loss is a reproductive disorder affecting about 1 to 5 % of pregnant women worldwide that requires our attention, especially considering that about 50 % of cases are idiopathic. The present study is focused on testing a possible association between extreme skewed X-chromosome inactivation patterns and/or shortened telomeres with idiopathic cases since both are considered non-consensual potential causes underlying recurrent pregnancy loss in the scientific community. For this purpose, two groups of women were analyzed and compared: a group of women with idiopathic recurrent pregnancy loss and a second group of age-matched women with proven fertility, and both X-chromosome inactivation patterns and telomere length were measured and compared from maternal DNA extracted from peripheral blood. Our data showed no statistically significant differences between groups, suggesting no association between extreme skewed X-chromosome inactivation or shortened telomeres with recurrent pregnancy losses. Additionally, the effect of maternal age on both X-chromosome inactivation pattern and telomere length was tested, but no significant correlation was observed between advanced maternal age and extreme skewed X-chromosome inactivation or telomere shortening. This study represents one more valid contribution to the investigation of causes underlying recurrent pregnancy loss suggesting that, new variables may be considered since the pattern of X-chromosome inactivation and telomere length do not seem to be related to this reproductive disorder. Briefly, considering its clinical relevance, it is mandatory a continuous effort in the scientific community to cover new potential recurrent pregnancy loss-related causes.</p></div>","PeriodicalId":21018,"journal":{"name":"Reproductive biology","volume":"24 4","pages":"Article 100933"},"PeriodicalIF":2.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1642431X24000792/pdfft?md5=2837c3b2dc195592509a89bc32f05d26&pid=1-s2.0-S1642431X24000792-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of supplementing freezing extender with Mn2+-, Zn2+- or Cu2+-nanosuccinate on select post-thaw characteristics of ram semen 在冷冻扩展剂中添加 Mn2+-、Zn2+- 或 Cu2+ 纳米琥珀酸盐对公羊精液特定解冻后特性的影响。

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-08-18 DOI: 10.1016/j.repbio.2024.100932

Olha Sharan , Vasyl Stefanyk , Pawel M. Bartlewski , Mykola Sharan

{"title":"The effect of supplementing freezing extender with Mn2+-, Zn2+- or Cu2+-nanosuccinate on select post-thaw characteristics of ram semen","authors":"Olha Sharan , Vasyl Stefanyk , Pawel M. Bartlewski , Mykola Sharan","doi":"10.1016/j.repbio.2024.100932","DOIUrl":"10.1016/j.repbio.2024.100932","url":null,"abstract":"<div><p>The effects of Mn<sup>2+</sup>-, Zn<sup>2+</sup>- or Cu<sup>2+</sup>-nanosuccinate added to freezing extender on select post-thaw semen characteristics were determined in six Texel rams (aged 2–4 years) during seasonal anestrus (April-May). Ejaculates (n = 6 per ram) collected into an artificial vagina were divided into ten isovolumetric fractions each. Semen was diluted in lactose-yolk-tris-citrate-glycerin medium and nanosuccinates (Mn<sup>2+</sup>- and Zn<sup>2+</sup>-nanosuccinate: 0.0 (control), 2.5, 5.0 and 7.5 μg/l; Cu<sup>2+</sup>-nanosuccinate: 0.0 (control), 1.25, 2.5 and 3.75 μg/l) were added to semen extender. Extended semen was loaded into 0.25-ml straws and frozen in liquid nitrogen. After thawing, sperm motility parameters were determined with computer assisted semen analysis (CASA), and the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) was measured with a spectrophotometric technique. The addition of 5.0 μg/l of Mn<sup>2+</sup>- and Zn<sup>2+</sup>-nanosuccinate significantly increased the sperm progressive motility and both 2.5 and 5.0 μg/l improved sperm motion kinetics. Further, both nanosuccinates at a dose of 5.0 μg/l significantly decreased SOD activity and stimulated an increase in GPx and CAT activity in semen samples. Alternatively, the addition of Cu<sup>2+</sup>-nanosuccinate (highest dose) significantly reduced the progressive motility and velocity of ram spermatozoa, increased the percentage of sperm with acrosomal/head defects and seminal SOD activity, and depressed CAT (highest dose) and GPx (all doses) activity. In summary, the addition of Mn<sup>2+</sup>- and Zn<sup>2+</sup>-nanosuccinate to semen extender had beneficial effects on sperm motility/motion kinetics and structural integrity, whereas Cu<sup>2+</sup>-nanosuccinate generally had debilitating effects on the post-thaw semen characteristics in rams.</p></div>","PeriodicalId":21018,"journal":{"name":"Reproductive biology","volume":"24 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Canine oocyte nuclear maturation with Nano-ozone (NZS) supplementation: The alterations of antioxidant, and oxidant status and CDK1, cyclin B1 expressions 补充纳米臭氧（NZS）后犬卵母细胞核成熟：抗氧化剂、氧化剂状态和 CDK1、细胞周期蛋白 B1 表达的改变

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-08-17 DOI: 10.1016/j.repbio.2024.100929

Ö. Bari , A.Ü. Sabancı , G. Avci , B. Bozkurt , B. Üstüner , B. Denk , G.R. Özalp

{"title":"Canine oocyte nuclear maturation with Nano-ozone (NZS) supplementation: The alterations of antioxidant, and oxidant status and CDK1, cyclin B1 expressions","authors":"Ö. Bari , A.Ü. Sabancı , G. Avci , B. Bozkurt , B. Üstüner , B. Denk , G.R. Özalp","doi":"10.1016/j.repbio.2024.100929","DOIUrl":"10.1016/j.repbio.2024.100929","url":null,"abstract":"<div><p>This study aims to evaluate the effects of nano-ozone solution (NZS) on canine oocyte nuclear maturation, associated with the alterations of antioxidant and oxidant status and cyclin-dependent kinase 1 (CDK1), cyclin B1 gene expressions. Oocytes were cultured in four distinct concentrations of NZS (0.5, 1, 2, and 5 µg/mL) and parthenogenetically activated. The rates of oocytes arrested at the Germinal Vesicle (GV), Germinal Vesicle Breakdown (GVBD), Metaphase I (MI), and Metaphase II (MII) stages were statistically different among groups (P < 0.05). The oocytes cultured in 1 µg/mL NZS yielded the best oocyte maturation rate at the MI and MII stages; however, the lowest maturation and high degeneration rates were observed in Group E. The measurements of Malondialdehyde (MDA), reduced Glutathione <strong>(</strong>GSH), Superoxide Dismutase (SOD), and Ferric Reducing/Antioxidant Power assay (FRAP) were performed from IVM culture media. No statistical difference was observed in SOD and MDA results (P > 0.05). GSH levels were statistically significant between Group A-Group E (p = 0.003), Group B-Group E (p = 0.045), and Group E-Group D (p = 0.021). The culture media in Group D and Group E had high FRAP concentrations and significantly differed between groups (P < 0.05). CDK1, and cyclin B1 genes, which are subunits of maturation-promoting factor (MPF), are upregulated in Group B and Group C, while are downregulated in oocytes of Group E.</p><p>This study showed that low, controlled doses of NZS (1 µg/mL) supplementation could improve the meiotic competence of canine oocytes and lead to positive response in expressions of CDK1 and cyclin B1 on the gene level.</p></div>","PeriodicalId":21018,"journal":{"name":"Reproductive biology","volume":"24 3","pages":"Article 100929"},"PeriodicalIF":2.5,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141998267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid content and G6PDH activity in relation to ooplasm morphology and oocyte maturational competence in the domestic cat model 家猫模型中脂质含量和 G6PDH 活性与卵原细胞形态和卵母细胞成熟能力的关系

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-08-14 DOI: 10.1016/j.repbio.2024.100927

Wiesława Młodawska, Bartosz Maliński, Gabriela Godyń, Beata Nosal

{"title":"Lipid content and G6PDH activity in relation to ooplasm morphology and oocyte maturational competence in the domestic cat model","authors":"Wiesława Młodawska, Bartosz Maliński, Gabriela Godyń, Beata Nosal","doi":"10.1016/j.repbio.2024.100927","DOIUrl":"10.1016/j.repbio.2024.100927","url":null,"abstract":"<div><p>The aim of the study was to investigate the relationship between ooplasm morphology, lipid content, glucose-6-phosphate dehydrogenase activity (G6PDH) and maturation potential of domestic cat oocytes. Cumulus-oocyte complexes were classified according to ooplasm morphology: evenly dark (dCOC), heterogeneous/mosaic (hCOC), or light/transparent (lCOC), however only dCOCs are thought to be the best-quality, the remaining ones are usually rejected, therefore little is known about their intracellular properties. Lipid droplets (LDs) were visualized and quantified using Oil Red O. G6PDH activity was assessed before in vitro maturation (IVM), using the brilliant cresyl blue (BCB) test. IVM-control oocytes underwent IVM without BCB staining. The dCOCs and hCOCs had different patterns of LD spatial distribution, but similar amounts of lipid, although this tended towards being lower in hCOCs. Low G6PDH activity (BCB+) was observed in 74 %, 60 % and 24 % (P < 0.01) of dCOCs, hCOCs, and lCOCs, respectively. Significantly more BCB+ /oocytes than BCB–/oocytes reached the metaphase II stage in all groups. The maturation rate of BCB+ /hCOCs was higher than that of IVM/hCOC-controls (40 % v.s. 20 %, P < 0.001), and was comparable to that of BCB+ /dCOCs (54 %; P > 0.05). lCOCs were the smallest (P < 0.01), contained fewer (P < 0.01) lipids than dCOCs or hCOCs, and displayed reduced maturational potential. Overall, LD content and distribution, as well as G6PDH activity, in cat oocytes were strongly associated with ooplasm morphology and oocyte maturational competence. Deeper understanding of the intrinsic properties of oocytes with different ooplasm morphology using the domestic cat model, may be particularly important in the context of the conservation of endangered felids.</p></div>","PeriodicalId":21018,"journal":{"name":"Reproductive biology","volume":"24 3","pages":"Article 100927"},"PeriodicalIF":2.5,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141985269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial formation of and sex differences in primordial germ cells in Japanese quail 日本鹌鹑原始生殖细胞的初始形成和性别差异。

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-08-09 DOI: 10.1016/j.repbio.2024.100922

Shusei Mizushima , Yuya Ogawa , Asato Kuroiwa

引用次数: 0

The novel stimulators of feline ovarian granulosa cell functions: Monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1 猫卵巢颗粒细胞功能的新型刺激物：单核细胞趋化蛋白-1 和纤溶酶原激活物抑制剂-1。

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-08-05 DOI: 10.1016/j.repbio.2024.100926

Alexander V. Sirotkin , Zuzana Fabová , Barbora Loncová , Abdel Halim Harrath

引用次数: 0

4-methylimidazole exposure impairs sperm mobility by reducing the expression of blood-testis barrier junction protein in mouse testes 暴露于4-甲基咪唑会降低小鼠睾丸中血睾屏障连接蛋白的表达，从而损害精子的活动能力。

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-07-30 DOI: 10.1016/j.repbio.2024.100928

Yajuan Lu , Wei Ma , Hanyu Tang , Xue Wu , Xiwen Yang , Fei Sun

{"title":"4-methylimidazole exposure impairs sperm mobility by reducing the expression of blood-testis barrier junction protein in mouse testes","authors":"Yajuan Lu , Wei Ma , Hanyu Tang , Xue Wu , Xiwen Yang , Fei Sun","doi":"10.1016/j.repbio.2024.100928","DOIUrl":"10.1016/j.repbio.2024.100928","url":null,"abstract":"<div><p>4-methylimidazole (4-MI), a derivative of imidazole, is a widely used component in caramel-colored food products such as soy sauce, beer and other soft drinks. The present study is aimed to investigate the effects of 4-MI on the male reproduction. The results revealed that 8 weeks of 4-MI exposure did not significantly alter the body weight and testicular weight of male mice. However, testicular morphology and computer-assisted sperm analysis showed that exposed to 4-MI caused irregular arrangement of spermatogenic cells in the testes and weakened sperm motility. Consistently, we observed the decreased fertilization ability in vivo of 4-MI-treated male mice. We further demonstrated that 4-MI disrupted the blood-testis barrier (BTB) integrity by decreasing the protein expression of BTB-related junction with permeability assay and western blot. In addition, the apoptosis of Sertoli cells (TM4) occurred in 4-MI treated mice, which might be caused by the generation of oxidative stress. Collectively, our findings document that 4-MI exposure damages the sperm mobility via disruption of BTB integrity.</p></div>","PeriodicalId":21018,"journal":{"name":"Reproductive biology","volume":"24 3","pages":"Article 100928"},"PeriodicalIF":2.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infertility: Focus on the therapeutic potential of extracellular vesicles 不孕症：关注细胞外囊泡的治疗潜力

IF 2.5 3区生物学

Reproductive biology Pub Date : 2024-07-16 DOI: 10.1016/j.repbio.2024.100925

Ali Parvin , Gisou Erabi , Donna Mohammadpour , Hadi Maleki-Kakelar , Sonia Sadeghpour , Mohammad Reza Pashaei , Mortaza Taheri-Anganeh , Hojat Ghasemnejad-Berenji

{"title":"Infertility: Focus on the therapeutic potential of extracellular vesicles","authors":"Ali Parvin , Gisou Erabi , Donna Mohammadpour , Hadi Maleki-Kakelar , Sonia Sadeghpour , Mohammad Reza Pashaei , Mortaza Taheri-Anganeh , Hojat Ghasemnejad-Berenji","doi":"10.1016/j.repbio.2024.100925","DOIUrl":"10.1016/j.repbio.2024.100925","url":null,"abstract":"<div><p>Infertility is a well-known problem that arises from a variety of reproductive diseases. Until now, researchers have tried various methods to restore fertility, including medication specific to the cause, hormone treatments, surgical removals, and assisted reproductive technologies. While these methods do produce results, they do not consistently lead to fertility restoration in every instance. The use of exosome therapy has significant potential in treating infertility in patients. This is because exosomes, microvesicles, and apoptotic bodies, which are different types of vesicles, play a crucial role in transferring bioactive molecules that aid in cell-to-cell communication. Reproductive fluids can transport a variety of molecular cargos, such as miRNAs, mRNAs, proteins, lipids, and DNA molecules. The percentage of these cargos in the fluids can be linked to their physiological and pathological status. EVs are involved in several physiological and pathological processes and offer interesting non-cellular therapeutic possibilities to treat infertility. EVs (extracellular vesicles) transplantation has been shown in many studies to be a key part of regenerating different parts of the reproductive system, including the production of oocytes and the start of sperm production. Nevertheless, the existing evidence necessitates testifying to the effectiveness of injecting EVs in resolving reproductive problems among humans. This review focuses on the current literature about infertility issues in both females and males, specifically examining the potential treatments involving extracellular vesicles (EVs).</p></div>","PeriodicalId":21018,"journal":{"name":"Reproductive biology","volume":"24 3","pages":"Article 100925"},"PeriodicalIF":2.5,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0