Recent advances in drug delivery and formulation最新文献_第4页

Vesicular Approach Review on Nanocarriers bearing Curcumin and Applications. 含姜黄素的纳米载体及其应用的囊状方法综述。

Recent advances in drug delivery and formulation Pub Date : 2022-04-04 DOI: 10.2174/2667387816666220404092415

Prashant Upadhyay, Deepak Singh, Sukirti Upadhyay

{"title":"Vesicular Approach Review on Nanocarriers bearing Curcumin and Applications.","authors":"Prashant Upadhyay, Deepak Singh, Sukirti Upadhyay","doi":"10.2174/2667387816666220404092415","DOIUrl":"10.2174/2667387816666220404092415","url":null,"abstract":"Phytoconstituents have been used to treat a variety of human diseases for a long time, but their use in pharmaceuticals is limited because of their low aqueous solubility. Researchers have created vesicular systems to address many of the issues associated with the bioavailability and therapeutic efficacy of poorly water-soluble drugs and target the drug to the desired location in the body. Several vesicular nanocarrier systems have been developed. Review contrasts various vesicular drug delivery systems, including liposomes, sphingosomes, emulsomes, niosomes, ethosomes, virosomes, phytosomes, aquasomes, proniosomes, transfersomes, pharmacosomes. Vesicular drug delivery systems have caused a scientific revolution, which has resulted in the development of novel dosage forms. This review aims to illustrate the applications, advantages, and disadvantages of the vesicular approach as nanocarriers bearing curcumin and widely used in gene delivery, tumor-targeting to the brain, oral formulations, and resolving various problems associated with drug stability and permeability issues. Nanocarriers also has wide application as green nanocomposites and for antitubercular drugs depending on their physical properties.","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75782003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug delivery platforms containing thermoresponsive polymers and mucoadhesive cellulose derivatives: state of the art and review of patents. 含有热敏聚合物和黏附纤维素衍生物的药物输送平台:技术现状和专利审查。

Recent advances in drug delivery and formulation Pub Date : 2022-04-04 DOI: 10.2174/2667387816666220404123625

J. B. da Silva, R. S. Dos Santos, C. F. Vecchi, M. Bruschi

{"title":"Drug delivery platforms containing thermoresponsive polymers and mucoadhesive cellulose derivatives: state of the art and review of patents.","authors":"J. B. da Silva, R. S. Dos Santos, C. F. Vecchi, M. Bruschi","doi":"10.2174/2667387816666220404123625","DOIUrl":"https://doi.org/10.2174/2667387816666220404123625","url":null,"abstract":"Nowadays, the development of mucoadhesive systems for drug delivery have gained keen interest, with enormous potential in applications through different routes. Mucoadhesion characterizes an attractive interaction between the pharmaceutical dosage form and the mucosal surface. Many polymers have shown the ability to interact with mucus, increasing the residence time of local and/or systemic administered preparations, such as tablets, patches, semi-solids, micro-and nanoparticles. Cellulose is the most abundant polymer on the earth. It is widely used in the pharmaceutical industry as an inert pharmaceutical ingredient, mainly in its covalently modified forms: methylcellulose, ethylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose and carboxymethylcellulose salts. Aiming to overcome the drawbacks of oral, ocular, nasal, vaginal, and rectal routes, and thereby maintaining patient compliance, innovative polymer blends have gained the interest of the pharmaceutical industry. Combining mucoadhesive and thermoresponsive polymers allows for simultaneous in situ gelation and mucoadhesion, thus enhancing the retention of the system at the site of administration and drug availability. Thermoresponsive polymers have the ability to change physicochemical properties triggered by temperature, which is particularly interesting considering physiological temperature. The present review provides an analysis of the main characteristics and applications of cellulose derivatives as mucoadhesive polymers and their use in blends together with thermoresponsive polymers, aiming platforms for drug delivery. Patents were reviewed, categorized, and discussed focusing the applications and pharmaceutical dosage forms using this innovative strategy. This review manuscript also provides a detailed introduction to the topic and a perspective on further developments.","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87748589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Meet the Editorial Board Member 与编辑委员会成员见面

Recent advances in drug delivery and formulation Pub Date : 2022-04-01 DOI: 10.2174/266738781601220408105333

A. Tiwary

引用次数: 0

Formulation Strategies and Therapeutic Applications of Shikonin and Related Derivatives. 紫草素及其衍生物的处方策略及治疗应用。

Recent advances in drug delivery and formulation Pub Date : 2022-03-02 DOI: 10.2174/2667387816666220302112201

Kirandeep Kaur, Atamjit Singh, Hamayal Sharma, Sanha Punj, Neena Bedi

引用次数: 4

Myths and Facts Regarding Particle Size Analysis of Pharmaceutical Powders. 关于药物粉末粒度分析的误区和事实。

Recent advances in drug delivery and formulation Pub Date : 2022-01-01 DOI: 10.2174/2667387816666220704124635

Ravikiran Allada, Hong Heng See

引用次数: 0

Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study. 溴芬酸钠负载Pluronic纳米胶束的研制:表征及角膜渗透研究。

Recent advances in drug delivery and formulation Pub Date : 2022-01-01 DOI: 10.2174/2667387816666220128123737

Miral Patel, Nithun Saha, Shruti Patel, Priyanka Ahlawat, Abhay Dharamsi, Asha Patel

{"title":"Development of Bromfenac Sodium Loaded Pluronic Nanomicelles: Characterization and Corneal Permeation Study.","authors":"Miral Patel, Nithun Saha, Shruti Patel, Priyanka Ahlawat, Abhay Dharamsi, Asha Patel","doi":"10.2174/2667387816666220128123737","DOIUrl":"https://doi.org/10.2174/2667387816666220128123737","url":null,"abstract":"Background: The Cataract is the leading cause of visual impairment and preventable blindness worldwide. Cataract removal surgery involves various post-operative complications like pain and inflammation.Objectives: The objective of this study is to screen the polymer concentration as well as optimize the formulation components to develop the pluronic micelles with nanosized characterization and for enhanced corneal permeation study.Methodology: For optimization, Central Composite design was employed to study the effect of independent variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2) on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity. The lyophilised powder was used for physical characterisation.Results: The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively. In-vitro drug release was found to be 91.72±1.2 percentage in 8 hours. Surface morphology revealed micelles were spherical in shape. Ocular irritancy study showed that formulation was safe and non-irritant. In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase in ocular availability without corneal damage compared to an aqueous suspension containing the same amount of drug in nanomicelles.Conclusion: In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac Sodium.","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39866139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

General Guide to Publish a Scientific Paper. 发表科学论文的一般指南。

Recent advances in drug delivery and formulation Pub Date : 2022-01-01 DOI: 10.2174/2667387816666220429093958

Brahma N Singh, Stefano Giovagnoli

引用次数: 0

Recent Progress in Hot Melt Extrusion Technology in Pharmaceutical Dosage Form Design. 热熔挤压技术在药物剂型设计中的最新进展。

Recent advances in drug delivery and formulation Pub Date : 2022-01-01 DOI: 10.2174/2667387816666220819124605

Sagar Salave, Kedar Prayag, Dhwani Rana, Prakash Amate, Rupali Pardhe, Ajinkya Jadhav, Anil B Jindal, Derajram Benival

{"title":"Recent Progress in Hot Melt Extrusion Technology in Pharmaceutical Dosage Form Design.","authors":"Sagar Salave, Kedar Prayag, Dhwani Rana, Prakash Amate, Rupali Pardhe, Ajinkya Jadhav, Anil B Jindal, Derajram Benival","doi":"10.2174/2667387816666220819124605","DOIUrl":"https://doi.org/10.2174/2667387816666220819124605","url":null,"abstract":"Background: The Hot Melt Extrusion (HME) technique has shown tremendous potential in transforming highly hydrophobic crystalline drug substances into amorphous solids without using solvents. This review explores in detail the general considerations involved in the process of HME, its applications and advances.Objective: The present review examines the physicochemical properties of polymers pertinent to the HME process. Theoretical approaches for the screening of polymers are highlighted as a part of successful HME processed drug products. The critical quality attributes associated with the process of HME are also discussed in this review. HME plays a significant role in the dosage form design, and the same has been mentioned with suitable examples. The role of HME in developing several sustained release formulations, films, and implants is described along with the research carried out in a similar domain.Methods: The method includes the collection of data from different search engines like PubMed, ScienceDirect, and SciFinder to get coverage of relevant literature for accumulating appropriate information regarding HME, its importance in pharmaceutical product development, and advanced applications.Results: HME is known to have advanced pharmaceutical applications in the domains related to 3D printing, nanotechnology, and PAT technology. HME-based technologies explored using Design-of- Experiments also lead to the systematic development of pharmaceutical formulations.Conclusion: HME remains an adaptable and differentiated technique for overall formulation development.","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40626198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

3D-Printed Microfluidics Potential in Combating Future and Current Pandemics (COVID-19). 3d打印微流体在对抗未来和当前流行病(COVID-19)中的潜力。

Recent advances in drug delivery and formulation Pub Date : 2022-01-01 DOI: 10.2174/2667387816666220727101214

Heba A Eassa, Nada A Helal, Ahmed M Amer, Aliaa Fouad, Asser F Bedair, Reem Nagib, Ihab Mansoor, Motaz Hawash, Maha Abdul-Latif, Kamilia H A Mohammed, Mohamed A Helal, Mohamed Ismail Nounou

{"title":"3D-Printed Microfluidics Potential in Combating Future and Current Pandemics (COVID-19).","authors":"Heba A Eassa, Nada A Helal, Ahmed M Amer, Aliaa Fouad, Asser F Bedair, Reem Nagib, Ihab Mansoor, Motaz Hawash, Maha Abdul-Latif, Kamilia H A Mohammed, Mohamed A Helal, Mohamed Ismail Nounou","doi":"10.2174/2667387816666220727101214","DOIUrl":"https://doi.org/10.2174/2667387816666220727101214","url":null,"abstract":"Coronavirus disease (COVID-19) emerged in China in December 2019. In March 2020, the WHO declared it a pandemic leading to worldwide lockdowns and travel restrictions. By May, it infected 4,789,205 and killed 318,789 people. This led to severe shortages in the medical sector besides devastating socio-economic effects. Many technologies such as artificial intelligence (AI), virtual reality (VR), microfluidics, 3D printing, and 3D scanning can step into contain the virus and hinder its extensive spread. This article aims to explore the potentials of 3D printing and microfluidic in accelerating the diagnosis and monitoring of the disease and fulfilling the shortages of personal protective equipment (PPE) and medical equipment. It highlights the main applications of 3D printers and microfluidics in providing PPE (masks, respirators, face shields, goggles, and isolation chambers/hoods), supportive care (respiratory equipment) and diagnostic supplies (sampling swabs & lab-on-chip) to ease the COVID-19 pressures. Also, the cost of such technology and regulation considerations are addressed. We conclude that 3D printing provided reusable and low-cost solutions to mitigate the shortages. However, safety, sterility, and compatibility with environmental protection standards need to be guaranteed through standardization and assessment by regulatory bodies. Finally, lessons learned from this pandemic can also help the world prepare for upcoming outbreaks.","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40636945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Differential Drug Release Kinetics from Paclitaxel-Loaded Polydioxanone Membranes and Capsules. 紫杉醇载聚二氧环酮膜和胶囊的差异药物释放动力学。

Recent advances in drug delivery and formulation Pub Date : 2022-01-01 DOI: 10.2174/2667387816666220707143330

Smrithi Padmakumar, Merin Mary Varghese, Deepthy Menon

{"title":"Differential Drug Release Kinetics from Paclitaxel-Loaded Polydioxanone Membranes and Capsules.","authors":"Smrithi Padmakumar, Merin Mary Varghese, Deepthy Menon","doi":"10.2174/2667387816666220707143330","DOIUrl":"https://doi.org/10.2174/2667387816666220707143330","url":null,"abstract":"Background: Drug laden implantable systems can provide drug release over several hours to years, which eventually aid in the therapy of both acute and chronic diseases. The present study focuses on a fundamental evaluation of the influence of implant properties such as morphology, architecture, porosity, surface area, and wettability in regulating the drug release kinetics from drug-loaded polymeric matrices.Methods: For this, Polydioxanone (PDS) was selected as the polymer and Paclitaxel (Ptx) as the model drug. Two different forms of the matrix implants, viz., reservoir type capsules developed by dip coating and matrix type membranes fabricated by phase inversion and electrospinning, were utilized for the study. Drug release from all the four different matrices prepared by simple techniques was evaluated in vitro in PBS and ex vivo in peritoneal wash fluid for ~4 weeks. The drug release profiles were thereafter correlated with the physicochemical parameters of the polymeric implants.Results: Reservoir-type capsules followed a slow and steady zero-order kinetics, while matrix-type electrospun and phase inversion membranes displayed typical biphasic kinetics.Conclusion: It was inferred that the slow degradation rate of PDS polymer as well as the implant properties like porosity and wettability play an important role in controlling the drug release rates.","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40591133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0