Prasanna Parida, A. K. Prusty, S. Patro, B. R. Jena
{"title":"口服蛋白质和肽类给药生物利用度方法的最新进展:专利综述","authors":"Prasanna Parida, A. K. Prusty, S. Patro, B. R. Jena","doi":"10.2174/0126673878299775240719061653","DOIUrl":null,"url":null,"abstract":"\n\nProtein and peptide-based drugs have greater therapeutic efficacy and potential application\nand lower toxicity compared to chemical entities in long-term use within optimum concentration\nas they are easily biodegradable due to biological origin. While oral administration is preferable,\nmost of these substances are currently administered intravenously or subcutaneously. This is\nprimarily due to the breakdown and poor absorption in the GI tract. Hence, ongoing research is focused\non investigating absorption enhancers, enzyme inhibitors, carrier systems, and stability enhancers\nas potential strategies to facilitate the oral administration of proteins and peptides. Investigations\nhave been directed towards advancing novel technologies to address gastrointestinal (GI)\nbarriers associated with protein and peptide medications. The current review intensifies formulation\nand stability approaches for oral protein & peptide drug delivery systems with all significant parameters\nintended for patient safety. Notably, certain innovative technologies have been patented\nand are currently undergoing clinical trials or have already been introduced into the market. All the\napproaches stated for the administration of protein and peptide drugs are critically discussed, having\ntheir current status, future directions, and recent patents published in the last decades.\n","PeriodicalId":20955,"journal":{"name":"Recent advances in drug delivery and formulation","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Current Advancements on Oral Protein and Peptide Drug Delivery Approaches to Bioavailability: Extensive Review on Patents\",\"authors\":\"Prasanna Parida, A. K. Prusty, S. Patro, B. R. Jena\",\"doi\":\"10.2174/0126673878299775240719061653\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nProtein and peptide-based drugs have greater therapeutic efficacy and potential application\\nand lower toxicity compared to chemical entities in long-term use within optimum concentration\\nas they are easily biodegradable due to biological origin. While oral administration is preferable,\\nmost of these substances are currently administered intravenously or subcutaneously. This is\\nprimarily due to the breakdown and poor absorption in the GI tract. Hence, ongoing research is focused\\non investigating absorption enhancers, enzyme inhibitors, carrier systems, and stability enhancers\\nas potential strategies to facilitate the oral administration of proteins and peptides. Investigations\\nhave been directed towards advancing novel technologies to address gastrointestinal (GI)\\nbarriers associated with protein and peptide medications. The current review intensifies formulation\\nand stability approaches for oral protein & peptide drug delivery systems with all significant parameters\\nintended for patient safety. Notably, certain innovative technologies have been patented\\nand are currently undergoing clinical trials or have already been introduced into the market. All the\\napproaches stated for the administration of protein and peptide drugs are critically discussed, having\\ntheir current status, future directions, and recent patents published in the last decades.\\n\",\"PeriodicalId\":20955,\"journal\":{\"name\":\"Recent advances in drug delivery and formulation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Recent advances in drug delivery and formulation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0126673878299775240719061653\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent advances in drug delivery and formulation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0126673878299775240719061653","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Current Advancements on Oral Protein and Peptide Drug Delivery Approaches to Bioavailability: Extensive Review on Patents
Protein and peptide-based drugs have greater therapeutic efficacy and potential application
and lower toxicity compared to chemical entities in long-term use within optimum concentration
as they are easily biodegradable due to biological origin. While oral administration is preferable,
most of these substances are currently administered intravenously or subcutaneously. This is
primarily due to the breakdown and poor absorption in the GI tract. Hence, ongoing research is focused
on investigating absorption enhancers, enzyme inhibitors, carrier systems, and stability enhancers
as potential strategies to facilitate the oral administration of proteins and peptides. Investigations
have been directed towards advancing novel technologies to address gastrointestinal (GI)
barriers associated with protein and peptide medications. The current review intensifies formulation
and stability approaches for oral protein & peptide drug delivery systems with all significant parameters
intended for patient safety. Notably, certain innovative technologies have been patented
and are currently undergoing clinical trials or have already been introduced into the market. All the
approaches stated for the administration of protein and peptide drugs are critically discussed, having
their current status, future directions, and recent patents published in the last decades.