Regenerative Biomaterials最新文献_第2页

Therapeutic biomaterials with liver X receptor agonists based on the horizon of material biology to regulate atherosclerotic plaque regression in situ for devices surface engineering. 基于材料生物学视野的肝 X 受体激动剂治疗生物材料，可在原位调节动脉粥样硬化斑块的消退，用于设备表面工程。

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI: 10.1093/rb/rbae089

Sainan Liu, Jinquan Huang, Jiayan Luo, Qihao Bian, Yajun Weng, Li Li, Junying Chen

{"title":"Therapeutic biomaterials with liver X receptor agonists based on the horizon of material biology to regulate atherosclerotic plaque regression in situ for devices surface engineering.","authors":"Sainan Liu, Jinquan Huang, Jiayan Luo, Qihao Bian, Yajun Weng, Li Li, Junying Chen","doi":"10.1093/rb/rbae089","DOIUrl":"10.1093/rb/rbae089","url":null,"abstract":"Percutaneous coronary interventional is the main treatment for coronary atherosclerosis. At present, most studies focus on blood components and smooth muscle cells to achieve anticoagulation or anti-proliferation effects, while the mediated effects of materials on macrophages are also the focus of attention. Macrophage foam cells loaded with elevated cholesterol is a prominent feature of atherosclerotic plaque. Activation of liver X receptor (LXR) to regulate cholesterol efflux and efferocytosis and reduce the number of macrophage foam cells in plaque is feasible for the regression of atherosclerosis. However, cholesterol efflux promotion remains confined to targeted therapies. Herein, LXR agonists (GW3965) were introduced on the surface of the material and delivered in situ to atherogenic macrophages to improve drug utilization for anti-atherogenic therapy and plaque regression. LXR agonists act as plaque inhibition mediated by multichannel regulation macrophages, including lipid metabolism (ABCA1, ABCG1 and low-density lipoprotein receptor), macrophage migration (CCR7) and efferocytosis (MerTK). Material loaded with LXR agonists significantly reduced plaque burden in atherosclerotic model rats, most importantly, it did not cause hepatotoxicity and adverse reactions such as restenosis and thrombosis after material implantation. Both in vivo and in vitro evaluations confirmed its anti-atherosclerotic capability and safety. Overall, multi-functional LXR agonist-loaded materials with pathological microenvironment regulation effect are expected to be promising candidates for anti-atherosclerosis and have potential applications in cardiovascular devices surface engineering.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11335375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bilayer bioengineered patch with sequential dual-growth factor release to promote vascularization in bladder reconstruction. 双层生物工程贴片可连续释放双重生长因子，促进膀胱重建中的血管化。

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-25 eCollection Date: 2024-01-01 DOI: 10.1093/rb/rbae083

Jian Zhao, Haoqian Zhang, Zhengyun Ling, Ziyan An, Shuwei Xiao, Pengchao Wang, Zhouyang Fu, Jinpeng Shao, Yanfeng Sun, Weijun Fu

{"title":"A bilayer bioengineered patch with sequential dual-growth factor release to promote vascularization in bladder reconstruction.","authors":"Jian Zhao, Haoqian Zhang, Zhengyun Ling, Ziyan An, Shuwei Xiao, Pengchao Wang, Zhouyang Fu, Jinpeng Shao, Yanfeng Sun, Weijun Fu","doi":"10.1093/rb/rbae083","DOIUrl":"10.1093/rb/rbae083","url":null,"abstract":"Bladder tissue engineering holds promise for addressing bladder defects resulting from congenital or acquired bladder diseases. However, inadequate vascularization significantly impacts the survival and function of engineered tissues after transplantation. Herein, a novel bilayer silk fibroin (BSF) scaffold was fabricated with the capability of vascular endothelial growth factor (VEGF) and platelet derived growth factor-BB (PDGF-BB) sequential release. The outer layer of the scaffold was composed of compact SF film with waterproofness to mimic the serosa of the bladder. The inner layer was constructed of porous SF matrix incorporated with SF microspheres (MS) loaded with VEGF and PDGF-BB. We found that the 5% (w/v) MS-incorporated scaffold exhibited a rapid release of VEGF, whereas the 0.2% (w/v) MS-incorporated scaffold demonstrated a slow and sustained release of PDGF-BB. The BSF scaffold exhibited good biocompatibility and promoted endothelial cell migration, tube formation and enhanced endothelial differentiation of adipose derived stem cells (ADSCs) in vitro. The BSF patch was constructed by seeding ADSCs on the BSF scaffold. After in vivo transplantation, not only could the BSF patch facilitate the regeneration of urothelium and smooth muscle, but more importantly, stimulate the regeneration of blood vessels. This study demonstrated that the BSF patch exhibited excellent vascularization capability in bladder reconstruction and offered a viable functional bioengineered patch for future clinical studies.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11286312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional 3D Matrixes Based on Flexible Bioglass Nanofibers for Potential Application in Postoperative Therapy of Osteosarcoma 基于柔性生物玻璃纳米纤维的多功能三维基质在骨肉瘤术后治疗中的潜在应用

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-24 DOI: 10.1093/rb/rbae088

Lihuan Wang, Liting Yuan, Yanbing Dong, Wenli Huang, Jichang Zhu, Xuexian Du, Chenglin Zhang, Pengbi Liu, Jinpeng Mo, Bingyan Li, Zijin Liu, Xi Yu, Hui Yu

{"title":"Multifunctional 3D Matrixes Based on Flexible Bioglass Nanofibers for Potential Application in Postoperative Therapy of Osteosarcoma","authors":"Lihuan Wang, Liting Yuan, Yanbing Dong, Wenli Huang, Jichang Zhu, Xuexian Du, Chenglin Zhang, Pengbi Liu, Jinpeng Mo, Bingyan Li, Zijin Liu, Xi Yu, Hui Yu","doi":"10.1093/rb/rbae088","DOIUrl":"https://doi.org/10.1093/rb/rbae088","url":null,"abstract":"\u0000 Postoperative treatment of osteosarcoma is one of the major challenging clinical issues since both elimination of residual tumors and acceleration of bone regeneration should be considered. Photothermal therapy has been widely studied due to its advantages of small side-effect, low-toxicity, high local selectivity, and noninversion, and bone tissue engineering is an inevitable trend in postoperative treatment of osteosarcoma. In this study, we combined the tissue engineering and photothermal therapy together, and developed a kind of multifunctional nanofibrous 3D matrixes for postoperative treatment of osteosarcoma. The flexible bioactive glass nanofibers (BGNFs) prepared by sol-gel electrospinning and calcination acted as the basic blocks, and the genipin-crosslinked gelatin (GNP-Gel) acted as the cement to bond the BGNFs forming a stable 3D structure. The stable porous 3D scaffolds were obtained through ice crystal templating method and freeze-drying technology. The obtained GNP-Gel/BGNF 3D matrixes showed a nanofibrous structure that highly biomimetics the extracellular matrix. The excellent compression recovery performance in water of these matrixes made them suitable for minimally invasive surgery. In addition, these 3D matrixes were not only biocompatible in vitro, but also benefit for the formation of mineralized bone in vivo. Furthermore, the dark blue GNP-Gel also acted as the photothermal agent, which e endowed the GNP-Gel/BGNF 3D matrixes with efficient photothermal antitumor and photothermal antibacterial performance without addition of other toxic photothermal agents. Therefore, this study provides an ingenious avenue to prepare multifunctional nanofibrous 3D matrixes with photothermal therapy for postoperative treatment of osteosarcoma.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory Science Promotes the Translation of Transcatheter Tricuspid Valve Repair/Replacement Devices 监管科学促进经导管三尖瓣修复/置换设备的转化

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-18 DOI: 10.1093/rb/rbae084

Maobo Cheng, Yun Xu, Wei Liu, Lanlan Mu, Xiaoqi Lian, Guobiao Gao, Lei Sun

{"title":"Regulatory Science Promotes the Translation of Transcatheter Tricuspid Valve Repair/Replacement Devices","authors":"Maobo Cheng, Yun Xu, Wei Liu, Lanlan Mu, Xiaoqi Lian, Guobiao Gao, Lei Sun","doi":"10.1093/rb/rbae084","DOIUrl":"https://doi.org/10.1093/rb/rbae084","url":null,"abstract":"\u0000 For patients with symptomatic and severe tricuspid regurgitation but inoperable with open surgery, transcatheter tricuspid valve intervention (TTVI) is a procedure of great clinical value. TTVI products includes repair and replacement devices. TTVI products are one of the hotspots of investigation now, with different innovative biomaterials and structural designs in trials to satisfy divergent indications and reduce complications. With the emerging biomaterials, the technical difficulty of structural design will be greatly reduced, spurring further product innovation and development. The innovativeness and complexity of TTVI products have brought challenges to academia, industry, and regulatory agencies. Regulatory science provides a bridge to address these difficulties and challenges. This perspective article introduces the latest development of the TTVI products. With traditional methods, regulatory agencies face challenges in evaluating the safety and efficacy of TTVr/TTVR devices given the uncertainty of clinical use and the diversity of innovative structural design. This perspective article analyzes the regulatory challenges and discusses regulatory science that can be developed to assess the safety, efficacy, quality, and performance of such products: including new approaches for innovative devices, pre-review path, computer modeling and simulation, accelerated wear testing methods for transcatheter heart valves, and evidence-based research. This article reveals for the first time how to apply regulatory science systematically to TTVI products, which is of great relevance to their development and translation.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable microspheres via orally deliver celastrol with ameliorated neuropathic pain in diabetes rats. 生物可降解微球通过口服输送西司他洛尔，可改善糖尿病大鼠的神经病理性疼痛。

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-17 eCollection Date: 2024-01-01 DOI: 10.1093/rb/rbae087

Haosen Zhao, Shurui Chen, Sen Lin, Xifan Mei

{"title":"Biodegradable microspheres via orally deliver celastrol with ameliorated neuropathic pain in diabetes rats.","authors":"Haosen Zhao, Shurui Chen, Sen Lin, Xifan Mei","doi":"10.1093/rb/rbae087","DOIUrl":"10.1093/rb/rbae087","url":null,"abstract":"The treatment of peripheral neuropathy resulting from diabetes primarily emphasizes neurotrophic medications. However, a growing body of clinical studies indicates that neuroinflammation plays a significant role in the pathogenesis of neuropathic pain. This has spurred active exploration of treatment strategies leveraging nanomedicine for diseases, aiming for superior therapeutic outcomes. In this context, we have developed biodegradable nanoparticles made of polylactic-co-glycolic acid, loaded with triptolide (pCel), designed to alleviate somatic cell neuropathic pain induced by diabetes. Treatment with pCel notably reduced levels of reactive oxygen species and apoptosis in vitro. Furthermore, the progression of streptozotocin-induced diabetes, characterized by elevated renal function indices (blood urea nitrogen, creatinine), liver function indices (bilirubin, alkaline phosphatase) and decreased levels of albumin and globulin, was mitigated following pCel administration. Importantly, oral treatment with pCel significantly inhibited mechanical allodynia and the activation of the sciatic glial cells in diabetic rats. These findings indicate that this synthetic, biodegradable nanomedicine exhibits excellent stability, biocompatibility and catalytic activity, making it a promising and innovative approach for the management of chronic pain conditions associated with diabetic neuropathy.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11272178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissolvable Microneedles Loaded Ginsenoside Rg3 liposome: A Transdermal Delivery Approach for Alopecia Treatment 装载人参皂苷 Rg3 脂质体的可溶解微针：治疗脱发的透皮给药方法

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-16 DOI: 10.1093/rb/rbae086

Qin Yang, Peng Guo, Pengkun Lei, Qiaolin Yang, Yuchun Liu, Ya Tian, Wen Shi, Chunxiao Zhu, Min Lei, Rui Zeng, Chen Zhang, Yan Qu

{"title":"Dissolvable Microneedles Loaded Ginsenoside Rg3 liposome: A Transdermal Delivery Approach for Alopecia Treatment","authors":"Qin Yang, Peng Guo, Pengkun Lei, Qiaolin Yang, Yuchun Liu, Ya Tian, Wen Shi, Chunxiao Zhu, Min Lei, Rui Zeng, Chen Zhang, Yan Qu","doi":"10.1093/rb/rbae086","DOIUrl":"https://doi.org/10.1093/rb/rbae086","url":null,"abstract":"\u0000 The skin stratum corneum (SC) barrier function will interfere with the absorption of topical treatment and reduce the drug's therapeutic effect on alopecia. Microneedles (MNs) can penetrate the skin barrier and deliver drugs to the dermis. Furthermore, MNs can mechanically stimulate the skin, which promotes hair growth. Thus, we designed a green and dissolvable composite microneedle made of hyaluronic acid (HA) and Bletilla striata polysaccharide (BSP) to encapsulate cholesterol-free ginsenoside Rg3 liposomes (Rg3-LPs) to avoid cholesterol metabolism-producing testosterone to inhibit hair regeneration and minimize the effect of the SC barrier on liposomes absorption. HA and BSP can enhance the mechanical strength of Rg3-MNs to ensure the transport of liposomes to the hair follicle region (HF) while causing minimal skin irritation and guaranteeing cell compatibility. In addition, HA increased hair density and was more conducive to hair regeneration. In telogen effluvium (TE) and testosterone-induced androgenetic alopecia (AGA) animals, Rg3-MNs achieved comparable efficacy to minoxidil with low-frequency treatment, and the quality of regenerated hair was higher. Furthermore, quantitative characterization and transcriptome sequencing results showed that Rg3-MNs promoted hair regeneration by promoting the expression of Wnt3a and Wnt10b genes, activating the Wnt/β-catenin pathway. Therefore, Rg3-MNs present broad prospects in the treatment of alopecia.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141643064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controllable self-assembly of tyrosine-rich triblock peptides into robust collagen mimetic bioscaffolds for aging skin rejuvenation 将富含酪氨酸的三嵌段肽可控地自组装成坚固的胶原蛋白仿生生物支架，用于老化皮肤的再年轻化

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-16 DOI: 10.1093/rb/rbae085

Linyan Yao, Biyang Ling, Wenjie Huang, Qi Wang, Xiangdong Cai, Jianxi Xiao

{"title":"Controllable self-assembly of tyrosine-rich triblock peptides into robust collagen mimetic bioscaffolds for aging skin rejuvenation","authors":"Linyan Yao, Biyang Ling, Wenjie Huang, Qi Wang, Xiangdong Cai, Jianxi Xiao","doi":"10.1093/rb/rbae085","DOIUrl":"https://doi.org/10.1093/rb/rbae085","url":null,"abstract":"\u0000 Skin aging, a complex physiological process characterized by alterations in skin structure and function, seriously affects human life. Collagen holds considerable potential in aging skin treatment, while animal-derived collagen poses risks of pathogen transmission. Self-assembled peptides have garnered increasing attention in creating collagen mimetic materials; however, previous reported self-assembled peptides rely on vulnerable non-covalent interactions or lack the capability of controlling morphology and incorporating functional motifs, limiting their ability to mimic collagen structure and function. We have herein created a controllable tyrosine-rich triblock peptide system capable of self-assembling into robust collagen mimetic bioscaffolds for rejuvenating aging skin. Through ruthenium-mediated crosslinking, these peptides self-assemble into well-defined nanospheres or collagen-mimetic scaffolds, precisely regulated by the triple-helical structure and tyrosine distribution. The self-assembled collagen mimetic scaffolds exhibit outstanding resistances to various solvents and pH conditions. The integrin-binding motif has been incorporated into the triple helical block without disrupting their assembly, while endowing them with superior bioactivities, effectively promoting cell adhesion and proliferation. In vivo studies demonstrated their efficacy in treating photoaging skin by accelerating collagen regeneration and activating fibroblasts. The self-assembled tyrosine-rich triblock peptides represent a versatile system for creating robust collagen mimetic biomaterials, providing great potential in skin rejuvenation and tissue regeneration.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-laponite encapsulated coaxial fiber scaffold promotes endochondral osteogenesis 纳米皂石封装同轴纤维支架促进软骨内骨生成

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-04 DOI: 10.1093/rb/rbae080

Li Yuan, Jiawei Wei, Shiqi Xiao, Shue Jin, Xue Xia, Huan Liu, Jiangshan Liu, Jiaxin Hu, Y. Zuo, Yubao Li, Fang Yang, Jidong Li

{"title":"Nano-laponite encapsulated coaxial fiber scaffold promotes endochondral osteogenesis","authors":"Li Yuan, Jiawei Wei, Shiqi Xiao, Shue Jin, Xue Xia, Huan Liu, Jiangshan Liu, Jiaxin Hu, Y. Zuo, Yubao Li, Fang Yang, Jidong Li","doi":"10.1093/rb/rbae080","DOIUrl":"https://doi.org/10.1093/rb/rbae080","url":null,"abstract":"\u0000 Osteoinductive supplements without side effects stand out from the growth factors and drugs widely used in bone tissue engineering. Lithium magnesium sodium silicate hydrate (Laponite) nanoflake is a promising bioactive component for bone regeneration, attributed to its inherent biosafety and effective osteoinductivity. Up to now, the in vivo osteogenic potential and mechanisms of laponite-encapsulated fibrous membranes remain largely unexplored. This study presents a unique method for homogeneously integrating high concentrations of laponite RDS into a polycaprolactone (PCL) matrix by dispersing laponite RDS sol into the polymer solution. Subsequently, a core-shell fibrous membrane (10RP-PG), embedding laponite-loaded PCL in its core, was crafted using coaxial electrospinning. The PCL core's slow degradation and the shell's gradient degradation enabled the sustained release of bioactive ions (Si and Mg) from laponite. In vivo studies on a critical-sized calvarial bone defect model demonstrated that the 10RP-PG membrane markedly enhanced bone formation and remodeling by accelerating the process of endochondral ossification. Further transcriptome analysis suggested that osteogenesis in the 10RP-PG membrane is driven by Mg and Si from endocytosed laponite, activating pathways related to ossification and endochondral ossification, including Hippo, Wnt, and Notch. The fabricated nanocomposite fibrous membranes hold great promise in the fileds of critical-sized bone defect repair.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Biomaterials for Oral-Maxillofacial Bone Regeneration: Spotlight on Periodontal and Alveolar Bone Strategies 口腔颌面骨再生生物材料的进展：聚焦牙周和牙槽骨策略

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-04 DOI: 10.1093/rb/rbae078

Nayun Li, Jinyu Wang, Guangxia Feng, Yuqing Liu, Yunsong Shi, Yifan Wang, Lili Chen

{"title":"Advances in Biomaterials for Oral-Maxillofacial Bone Regeneration: Spotlight on Periodontal and Alveolar Bone Strategies","authors":"Nayun Li, Jinyu Wang, Guangxia Feng, Yuqing Liu, Yunsong Shi, Yifan Wang, Lili Chen","doi":"10.1093/rb/rbae078","DOIUrl":"https://doi.org/10.1093/rb/rbae078","url":null,"abstract":"\u0000 The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing the repair and regeneration of oral-maxillofacial bone defects. Numerous characteristics should be noticed in oral-maxillofacial bone repair, such as irregular morphology of bone defects, homeostasis between hosts and microorganisms in the oral cavity, and complex periodontal structures that facilitate epithelial ingrowth. Therefore, oral-maxillofacial bone repair necessitates restoration materials that adhere to stringent and specific demands. This review starts with exploring these particular requirements by introducing the particular characteristics of oral-maxillofacial bones, and then summarizes the classifications of current bone repair materials in respect of composition and structure. Additionally, we discuss the modifications in current bone repair materials including improving mechanical properties, optimizing surface topography and pore structure, and adding bioactive components such as elements, compounds, cells, and their derivatives. Ultimately, we organize a range of potential optimization strategies and future perspectives for enhancing oral-maxillofacial bone repair materials, including physical environment manipulation, oral microbial homeostasis modulation, osteo-immune regulation, smart stimuli-responsive strategies and multifaceted approach for poly-pathic treatment, in the hope of providing some insights for researchers in this field. In summary, this review analyzes the complex demands of oral-maxillofacial bone repair, especially for periodontal and alveolar bone, concludes multifaceted strategies for corresponding biomaterials, and aims to inspire future research in the pursuit of more effective treatment outcomes.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corilagin functionalized decellularized extracellular matrix as artificial blood vessels with improved endothelialization and anti-inflammation by reactive oxygen species scavenging 科里拉金功能化脱细胞细胞外基质作为人造血管，通过清除活性氧改善内皮化和抗炎作用

IF 5.6 1区医学

Regenerative Biomaterials Pub Date : 2024-07-01 DOI: 10.1093/rb/rbae074

Xu Wang, Hanmei Fu, Huibin Wu, Xiaohua Peng, Xu Peng, Xixun Yu, Hui Liu, Junmei Wu, Ling Luo, Shan Yan, Xinglin Cheng, Xiong Zhou, Xiangyang Yuan

{"title":"Corilagin functionalized decellularized extracellular matrix as artificial blood vessels with improved endothelialization and anti-inflammation by reactive oxygen species scavenging","authors":"Xu Wang, Hanmei Fu, Huibin Wu, Xiaohua Peng, Xu Peng, Xixun Yu, Hui Liu, Junmei Wu, Ling Luo, Shan Yan, Xinglin Cheng, Xiong Zhou, Xiangyang Yuan","doi":"10.1093/rb/rbae074","DOIUrl":"https://doi.org/10.1093/rb/rbae074","url":null,"abstract":"\u0000 The performance of biological-originated blood vessels in clinical remains disappointing due to fast occlusion caused by acute thrombosis or long-standing inflammation. How to prevent rapid degradation and inhibit acute inflammation but maintain their high bioactivity is still a significant challenge. As a bioactive polyphenol in various traditional Chinese medicine, Corilagin (Cor) exhibits excellent anticoagulant, anti-inflammatory, and rapid ROS consumption properties. Inspired by abundant supramolecular interactions in organisms, we selected it to crosslink tissues via purely H-bonds to simulate these natural interactions without introducing potential toxic aldehyde or carboxyl groups. Results show that 2 mg/mL was selected as the optimal corilagin concentration to form a stable crosslinking network (FI > 95%) and effectively delay their degradation. Corilagin modification not only enhances ECs adhesion and monolayer function via accelerating VEGF and TGF-β secretion but also promotes macrophage transformation from pro-inflammatory M1 phenotype to anti-inflammatory M2 ones. In vitro and ex-vivo studies implied that corilagin-crosslinked samples exhibited low platelet accumulation and decreased thrombin generation. In vivo evaluation further confirmed that corilagin-introducing could effectively consume ROS, thus exhibiting rapid endothelialization, suppressed inflammation, and reduced mineral deposition. Overall, corilagin crosslinking provided a bright future for blood vessels’ long-term patency and adapted to various blood-contacting surfaces.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0