Reviews in cardiovascular medicine最新文献

{"title":"Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs.","authors":"Yuehan Wang, Yingzhuo Wang, Weifang Zhang","doi":"10.31083/RCM25781","DOIUrl":"10.31083/RCM25781","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) is a life-threatening condition characterized by right ventricular (RV) remodeling, which is a major determinant of patient survival. The progression of right ventricular remodeling is significantly influenced by mitochondrial dysfunction, providing profound insights into vascular health and cardiovascular risk. In this review, we discuss the molecular targets, pathophysiological characteristics, and potential mechanisms underlying mitochondrial dysfunction in PH, encompassing disturbances in mitochondrial dynamics, inflammation, and dysregulation of mitochondrial energy metabolism. Finally, we review the primary therapeutic targets currently utilized to address cardiac dysfunction resulting from mitochondrial damage. Hopefully, this might inspire novel approaches to the management of cardiovascular disorders.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"25781"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Metabolic Syndrome Criteria Considering Cardio-Ankle Vascular Index (CAVI) and A Body Shape Index (ABSI): Implications for Kidney Risk.","authors":"Daiji Nagayama, Yasuhiro Watanabe, Kohji Shirai, Masahiro Ohira, Atsuhito Saiki","doi":"10.31083/RCM26583","DOIUrl":"10.31083/RCM26583","url":null,"abstract":"<p><p>Waist circumference (WC), an abdominal obesity index in the current metabolic syndrome (MetS) criteria, may not adequately reflect visceral fat accumulation. This brief review aims to examine the clinical significance of utilizing a body shape index (ABSI), a novel abdominal obesity index, to modify the MetS criteria, considering the predictive ability for vascular dysfunction indicated by the cardio-ankle vascular index (CAVI), as well as kidney function decline. First, the relationship of CAVI with kidney function is presented. Next, whether modification of the MetS diagnostic criteria by replacing the current high waist circumference (WC-MetS) with high ABSI (ABSI-MetS) improves the predictive ability for vascular and kidney dysfunction is discussed. Although limited to Asian populations, several cross-sectional and longitudinal studies support the relationship of CAVI with kidney function. Increased CAVI is associated with kidney function decline, and the CAVI cutoff for kidney outcomes is considered to be 8-9. In urban residents who underwent health screening, an increase in ABSI, but not body mass index (BMI) or WC, was associated with increased CAVI, suggesting that ABSI reflects vasoinjurious body composition. In several cross-sectional studies, ABSI-MetS was superior to WC-MetS in identifying individuals with increased CAVI. Furthermore, the predictive ability of ABSI-MetS in assessing kidney function decline was enhanced only in individuals with MetS, as determined in a longitudinal analysis. Using WC as a major criterion for MetS diagnosis may not adequately identify individuals at risk of vascular dysfunction and kidney function decline. This review shows that this problem may be solved by replacing WC with ABSI. Future research should explore whether ABSI-MetS also predicts cardiovascular events, and whether therapeutic intervention that reduces ABSI improves clinical outcomes.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26583"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Association between Systolic Blood Pressure Time in Target Range and Cardiovascular Outcomes: A Post-Hoc Analysis of the SPRINT Trial.","authors":"Yuekun Zhang, Wen Zheng, Chao Jiang, Wen Hao, Wei Gong, Yan Yan, Xiao Wang, Changsheng Ma, Shaoping Nie","doi":"10.31083/RCM26262","DOIUrl":"10.31083/RCM26262","url":null,"abstract":"<p><strong>Background: </strong>Systolic blood pressure time in target range (SBP TTR) is a novel metric for blood pressure control. Previous studies have demonstrated an inverse association between SBP TTR and risks of cardiovascular events, but sex differences have never been reported. This study aims to investigate the sex-specific differences in the relationship using data from the Systolic Blood Pressure Intervention Trial (SPRINT).</p><p><strong>Methods: </strong>This post hoc analysis included 8822 SPRINT participants with at least three follow-up systolic blood pressure (SBP) measurements within the first three months. SBP TTR was calculated using the Rosendaal method of linear interpolation. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE). Cox proportional hazards models and restricted cubic splines (RCS) were used to assess the association between SBP TTR and cardiovascular events.</p><p><strong>Results: </strong>Women accounted for 35.3% with a mean age of 68.6 ± 9.5 years, having a higher body mass index (<i>p</i> = 0.007) and a lower SBP TTR compared to men (<i>p</i> < 0.001). In the overall population and in women, each standard deviation (SD) increase in SBP TTR was associated with a reduced risk of MACCE (adjusted hazard ratio (HR) 0.89; 95% confidence interval (CI) 0.82-0.97; <i>p</i> = 0.007, and adjusted HR 0.85; 95% CI 0.74-0.99; <i>p</i> = 0.039, respectively) and acute decompensated heart failure (adjusted HR 0.86; 95% CI 0.73-0.99; <i>p</i> = 0.047, and adjusted HR 0.68; 95% CI 0.51-0.92; <i>p</i> = 0.011, respectively), while this was not observed in men. RCS indicated a similar trend in men only when SBP TTR exceeded 39%. Additional adjustments for mean SBP and SBP variability yielded similar outcomes.</p><p><strong>Conclusions: </strong>The study demonstrates that in women, a higher SBP TTR is associated with a reduced risk of MACCE and acute decompensated heart failure, while in men, a similar trend is observed only when SBP TTR is higher, underscoring the necessity of considering sex differences in personalized blood pressure management strategies.</p><p><strong>Clinical trial registration: </strong>NCT01206062, https://www.clinicaltrials.gov/expert-search?term=NCT01206062.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26262"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial DNA Polymorphisms of Peripheral Blood Mononuclear Cells Associated with Sustained Ventricular Tachycardia in Patients with Cardioverter-Defibrillator Implantation Indications.","authors":"Tariel Atabekov, Viacheslav Korepanov, Sergey Krivolapov, Mikhail Khlynin, Sergey Afanasiev, Maria Golubenko, Roman Batalov, Sergey Popov","doi":"10.31083/RCM26744","DOIUrl":"10.31083/RCM26744","url":null,"abstract":"<p><strong>Background: </strong>Mitochondrial dysfunction in myocardium cells has been implicated in arrhythmogenesis, including ventricular tachycardia (VT). A carriage of point mitochondrial DNA (mtDNA) polymorphisms may contribute to the risk of certain arrhythmias. Therefore, it is hypothesized that mtDNA genotype could predict the risk of sustained VT (_SVT). We aimed to explore whether specific mtDNA polymorphisms of peripheral blood mononuclear cells (PBMC) can serve as biomarkers for predicting the risk of _SVT in patients with indications for an implantable cardioverter-defibrillator (ICD).</p><p><strong>Methods: </strong>A total of 122 patients with ICD implantation indications who underwent transthoracic echocardiography (TTE) were enrolled in the study. Total DNA from PBMC was isolated using the phenol-chloroform extraction method. Genotyping of mtDNA polymorphisms A2706G, G3010A and G9055A was performed using restriction fragment length polymorphism analysis. Correlations between clinical parameters and mtDNA polymorphisms with _SVT registered prior to ICD implantation were evaluated. Based on our data, we developed a risk model for _SVT.</p><p><strong>Results: </strong>Prior to ICD implantation, 70 (56.6%) patients had _SVT (1st group) and 52 (43.4%) patients did not have _SVT (2nd group). Patients with _SVT were significantly older than patients without _SVT (66.9 ± 9.9 year vs. 59.5 ± 10.6 year, <i>p</i> < 0.001), had a lower value estimated glomerular filtration rate (_eGFR) (65.7 ± 19.7 mL/min/1.73 m² vs. 77.9 ± 16.1 mL/min/1.73 m², <i>p</i> < 0.001) and less frequently had A2706G mtDNA polymorphism (55.7% vs. 76.9%, <i>p</i> = 0.015). According to the multivariable logistic regression, age (odds ratio (OR) = 1.055, 95% confidence interval (CI) 1.009-1.103, <i>p</i> = 0.017), _eGFR (OR = 0.974, 95% CI 0.949-0.999, <i>p</i> = 0.041) and absence of A2706G mtDNA polymorphism (OR = 0.335, 95% CI 0.141-0.797, <i>p</i> = 0.013) were independently associated with the _SVT. We constructed a logistic equation with calculation of the cut-off value. The discriminative ability of the receiver operating characteristic curve (area under the curve) was 0.761 (95% confidence interval 0.675-0.833; sensitivity 65.71%; specificity 76.92%).</p><p><strong>Conclusions: </strong>In patients with ICD implantation indications, a carriage of mtDNA polymorphism A2706G is associated with _SVT. Our risk model including age, _eGFR and absence of A2706G mtDNA substitution was able to distinguish patients with _SVT. Further investigations of their predictive significance are warranted.</p><p><strong>Clinical trial registration: </strong>NCT03667989 (https://clinicaltrials.gov/study/NCT03667989).</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26744"},"PeriodicalIF":1.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Adverse Outcomes in Connective Tissue Disease-Associated Pulmonary Hypertension.","authors":"Gayane Matusov, Maryam Shams, Karim Ibrahim, Areg Hovsepyan, Yuri Matusov","doi":"10.31083/RCM26877","DOIUrl":"10.31083/RCM26877","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) is a rare, life-threatening condition that can be associated with connective tissue disease (CTD). The incidence and prevalence of PH in CTD varies by disease, whereby certain disease manifestations are particularly associated with PH; nonetheless, once present, PH is almost uniformly a major driver of adverse outcomes. In this paper, the authors review the published literature on major CTDs, including systemic sclerosis and systemic lupus erythematosus, and summarize the risk factors for developing PH in each disease and risk factors for adverse outcomes and mortality among patients with CTD-PH. This review highlights the need for early diagnosis of PH in CTD and the impact of PH overlap syndromes on patient outcomes, providing the practicing clinician with a practical summary of CTD-PH.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26877"},"PeriodicalIF":1.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Real-Time Computer-Aided Diagnosis System for Coronary Heart Disease Prediction Using Clinical Information.","authors":"Huiqian Tao, Chengfeng Wang, Hongxia Qi, Hui Li, Yane Li, Ruifei Xie, Yuzhu Dai, Qingyang Sun, Yingqiang Zhang, Xinyi Yu, Tingting Shen","doi":"10.31083/RCM26204","DOIUrl":"10.31083/RCM26204","url":null,"abstract":"<p><strong>Background: </strong>It is important to establish a coronary heart disease (CHD) prediction model with high efficiency and precision for early diagnosis of CHD using clinical information. While existing deep learning-based CHD prediction models possess the limitations of large datasets and long training time, existing machine learning-based CHD prediction models have the limitations of low accuracy and robustness, which are unsuitable for clinical application. This study aimed to design a fast and high-precision intelligent model using clinical information to predict CHD.</p><p><strong>Methods: </strong>Five public datasets, including 303, 293, 303, 200, and 123 patients with 55, 14, 14, 14, and 14 attributes, respectively, were used for model training and testing. After data preprocessing, the singular value decomposition method was utilized to extract features to build the CHD prediction model. Then, the CHD prediction model was established using the 5-fold cross-validation method with a multilayer perceptron approach.</p><p><strong>Results: </strong>Results show that the established model performs better on the total dataset than the other models we built in this study. This machine learning-based CHD prediction model achieved an improved area under the curve (AUC<i>)</i> of 99.10%, with 96.63% accuracy, 96.50% precision, 97.4% recall, and 97.0% <i>F</i> ₁-score on the total dataset.</p><p><strong>Conclusions: </strong>This high precision and efficiency achieved by the proposed model on different datasets would be significant for the prediction of CHD for medical and clinical diagnosis purposes.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26204"},"PeriodicalIF":1.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Values of the CatLet© Angiographic Scoring System for 30-Day Cardiac Mortality in Patients after Primary Percutaneous Coronary Intervention.","authors":"Chenjie Zhang, Wenhui Liang, Zongliang Yu, Yongming He","doi":"10.31083/RCM28198","DOIUrl":"10.31083/RCM28198","url":null,"abstract":"<p><strong>Background: </strong>The Coronary Artery Tree Description and Lesion Evaluation (CatLet©) angiographic scoring system is a newly developed tool to predict the long-term clinical outcomes for patients with acute myocardial infarction (AMI). This study aimed to evaluate the predictive value of this novel angiographic scoring system for cardiac mortality in AMI patients within 30 days of primary percutaneous coronary intervention (pPCI) in AMI patients.</p><p><strong>Methods: </strong>Patients with AMI undergoing pPCI were consecutively enrolled between January 2012 and July 2013. The CatLet© score was calculated for all the lesions in the non-occlusive status and were tertile partitioned into three groups: CatLet-low ≤14 (N = 124), CatLet-mid 14-22 (N = 82), and CatLet-top ≥22 (N = 102). The primary endpoint was cardiac mortality at 30 days after the procedure. Survival curves were generated using the Kaplan-Meier method, and survival rates among the CatLet© score tertiles were compared using the Log-rank test. Furthermore, Cox regression analysis was performed to identify the associations between the predictors and clinical outcomes.</p><p><strong>Results: </strong>A total of 308 patients were included in the final analysis. The included patients were followed up for 30 days, with 19 (6.17%) cardiac death. Kaplan-Meier curves indicated that the CatLet-top tertile exhibited a significant increase in the risk of cardiac mortality when compared with the low and mid tertiles (<i>p</i> for trend <0.01); the CatLet© score remained an independent predictor of 30-day cardiac mortality in AMI patients after adjusting for clinical variables (HR (95% CI): 6.13 (1.29-29.17); <i>p</i> < 0.01). The multivariable analysis demonstrated that a per 1 unit increase in CatLet© score was associated with a 1.04 (1.01-1.06)-fold increased risk of cardiac death. The area under the receiver operating characteristic (ROC) curve (AUC) statistic for the CatLet© score was 0.80 (95% CI, 0.69-0.91), with a good calibration (χ² = 12.92; <i>p</i> = 0.12).</p><p><strong>Conclusion: </strong>The CatLet© score can be used to predict the short-term cardiac death in AMI patients. A CatLet© score ≥22 or ≥11 myocardial segments involved relative to the total 17 segments (the score divided by 2), including culprit or non-culprit vessels, accounting for 65% (11/17) of left ventricle mass involved, is significantly associated with poor prognosis. The current study has extended the application of the CatLet© score in clinical practice.</p><p><strong>Clinical trial registration: </strong>ChiCTR-POC-17013536. Registered 25 November, 2017, https://www.chictr.org.cn/showproj.html?proj=22814.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"28198"},"PeriodicalIF":1.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Utility of the 4S-AF Scheme in Predicting Atrial Fibrillation Recurrence after Radiofrequency Catheter Ablation.","authors":"Naiyuan Cui, Haiwei Li, Weiping Sun, Zefeng Wang, Zhongyu Yuan, Botao Zhu, Yutong Liu, Huanfu Liu, Yongquan Wu, Xiaoping Zhang","doi":"10.31083/RCM26318","DOIUrl":"10.31083/RCM26318","url":null,"abstract":"<p><strong>Background: </strong>The 4S-AF scheme, which comprises four domains related to atrial fibrillation (AF), stroke risk (St), symptom severity (Sy), severity of AF burden (Sb), and substrate (Su), represents a novel approach for structurally characterizing AF. This study aimed to assess the clinical utility of the scheme in predicting AF recurrence following radiofrequency catheter ablation (RFCA).</p><p><strong>Methods: </strong>We prospectively enrolled 345 consecutive patients with AF who underwent initial RFCA between January 2019 and December 2019. The 4S-AF scheme score was calculated and used to characterize AF. The primary outcome assessed was AF recurrence after RFCA, defined as any documented atrial tachyarrhythmia episode lasting at least 30 seconds.</p><p><strong>Results: </strong>In total, 345 patients (age 61 (interquartile range (IQR): 53-68) years, 34.2% female, 70.7% paroxysmal AF) were analyzed. The median duration of AF history was 12 (IQR: 3-36) months, and the median number of comorbidities was 2 (IQR: 1-3), and 157 (45.5%) patients had left atrial enlargement. During a median follow-up period of 28 (IQR: 13-37) months, AF recurrence occurred in 34.4% of patients. After eliminating the Sy and St domains, both the 4S-AF scheme (hazard ratio (HR) 1.38, 95% confidence interval (CI): 1.19-1.59, <i>p</i> < 0.001) and severity of burden and substrate of atrial fibrillation (2S-AF) scheme scores (HR 1.59, 95% CI: 1.33-1.89, <i>p</i> < 0.001) were independent predictors of AF recurrence following RFCA. For each domain, we found that the independent predictors were Sb (HR 1.84, 95% CI: 1.25-2.72, <i>p</i> = 0.002) and Su (HR 1.71, 95% CI: 1.36-2.14, <i>p</i> < 0.001). Furthermore, the 4S-AF (area under the curve (AUC) 65.2%, 95% CI: 59.3-71.1) and 2S-AF scheme score (AUC 66.2%, 95% CI: 60.2-72.1) had a modest ability to predict AF recurrence after RFCA.</p><p><strong>Conclusions: </strong>The novel 4S-AF scheme is feasible for evaluating and characterizing AF patients who undergo RFCA. A higher 4S-AF scheme score is independently associated with AF recurrence after RFCA. However, the ability of the 4S-AF scheme to discriminate between patients at high risk of recurrence was limited.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26318"},"PeriodicalIF":1.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderating Role of Anemia on the Association between Blood Urea Nitrogen and Atherosclerotic Cardiovascular Disease in Hypertension.","authors":"Qianqian Yu, Haitao Yu","doi":"10.31083/RCM26245","DOIUrl":"10.31083/RCM26245","url":null,"abstract":"<p><strong>Background: </strong>Anemia or blood urea nitrogen (BUN) are both associated with atherosclerotic cardiovascular disease (ASCVD) in hypertension (HTN). However, the relationship between anemia, BUN, and ASCVD remains unclear in HTN. This study aimed to investigate the relationship between BUN, anemia, and ASCVD in HTN patients, and further investigated the moderating effect of anemia on the relationship between BUN and ASCVD.</p><p><strong>Methods: </strong>In total, 15,109 HTN patients were included based on the National Health and Nutritional Examination Survey (NHANES) from 1999 to 2018. The weighted univariate logistic regression model was utilized to select potential covariates. The relationship between BUN, anemia, and ASCVD was investigated using weighted univariate and multivariate logistic regression models. All results were expressed as odds ratios (ORs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>A total of 15,109 HTN patients were included for final analysis. BUN level ≥4.69 mmol/L was related to higher odds of ASCVD in HTN patients (OR = 1.68, 95% CI: 1.51-1.88). Similarly, anemia was also associated with increased odds of ASCVD in HTN patients (OR = 1.45, 95% CI: 1.22-1.73). In patients with anemia, a BUN level ≥4.69 mmol/L was associated with increased odds of ASCVD when compared to patients who had a BUN level <4.69 mmol/L (OR = 2.95, 95% CI: 2.05-4.25). Anemia affected the association between BUN and ASCVD in HTN patients.</p><p><strong>Conclusions: </strong>Anemia moderates the association between BUN and ASCVD in HTN patients, amplifying the adverse effects. The findings show the importance of comprehensive management strategies that included renal function monitoring and anemia treatment in HTN patients.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26245"},"PeriodicalIF":1.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Epicardial/Pericardial Adipose Tissue in Cardiovascular Diseases: A Novel Therapeutic Strategy.","authors":"Yue Ding, Fang Lin, Zhongmin Liu, Xiaohui Zhou, Xiaoting Liang","doi":"10.31083/RCM26128","DOIUrl":"10.31083/RCM26128","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) remain a global health concern, prompting ongoing research into novel contributors to their pathogenesis. Due to the proximity of the coronary arteries and the myocardium in epicardial adipose tissue (EAT) and pericardial adipose tissue (PAT), these tissues have emerged as key areas of interest for their potential influence on cardiac function and vascular health. This review synthesizes current research on the physiological and biological characteristics of EAT and PAT, exploring their composition and clinical measurement approaches. The roles of EAT and PAT in coronary artery disease (CAD), atrial fibrillation, and heart failure are discussed, and the contributions of EAT and PAT to these cardiovascular conditions are highlighted alongside their potential as therapeutic targets.</p>","PeriodicalId":20989,"journal":{"name":"Reviews in cardiovascular medicine","volume":"26 3","pages":"26128"},"PeriodicalIF":1.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}