A Critical Appraisal of Lipid Nanoparticles Deployed in Cancer Pharmacotherapy.

Santanu Chakraborty, Manami Dhibar, Aliviya Das, Kalpana Swain, Satyanarayan Pattnaik
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Abstract

Treatment modalities of various cancers and the delivery strategies of anticancer agents have evolved significantly in the recent past. The severity and fatality of the disease and hurdles to the effective delivery of therapeutic agents have drawn the attention of researchers across the world for proposing novel and effective drug delivery strategies for anticancer therapeutics. Attempts have been made to propose solutions to the diverse limitations like poor pharmacokinetics and higher systemic toxicities of the traditional delivery of anticancer agents. Nanotechnology-based drug delivery systems including lipid-based nanocarriers have demonstrated significant efficiency in this scenario. The review critically assessed the different types of lipid nanocarrier systems for the effective and optimal delivery of anticancer therapeutic agents. The diverse synthesis approaches are discussed for the laboratory scale and commercial development of different categories of lipid nanocarriers. Further, their application in anticancer drug delivery is illustrated in detail followed by a critical appraisal of their safety and toxicity.

脂质纳米颗粒在癌症药物治疗中的应用。
近年来,各种癌症的治疗方式和抗癌药物的递送策略发生了重大变化。这种疾病的严重性和致死率以及治疗药物有效递送的障碍引起了世界各地研究人员的注意,他们提出了新的有效的抗癌药物递送策略。人们已经尝试提出解决各种限制的方法,如传统抗癌药物的药代动力学差和较高的全身毒性。基于纳米技术的药物输送系统,包括基于脂质的纳米载体,在这种情况下已经证明了显著的效率。该综述严格评估了不同类型的脂质纳米载体系统对抗癌治疗剂的有效和最佳递送。讨论了不同种类的脂质纳米载体的实验室规模和商业开发的各种合成方法。此外,详细说明了它们在抗癌药物输送中的应用,随后对它们的安全性和毒性进行了严格的评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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