Radiation and Environmental Biophysics最新文献

{"title":"Quantitative stakeholder-driven assessment of radiation protection issues via a PIANOFORTE online survey.","authors":"Veronika Groma, Balázs Madas, Florian Rauser, Mandy Birschwilks, Andreas Blume, Almudena Real, Rein Murakas, Boguslaw Michalik, Isabel Paiva, Tone-Mette Sjømoen, Alan H Tkaczyk, Jelena Mrdakovic Popic","doi":"10.1007/s00411-024-01084-1","DOIUrl":"10.1007/s00411-024-01084-1","url":null,"abstract":"<p><p>To enhance stakeholder engagement and foster the inclusion of interests of citizens in radiation protection research, a comprehensive online survey was developed within the framework of the European Partnership PIANOFORTE. This survey was performed in 2022 and presented an opportunity for a wide range of stakeholders to voice their opinions on research priorities in radiation protection for the foreseeable future. Simultaneously, it delved into pertinent issues surrounding general radiation protection. The PIANOFORTE e-survey was conducted in the English language, accommodating a diverse range of participants. Overall, 440 respondents provided their insights and feedback, representing a broad geographical reach encompassing 29 European countries, as well as Canada, China, Colombia, India, and the United States. To assess the outcomes, the Positive Matrix Factorization numerical model was applied, in addition to qualitative and quantitative assessment of individual responses, enabling the discernment of four distinct stakeholder groups with varying attitudes. While the questionnaire may not fully represent all stakeholders due to the limited respondent pool, it is noteworthy that approximately 70% of the participants were newcomers to comparable surveys, demonstrating a proactive attitude, a strong willingness to collaborate and the necessity to continuously engage with stakeholder groups. Among the individual respondents, distinct opinions emerged particularly regarding health effects of radiation exposure, medical use of radiation, radiation protection of workers and the public, as well as emergency and recovery preparedness and response. In cluster analysis, none of the identified groups had clear preferences concerning the prioritization of future radiation protection research topics.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"307-322"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-made low-cost dosemeter for photon dose measurements in radiobiological experiments and for education in the field of radiation sciences.","authors":"August Blomgren, Adrianna Tartas, Prabodha Kumar Meher, Samuel Silverstein, Andrzej Wojcik, Beata Brzozowska","doi":"10.1007/s00411-024-01076-1","DOIUrl":"10.1007/s00411-024-01076-1","url":null,"abstract":"<p><p>Reliable dosimetry systems are crucial for radiobiological experiments either to quantify the biological consequences of ionizing radiation or to reproduce results by other laboratories. Also, they are essential for didactic purposes in the field of radiation research. Professional dosemeters are expensive and difficult to use in exposure facilities with closed exposure chambers. Consequently, a simple, inexpensive, battery-driven dosemeter was developed that can be easily built using readily available components. Measurements were performed to validate its readout with photons of different energy and dose rate and to demonstrate the applicability of the dosemeter. It turned out that the accuracy of the dose measurements using the developed dosemeter was better than 10%, which is satisfactory for radiobiological experiments. It is concluded that this dosemeter can be used both for determining the dose rates of an exposure facility and for educational purposes.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"395-404"},"PeriodicalIF":1.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Administration of low dose intranasal ketamine exerts a neuroprotective effect on whole brain irradiation injury model in wistar rats","authors":"Gökhan Yaprak, Nilsu Çini, Özüm Büke Atasoy, Yiğit Uyanikgil, Mumin Alper Erdogan, Oytun Erbaş","doi":"10.1007/s00411-024-01085-0","DOIUrl":"https://doi.org/10.1007/s00411-024-01085-0","url":null,"abstract":"<p>Exposure to ionizing radiation leads to oxidative stress and neuroinflammation, resulting in neurocognitive impairments. Adverse effects are also associated with glutamate-induced excitotoxicity due to alterations in the composition of glutamate receptors. Ketamine, which is a noncompetitive NMDA glutamate receptor antagonist, has been stated to exert an impact on glutamatergic receptors. This study aims to reveal the possible alleviating or preventive effects of ketamine, which maintains glutamate homeostasis and decreases neurodegeneration, in a radiation-induced neurotoxicity model. Twenty-one female Wistar Queryrats were included in the study and 14 of these underwent whole brain irradiation (IR) with a 20 Gray single dose. Animals were allocated into three groups. Group 1: Normal control; Group 2: Placebo / IR + Saline; Group 3: IR + Ketamine. Ketamine was administered in addition to IR to rats in Group 3. The one-way ANOVA statistical test was used to compare groups. The value of <i>p</i> &lt; 0.05 was considered statistically significant. When administered in addition to irradiation, ketamine treatment significantly increased scores in the three-chamber sociability test, open field test, and passive avoidance learning test. It also raised neuron counts in the hippocampal CA1 and CA3 regions as well as in Purkinje cells, and enhanced levels of brain-derived neurotrophic factor and tyrosine receptor kinase-B. Furthermore, ketamine administration resulted in decreased levels of glial fibrillary acidic protein, malondialdehyde, and tumor necrosis factor-alpha, indicating a reduction in neuroinflammation and oxidative stress. Ketamine exerted a significant protective impact on radiation-induced neurocognitive impairments and enhanced social-memory capacity by reducing neuronal loss, oxidative stress, and neuroinflammation. Our findings suggest that ketamine is beneficial in the treatment or prevention of neurodegeneration via the regulation of the BDNF/TrkB signaling pathway besides decreasing neuroinflammation and blocking NMDA receptors.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":"14 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141780731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of simultaneous integrated boost and sequential boost radiotherapy in node-positive cervical cancer: dosimetric and radiobiological considerations.","authors":"Ritusha Mishra, Shreya Singh, Ganesh Patel, Abhijit Mandal, Himanshu Mishra, Ankita Pandey, Bajarang Bahadur, Pramod Kumar Singh, Shikha Sachan, Mallika Tewari","doi":"10.1007/s00411-024-01069-0","DOIUrl":"10.1007/s00411-024-01069-0","url":null,"abstract":"<p><p>For locally advanced cervical cancer, the standard therapeutic approach involves concomitant chemoradiation therapy, supplemented by a brachytherapy boost. Moreover, an external beam radiotherapy (RT) boost should be considered for treating gross lymph node (LN) volumes. Two boost approaches exist with Volumetric Intensity Modulated Arc Therapy (VMAT): Sequential (SEQ) and Simultaneous Integrated Boost (SIB). This study undertakes a comprehensive dosimetric and radiobiological comparison between these two boost strategies. The study encompassed ten patients who underwent RT for cervical cancer with node-positive disease. Two sets of treatment plans were generated for each patient: SIB-VMAT and SEQ-VMAT. Dosimetric as well as radiobiological parameters including tumour control probability (TCP) and normal tissue complication probability (NTCP) were compared. Both techniques were analyzed for two different levels of LN involvement - only pelvic LNs and pelvic with para-aortic LNs. Statistical analysis was performed using SPSS software version 25.0. SIB-VMAT exhibited superior target coverage, yielding improved doses to the planning target volume (PTV) and gross tumour volume (GTV). Notably, SIB-VMAT plans displayed markedly superior dose conformity. While SEQ-VMAT displayed favorable organ sparing for femoral heads, SIB-VMAT appeared as the more efficient approach for mitigating bladder and bowel doses. TCP was significantly higher with SIB-VMAT, suggesting a higher likelihood of successful tumour control. Conversely, no statistically significant difference in NTCP was observed between the two techniques. This study's findings underscore the advantages of SIB-VMAT over SEQ-VMAT in terms of improved target coverage, dose conformity, and tumour control probability. In particular, SIB-VMAT demonstrated potential benefits for cases involving para-aortic nodes. It is concluded that SIB-VMAT should be the preferred approach in all cases of locally advanced cervical cancer.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"297-306"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum reporting standards about dosimetry of radiation sources used in radiation research studies.","authors":"Andrzej Wojcik, Isabelle Thierry-Chef, Anna A Friedl, Werner Rühm","doi":"10.1007/s00411-024-01063-6","DOIUrl":"10.1007/s00411-024-01063-6","url":null,"abstract":"<p><p>The necessity of precise dosimetry and its documentation in research is less obvious than in medicine and in radiological protection. However, in radiation research, results can only be validated if experiments were carried out with sufficient precision and described with sufficient details, especially information regarding dosimetry. In order to ensure this, an initiative was launched to establish reproducible dosimetry reporting parameters in published studies. Minimum standards for reporting radiation dosimetry information were developed and published in parallel in the International Journal of Radiation Biology and Radiation Research. As editors of Radiation and Environmental Biophysics, we support this initiative and reproduce the agreed minimum irradiation parameters that should be reported in publications on radiation biology submitted to our journal.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"181-183"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usability of sand samples in TL Radiation Dosimetry.","authors":"Waiel E Madcour, Amany Y Shahein, Hanaa S Hafez","doi":"10.1007/s00411-024-01070-7","DOIUrl":"10.1007/s00411-024-01070-7","url":null,"abstract":"<p><p>This study investigated natural sand thermoluminescence (TL) response as a possible option for retrospective high-dose gamma dosimetry. The natural sand under investigation was collected from six locations with selection criteria for sampling sites covering the highest probability of exposure to unexpected radiation on the Egyptian coast. Dose-response, glow curve, chemical composition, linearity, and fading rate for different sand samples were studied. Energy Dispersive X-ray Spectroscopy (EDX) analysis revealed differences in chemical composition among the various geological sites, leading to variations in TL glow curve intensity. Sand samples collected from Ras Sedr, Taba, Suez, and Enshas showed similar TL patterns, although with different TL intensities. Beach sands of Matrouh and North Coastal with a high calcite content did not show a clear linear response to the TL technique, in the dose range of 10 Gy up to 30 kGy. The results show that most sand samples are suitable as a radiation dosimeter at accidental levels of exposure. It is proposed here that for high-dose gamma dosimetry with doses ranging from 3 to 10 kGy, a single calibration factor might be enough for TL measurements using sand samples. However, proper calibration might allow dose assessment for doses even up to 30 kGy. Most of the investigated sand samples had nearly stable fading rates after seven days of storage. The Ras Sedr sands sample was the most reliable for retrospective dose reconstruction.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"195-202"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of stereotactic high-resolution detectors for stereotactic body radiotherapy: comparative analysis between myQA® SRS and Gafchromic EBT-XD films","authors":"Dinesan Chinnaiya, Gopinath Mudhana","doi":"10.1007/s00411-024-01071-6","DOIUrl":"https://doi.org/10.1007/s00411-024-01071-6","url":null,"abstract":"<p>The study aimed to evaluate dosimetry systems used for stereotactic body radiotherapy (SBRT), specifically 2D array dosimetry and film dosimetry systems, for exploring their characteristics and clinical suitability. For this, high-resolution myQA SRS detectors and Gafchromic EBT-XD films were employed. Film analysis included net optical density (OD) values depending on energy, dose rate, scanner orientation, scanning side, and post-exposure growth. For myQA SRS, signal values were evaluated in terms of dose rate (400–1400 MU/min) and angular dependence (0–180° at 30° intervals) along with couch angles of 0°, 45°, and 90°. Pre-treatment verification included 32 SBRT patients for whom myQA SRS results were compared with those obtained with Gafchromic EBT-XD films. Analysis revealed less than 1% deviation in net OD for energy and dose rate dependence. Scanner orientation caused 2.5% net OD variation, with minimal differences between film front and back scan orientations (variance &lt; 1.0%). A rapid OD rise occurred within six hours post-exposure, followed by gradual increase. The myQA SRS detector showed − 3.7% dose rate dependence (400 MU/min), while the angular dependence at 90° was − 26.7%. A correction factor effectively reduced these differences to &lt; 1%. For myQA SRS, gamma passing rates were—93.6% (2%/1 mm), while those for EBT-XD films were—92.8%. Improved rates were observed with 3%/1 mm: for myQA SRS—97.9%, and for EBT-XD film—98.16%. In contrast, for 2%/2 mm with 10% threshold, for myQA SRS—97.7% and for EBT-XD film—98.97% were obtained. It is concluded that both myQA SRS detectors and EBT-XD films are suitable for SBRT pre-treatment verification, ensuring accuracy and reliability. However, myQA SRS detectors are preferred over EBT-XD film due to the fact that they offer real-time measurements and user-friendly features.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":"45 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140835008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of re-irradiation on the chemical and morphological properties of permanent teeth","authors":"Thais Tedeschi dos Santos, Vicente Silva Mattos, Kelly Fernanda Molena, Francisco Wanderley Garcia de Paula-Silva, Harley Francisco de Oliveira, Juliana Jendiroba Faraoni, Paulo Nelson-Filho, Jarbas Caiado de Castro Neto, Regina Guenka Palma-Dibb, Alexandra Mussolino de Queiroz","doi":"10.1007/s00411-024-01068-1","DOIUrl":"https://doi.org/10.1007/s00411-024-01068-1","url":null,"abstract":"<p>This study aimed to assess the in vitro effects of re-irradiation on enamel and dentin properties, simulating head and neck cancer radiotherapy retreatment. Forty-five human permanent molars were classified into five groups: non-irradiated; irradiated 60 Gy, and re-irradiated with doses of 30, 40, and 50 Gy. Raman spectroscopy, scanning electron microscopy (SEM), and energy dispersive x-ray spectroscopy (EDS) were employed for analysis. Raman spectroscopy assessed intensity, spectral area, and specific peaks comparatively. Statistical analysis involved Kolmogorov–Smirnov and One-Way ANOVA tests, with Tukey’s post-test (significance level set at 5%). Significant changes in irradiated, non-irradiated, and re-irradiated enamel peaks were observed, including phosphate (438 nm), hydroxyapatite (582 nm), phosphate (960 nm), and carbonate (1070 nm) (<i>p</i> &lt; 0.05). Re-irradiation affected the entire tooth (<i>p</i> &gt; 0.05), leading to interprismatic region degradation, enamel prism destruction, and hydroxyapatite crystal damage. Dentin exhibited tubule obliteration, crack formation, and progressive collagen fiber fragmentation. EDX revealed increased oxygen percentage and decreased phosphorus and calcium post-reirradiation. It is concluded that chemical and morphological changes in irradiated permanent teeth were dose-dependent, exacerbated by re-irradiation, causing substantial damage in enamel and dentin.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":"40 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of nuclear fragmentations in high energy transfers to a micro-object exposed to primary space radiation","authors":"S. N. Fedotov, V. V. Kushin","doi":"10.1007/s00411-024-01064-5","DOIUrl":"https://doi.org/10.1007/s00411-024-01064-5","url":null,"abstract":"<p>This paper describes events of anomalously high energy transfer to a micro-object by fragments of nuclei generated in nuclear interactions in the environment on board a spacecraft in flight in low-Earth orbit. An algorithm has been developed that allows for the calculation of the absorbed energy from one or more fragments - products of nuclear interaction. With this algorithm the energy distributions for a spherical micro-volume in an aqueous medium were calculated. And the resulting absorbed energy spectra from nuclear fragments and from primary cosmic rays were compared. The role of nuclear interactions in events of large energy transfers in micro-objects in the field of primary cosmic radiation has been evaluated. The calculations performed in this study showed that the energy in a micro-volume from nuclear events can be several times higher compared to the energy imparted by primary space radiation.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":"162 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The activity of ²¹⁰Pb in cigarette smoked in Kazakhstan.","authors":"Yuliya Zaripova, Vyacheslav Dyachkov, Mirgul Bigeldiyeva, Alexandr Yushkov","doi":"10.1007/s00411-023-01048-x","DOIUrl":"10.1007/s00411-023-01048-x","url":null,"abstract":"<p><p>The radon decay product ²¹⁰Pb is a known component of tobacco. In this study, the activity concentration of ²¹⁰Pb in the most popular cigarette brands (six samples) for Kazakhstan consumers was determined by beta spectrometry. The activity levels of ²¹⁰Pb ranged between 2.69 ± 0.27 and 27.42 ± 2.74 mBq per cigarette. Higher activity concentrations for ²¹⁰Pb were found in Sample No.4 and showed an excess of the world average by 1.8 times. The average activity concentrations of ²¹⁰Pb in cigarette tobacco were 10.42 ± 1.04 mBq cig^-1. The daily activities inhaled in the lungs of a smoker, and the resulting effective doses due to cigarette smoking were calculated. Effective doses per year due to cigarette smoking were calculated assuming that 42.13% of the ²¹⁰Pb in tobacco were retained in the lungs of the smokers. It is concluded that for a smoker in Kazakhstan, the average effective dose ranges from 9.1 ± 0.9 μSv/year to 92.8 ± 9.3 μSv/year for a cigarette consumption of one pack of cigarettes per day. The results indicate that the annual effective doses from inhalation of ²¹⁰Pb due to smoking one pack of cigarettes per day are from 7 to 58 times (for different types of cigarettes) greater than the annual effective doses from ingestion of radionuclides via the diet.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":" ","pages":"125-131"},"PeriodicalIF":1.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}