Tertiary Nanosystem Composed of Graphene Quantum Dots, Levofloxacin and Silver Nitrate for Microbiological Control.

Recent advances in drug delivery and formulation Pub Date : 2022-01-01 DOI:10.2174/2667387816666220715121107

Thamires Oliveira Vieira, Eduardo Ricci-Junior, Aline Oiveira da Silva de Barros, Luciana Magalhães Rebelo Alencar, Marcia Regina Spuri Ferreira, Terezinha de Jesus Andreoli Pinto, Ralph Santos-Oliveira, Diego de Holanda Saboya Souza

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Abstract

Background: Infectious diseases have the highest mortality rate in the world and these numbers are associated with scarce and/or ineffective diagnosis and bacterial resistance. Currently, with the development of new pharmaceutical formulations, nanotechnology is gaining prominence.

Methods: Nanomicelles were produced by ultrasonication. The particle size and shape were evaluated by scanning electron microscopy and confirmed by dynamic light scattering, also thermogravimetric analysis was performed to evaluate the thermal stability. Finally, antibacterial activity has been performed.

Results: The results showed that a rod-shaped nanosystem, with 316.1 nm and PDI of 0.243 was formed. The nanosystem was efficient against Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis subsp. spizizenii with MIC inferior to 0.98 and a synergistic effect between silver graphene quantum dots and levofloxacin was observed.

Conclusion: The nanosystem produced may rise as a promising agent against the bacterial threat, especially regarding bacterial resistance.

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由石墨烯量子点、左氧氟沙星和硝酸银组成的三级纳米系统用于微生物控制。

背景:传染病是世界上死亡率最高的疾病，这些数字与诊断不足和/或无效以及细菌耐药性有关。目前，随着新药物配方的发展，纳米技术日益受到重视。方法:采用超声法制备纳米胶束。通过扫描电子显微镜和动态光散射对颗粒大小和形状进行了评价，并通过热重分析对热稳定性进行了评价。最后，进行了抗菌活性实验。结果:制备出了直径为316.1 nm、PDI为0.243的棒状纳米体系。该纳米系统对金黄色葡萄球菌、铜绿假单胞菌和枯草芽孢杆菌亚种均有较好的抑制作用。在MIC小于0.98的情况下，观察了银石墨烯量子点与左氧氟沙星之间的协同效应。结论:所制备的纳米系统有望成为对抗细菌威胁的一种有前景的药物，特别是在细菌耐药性方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances in drug delivery and formulation

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