用于大麻素递送的纳米载体:提高治疗潜力

Varun Singh, Samar Vihal, Rupali Rana, Charul Rathore
{"title":"用于大麻素递送的纳米载体:提高治疗潜力","authors":"Varun Singh, Samar Vihal, Rupali Rana, Charul Rathore","doi":"10.2174/0126673878300347240718100814","DOIUrl":null,"url":null,"abstract":"\n\nMedical cannabis has potential therapeutic benefits in managing pain, anxiety, depression, and neurological and movement disorders. Phytocannabinoids derived from the cannabis plant\nare responsible for their pharmacological and therapeutic properties. However, the complexity of\ncannabis components, especially cannabinoids, poses a challenge to effective medicinal administration. Even with the increasing acceptance of cannabis-based medicines, achieving consistent bioavailability and targeted distribution remains difficult. Conventional administration methods are\nplagued by solubility and absorption problems requiring innovative solutions. After conducting a\nthorough review of research papers and patents, it has become evident that nanotechnology holds\ngreat promise as a solution. The comprehensive review of 36 research papers has yielded valuable\ninsights, with 7 papers reporting enhanced bioavailability, while others have focused on improvements in release, solubility, and stability. Additionally, 19 patents have been analyzed, of which 7\nspecifically claim enhanced bioavailability, while the remaining patents describe various formulation methods. These patents outline effective techniques for encapsulating cannabis using nanocarriers, effectively addressing solubility and controlled release. Studies on the delivery of cannabis\nusing nanocarriers focus on improving bioavailability, prolonging release, and targeting specific areas. This synthesis highlights the potential of nanotechnology to enhance cannabis therapies and\npave the way for innovative interventions and precision medicine.\n","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanocarriers for Cannabinoid Delivery: Enhancing Therapeutic Potential\",\"authors\":\"Varun Singh, Samar Vihal, Rupali Rana, Charul Rathore\",\"doi\":\"10.2174/0126673878300347240718100814\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nMedical cannabis has potential therapeutic benefits in managing pain, anxiety, depression, and neurological and movement disorders. Phytocannabinoids derived from the cannabis plant\\nare responsible for their pharmacological and therapeutic properties. However, the complexity of\\ncannabis components, especially cannabinoids, poses a challenge to effective medicinal administration. Even with the increasing acceptance of cannabis-based medicines, achieving consistent bioavailability and targeted distribution remains difficult. Conventional administration methods are\\nplagued by solubility and absorption problems requiring innovative solutions. After conducting a\\nthorough review of research papers and patents, it has become evident that nanotechnology holds\\ngreat promise as a solution. The comprehensive review of 36 research papers has yielded valuable\\ninsights, with 7 papers reporting enhanced bioavailability, while others have focused on improvements in release, solubility, and stability. Additionally, 19 patents have been analyzed, of which 7\\nspecifically claim enhanced bioavailability, while the remaining patents describe various formulation methods. These patents outline effective techniques for encapsulating cannabis using nanocarriers, effectively addressing solubility and controlled release. Studies on the delivery of cannabis\\nusing nanocarriers focus on improving bioavailability, prolonging release, and targeting specific areas. This synthesis highlights the potential of nanotechnology to enhance cannabis therapies and\\npave the way for innovative interventions and precision medicine.\\n\",\"PeriodicalId\":20955,\"journal\":{\"name\":\"Recent advances in drug delivery and formulation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Recent advances in drug delivery and formulation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0126673878300347240718100814\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent advances in drug delivery and formulation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0126673878300347240718100814","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

医用大麻在控制疼痛、焦虑、抑郁以及神经和运动障碍方面具有潜在的治疗功效。从大麻植物中提取的植物大麻素具有药理和治疗特性。然而,大麻成分(尤其是大麻素)的复杂性给有效用药带来了挑战。即使人们对以大麻为基础的药物的接受度越来越高,但要实现一致的生物利用度和有针对性的分布仍然十分困难。传统给药方法存在溶解和吸收问题,需要创新的解决方案。在对研究论文和专利进行全面审查后,纳米技术显然是一种大有可为的解决方案。对 36 篇研究论文的全面审查得出了宝贵的见解,其中 7 篇论文报告了生物利用度的提高,其他论文则侧重于释放、溶解度和稳定性的改善。此外,还对 19 项专利进行了分析,其中 7 项专利明确声称提高了生物利用度,其余专利则描述了各种制剂方法。这些专利概述了使用纳米载体封装大麻的有效技术,有效地解决了溶解性和控释问题。利用纳米载体输送大麻的研究主要集中在提高生物利用率、延长释放时间和针对特定区域。本综述强调了纳米技术在增强大麻疗法方面的潜力,并为创新干预和精准医疗铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanocarriers for Cannabinoid Delivery: Enhancing Therapeutic Potential
Medical cannabis has potential therapeutic benefits in managing pain, anxiety, depression, and neurological and movement disorders. Phytocannabinoids derived from the cannabis plant are responsible for their pharmacological and therapeutic properties. However, the complexity of cannabis components, especially cannabinoids, poses a challenge to effective medicinal administration. Even with the increasing acceptance of cannabis-based medicines, achieving consistent bioavailability and targeted distribution remains difficult. Conventional administration methods are plagued by solubility and absorption problems requiring innovative solutions. After conducting a thorough review of research papers and patents, it has become evident that nanotechnology holds great promise as a solution. The comprehensive review of 36 research papers has yielded valuable insights, with 7 papers reporting enhanced bioavailability, while others have focused on improvements in release, solubility, and stability. Additionally, 19 patents have been analyzed, of which 7 specifically claim enhanced bioavailability, while the remaining patents describe various formulation methods. These patents outline effective techniques for encapsulating cannabis using nanocarriers, effectively addressing solubility and controlled release. Studies on the delivery of cannabis using nanocarriers focus on improving bioavailability, prolonging release, and targeting specific areas. This synthesis highlights the potential of nanotechnology to enhance cannabis therapies and pave the way for innovative interventions and precision medicine.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信