Recent advances in drug delivery and formulation最新文献

{"title":"Current Advancements on Oral Protein and Peptide Drug Delivery Approaches to Bioavailability: Extensive Review on Patents","authors":"Prasanna Parida, A. K. Prusty, S. Patro, B. R. Jena","doi":"10.2174/0126673878299775240719061653","DOIUrl":"https://doi.org/10.2174/0126673878299775240719061653","url":null,"abstract":"\u0000\u0000Protein and peptide-based drugs have greater therapeutic efficacy and potential application\u0000and lower toxicity compared to chemical entities in long-term use within optimum concentration\u0000as they are easily biodegradable due to biological origin. While oral administration is preferable,\u0000most of these substances are currently administered intravenously or subcutaneously. This is\u0000primarily due to the breakdown and poor absorption in the GI tract. Hence, ongoing research is focused\u0000on investigating absorption enhancers, enzyme inhibitors, carrier systems, and stability enhancers\u0000as potential strategies to facilitate the oral administration of proteins and peptides. Investigations\u0000have been directed towards advancing novel technologies to address gastrointestinal (GI)\u0000barriers associated with protein and peptide medications. The current review intensifies formulation\u0000and stability approaches for oral protein & peptide drug delivery systems with all significant parameters\u0000intended for patient safety. Notably, certain innovative technologies have been patented\u0000and are currently undergoing clinical trials or have already been introduced into the market. All the\u0000approaches stated for the administration of protein and peptide drugs are critically discussed, having\u0000their current status, future directions, and recent patents published in the last decades.\u0000","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocarriers for Cannabinoid Delivery: Enhancing Therapeutic Potential","authors":"Varun Singh, Samar Vihal, Rupali Rana, Charul Rathore","doi":"10.2174/0126673878300347240718100814","DOIUrl":"https://doi.org/10.2174/0126673878300347240718100814","url":null,"abstract":"\u0000\u0000Medical cannabis has potential therapeutic benefits in managing pain, anxiety, depression, and neurological and movement disorders. Phytocannabinoids derived from the cannabis plant\u0000are responsible for their pharmacological and therapeutic properties. However, the complexity of\u0000cannabis components, especially cannabinoids, poses a challenge to effective medicinal administration. Even with the increasing acceptance of cannabis-based medicines, achieving consistent bioavailability and targeted distribution remains difficult. Conventional administration methods are\u0000plagued by solubility and absorption problems requiring innovative solutions. After conducting a\u0000thorough review of research papers and patents, it has become evident that nanotechnology holds\u0000great promise as a solution. The comprehensive review of 36 research papers has yielded valuable\u0000insights, with 7 papers reporting enhanced bioavailability, while others have focused on improvements in release, solubility, and stability. Additionally, 19 patents have been analyzed, of which 7\u0000specifically claim enhanced bioavailability, while the remaining patents describe various formulation methods. These patents outline effective techniques for encapsulating cannabis using nanocarriers, effectively addressing solubility and controlled release. Studies on the delivery of cannabis\u0000using nanocarriers focus on improving bioavailability, prolonging release, and targeting specific areas. This synthesis highlights the potential of nanotechnology to enhance cannabis therapies and\u0000pave the way for innovative interventions and precision medicine.\u0000","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Microfluidic Channel Design with High-Performance Materials for Safe Neonatal Drug Delivery","authors":"T. Archana, N. Nachammai, S. Praveenkumar","doi":"10.2174/0126673878292962240718055526","DOIUrl":"https://doi.org/10.2174/0126673878292962240718055526","url":null,"abstract":"\u0000\u0000Designing the microfluidic channel for neonatal drug delivery requires\u0000proper considerations to enhance the efficiency and safety of drug substances when used in neonates.\u0000Thus, this research aims to evaluate high-performance materials and optimize the channel design\u0000by modeling and simulation using COMSOL multiphysics in order to deliver an optimum flow\u0000rate between 0. 3 and 1 mL/hr.\u0000\u0000\u0000\u0000Some of the materials used in the study included PDMS, glass, COC, PMMA, PC, TPE,\u0000and hydrogels, and the evaluation criterion involved biocompatibility, mechanical properties, chemical\u0000resistance, and ease of fabrication. The simulation was carried out in the COMSOL multiphysics\u0000platform and demonstrated the fog fluid behavior in different channel geometries, including\u0000laminar flow and turbulence. The study then used systematic changes in design parameters with the\u0000aim of establishing the best implementation models that can improve the efficiency and reliability\u0000of the drug delivery system. The comparison was based mostly on each material and its appropriateness\u0000in microfluidic usage, primarily in neonatal drug delivery. The biocompatibility of the developed\u0000materials was verified using the literature analysis and adherence to the ISO 10993 standard,\u0000thus providing safety for the use of neonatal devices. Tensile strength was included to check\u0000the strength of each material to withstand its operation conditions. Chemical resistance was also\u0000tested in order to determine the compatibility of the materials with various drugs, and the possibility\u0000of fabrication was also taken into consideration to identify appropriate materials that could be used\u0000in the rapid manufacturing of the product.\u0000\u0000\u0000\u0000The results we obtained show that PDMS, due to its flexibility and simplicity in simulation\u0000coupled with more efficient channel designs which have been extracted from COMSOL, present a\u0000feasible solution to neonatal drug delivery.\u0000\u0000\u0000\u0000The present comparative study serves as a guide on the choice of materials and design\u0000of microfluidic devices to help achieve safer and enhanced drug delivery systems suitable for the\u0000delicate reception of fragile neonates.\u0000","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Selection:","authors":"","doi":"10.2174/266738781801240307095846","DOIUrl":"https://doi.org/10.2174/266738781801240307095846","url":null,"abstract":"","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140406572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Solution to Drug Formulation Problems at Research and\u0000Development Stages by Amorphous Solid Dispersion Technology","authors":"Devika Tripathi, Manjunatha Prabhu B.H, Jagannath Sahoo, Jyoti Kumari","doi":"10.2174/0126673878271641231201065151","DOIUrl":"https://doi.org/10.2174/0126673878271641231201065151","url":null,"abstract":"\u0000\u0000Amorphous Solid Dispersions (ASDs) have indeed revolutionized the pharmaceutical industry, particularly in drug solubility enhancement. The amorphous state of a drug, which is a highenergy metastable state, can lead to an increase in the apparent solubility of the drug. This is due to\u0000the absence of a long-range molecular order, which results in higher molecular mobility and free\u0000volume, and consequently, higher solubility. The success of ASD preparation depends on the selection of appropriate excipients, particularly polymers that play a crucial role in drug solubility and\u0000physical stability. However, ASDs face challenges due to their thermodynamic instability or tendency to recrystallize. Measuring the crystallinity of the active pharmaceutical ingredient (API) and\u0000drug solubility is a complex process that requires a thorough understanding of drug-polymer miscibility and molecular interactions. Therefore, it is important to monitor drug solids closely during\u0000preparation, storage, and application. Techniques such as solid-state nuclear magnetic resonance\u0000(ssNMR), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), Raman\u0000spectroscopy, and dielectric spectroscopy have been successful in understanding the mechanism of\u0000drug crystallization. In addition, the continuous downstream processing of drug-loaded ASDs has\u0000introduced new automated methods for consistent ASD production. Advanced techniques such as\u0000hot melt extrusion, KinetiSol, electro spraying, and electrospinning have gained popularity. This review provides a comprehensive overview of Amorphous Solid Dispersions (ASDs) for oral drug delivery. It highlights the critical challenges faced during formulation, the impact of manufacturing\u0000variables, theoretical aspects of drug-polymer interaction, and factors related to drug-polymer miscibility. ASDs have been recognized as a promising strategy to improve the oral bioavailability of\u0000poorly water-soluble drugs. However, the successful development of an ASD-based drug product is\u0000not straightforward due to the complexity of the ASD systems. The formulation and process parameters can significantly influence the performance of the final product. Understanding the interactions between the drug and polymer in ASDs is crucial for predicting their stability and performance.\u0000","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138591334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Evaluation of Chitosan-Titanium Dioxide Nanopowder as Wound Dressing Material.","authors":"Nusaiba Al-Nemrawi,&nbsp;Ruba S Darweesh,&nbsp;Dana Alrousan","doi":"10.2174/2667387817666230911115541","DOIUrl":"https://doi.org/10.2174/2667387817666230911115541","url":null,"abstract":"<p><strong>Background: </strong>Films used for wound healing have many advantages, but should be flexible, robust, adherable and prevent maceration. Both Chitosan (CS) and Titanium dioxide nanopowder (TiO2 NP) have good properties to accelerate wound healing and can be used in preparing films.</p><p><strong>Objective: </strong>CS and TiO2 NP are combined to formulate films for wound healing. The physical, thermal, chemical, and mechanical characteristics of these films are to be assessed. The antibacterial activity of the films and their performance on wounded rats will be explored.</p><p><strong>Methods: </strong>Films made of CS and TiO2 NP were characterized by FTIR, TGA, DSC, XRD, and SEM. The films' mechanical characteristics and antimicrobial activity were tested. Films with acceptable mechanical properties were evaluated on rats.</p><p><strong>Results: </strong>Generally, CS-TiO2 films had higher weight and thickness but lowered flexibility compared to films prepared using CS only. The chosen film showed excellent folding endurance with weight and thickness of around 21.98 mg and 0.16 mm. The surface pH for CS-TiO2 films was acidic, and for the selected film, it was 5.18. CS-TiO2 film was active against all studied bacteria and significantly higher than CS films. The antimicrobial activity of Gram-negative bacteria (P. aeruginosa and E. coli) was higher than that of Gram-positive bacteria (S. aureus). Finally, adding TiO2 NP to the films accelerated the healing process of the created wounds in a murine model, compared to control and CS-treated groups.</p><p><strong>Conclusion: </strong>Films of TiO2 NP and CS have suitable properties to be used in wound healing and can be further used in the future to load drugs.</p>","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10590720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Development of Levothyroxine Sodium Orodispersible Mini Tablets for the Treatment of Pediatrics Hypothyroidism.","authors":"Cecilia Henestrosa,&nbsp;Camila Olivera,&nbsp;Sabrina Flor,&nbsp;Silvia Lucangioli,&nbsp;Ariel Vacatello,&nbsp;Claudia A Ortega,&nbsp;Laura S Favier,&nbsp;Diego A Cifuente","doi":"10.2174/2667387817666230908092551","DOIUrl":"https://doi.org/10.2174/2667387817666230908092551","url":null,"abstract":"<p><strong>Background: </strong>In pediatrics, developing new pharmaceutical forms that offer safety and efficacy is crucial to improve pediatric pharmaceutical care. Orodispersible tablets do not require swallowing because orodispersible tablets dissolve quickly in the mouth, reducing the risk of choking and making medication administration safer and more straightforward. There is no solid dosage form in the pharmaceutical market offering a unit dose of Levothyroxine for pediatric hypothyroidism patients.</p><p><strong>Objective: </strong>The objective of this study is to design and develop Orodispersible mini tablets of Levothyroxine Sodium (LT4 ODMTs) for pediatric doses.</p><p><strong>Methods: </strong>LT4 ODMTs were prepared by direct compression with 10 and 15 μg, respectively, using StarLac® and Disolcel® as excipients. United States Pharmacopeia (USP-43) guidelines evaluated and determined pre-compression properties and quality control parameters.</p><p><strong>Results: </strong>The LT4 ODMTs met the specified limits for quality controls. The Drug Content Uniformity was 97%, Hardness was less than 2.5 N, Friability was less than 0.3%, Disintegration time was less than 25 s, and dissolution profiles (Q 80% > 45 s) followed the USP requirements. Additionally, stability and microbiology assays were realized.</p><p><strong>Conclusion: </strong>These formulations are optimal for developing new LT4 ODMTs suitable for treating pediatric hypothyroidism.</p>","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10657900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Appraisal of Lipid Nanoparticles Deployed in Cancer Pharmacotherapy.","authors":"Santanu Chakraborty,&nbsp;Manami Dhibar,&nbsp;Aliviya Das,&nbsp;Kalpana Swain,&nbsp;Satyanarayan Pattnaik","doi":"10.2174/2667387817666230726140745","DOIUrl":"https://doi.org/10.2174/2667387817666230726140745","url":null,"abstract":"<p><p>Treatment modalities of various cancers and the delivery strategies of anticancer agents have evolved significantly in the recent past. The severity and fatality of the disease and hurdles to the effective delivery of therapeutic agents have drawn the attention of researchers across the world for proposing novel and effective drug delivery strategies for anticancer therapeutics. Attempts have been made to propose solutions to the diverse limitations like poor pharmacokinetics and higher systemic toxicities of the traditional delivery of anticancer agents. Nanotechnology-based drug delivery systems including lipid-based nanocarriers have demonstrated significant efficiency in this scenario. The review critically assessed the different types of lipid nanocarrier systems for the effective and optimal delivery of anticancer therapeutic agents. The diverse synthesis approaches are discussed for the laboratory scale and commercial development of different categories of lipid nanocarriers. Further, their application in anticancer drug delivery is illustrated in detail followed by a critical appraisal of their safety and toxicity.</p>","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9861947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent Selections:","authors":"","doi":"10.2174/266738781702231013142408","DOIUrl":"https://doi.org/10.2174/266738781702231013142408","url":null,"abstract":"","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135194849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"Ashok K. Tiwary","doi":"10.2174/266738781702231013122449","DOIUrl":"https://doi.org/10.2174/266738781702231013122449","url":null,"abstract":"","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135194847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}