Regenerative Biomaterials最新文献

{"title":"3D printed scaffolds with multistage osteogenic activity for bone defect repair.","authors":"Bing Li, Yichao Ma, Kanwal Fatima, Xiaojun Zhou, Shuo Chen, Chuanglong He","doi":"10.1093/rb/rbaf010","DOIUrl":"10.1093/rb/rbaf010","url":null,"abstract":"<p><p>The bone defect repair is a complex process including immune regulation, stem cell osteogenic differentiation and extracellular matrix mineralization. Current bone tissue engineering approaches often fail to adapt throughout the above osteogenic process, resulting in suboptimal repair outcomes. To address this problem, a 3D-printed scaffold with multistage osteogenic activity based on shape-memory elastomer and electroactive material is developed. The scaffold exhibits excellent shape memory performance and can trigger shape recovery by physiological temperature. The physiological temperature-triggered shape-memory behavior makes the scaffold promising for minimally invasive implantation. After electric field polarization, the scaffold's surface carries the negative charge, which can activate the PI3K/Akt signaling pathway to promote the polarization of macrophages to M2 phenotype and activate the FAK/ERK signaling pathway to promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), indicating that the scaffold can effectively participate in immune microenvironment regulation and stem cell osteogenic differentiation. Additionally, the negative charge on the scaffold's surface can attract calcium and phosphate ions, forming a mineralized matrix and promoting late-stage extracellular matrix mineralization by continuously supplying mineralizing ions such as calcium and phosphate. Overall, this study introduces a 3D-printed scaffold with multistage osteogenic activity, offering a promising strategy for bone defect repair.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf010"},"PeriodicalIF":5.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterials for neuroengineering: applications and challenges.","authors":"Huanghui Wu, Enduo Feng, Huanxin Yin, Yuxin Zhang, Guozhong Chen, Beier Zhu, Xuezheng Yue, Haiguang Zhang, Qiong Liu, Lize Xiong","doi":"10.1093/rb/rbae137","DOIUrl":"10.1093/rb/rbae137","url":null,"abstract":"<p><p>Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining and enhancement therapies are seen as the most promising strategies for restoring neural function, offering hope for individuals affected by these conditions. Despite their promise, the path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through the use of biomaterials, has emerged as a key field that is paving the way for innovative solutions to these challenges. It seeks to understand and treat neurological disorders, unravel the nature of consciousness, and explore the mechanisms of memory and the brain's relationship with behavior, offering solutions for neural tissue engineering, neural interfaces and targeted drug delivery systems. These biomaterials, including both natural and synthetic types, are designed to replicate the cellular environment of the brain, thereby facilitating neural repair. This review aims to provide a comprehensive overview for biomaterials in neuroengineering, highlighting their application in neural functional regaining and enhancement across both basic research and clinical practice. It covers recent developments in biomaterial-based products, including 2D to 3D bioprinted scaffolds for cell and organoid culture, brain-on-a-chip systems, biomimetic electrodes and brain-computer interfaces. It also explores artificial synapses and neural networks, discussing their applications in modeling neural microenvironments for repair and regeneration, neural modulation and manipulation and the integration of traditional Chinese medicine. This review serves as a comprehensive guide to the role of biomaterials in advancing neuroengineering solutions, providing insights into the ongoing efforts to bridge the gap between innovation and clinical application.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbae137"},"PeriodicalIF":5.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11855295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined magnesium and silicon ions synergistically promote functional regeneration of skeletal muscle by regulating satellite cell fate.","authors":"Hangbin Xia, Chen Yang, Huili Li, Lingwei Huang, Zhen Zeng, Runrun Chi, Ziwei Yang, Yuzen Wang, Jiang Chang, Yiren Jiao, Wenzhong Li","doi":"10.1093/rb/rbaf008","DOIUrl":"10.1093/rb/rbaf008","url":null,"abstract":"<p><p>Muscle satellite cells (MuSCs) play a vital role in skeletal muscle regeneration. However, in intractable muscle diseases such as volumetric muscle loss (VML), the quantity and function of MuSCs are significantly reduced, severely limiting the body's inherent muscle regeneration capability. In this study, we propose a novel strategy to modulate the fate of MuSCs using a combination of bioactive magnesium (Mg) and silicon (Si) ions, sustainably delivered through magnesium silicate (MgSiO₃, MS) bioceramic-based scaffolds. <i>In vitro</i>, Mg and Si ions synergistically promote the proliferation and differentiation of MuSCs. Similarly, Mg and Si ions derived from MS/poly(L-lactic acid) (MS/PLLA) composite scaffold also increase the proliferation and differentiation ability of MuSCs. Furthermore, MS/PLLA composite scaffolds facilitate the activation of MuSCs, regeneration of muscle fiber and neovascularization, while inhibiting fibrosis, thereby effectively restoring muscle function and promoting tibialis anterior muscle functional regeneration in a VML mouse model. Mechanistically, the combination of Mg and Si ions promotes the activation and proliferation of MuSCs by activating the Notch1-Hes1 pathway. Besides, the combination of Mg and Si ions also improves the differentiation of MuSCs by up-regulating Myod and Myog, and enhances fusion by up-regulating Mymk and Mymx expression. The outcomes of our research introduce a promising approach to the treatment of skeletal muscle injuries and related diseases.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf008"},"PeriodicalIF":5.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal regulation of the bone immune microenvironment via a 'Zn²⁺-quercetin' hierarchical delivery system for bone regeneration.","authors":"Hengliang Sun, Yedan Chen, Xiaoqin Sang, Qingxiang Liu, Haoran Yu, Shaojun Hu, Yingji Mao, Li Zhang","doi":"10.1093/rb/rbaf006","DOIUrl":"10.1093/rb/rbaf006","url":null,"abstract":"<p><p>The immunoregulation of tissue-engineered bone has emerged as a prominent area for bone defect repair. While this field demonstrates considerable potential, effectively managing relevant factors and maintaining a balanced immune microenvironment in practical applications remain substantial challenges that require resolution. In this study, we tested a novel comprehensive hierarchical delivery system based on the requirements of a natural immune microenvironment for inflammatory factors, to optimize local immune responses through precise regulation of drug release. Quercetin (Que)-loaded zeolite imidazolate framework-8 (ZIF-8) nanoparticles were embedded in gelatin methacrylate to create a drug-release system featuring a Zn²⁺ shell and quercetin core. <i>In vivo</i> and <i>in vitro</i> studies demonstrated that this dual sustained-release hydrogel-ZIF-8 system can produce low concentrations of Zn²⁺ at an early stage, resulting in a mild anti-inflammatory effect and proliferation of bone marrow mesenchymal stem cells. Moreover, as inflammation advances, the release of quercetin works synergistically with Zn²⁺ to enhance anti-inflammatory responses, reconfigure the local microenvironment, and mitigate the inflammatory response that adversely impacts bone health by inhibiting the Nuclear Factor-kappa B (NF-κB) signaling pathway, thereby promoting osteogenic differentiation. This system is pioneering for sequential microenvironment regulation based on its diverse anti-inflammatory properties, offering a novel and comprehensive strategy for bone immune regulation in the clinical treatment of bone defects.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf006"},"PeriodicalIF":5.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing β-TCP with E-rhBMP-2-infused fibrin for vertical bone regeneration in a mouse calvarium model.","authors":"Kun Zhao, Mitsuaki Ono, Xindi Mu, Ziyi Wang, Shichao Xie, Tomoko Yonezawa, Masahiro Okada, Takuya Matsumoto, Takuo Kuboki, Toshitaka Oohashi","doi":"10.1093/rb/rbae144","DOIUrl":"10.1093/rb/rbae144","url":null,"abstract":"<p><p>Effective reconstruction of large bone defects, particularly in thickness, remains one of the major challenges in orthopedic and dental fields. We previously produced an <i>Escherichia coli</i>-based industrial-scale GMP-grade recombinant human bone morphogenetic protein-2 (E-rhBMP-2) and showed that the combination of E-rhBMP-2 with beta-tricalcium phosphate (β-TCP/E-rhBMP-2) can effectively promote bone reconstruction. However, the limited mechanical strength and poor morphology retention of β-TCP granules are key points that need optimization to obtain more effective grafts and further expand its clinical applications. Therefore, we combined β-TCP/E-rhBMP-2 with fibrin gel to enhance its mechanical properties and usability for vertical bone regeneration. We investigated the mechanical properties and vertical bone regeneration effects of the materials applied, with or without fibrin containing E-rhBMP-2, in a calvarial defect model in mice. Compression tests were conducted to assess the initial stability of the materials. Scanning electron microscopy and Fourier transform infrared spectroscopy were conducted to characterize the presence of fibrin on the scaffold. After 4 and 12 weeks of implantation, micro-computed tomography and histological and immunofluorescent analyses were performed to assess the morphology and volume of the newly formed bone. The fibrin-containing groups had significantly higher initial mechanical strength and higher ability to maintain their morphology <i>in vivo</i> compared to the counterparts without fibrin. However, fibrin gel alone suppressed the bone formation ability of β-TCP/E-rhBMP-2 whereas the presence of high doses of E-rhBMP-2 in fibrin gel resulted in material resorption and enhanced new bone formation. In conclusion, fibrin gel significantly improved the mechanical strength and surgical manageability of the β-TCP/E-rhBMP-2 scaffold, and the addition of E-rhBMP-2 to the fibrin gel further enhanced the vertical bone regeneration and initial structural integrity of the scaffold.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbae144"},"PeriodicalIF":5.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Up IGF-I via high-toughness adaptive hydrogels for remodeling growth plate of children.","authors":"Zhiqiang Zhang, Haodong Li, Manning Qian, Yiming Zheng, Luhan Bao, Wenguo Cui, Dahui Wang","doi":"10.1093/rb/rbaf004","DOIUrl":"10.1093/rb/rbaf004","url":null,"abstract":"<p><p>The growth plate is crucial for skeletal growth in children, but research on repairing growth plate damage and restoring growth is limited. Here, a high-toughness adaptive dual-crosslinked hydrogel is designed to mimic the growth plate's structure, supporting regeneration and bone growth. Composed of aldehyde-modified bacterial cellulose (DBNC), methacrylated gelatin (GelMA) and sodium alginate (Alg), the hydrogel is engineered through ionic bonding and Schiff base reactions, creating a macroporous structure. This structure can transform into a denser form by binding with calcium ions. <i>In vitro</i>, the loose macroporous structure of the hydrogels can promote chondrogenic differentiation, and when it forms a dense structure by binding with calcium ions, it also can activate relevant chondrogenic signaling pathways under the influence of insulin-like growth factor I (IGF-1), further inhibiting osteogenesis. <i>In vivo</i> experiments in a rat model of growth plate injury demonstrated that the hydrogel promoted growth plate cartilage regeneration and minimized bone bridge formation by creating a hypoxic microenvironment that activates IGF-1-related pathways. This environment encourages chondrogenic differentiation while preventing the undesired formation of bone tissue within the growth plate area. Overall, the dual-crosslinked hydrogel not only mimics the growth plate's structure but also facilitates localized IGF-1 expression, effectively reshaping the growth plate's function. This approach represents a promising therapeutic strategy for treating growth plate injuries, potentially addressing challenges associated with skeletal growth restoration in pediatric patients.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf004"},"PeriodicalIF":5.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing sterilization and functional properties in Poloxamer 407 hydrogels: comparing heat and radiation techniques.","authors":"Angela De Lauretis, Anne Eriksson Agger, Antara Pal, Jan Skov Pedersen, Szymon Mikolaj Szostak, Reidar Lund, Ståle Petter Lyngstadaas, Jan Eirik Ellingsen, Dirk Linke, Håvard Jostein Haugen","doi":"10.1093/rb/rbaf005","DOIUrl":"10.1093/rb/rbaf005","url":null,"abstract":"<p><p>Poloxamer 407, also known as Pluronic^® F127, is gaining interest in the cosmetic, biomedical and pharmaceutical fields for its biocompatibility, safety and thermo-sensitive properties. Ensuring sterility is critical in clinical applications, and sterilization is often preferred over aseptic processing. However, sterilization can impact the functional properties of the hydrogel. In this study, we investigate the effects of steam heat (121°C, 20 min), dry heat (160°C, 1 h), gamma irradiation (25 kGy) and electron beam (e-beam) irradiation (15 and 25 kGy) on a 30% w/v Poloxamer 407 hydrogel formulation. Our analysis encompasses gelling properties, pH, Fourier-transform infrared spectroscopy, gel permeation chromatography, small-angle X-ray scattering, rheology, swelling, degradation by-products and lactate dehydrogenase release of the sterilized hydrogels, comparing them to a non-sterile counterpart. We demonstrated that heat sterilization alters the hydrogel's gelling and structural properties due to water evaporation and oxidation under harsh temperature conditions, especially when applying the dry heat method. Gamma irradiation proved unsuitable, resulting in an acidic and cytotoxic hydrogel due to oxidative degradation. In contrast, e-beam irradiation preserves the hydrogel's elasticity, gelling and structural properties while enhancing mechanical resilience and moderating swelling. Therefore, e-beam irradiation within the 15-25 kGy range appears to be the most suitable method for sterilizing a 30% w/v Poloxamer 407 hydrogel.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf005"},"PeriodicalIF":5.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocytosis-mediated healing: recombinant human collagen type III chain-induced wound healing for scar-free recovery.","authors":"Jian Jin, Haihang Li, Zhengli Chen, Qingsong Liu, Jiqiu Chen, Zihan Tao, Xudong Hong, Yinjia Ding, Yue Zhou, Aifen Chen, Xudong Zhang, Kaiyang Lv, Liangliang Zhu, Shihui Zhu","doi":"10.1093/rb/rbae149","DOIUrl":"10.1093/rb/rbae149","url":null,"abstract":"<p><p>Scar formation can be effectively prevented when the proportion of collagen type I (Col I)/type III (Col III) is reduced. Unlike Col III, recombinant human collagen type III chain (RHC III chain) does not possess a triple helical structure. This study aimed to elucidate the capacity of fibroblasts to uptake RHC III chain, reduce the Col I/Col III ratio and determine its effects on wound healing and scar. RHC III chain demonstrates qualified cell compatibility. In cell experiments, immunofluorescence and western blot (WB) analyses revealed an increase in the polyhistidine tag level, indicating that RHC III chain in internalized by these cells. Transmission electron microscopy showed increased intracellular phagocytic activity, indicating that RHC III chain enters fibroblasts by endocytosis. The immunofluorescence and WB showed that Col III synthesis enhanced, and Col I/Col III ratio reduced. However, the polyhistidine tag disappeared with time, indicating that RHC III chain degraded within cells and then synthesized into Col III. The content of newly synthesized Col III increases, but real-time fluorescence quantitative showed a decrease in Col III related gene content suggests the formation of negative feedback. However, due to the sufficient raw materials, the amount of Col III synthesis is still increasing, leading to the reduction of the ratio of type I collagen/type III collagen, which beneficial to wound healing and reduce scar hyperplasia. In animal experiments, the SD rat full-thickness skin defect model of wound suggests that RHC III chain also takes effect through endocytosis and ultimately promotes wound healing. The rabbit ear scar model suggests that RHC III chain inhibits scar proliferation by reducing the ratio of Col I/Col III. In summary, RHC III chain was endocytosed by fibroblasts to promote native Col III synthesis, as well as promote wound healing and reduce scar hyperplasia.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbae149"},"PeriodicalIF":5.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria-targeting nanomedicines with autophagy inhibitor to enhance cancer photothermal-chemotherapy.","authors":"Shuqi Chen, Wenxia Gao, Shuhua Chang, Bin He, Congbo Zhang, Miaochang Liu, Xueting Ye","doi":"10.1093/rb/rbae141","DOIUrl":"10.1093/rb/rbae141","url":null,"abstract":"<p><p>In this article, we fabricated nanomedicines with mitochondrial targeting function and autophagy inhibitor for enhancing cancer photothermal-chemotherapy. The nanoparticles were fabricated with gold nanoparticles (AuNPs) as cores and amphiphilic dextran with (3-carboxypropyl) triphenyl phosphorus bromide and β-cyclodextrin (β-CD) modification (TPP-DCD) as shells; the chemotherapeutic doxorubicin (DOX) and autophagy inhibitor chloroquine (CQ) were encapsulated in the nanoparticles. The TPP-DCD was synthesized via the immobilization of 2-aminoethanethiol modified β-CD and (3-carboxypropyl) triphenylphosphonium bromide on dextran to receive coordination interaction with AuNPs and mitochondria targeting. The size, morphology and properties of the Au@DOX/CQ@TPP-DCD nanoparticles were studied. The nanomedicines efficiently targeted cellular mitochondria to produce reactive oxygen species and photothermal effect under NIR irradiation. The released DOX and CQ could not only kill tumor cells directly, but also inhibit the autophagy of cancer cells to enhance therapeutic effects. Both <i>in vitro</i> and <i>in vivo</i> anticancer activities of the nanomedicines were investigated in detail. The <i>in vivo</i> imaging demonstrated that the Au@DOX/CQ@TPP-DCD nanomedicines exhibited efficient targeting, accumulation and retention in tumor-bearing mice. The apoptosis of cancer cells and tumor suppression were greatly accelerated with the addition of 808 nm NIR irradiation. The Au@DOX/CQ@TPP-DCD nanomedicine exhibited significant synergistic therapy, as 75% of tumors in mice disappeared. The Au@DOX/CQ@TPP-DCD nanoparticle is a promising nanomedicine for cancer therapy with synergistic effects.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbae141"},"PeriodicalIF":5.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photothermally controlled ICG@ZIF-8/PLGA coating to modify the degradation behavior and biocompatibility of Zn-Li alloy for bone implants.","authors":"Ting Zhang, Yameng Yu, Wei Yuan, Zeqi Ren, Yan Cheng, Shuilin Wu, Yufeng Zheng, Dandan Xia","doi":"10.1093/rb/rbaf001","DOIUrl":"10.1093/rb/rbaf001","url":null,"abstract":"<p><p>Biodegradable Zn alloy has recently gained attention for use in bone implants considering its biodegradability, attractive mechanical properties and bioactivity. However, excessive corrosion of Zn alloy at the early stage of implantation may cause severe cytotoxicity, resulting in insufficient osseointegration, which hinders the clinical use of Zn alloy. In this study, we designed a photothermally controlled degradative hybrid coating as a corrosion-protective barrier with the intention of preventing Zn ion burst release during the early stages of implantation and regaining the alloy's corrosion advantage later on. The coating consists of zeolite imidazole skeleton-encapsulated indocyanine green core-shell-structured nanoparticles and polylactic coglycolic acid (ICG@ZIF-8/PLGA) on pristine Zn-0.8 (wt.%) Li (ZL) alloy. The electrochemical test results indicated that coating ZL with ICG@ZIF-8/PLGA can effectively reduce its corrosion current density (i_corr) from 2.48 × 10^-5 A·cm^-2 to 2.10 × 10^-8 A·cm^-2. After near-infrared (NIR) light irradiation, ICG@ZIF-8 heated PLGA coating to reach Tg, causing the coating to degrade and the i_corr of the coated ZL alloy decreased to 2.50 × 10^-7 A·cm^-2, thus restoring corrosion advantage. Both <i>in vitro</i> and <i>in vivo</i> investigations showed that the coated ZL alloy had acceptable biocompatibility. Overall, the developed photothermally controlled coating improved the Zn alloy's resistance to corrosion and allowed for the adjustment of the Zn alloy's degradation rate through 808-nm NIR light irradiation.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf001"},"PeriodicalIF":5.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}