Regenerative Biomaterials最新文献

{"title":"Correction to: Recombinant collagen for the repair of skin wounds and photo-aging damage.","authors":"","doi":"10.1093/rb/rbaf064","DOIUrl":"https://doi.org/10.1093/rb/rbaf064","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/rb/rbae108.].</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf064"},"PeriodicalIF":5.6,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12206520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Degradation behavior of porous magnesium alloy scaffold under the low-intensity pulsed ultrasound intervention and their effect on bone defects repair.","authors":"","doi":"10.1093/rb/rbaf055","DOIUrl":"https://doi.org/10.1093/rb/rbaf055","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/rb/rbaf011.].</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf055"},"PeriodicalIF":5.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterial-assisted pancreatic cancer theranostics.","authors":"Yaqi Liu, Huachun Xu, Shihao Bai, Tianxiang Chen, Xuehua Ma, Jie Lin, Linglin Sun, Changyong Gao, Aiguo Wu, Qiang Li","doi":"10.1093/rb/rbaf054","DOIUrl":"10.1093/rb/rbaf054","url":null,"abstract":"<p><p>Pancreatic cancer is one of the most lethal malignancies, largely due to the limitations of current imaging technologies and treatment strategies, which hinder early diagnosis and effective disease management. Achieving precise theranostics for pancreatic cancer has become a priority, and recent advances have focused on the development of novel nanomaterials with enhanced imaging capabilities and therapeutic functionalities. These nanomaterials, through surface modifications, can significantly improve the targeting and precision of both diagnostic and therapeutic applications. Recent progress in nanomaterial design has led to the creation of multifunctional platforms that not only enhance imaging but also improve therapeutic efficacy. These innovations have spurred significant interest in the application of nanomaterials for pancreatic cancer theranostics. In this review, we highlight recent developments in the use of nanomaterials for diagnostic imaging and precision therapy in pancreatic cancer. Various applications, including magnetic, optical, acoustic and radiological imaging, as well as therapeutic strategies such as chemodynamic therapy, light-based therapy, sonodynamic therapy and gene therapy, are discussed. Despite the promising potential of these nanomaterials, several challenges remain. These include optimizing targeting mechanisms, enhancing nanomaterial stability <i>in vivo</i>, overcoming biological barriers and ensuring safe and effective translation to clinical settings. Addressing these challenges will require further research and innovation. With sustained efforts, nanomaterial-assisted diagnostics and therapeutics have the potential to revolutionize the management of pancreatic cancer, ultimately improving early detection and treatment outcomes. Continued progress in this field could significantly enhance the overall prognosis for pancreatic cancer patients, making it a more treatable disease in the future.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf054"},"PeriodicalIF":5.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of nanomaterials in osteoarthritis treatment and immune modulation.","authors":"Wei Deng, Tianshu Wang, Lei Li, Xuanyu Xiao, Yuanyuan Xu, Qiujiang Li, Qingsong Zhou, Yong Yin, Hongsheng Yang, Kai Gong, Yue Zhou, Yunbing Wang","doi":"10.1093/rb/rbaf048","DOIUrl":"10.1093/rb/rbaf048","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a highly prevalent degenerative cartilage disease globally. The medical community has recognized it as one of the major public health problems today. Nanomaterials are considered the most promising avenue for OA treatment because they exhibit unique physicochemical properties such as high catalytic activity, bio-enzyme-like reaction kinetics, and modulation of joint immune responses. Besides, nanomaterials can exert higher targeting to improve therapeutic efficacy and reduce side effects. These unique advantages have led to the widespread development of nanomaterials for OA treatment, and they are gradually seeing their most prosperous moment. A timely and comprehensive review of OA pathogenesis-immunomodulation-therapeutic efficacy from a nanomaterials perspective would greatly broaden this research area. This review summarizes the recent advances in nanomaterials for OA treatment. Finally, the main challenges and opportunities for nanomaterials to modulate the immune system for OA treatment are discussed.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf048"},"PeriodicalIF":5.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in skeletal muscle tissue engineering: strategies for repair and regeneration of skeletal muscle beyond self-repair.","authors":"Lei Qi, Fengyuan Zhang, Kexin Wang, Bingqian Chen, Xia Li, Jin Xu, Jiacheng Sun, Boya Liu, Zihui Gao, Yanan Ji, Leilei Gong, Youhua Wang, Xinlei Yao, Xiaosong Gu, Hualin Sun","doi":"10.1093/rb/rbaf050","DOIUrl":"10.1093/rb/rbaf050","url":null,"abstract":"<p><p>Skeletal muscle is a vital organ of exercise and energy metabolism, playing a crucial role in maintaining body posture, enabling movement and supporting overall health. When skeletal muscle undergoes minor injuries, it has the inherent ability to self-repair and regain function. However, the ability of skeletal muscle self-repair is affected in severe muscle damage, resulting in significant muscle loss and functional impairments. For the severe muscle injury, tissue engineering strategies are used as the new methods to promote the repair and regeneration of skeletal muscle. Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate skeletal muscle using seed cells, scaffolds, bioactive molecules or their combinations to reverse muscle loss caused by traumatic injury or congenital muscle defects. In this study, we provide an overview of the structure and contraction process of skeletal muscle, as well as its mechanisms of natural repair and regeneration. We describe the seed cells with myogenic potential and show natural, synthetic and composite biomaterials, as well as advanced technologies for manufacturing scaffolds used in SMTE. SMTE has broad prospects, but it still faces many challenges before clinical application. The continued advancement of muscle tissue engineering will yield innovative outcomes with significant clinical potential for skeletal muscle regeneration.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf050"},"PeriodicalIF":5.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porous PLLA microspheres dispersed in HA/collagen hydrogel as injectable facial fillers to enhance aesthetic effects.","authors":"Miaoran Zhao, Shuhua Chang, Yunpeng Wang, Jun Cao, Yuji Pu, Bin He, Shengsheng Pan","doi":"10.1093/rb/rbaf049","DOIUrl":"10.1093/rb/rbaf049","url":null,"abstract":"<p><p>Injectable facial fillers such as Sculptra^® stimulate collagen regeneration to fill wrinkles; however, the collagen regeneration is not satisfactory due to the slow emergence of filling effect. In this study, we designed a regenerative dermal filler to provide both immediate and long-lasting filling effects. A hydrogel matrix composed of crosslinked hyaluronic acid (HA) and collagen was engineered to encapsulate porous poly(L-lactide) (PLLA) microspheres and tranexamic acid (TXA). The hydrogel matrix was administered via intradermal injection to achieve wrinkle filling. TXA is released to exert skin-whitening effects, while the porous PLLA microspheres and their degradation product, lactic acid, continuously stimulate collagen regeneration over an extended period. Facial volume increased immediately following hydrogel injection. Large amounts of new Type I and Type III collagen are generated. The porous structure of PLLA microspheres facilitated the 'penetrating growth' of collagen fibers, which effectively filled facial depressions and smoothed wrinkles. Overall, the HA/collagen composite hydrogel filler exhibited excellent esthetic effects.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf049"},"PeriodicalIF":5.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Sulfated GAG mimetic peptide nanofibers enhance chondrogenic differentiation of mesenchymal stem cells in 3D <i>in vitro</i> models.","authors":"","doi":"10.1093/rb/rbaf045","DOIUrl":"https://doi.org/10.1093/rb/rbaf045","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/rb/rbac084.].</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf045"},"PeriodicalIF":5.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis boosting system based on a sonodynamic therapy cascade-augmented strategy for triple-negative breast cancer therapy.","authors":"Juying Zhang, Hanmei Li, Litao Ye, Yihan Leng, Xiaoqing Wang, You Yang, Qiong Jiang, Linli Feng, Ling Li, Yang Li, Jinhong Yu","doi":"10.1093/rb/rbaf042","DOIUrl":"10.1093/rb/rbaf042","url":null,"abstract":"<p><p>One of the novel forms of programmed cell death, ferroptosis, has recently emerged as a hopeful treatment strategy for triple-negative breast cancer (TNBC). However, insufficient levels of intracellular reactive oxygen species (ROS) and high levels of ROS scavengers in the tumor microenvironment (TME), such as glutathione (GSH), hamper the efficacy of ferroptosis therapy. In this study, the introduction of manganese dioxide nanoparticles (MnO₂ NPs) generated cytotoxic hydroxyl radicals (⋅OH) in the TME. Importantly, MnO₂ NPs act as a nanosensitizer by consuming H₂O₂/GSH in the TME, generating oxygen (O₂) to relieve the oxygen deficiency of tumors, induce tumor oxidative stress and ultimately enhance SDT-induced ferroptosis. Additionally, oxygen, as an ultrasound contrast agent, enables the visualization of the TNBC treatment process. Meanwhile, GSH depletion in the TME leads to failure of the major cellular system defending against ferroptosis, which also promotes the accumulation of lipid peroxidation in tumor tissue. Specifically, robust autophagy induced by ROS enhances the intracellular iron pool by breaking down ferritin, thereby promoting ferroptosis in cancer cells, leading to the optimal antitumor effect. Consequently, a ferroptosis boosting system that simultaneously encapsulates MnO₂ NPs and chlorin e6 (Ce6) was constructed for the intervention of TNBC. Both the <i>in vitro</i> and <i>in vivo</i> results demonstrated that Ce6-MnO₂-BSA nanoparticles can generate a significant ROS storm under ultrasound irradiation, eliminating GSH and inducing an autophagic response that increases the effectiveness of ferroptosis, thus, inhibiting the growth of TNBC without obvious toxic side effects. This effective strategy can cascade-augment cancer cell ferroptosis, providing a new perspective for the clinical treatment of TNBC.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf042"},"PeriodicalIF":5.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a mechanical adaptable, moisture retention capable, injectable and adhesive organohydrogel for nucleus pulposus repairing.","authors":"Yaping Wang, Dong Wang, Chu Gao, Chuxin Zhou, Xiao Lin, Di Wang, Liu Yang, Huan Zhou, Lei Yang","doi":"10.1093/rb/rbaf047","DOIUrl":"10.1093/rb/rbaf047","url":null,"abstract":"<p><p>Developing mechanical adaptable injectable gel with nucleus pulposus (NP) repairing capability for minimally invasive treatment of intervertebral disc degeneration (IDD) is of great importance in medical practice. In current work, inspired by the outcomes of polyvinyl alcohol and glycerol based injectable organohydrogel (GPG) in IDD control and the great potential of animal glue in tissue adhesion, a novel injectable and self-crosslinking adhesive organohydrogel GPG-AG was fabricated. The mechanical performance of the GPG-AG was systematically studied, possessing viscoelastic properties close to NP accompanied with strong adhesion to intervertebral disc to avoid dynamic loading induced leakage postinjection. In addition, the swelling behavior, water retention capability and degradation of the organohydrogel <i>in situ</i> was also explored. <i>In vitro</i> cellular test showed the as-fabricated organohydrogel was able to upgrade aggrecan expression while downregulate matrix metallopeptidase-13 (MMP-13) synthesis. Astoundingly, the organohydrogel revealed anti-inflammation potential of alleviating excessive reactive oxygen species, consequently creating a favored microenvironment for NP repairing. The corresponding <i>in vivo</i> study showed the outcome in intervertebral disc height index of the GPG-AG treated group after needle puncture was superior to previously reported GPG and control group. Taken together, this organohydrogel is expected to serve as a promising candidate for IDD control.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf047"},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tartaric acid-branched polyethyleneimine carbon dots promote repair of bone defect via osteogenic differentiation.","authors":"Soon Chul Heo, Hae Won Shin, Dong Joon Lee, Franklin Garcia-Godoy, Bo Ram Keum, Yong Hoon Kwon, Hyung Joon Kim","doi":"10.1093/rb/rbaf030","DOIUrl":"10.1093/rb/rbaf030","url":null,"abstract":"<p><p>Treating bone defects is a critical challenge in regenerative medicine. Carbon nanomaterials, with their unique physicochemical properties, offer significant potential for enhancing bone regeneration. In this study, we developed tartaric acid (TA)-based carbon dots (CDs) by synthesizing TA with branched polyethyleneimine (bPEI). These TA-bPEI CDs were systematically evaluated to determine their effects on osteogenic differentiation in human bone marrow-derived mesenchymal stem cells (BMSCs) and their capacity to repair calvarial defects in an <i>in vivo</i> model. Characterization of TA-bPEI CDs revealed a size of approximately 10 nm and a positive surface charge. The CDs exhibited fluorescence emission peaks between 464 and 506 nm under excitation wavelengths of 340-440 nm. Cytotoxicity assays demonstrated that TA-bPEI CDs maintained BMSC viability at concentrations up to 250 μg/ml. However, at concentrations of 500 μg/ml and above, apoptosis was induced. Treatment with TA-bPEI significantly enhanced osteogenic differentiation <i>in vitro</i>, as evidenced by increased expression of osteogenic-specific proteins such as Runx2, ALP, OCN and OPN. <i>In vivo</i>, the application of TA-bPEI CDs in a mouse calvarial defect model promoted robust new bone formation, reduced defect gaps, and improved bone morphometric parameters, including bone volume fraction and trabecular thickness. These results suggest that TA-bPEI CDs enhance osteogenesis by directly stimulating osteogenic differentiation and upregulating osteogenesis-specific genes. This study demonstrates the high potential of TA-bPEI CDs as a novel nanomaterial for bone regeneration applications.</p>","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"12 ","pages":"rbaf030"},"PeriodicalIF":5.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}