Reproductive Biology and Endocrinology最新文献

{"title":"Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study.","authors":"Huijing Shao, Chang Xu, Haoran Wang, Nan Lu, Hang Gu, Caihong Zhang, Lirong Li, Qianqian Sun, Rui Guan, Beibei Xuan","doi":"10.1186/s12958-025-01406-y","DOIUrl":"https://doi.org/10.1186/s12958-025-01406-y","url":null,"abstract":"<p><strong>Background: </strong>While the phenotypic link between body mass index (BMI) and some female reproductive disorders is well established, the genetic architecture and causal relationships have not been systematically studied. We aimed to create an atlas of the shared genetic associations of BMI and 16 female reproductive disorders and to identify their common risk loci, biological pathways, and potential mechanisms.</p><p><strong>Methods: </strong>We assessed the genetic correlations between BMI and 16 reproductive disorders using summary data from large-scale genome-wide association studies. Cross-trait pleiotropic analysis identified shared loci and genes, while functional annotation and tissue-specific analysis revealed relevant biological pathways and tissues. Multi-trait colocalization analysis examined the role of hormones and metabolites in these traits. Additionally, bidirectional Mendelian randomization (MR) analysis was employed to assess causal relationships between BMI and reproductive outcomes. We also conducted summary data-based MR (SMR) analysis to identify potential drug targets.</p><p><strong>Results: </strong>Our results revealed a significant genetic correlation between BMI and eight female reproductive diseases. Furthermore, we identified 50 shared pleiotropic loci between BMI and these traits, with 21 of them showing significant colocalization, suggesting a complex shared genetic architecture across the genome. In addition, the top biological pathways and tissues enriched with these pleiotropic loci were associated with RNA metabolism, macromolecule biosynthesis, type B pancreatic cell apoptosis, various brain regions, and the pituitary. Moreover, multi-trait colocalization indicated that insulin, lipid metabolites, glucose, glycine, and glutamine mediate shared mechanisms between BMI, gestational diabetes mellitus (GDM), and endometrial cancer. MR analysis suggested BMI may cause several reproductive diseases, with only GDM affecting BMI reversely. Finally, SMR analysis revealed EIF2S2P3 and MCM6, which may have a causative effect on both BMI & GDM and BMI & gestational hypertension.</p><p><strong>Conclusion: </strong>Our results suggest a significant genetic link between BMI and eight female reproductive diseases, highlighting a shared and causal genetic basis. Reducing BMI in women may serve as an effective strategy to lower the risk of female reproductive disorders. The identified pleiotropic loci, genes, and shared pathways could provide new therapeutic targets for both obesity and reproductive diseases, along with their comorbidities.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"71"},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphate concentrations in follicular fluid during assisted reproductive treatment: relevance for ovarian function and fertility outcomes.","authors":"Signe Marie Wulff, Mads Joon Jorsal, Ireen Kooij, Hans Krog, Ursula Bentin-Ley, Martin Blomberg Jensen, Sam Kafai Yahyavi","doi":"10.1186/s12958-025-01408-w","DOIUrl":"10.1186/s12958-025-01408-w","url":null,"abstract":"<p><strong>Background: </strong>The role of follicular fluid phosphate for reproductive health and oocyte maturation is unclear. This study investigates the relationship between follicular fluid vs serum phosphate concentrations and the possible link with sex steroids during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) at a Danish fertility clinic.</p><p><strong>Methods: </strong>A prospective cohort of infertile women who attended Danfert Fertility clinic (Copenhagen, Denmark) and received IVF or ICSI treatment between June 2015 and February 2017. Correlation analyses were performed with Spearman's Rank or Pearson's correlation, while categorical variables were analyzed with Chi-squared test.</p><p><strong>Results: </strong>In total, 110 participants were included in the study, and 33 of these achieved a live birth. Phosphate concentrations were higher in the follicular fluid compared to corresponding serum samples (1.16 mmol/L vs. 1.06 mmol/L, p = 0.002) and there was a positive correlation between serum and follicular fluid phosphate concentrations (r = 0.43, p = 0.007). A positive trend was also found for calcium concentrations, though not statistically significant (r = 0.31, p = 0.060). Correlation analysis also showed a positive correlation between concentrations of phosphate and calcium in follicular fluid (r = 0.41, p < 0.001). A positive correlation was observed between concentrations of phosphate and testosterone in follicular fluid (r = 0.34, p < 0.001). When stratified into tertiles, we found no significant differences between live birth rates in follicular fluid phosphate (p = 0.624), calcium (p = 0.207), or testosterone (p = 0.841).</p><p><strong>Conclusions: </strong>This study found that follicular fluid phosphate concentrations are higher than serum phosphate concentrations, suggesting possible local regulation. However, no significant association was found between follicular phosphate and ART outcomes. Further research is needed to explore its potential role in reproductive physiology.</p><p><strong>Clinical trial: </strong>Clinicaltrials.gov (NCT02437578; registration date 2015/04/16).</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"69"},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The aryl hydrocarbon receptor: a new frontier in male reproductive system.","authors":"Ghadeer Bustani, Hasan Alghetaa, Amira Mohammed, Mitzi Nagarkatti, Prakash Nagarkatti","doi":"10.1186/s12958-025-01401-3","DOIUrl":"https://doi.org/10.1186/s12958-025-01401-3","url":null,"abstract":"<p><strong>Background: </strong>The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically recognized for its role in the regulation of toxicity mediated by environmental chemicals. Recent research points to AhR's critical participation in male reproductive physiology, particularly in spermatogenesis, hormone signaling, and the maintenance of sperm quality. Both endogenous ligands (e.g., dietary and gut microbiota-derived metabolites) and exogenous pollutants (e.g., dioxins and benzo-α-pyrene) influence AhR-mediated pathways, making it a key link between environmental exposures and male fertility.</p><p><strong>Results: </strong>This review highlights AhR's influence on the male reproductive system, emphasizing the role of endogenous AhR ligands and AhR expression in the maturation and function of male reproductive organs. Environmental AhR agonists have been shown to induce oxidative stress, hormonal imbalance, and sperm DNA damage, which impact harmfully on the spermatogenesis process, which leads to reproductive abnormalities. Conversely, certain natural compounds such as resveratrol, curcumin, and lycopene appear to antagonize AhR activation and reduce its negative effects, thus offering potential protective benefits against male reproductive toxicity. Nevertheless, discrepancies persist regarding the exact interplay between AhR signaling and critical reproductive hormones such as testosterone and LH, and it remains unclear how transgenerational epigenetic changes triggered by AhR activation might affect long-term male fertility.</p><p><strong>Conclusion: </strong>AhR is pivotal in male reproductive physiology, influencing spermatogenesis, sperm quality, and hormone regulation through its interactions with both endogenous and environmental ligands. Persistent pollutants such as dioxins and polycyclic aromatic hydrocarbons cause oxidative damage and hormonal disturbances via AhR, contributing to reduced sperm quality and fertility.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"70"},"PeriodicalIF":4.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the euploidy rate in preimplantation genetic testing for aneuploidy cycles following progestin-primed versus gonadotropin-releasing hormone antagonist protocol: a randomized controlled study.","authors":"Lu Wang, Jing Yun Wang, Yuan Zhang, Chen Qian, Xiao Hui Wang, Ernest Hung Yu Ng, Ai Ai, Zhi Qin Chen","doi":"10.1186/s12958-025-01404-0","DOIUrl":"10.1186/s12958-025-01404-0","url":null,"abstract":"<p><strong>Background: </strong>Progestins can block endogenous luteinizing hormone secretion from the pituitary gland and have shown similar efficacy in terms of collecting competent oocytes and embryos; however, some inconsistencies have been proposed by the previous papers regarding the quality of oocytes and embryos obtained with the use of progestins. This study aimed to compare the euploidy rate between women treated with progestin-primed ovarian stimulation (PPOS) and the gonadotropin-releasing hormone (GnRH) antagonist protocol.</p><p><strong>Methods: </strong>This is a prospective randomized study of 240 infertile women undergoing PGT-A between August 2021 and July 2023. Infertile women with advanced maternal age (38-45 years), recurrent pregnancy loss (≥ 2 or 3 consecutive miscarriages), and repeated implantation failure (≥ 4 embryos replaced or ≥ 2 blastocysts replaced without success) undergoing PGT-A cycles were included. Women were randomly assigned into the PPOS group (n = 120) or the antagonist group (n = 120) according to a computer-generated randomization list. Dydrogesterone 20 mg per day was given from the start of ovarian stimulation until the trigger day in the PPOS group. In the antagonist group, an antagonist 0.25 mg was given daily from the sixth day of ovarian stimulation until the trigger day. The primary outcome measure was the euploidy rate, defined as the number of euploid blastocysts per injected oocyte.</p><p><strong>Results: </strong>No significant differences were observed in the demographic and ovarian stimulation characteristics between the two groups. The euploidy rate was comparable between the PPOS and antagonist group (12.5% vs. 16.0% respectively, P > 0.05). No significant differences were observed between the two groups in positive pregnancy test, clinical pregnancy, miscarriage, ectopic pregnancy, or live birth rates per transfer in the first frozen embryo transfer cycles.</p><p><strong>Conclusion: </strong>Both PPOS and antagonist protocols had similar euploidy rates in PGT-A cycles.</p><p><strong>Trial registration: </strong>Clinicaltrials. gov identifier: NCT04989348 ( https://www.</p><p><strong>Clinicaltrials: </strong>gov/ ). Trial registration date: Clinicaltrials. gov: 30 July 2021.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"67"},"PeriodicalIF":4.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral infection and its impact on fertility, medically assisted reproduction and early pregnancy - a narrative review.","authors":"Piotr Laudański, Aleksandra Zyguła, Adam Czyżyk, Katarzyna Olszak-Wasik, Damian Warzecha, Cezary Wojtyła, Rafał Kurzawa","doi":"10.1186/s12958-025-01392-1","DOIUrl":"10.1186/s12958-025-01392-1","url":null,"abstract":"<p><p>Viral infections can significantly affect the physiopathology of reproductive organs, leading to fertility problems, reducing the success rates of assisted reproductive technologies, and negatively impacting pregnancy. This review aims to summarize the current evidence on viral pathogens that are either suspected or confirmed to play a role in reproductive medicine and their effects on early pregnancy. For instance, viral hepatitis and human immunodeficiency virus can decrease sperm quality. Human papilloma virus infection in men appears to cause infertility, while herpesviruses pose a greater risk to fetuses rather than to fertility. The Zika virus disrupts early embryo development, necessitating a delay in conception for those suspected or confirmed to be infected. The effects of SARS-CoV-2 on reproduction are still unclear. Rubella and cytomegalovirus can cause serious congenital defects, making pre-conception screening essential, and a Rubella vaccine is recommended. More rigorous studies are needed to clarify the roles of various infectious agents, enhance fertility treatments, and improve pregnancy outcomes while reducing complications.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"68"},"PeriodicalIF":4.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"United States racial/ethnic disparities in PGT-A use: an analysis of 2014-2020 SART CORS database.","authors":"Akailah Mason-Otey, David B Seifer","doi":"10.1186/s12958-025-01399-8","DOIUrl":"https://doi.org/10.1186/s12958-025-01399-8","url":null,"abstract":"<p><strong>Background: </strong>The use of preimplantation genetic testing for aneuploidy (PGT-A) allows for the selection of euploid embryos and has been thought to improve outcomes in ART, particularly in women ≥ 35 years old. However, little is known regarding PGT-A utilization among minority women in the United States (US). The objective of this study was to determine the trend of utilization of PGT-A in the US among minority women.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) database. We included initial autologous ART cycles performed between 2014 and 2020. We assessed the rate of PGT-A utilization by race/ethnicity.</p><p><strong>Results: </strong>This study included 150,604 PGT-A and 287,979 non-PGT-A initial autologous cycles. The overall trend of PGT-A utilization, regardless of race/ethnicity, increased from 11.5 to 49.0% (p < 0.001) over seven years. Of all ART cycles, 33% of White women used PGT-A, in comparison to 24% of Black women, 31% of Hispanic women, and 44% of Asian women (p < 0.001). Multiple Logistic Regression (MLR) determined race/ethnicity as an independent predictor of PGT-A utilization when adjusting for age, BMI, and AMH (p < 0.001). Compared to White women, MLR showed that Black and Hispanic women were 35% and 16% less likely to use PGT-A (aOR = 0.65, 95% CI 0.63-0.67, and aOR = 0.86, 95% CI 0.84-0.88, respectively, p < 0.001). In contrast, Asian women were 41% (aOR = 1.41, 95% CI 1.39-1.44) more likely to use PGT-A (p < 0.001). Overall, regardless of race/ethnicity, women 35 and older were 71% (aOR = 1.71, 95% CI 1.69-1.74) more likely to use PGT-A compared to women younger than 35 (p < 0.001).</p><p><strong>Conclusion: </strong>Despite a significant increase in overall PGT-A utilization in the US over 7 years, utilization has been consistently less in ART cycles for Black and Hispanic women, in comparison to White women. This is in marked contrast to an increase in PGT-A utilization in cycles for Asian women.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"66"},"PeriodicalIF":4.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopharmacological interventions among people who use Assisted Reproductive Technology (ART) - a scoping review.","authors":"Storman Dawid, Jemioło Paweł, Adamska Dominika, Sawiec Zuzanna","doi":"10.1186/s12958-025-01400-4","DOIUrl":"10.1186/s12958-025-01400-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;One in six people experience infertility, often leading couples to seek Assisted Reproductive Technology (ART), which can be emotionally taxing. Anxiety and depression are common among individuals undergoing ART, highlighting the need for integrated mental health support, especially for women who face heightened risk of psychiatric disorders during their reproductive years. Despite the importance of psychiatric care, there is limited knowledge regarding the use of psychiatric medications among individuals undergoing ART.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Following a pre-written protocol (osf.io/egxw8/), we systematically searched electronic databases (Ovid MEDLINE, Embase, CENTRAL, Web of Science, PsycInfo, Scopus) up to 15.02.2025 to identify any study focused on psychopharmacotherapy among people undergoing ART. Two independent reviewers screened titles, abstracts, and full texts, performed data extraction, and resolved conflicts through discussion or consultation with a third reviewer. We synthesized data using descriptive analysis and performed analysis within the following subgroups: (1) group of medication according to Neuroscience-based Nomenclature (NbN) classes; (2) indication for using a specific medication (psychiatric / non-psychiatric).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;We included 29 studies published in 31 papers. Psychiatric medications were primarily administered for the treatment of depression (n=12/29 studies, 41.38%) and anxiety disorders (n=8/29, 27.59%). Among all groups of medication serotonin reuptake inhibitors were the most commonly studied class of medications (n=15/29 studies, 51.72%), with fluoxetine being the most frequently used medication (n=8/29, 27.59%). Among medications for anxiety, GABA Positive Allosteric Modulators with midazolam occurred the most frequently (n=6/29, 20.69%). Medications for psychosis included single drugs: olanzapine, clozapine, risperidone, quetiapine, aripiprazole, haloperidol, and promethazine. Among medications that could be used in bipolar disorder there were: valproic acid, lithium, and lamotrigine. The most commonly reported endpoints in the studies were psychiatric symptom severity (n=11/29, 37.93%) and ART efficacy (n=10/29, 34.48%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Evidence on the use of psychopharmacotherapy in ART primarily concerns women. Available literature indicates that psychopharmacotherapy for individuals undergoing ART frequently involves medications commonly used in general psychiatric practice, with a tendency toward lower dosing and a preference for serotonin reuptake inhibitors. However, this observation should be interpreted cautiously, as current evidence remains limited and further research is warranted to establish treatment patterns more conclusively. The variability in study designs and reporting standards further highlights the need for standardized methodologies and improved adherence to reporting guidelines to enhance the qualit","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"65"},"PeriodicalIF":4.2,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progestin-primed ovarian stimulation for oocyte cryopreservation in patients with nonmedical indications: a case-control study.","authors":"Ophélie Sounigo, Léah Cohen Aloro, Michael Grynberg, Céleste Becquart, Maxence Majer, Vincent Puy, Christophe Sifer, Claire Vinolas, Florence Eustache, Laetita Hesters, Anne Mayeur, Isabelle Cedrin-Durnerin, Charlotte Sonigo, Maeliss Peigné","doi":"10.1186/s12958-025-01402-2","DOIUrl":"10.1186/s12958-025-01402-2","url":null,"abstract":"<p><strong>Background: </strong>The PPOS (Progestin Primed Ovarian Stimulation) protocol has been evaluated and has proved its effectiveness in preventing the LH (luteinizing hormone) surge. This protocol is often used for cryopreservation for social reasons because it is simpler and more cost-effective. The objective of our study was to evaluate the efficacy and the convenience of the PPOS protocol in the context of oocyte cryopreservation for social reasons.</p><p><strong>Methods: </strong>In this bicentric matched case‒control study, all PPOS cycles performed for nonmedical reasons between January 2021 and June 2023 were included. Each PPOS cycle was matched with 2 control cycles performed with the antagonist protocol on the basis of the antral follicle count (+/- 5), BMI (+/- 2 kg/cm²) and starting gonadotropin dose (+/- 75 UI). The primary endpoint was the number of mature oocytes. The secondary endpoints were other parameters and outcomes of COS. We evaluated the convenience of PPOS by analysing the frequency of monitoring sessions. Univariate analysis was performed via univariate conditional logistic regression. Multivariate analysis was performed via conditional multivariate logistic regression for significant parameters in the univariate analysis (p < 0.2).</p><p><strong>Results: </strong>The patient characteristics were comparable, except the median age, which was lower in the antagonist group (35.5 vs. 34.6 years, p < 0.001). Multivariate analysis revealed no statistically significant difference in the number of metaphase II (MII) oocytes between the groups (p = 0.91) or in the total number of COCs retrieved (0.94). There was no statistically significant difference between the groups in terms of the maturation rate or the OSI (p = 0.38 and p = 0.16). The number of monitoring sessions was significantly lower in the PPOS protocol group (p < 0.001).</p><p><strong>Conclusion: </strong>The response to ovarian stimulation with the PPOS protocol for oocyte cryopreservation in patients with nonmedical indications does not differ statistically from that with the antagonist protocol in terms of the number of MII oocytes. This protocol offers the advantages of a more patient-friendly approach through oral administration, a significantly lower number of monitoring sessions with the same efficacy as the antagonist protocol and could be offered as a first line treatment.</p><p><strong>Clinical trial number: </strong>NA.</p><p><strong>Trial registration date: </strong>NA.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"64"},"PeriodicalIF":4.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infertile women with a history of fertility-sparing surgery for borderline ovarian tumors: IVF outcomes and the association between IVF and tumor recurrence.","authors":"Yujie Li, Weie Zhao, Panyu Chen, Weiwei Zeng, Yaqi Xu, Jintao Peng, Jingjie Li","doi":"10.1186/s12958-025-01397-w","DOIUrl":"https://doi.org/10.1186/s12958-025-01397-w","url":null,"abstract":"<p><strong>Background: </strong>Borderline ovarian tumors (BOTs) are neoplasms of low malignant potential that predominantly affect women of reproductive age. Fertility preservation through fertility-sparing surgery is widely practiced; however, concerns remain regarding the risk of tumor recurrence and the reproductive outcomes following in vitro fertilization (IVF). This study aimed to evaluate IVF/ intracytoplasmic sperm injection (ICSI) outcomes in BOTs patients post-FSS and to assess the association between ovarian stimulation parameters and tumor recurrence.</p><p><strong>Methods: </strong>In this retrospective cohort study conducted at Sixth Hospital of Sun Yat-sen University from May 2010 to May 2023, 65 women with a history of FSS for BOTs who underwent IVF/ICSI were identified. After propensity score matching, 61 BOTs patients were compared with 181 control patients without ovarian tumors. Key outcomes evaluated included ovarian stimulation parameters, live birth rates, neonatal outcomes and risk factors for tumor recurrence.</p><p><strong>Results: </strong>The BOTs and control groups exhibited similar outcomes regarding the number of oocytes retrieved, the quality and number of embryos, and live birth rates from the first IVF/ICSI cycles. The cumulative live birth rate over 13 years and neonatal parameters (gestational age, birth weight, and body length) were also comparable between groups. Tumor recurrence was observed in 8.62% of BOTs patients, with no significant association identified between recurrence and ovarian stimulation parameters or peak estradiol levels.</p><p><strong>Conclusions: </strong>IVF/ICSI following fertility-sparing surgery for BOTs patients yields reproductive and neonatal outcomes comparable to those in patients without BOTs and does not increase the risk of tumor recurrence. These findings support the safety and efficacy of IVF as a fertility treatment option for BOTs patients after conservative surgery. Further prospective studies with larger cohorts are warranted to validate these results and refine ovarian stimulation strategies.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"63"},"PeriodicalIF":4.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of endometrial gland imaging and pinopode detection for assessing endometrial receptivity.","authors":"Min-Bo Zhu, Bei-Lei Chen, Meng Cen, Li-Ping Chen, Zheng Shi","doi":"10.1186/s12958-025-01395-y","DOIUrl":"https://doi.org/10.1186/s12958-025-01395-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to obtain high-resolution endometrial gland images under high-definition hysteroscopy from in vitro fertilization and embryo transfer (IVF-ET) patients and perform image recognition to analyze their density and opening size. Concurrently, the number and morphology of pinopodes in the endometrial samples were observed using scanning electron microscopy (SEM). The objective was to compare the correlation between the two methods in evaluating endometrial receptivity and predicting pregnancy outcomes and to assess the consistency between the quantitative curves and pregnancy outcomes of the two methods in the cohort study.</p><p><strong>Methods: </strong>67 patients undergoing hysteroscopic surgery who had undergone controlled ovarian hyperstimulation treatment within 1-3 menstrual cycles before the surgery were selected. Hysteroscopic exploration was performed on the 3-5 days after ovulation (during the implantation window period). Endometrial images and tissues were collected under hysteroscopy. The endometrial glands were counted, the sizes of gland openings were calculated using an image recognition algorithm, and the number and morphology of endometrial pinopodes were observed through SEM. All patients underwent embryo transfer surgery within 1-3 menstrual cycles after hysteroscopy. Patients were divided into pregnancy and non-pregnancy groups based on pregnancy outcomes. The density and size of endometrial glands, as well as the number and morphology of pinopodes were compared between the two groups.</p><p><strong>Results: </strong>The endometrial gland density and the size of the endometrial gland opening in the pregnancy group were higher than that in the non-pregnancy group (P < 0.05). In contrast, both the average pinopode count per image and the developmental maturity grading of pinopodes were significantly higher in the pregnancy group compared to the non-pregnancy group.</p><p><strong>Conclusions: </strong>Both hysteroscopic endometrial gland image recognition technology and pinopode detection can effectively reflect endometrial receptivity and predict pregnancy outcomes. However, image recognition technology has clear economic and promotional advantages.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":21011,"journal":{"name":"Reproductive Biology and Endocrinology","volume":"23 1","pages":"62"},"PeriodicalIF":4.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}