Radiation and Environmental Biophysics最新文献

{"title":"Spectral luminescence of fossil coral: A Multi-Analytical approach.","authors":"K S Almugren, Siti Norbaini Sabtu, S F Abdul Sani, Priyaa Nandagopal, Anis Syahirah, Safwan Steven, M N Nurul Shahira, A S Siti Shafiqah, D A Bradley","doi":"10.1007/s00411-025-01168-6","DOIUrl":"10.1007/s00411-025-01168-6","url":null,"abstract":"<p><p>This study investigates the luminescence properties of calcite within coral skeletons collected from Pulau Redang, Malaysia, focusing on the effects of gamma irradiation. Using Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, and luminescence measurements, we examined structural and compositional changes in corals subjected to varying doses of gamma radiation. Present results indicate significant lattice disorder and structural breakdown at higher radiation doses, evidenced by increased porosity and altered elemental composition. Despite these changes, specific luminescent properties persisted, suggesting a degree of adaptability in the coral calcite. Thermoluminescence (TL) and photoluminescence (PL) analyses revealed that gamma irradiation created new electron traps, maintaining luminescence despite structural disruptions. The study highlights potential risks to coral structural integrity due to radiation while also revealing an inherent resilience in luminescent properties. These findings provide valuable insights into the effects of environmental stressors on coral calcite, informing conservation strategies aimed at preserving coral reefs under changing conditions.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"597-611"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of dosimetric and radiobiological parameters (TCP/NTCP) based on daily CBCT in lung cancer patients.","authors":"Esil Kara, Ayse Hicsonmez, Faruk Zorlu","doi":"10.1007/s00411-025-01164-w","DOIUrl":"10.1007/s00411-025-01164-w","url":null,"abstract":"<p><p>Radiotherapy for non-small-cell lung cancer (NSCLC) requires precise tumour targeting and monitoring of anatomical changes to optimize outcomes. Daily kilovoltage cone-beam computed tomography (kV-CBCT) enables real-time tracking of tumour volume and electron density changes, which may affect dose distribution and radiobiological outcomes, such as Tumour Control Probability (TCP) and Normal Tissue Complication Probability (NTCP). This study evaluated inter-fractional changes in gross tumour volume (GTV) and electron density using kV-CBCT and their impact on dosimetric and radiobiological endpoints to assess the role of CBCT in adaptive radiotherapy. Twenty inoperable NSCLC patients receiving intensity-modulated radiotherapy (IMRT) with a prescribed dose of 60 Gy in 30 fractions were included in this retrospective study. Daily kV-CBCT images were acquired on the 1st, 15th, and 30th fraction to re-contour GTV and measure electron density changes in the GTV and ipsilateral lung (V30 volume, defined as lung volume receiving ≥ 30 Gy excluding GTV). CBCT images were fused with planning CT for dose recalculation using a Hounsfield unit-to-density calibration. Changes in GTV volume, electron density, maximum dose, and volume receiving ≥ 2.1 Gy/fraction were analyzed. TCP and NTCP were calculated using the Equivalent Uniform Dose (EUD) and Lyman-Kutcher-Burman (LKB) models, respectively. Statistical significance was assessed using ANOVA (p < 0.05). GTV volume decreased significantly by 3.4-59.7% by the 30th fraction (p < 0.05). Mean electron density in the GTV reduced by 3.04% at 30 Gy and 5.76% at 60 Gy, while the V30 volume showed reductions of 4.61% and 17.17% at the 15th and 30th fractions, respectively (p < 0.05). These changes resulted in a 1.39% increase in maximum GTV dose and a 7.48% increase in the volume receiving ≥ 2.1 Gy/fraction by the 30th fraction. TCP increased modestly from 81.91 ± 10.25% to 83.4 ± 11.32%, while NTCP rose significantly from 6.64 ± 2.31% to 10.54 ± 1.94% (p < 0.05). Thus, daily kV-CBCT demonstrated significant GTV volume and electron density reductions during NSCLC radiotherapy, leading to dose heterogeneity and increased NTCP. These findings underscore the potential of CBCT as a tool for adaptive radiotherapy to enhance treatment precision and minimize radiation toxicity. Prospective studies with larger cohorts and clinical outcome data are needed to establish thresholds for adaptive replanning.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"377-385"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA sequence-dependent damage by Auger electrons in fibroblast cell: a geant4-DNA study.","authors":"Ali Azizi Ganjgah, Payvand Taherparvar","doi":"10.1007/s00411-026-01204-z","DOIUrl":"10.1007/s00411-026-01204-z","url":null,"abstract":"<p><p>This research investigated the effects of DNA sequence on the single strand breaks (SSBs) and double strand breaks (DSBs) of DNA induced by Auger electron-emitting radionuclides in an atomic model of fibroblast cells using the Geant4-DNA toolkit. For this, two cells (C1 and C2) and their nuclei (N1 and N2), defined as homogeneous ellipsoids of liquid water of unit density, were considered. An atomic DNA model constructed in the Geant4-DNA toolkit was placed inside N1 and N2. While N1 solely consisted of Cytosine-Guanine (C-G) sequences, N2 contained a novel DNA sequence (damage-specific DNA-binding protein 2 (DDB2)), which has not been investigated to date. This sequence includes nucleotide motifs such as C-G, Adenine-Thymine (A-T), Guanine-Cytosine (G-C), and Thymine-Adenine (T-A). The total numbers of direct and indirect SSBs, DSBs, and hybrid DSBs (HDSBs), caused by five widely-used Auger electron-emitting radionuclides, including 99mTc, 111In, 123I, 125I, and 201Tl were quantified at the cellular level. The results show that the total DNA damage, from greatest to least, corresponds to 201Tl, 125I, 123I, 111In, and 99mTc. In addition, incorporating DDB2 base pairs (bp) into the DNA sequences increased the DNA damage by approximately 31% compared to the case with only C–G bp. The findings of the present study indicate that 201Tl and 125I, due to their higher decay yields of sub-1 keV electron emissions (enabling highly localized energy deposition within the DNA strands), are more effective candidates for inducing DNA strand breaks in a single tumour cell compared to 123I, 111In, and 99mTc.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"307-325"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rebuttal to the Correspondence on \"Direct radiation damage to human tooth under IMRT for head and neck cancer: physicochemical evidence supporting a non-salivary mechanism for radiation-related caries\".","authors":"Toru Tamahara","doi":"10.1007/s00411-026-01210-1","DOIUrl":"10.1007/s00411-026-01210-1","url":null,"abstract":"","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"631-633"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and sex- specific dose coefficients to convert ingested ⁹⁰Sr activity into cumulative dose in active marrow.","authors":"E A Shishkina, E I Tolstykh, P A Sharagin, M A Smith, B A Napier","doi":"10.1007/s00411-026-01195-x","DOIUrl":"10.1007/s00411-026-01195-x","url":null,"abstract":"<p><p>Evaluation of active marrow (AM) dose of radiation and associated uncertainty from ingested bone-seeking 90Sr, which may chronically irradiate the AM during the lifetime after intake, is of utmost importance. Consequently, the aim of the present study was to evaluate dose coefficients used to convert radionuclide intakes into dose to AM, which depend on sex, age at intake and time after intake. For this purpose, three tasks were solved. The first, dosimetric modeling was performed to obtain dose factors that convert 90Sr activity concentration in cortical and trabecular bones into the respective dose rates in AM. The second task combined the dosimetric and biokinetic models to obtain age and sex specific dose coefficients. The third task evaluated dose coefficients uncertainties. The first task was solved using the stochastic parametric skeleton dosimetry approach for generation of computational phantoms as well as Monte Carlo simulation of radiation transport. The second task was done assuming a single intake at birth, 1-year, 5- year, 10- year, 13-year, 15 and 24 (adults) years old using the original biokinetic model. Uncertainties were evaluated using Monte Carlo modeling. Skeleton-average dose factors (DFs) for 90Sr in trabecular bone vary in the range of 3.93 × 10− 11 – 5.45 × 10− 11 (Gy s− 1) per (Bq g− 1). Skeleton-average DFs for 90Sr in cortical bone vary in the range of 1.03 × 10− 11 − 2.39 × 10− 11 (Gy s− 1) per (Bq g− 1). Dose coefficients (DCs) (cumulated dose per unit of an intake) may differ by up to 46 times depending on the age at the time of intake and sex. 99% of the total absorbed dose accumulates during ≤ 50 yeas after a single 90Sr intake; 50 years of dose accumulation leads to 2 × 10− 7 Gy Bq− 1 for an adult male to 92 × 10− 7 Gy Bq− 1 for a newborn. The relative uncertainty for DCs are as follows: 50% for intake at age < 10 years old independent of sex; 45% for intake at age equal to 10 years independent of sex and 13 years old male; 40% for female of 13 years old as well as 15 years old and adults independent of sex. The obtained results are suitable for estimation of bone marrow dose accumulated more than two months after ingestion. The implication of age and sex specific DCs is significant to avoid underestimation of both reconstructed and predicted AM doses. In terms of absorbed dose reconstruction, the obtained results improve the accuracy of estimations of radiation risks in epidemiological studies of Urals population that resided on the contaminated territories.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"349-363"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Direct radiation damage to human tooth under IMRT for head and neck cancer\" by Tamahara and Kouketsu.","authors":"Erkan Topkan, Efsun Somay, Sibel Bascil, Ugur Selek","doi":"10.1007/s00411-026-01211-0","DOIUrl":"10.1007/s00411-026-01211-0","url":null,"abstract":"<p><p>We found the article by Tamahara and Kouketsu (Radiat Environ Biophys 2025. https://doi.org/10.1007/s00411-025-01180-w ) interesting because it examined the direct physicochemical effects of therapeutic irradiation on human dental hard tissues as a possible non-salivary cause of radiation-related caries (RRC). The authors investigate a clinically significant and mechanistically fascinating question, utilizing a controlled in vitro approach to analyze radiation-induced modifications in enamel and dentin. The research provides comprehensive information on microhardness, calcium release, collagen autofluorescence, and localized pH variations following irradiation. Nonetheless, specific methodological and interpretation concerns significantly impact the robustness and breadth of the authors’ conclusions, necessitating further scrutiny.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"627-629"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANFSq-Net: Adaptive neuro fuzzy inference system for lung cancer detection and severity level classification using CT image.","authors":"Sudhakar Raju, Peddireddy Veera Venkateswara Rao","doi":"10.1007/s00411-026-01205-y","DOIUrl":"10.1007/s00411-026-01205-y","url":null,"abstract":"<p><p>The high mortality rate of lung cancer worldwide is largely attributed to its late-stage diagnosis. Assessing lung cancer severity promptly plays a vital role in guiding treatment decisions and enhancing patient survival rates. This study introduces an Adaptive Neuro-Fuzzy SqueezeNet (ANFSq-Net) framework for lung cancer detection and severity level classification using Computed Tomography (CT) images. The proposed method integrates the strengths of the Adaptive Neuro-Fuzzy Inference System (ANFIS) and SqueezeNet, supported by fractional calculus (FC) regression, to enhance feature adaptability, reduce computational complexity, and improve learning efficiency. To preprocess the CT images, noise is removed with a bilateral filter, followed by lung lobe segmentation through a Conditional Generative Adversarial Network (CGAN). Key features such as Local Ternary Pattern (LTP), homogeneity, and entropy are extracted for accurate classification of lung cancer into mild, moderate, and severe levels. The ANFSq-Net model achieves excellent performance metrics, including 94.876% accuracy, 96.877% sensitivity, 92.987% specificity, 93.988% precision, and a 95.411% F1-score. It is concluded that the combined application of ANFIS, SqueezeNet, and FC regression enables precise and efficient classification performance.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"519-538"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of KMnO4-modified fly ash sorbent for ²²⁶Ra dose evaluation in bottled mineral waters in Slovakia.","authors":"Veronika Demovics Silliková, Silvia Dulanská, Klára Gebeová, Michal Trnka, Jana Jakubčinová, Ján Pánik","doi":"10.1007/s00411-025-01162-y","DOIUrl":"10.1007/s00411-025-01162-y","url":null,"abstract":"<p><p>Monitoring of ²²⁶Ra in drinking water is critical due to its radiotoxicity and potential health risks. This study presents a novel method for ²²⁶Ra determination in bottled mineral waters using a KMnO₄-modified fly ash sorbent. The sorbent, prepared by manganese dioxide surface modification, demonstrated significantly enhanced radium sorption capacity. Method validation, including linear regression and equivalence tests, confirmed that the modified fly ash sorbent and commercial MnO₂-PAN resin yield statistically equivalent results for ²²⁶Ra determination in mineral waters. Thus, it is concluded that application of the modified sorbent represents a reliable and cost-effective alternative to commercial methods. Application to 20 commercially available Slovak bottled mineral waters revealed ²²⁶Ra activity concentrations corresponding to annual committed effective doses ranging from 1 to 154 µSv/y. While the average dose (41.8 µSv/y) remained well below national and international safety limits, three samples exceeded the Slovak regulatory threshold of 100 µSv/y. These findings emphasize the need for ongoing monitoring and demonstrate the suitability of the KMnO₄-modified fly ash sorbent for routine radiological quality control of bottled mineral waters.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"577-585"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145506608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons learned on stakeholder engagement in radiation protection, and communication and dissemination of results from the radonorm project.","authors":"Nadja Železnik, Barbara Horvat, Warren John, Paul N Schofield","doi":"10.1007/s00411-025-01184-6","DOIUrl":"10.1007/s00411-025-01184-6","url":null,"abstract":"<p><p>Effectively addressing radon and NORM exposure requires not just scientific progress but a strategic, transdisciplinary approach to transferring knowledge into practice through stakeholder engagement and policy integration. Therefore, to maximise the impact and sustainability of the radiation protection outputs created in the RadoNorm project, an integrated and participatory communication framework was designed. The framework enabled the flow of knowledge across scientific, policy, and public domains through the tailored outreach tools, while wide visibility was ensured through digital platforms, and meaningful public involvement through initiatives such as the Citizen Science Incubator and the European Radon Behavioural Atlas. The RadoNorm project also elevated engagement of stakeholders in the research process from end-users to contributors by shifting the paradigm from one-way dissemination to co-creation, leading to enhanced trust, relevance, and long-term usability of results. RadoNorm's replicable model for \"how complex research can be translated into societal value\", i.e., fostering inclusion, transparency, and ethically responsible science communication, should be an integral part of future projects. Namely, by full-scale incorporation of communication and engagement activities developed in the RadoNorm project, by ensuring that all data are openly available in repositories, like the STORE database, and by utilisation of the interdisciplinary teams that incorporate social and behavioural expertise, the usability and sustainability of the created results in any future projects are ensured.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"121-133"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146087083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on seasonal variation of indoor radon, thoron and their progeny in Thoubal District, Manipur, India.","authors":"Sunita Khangembam, Rosaline Mishra, B K Sahoo, Sumitra Phanjoubam","doi":"10.1007/s00411-025-01192-6","DOIUrl":"10.1007/s00411-025-01192-6","url":null,"abstract":"<p><p>The naturally occurring radioactive gases radon (222Rn), thoron (220Rn) and their decay products contribute approximately 50% of the ionizing radiation dose received by the human population. The present paper reports on a systematic approach to estimate the indoor radon, thoron and their progeny concentration along with the inhalation dose in the Thoubal district of Manipur, a north eastern state of India. Sixty dwellings of different types such as mud, concrete and semi pucca houses have been selected from 13 different villages of the district after conducting a preliminary survey of outdoor gamma exposure rate using a gamma survey meter. Pin hole-based twin cup dosimeters and deposition-based direct radon/thoron progeny sensors (DRPS/DTPS) were used for time integrated passive measurements of radon/thoron concentration and the progeny concentrations, respectively. The dosimeters were deployed in the selected houses during three different seasons comprising of four months viz., summer, winter and rainy season. The observed values were used to determine the total annual effective inhalation dose. Seasonal variation was observed in the measured parameters with winter season showing the highest radon and thoron concentrations. Variation was also observed in the different types of dwellings. This study is the first reporting the results of such measurements in this region and may serve as a foundation for further research and investigations.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"175-185"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}