Regenerative Biomaterials最新文献_第10页

Effects of serum proteins on corrosion rates and product bioabsorbability of biodegradable metals 血清蛋白对可生物降解金属的腐蚀速率和产品生物可吸收性的影响

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-12-12 DOI: 10.1093/rb/rbad112

Hongjie Zhang, Xin Li, Zehua Qu, Wanqian Zhang, Qunsong Wang, Dinglingge Cao, Yaoben Wang, Xin Wang, Yang Wang, Lin Yu, Jiandong Ding

{"title":"Effects of serum proteins on corrosion rates and product bioabsorbability of biodegradable metals","authors":"Hongjie Zhang, Xin Li, Zehua Qu, Wanqian Zhang, Qunsong Wang, Dinglingge Cao, Yaoben Wang, Xin Wang, Yang Wang, Lin Yu, Jiandong Ding","doi":"10.1093/rb/rbad112","DOIUrl":"https://doi.org/10.1093/rb/rbad112","url":null,"abstract":"Corrodible metals are the newest kind of biodegradable materials and raise a new problem of the corrosion products. However, the removal of the precipitated products has been unclear and even largely ignored in publications. Herein, we find that albumin, an abundant macromolecule in serum enhances the solubility of corrosion products of iron in blood mimetic Hank’s solution significantly. This is universal for other main biodegradable metals such as magnesium, zinc and polyester-coated iron. Albumin also influences corrosion rates in diverse trends in Hank’s solution and normal saline. Based on quantitative study theoretically and experimentally, both the effects on corrosion rates and soluble fractions are interpreted by a unified mechanism, and the key factor leading to different corrosion behaviors in corrosion media is the interference of albumin to the Ca/P passivation layer on the metal surface. This work has illustrated that the interactions between metals and media macromolecules should be taken into consideration in the design of the next-generation metal-based biodegradable medical devices in the formulism of precision medicine. The improved Hank’s solution in presence of albumin and with a higher content of initial calcium salt is suggested to access biodegradable metals potentially for cardiovascular medical devices, where the content of calcium salt is calculated after consideration of chelating of calcium ions by albumin resulting in the physiological concentration of free calcium ions.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"110 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138579631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Protein Corona Composition: Predicting with Resampling Embedding and Machine Learning 揭开蛋白质冠层构成的神秘面纱：利用重采样嵌入和机器学习进行预测

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-12-12 DOI: 10.1093/rb/rbad082

Rong Liao, Yan Zhuang, Xiangfeng Li, Ke Chen, Xingming Wang, Cong Feng, Guangfu Yin, Xiangdong Zhu, Jiangli Lin, Xingdong Zhang

{"title":"Unveiling Protein Corona Composition: Predicting with Resampling Embedding and Machine Learning","authors":"Rong Liao, Yan Zhuang, Xiangfeng Li, Ke Chen, Xingming Wang, Cong Feng, Guangfu Yin, Xiangdong Zhu, Jiangli Lin, Xingdong Zhang","doi":"10.1093/rb/rbad082","DOIUrl":"https://doi.org/10.1093/rb/rbad082","url":null,"abstract":"Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue regeneration. When nanoparticles (NPs) enter the living system, they quickly interact with proteins in the body fluid, forming the protein corona (PC). The accurate prediction of the PC composition is critical for analyzing the osteoinductivity of biomaterials and guiding the reverse design of NPs. However, achieving accurate predictions remains a significant challenge. Although several machine learning (ML) models like RandomForest (RF) have been used for PC prediction, they often fail to consider the extreme values in the abundance region of PC absorption and struggle to improve accuracy due to the imbalanced data distribution. In this study, resampling embedding was introduced to resolve the issue of imbalanced distribution in PC data. Various ML models were evaluated, and RF model was finally used for prediction, and good correlation coefficient (R2) and Root-mean-square deviation (RMSE) values were obtained. Our ablation experiments demonstrated that the proposed method achieved an R2 of 0.68, indicating an improvement of approximately 10%, and an RMSE of 0.90, representing a reduction of approximately 10%. Furthermore, through the verification of label-free quantification of 4 NPs: hydroxyapatite (HA), titanium dioxide (TiO2), silicon dioxide (SiO2) and silver (Ag), and we achieved a prediction performance with an R2 value above 0.70 using Random Oversampling. Additionally, the feature analysis revealed that the composition of the PC is most significantly influenced by the incubation plasma concentration, PDI and surface modification.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"25 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138579808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds 时空顺序递送抗菌药和消炎药的 ROS 响应水凝胶用于修复 MRSA 感染的伤口

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-12-08 DOI: 10.1093/rb/rbad110

Bowen Qiao, Jiaxin Wang, Lipeng Qiao, Aziz Maleki, Yongping Liang, Baolin Guo

{"title":"ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds","authors":"Bowen Qiao, Jiaxin Wang, Lipeng Qiao, Aziz Maleki, Yongping Liang, Baolin Guo","doi":"10.1093/rb/rbad110","DOIUrl":"https://doi.org/10.1093/rb/rbad110","url":null,"abstract":"For the treatment of MRSA-infected wounds, the spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs is a promising strategy. In this study, ROS responsive HA-PBA/PVA (HPA) hydrogel was prepared by phenylborate ester bond cross-linking between hyaluronic acid grafted 3-aminophenylboronic acid (HA-PBA) and polyvinyl alcohol (PVA) to achieve spatiotemporally controlled release of two kinds of drug to treat MRSA-infected wound. The hydrophilic antibiotic moxifloxacin (M) was directly loaded in the hydrogel. And hydrophobic curcumin (Cur) with anti-inflammatory function was first mixed with Pluronic F127 (PF) to form curcumin encapsulated PF micelles (Cur-PF), and then loaded into the HPA hydrogel. Due to the different hydrophilic and hydrophobic nature of moxifloxacin and curcumin and their different existing forms in the HPA hydrogel, the final HPA/M&Cur-PF hydrogel can achieve different spatiotemporally sequential delivery of the two drugs. In addition, the swelling, degradation, self-healing, antibacterial, anti-inflammatory, antioxidant property, and biocompatibility of hydrogels were tested. Finally, in the MRSA-infected mouse skin wound, the hydrogel treated group showed faster wound closure, less inflammation and more collagen deposition. Immunofluorescence experiments further confirmed that the hydrogel promoted better repair by reducing inflammation (TNF-α) and promoting vascular (VEGF) regeneration. In conclusion, this HPA/M&Cur-PF hydrogel that can spatiotemporally sequential deliver antibacterial and anti-inflammatory drugs showed great potential for the repair of MRSA-infected skin wounds.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"9 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138560458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine 用于组织工程和再生医学的脱细胞细胞外基质复合支架

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-12-01 DOI: 10.1093/rb/rbad107

Peiyao Xu, Ranjith Kumar Kankala, Shibin Wang, Aizheng Chen

{"title":"Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine","authors":"Peiyao Xu, Ranjith Kumar Kankala, Shibin Wang, Aizheng Chen","doi":"10.1093/rb/rbad107","DOIUrl":"https://doi.org/10.1093/rb/rbad107","url":null,"abstract":"Despite the considerable advancements in fabricating polymeric-based scaffolds for tissue engineering, the clinical transformation of these scaffolds remained a big challenge because of the difficulty of simulating native organs/tissues' microenvironment. As a kind of natural tissue-derived biomaterials, decellularized extracellular matrix (dECM)-based scaffolds have gained attention due to their unique biomimetic properties, providing a specific microenvironment suitable for promoting cell proliferation, migration, attachment, and regulating differentiation. The medical applications of dECM-based scaffolds have addressed critical challenges, including poor mechanical strength and insufficient stability. For promoting the reconstruction of damaged tissues or organs, different types of dECM-based composite platforms have been designed to mimic tissue microenvironment, including by integrating with natural polymer or/and syntenic polymer or adding bioactive factors. In this review, we summarized the research progress of dECM-based composite scaffolds in regenerative medicine, highlighting the critical challenges and future perspectives related to the medical application of these composite materials.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"38 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138531046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Status and Developmental Trends in Recombinant Collagen Preparation Technology 重组胶原蛋白制备技术现状及发展趋势

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-11-29 DOI: 10.1093/rb/rbad106

Xiaolei Guo, Yuan Ma, Hang Wang, Hongping Yin, Xinli Shi, Yiqin Chen, Guobiao Gao, Lei Sun, Jiadao Wang, Yunbing Wang, Daidi Fan

引用次数: 0

Sol-gel derived B2O3-CaO borate bioactive glasses with hemostatic, antibacterial and pro-angiogenic activities 溶胶-凝胶衍生的B2O3-CaO硼酸生物活性玻璃具有止血、抗菌和促血管生成活性

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-11-24 DOI: 10.1093/rb/rbad105

Kai Zheng, Faina Bider, Mahshid Monavari, Zhiyan Xu, Christina Janko, Christoph Alexiou, Ana Maria Beltrán, Aldo R Boccaccini

{"title":"Sol-gel derived B2O3-CaO borate bioactive glasses with hemostatic, antibacterial and pro-angiogenic activities","authors":"Kai Zheng, Faina Bider, Mahshid Monavari, Zhiyan Xu, Christina Janko, Christoph Alexiou, Ana Maria Beltrán, Aldo R Boccaccini","doi":"10.1093/rb/rbad105","DOIUrl":"https://doi.org/10.1093/rb/rbad105","url":null,"abstract":"Sol-gel borate bioactive glasses (BGs) are promising ion-releasing biomaterials for wound healing applications. Here we report the synthesis of a series of binary B2O3-CaO borate BGs (Ca ranging from 50 to 90 mol%) using a sol-gel-based method. The influence of CaO content in B2O3-CaO borate BG on morphology, structure and ion release behavior was investigated in detail. Reduced dissolution (ion release) and crystallization could be observed in borate BGs when CaO content increased, while the morphology was not significantly altered by CaO incorporation. Our results evidenced that the ion release behavior of borate BGs could be tailored by tuning the B2O3/CaO molar ratio. We also evaluated the in vitro cytotoxicity, hemostatic, antibacterial and angiogenic activities of borate BGs. Cytocompatibility was validated for all borate BGs. However, borate BGs exhibited composition-dependent hemostatic, antibacterial and angiogenic activities. Generally, higher contents of Ca in borate BGs facilitated hemostatic activity, while higher contents of B were beneficial for pro-angiogenic activity. The synthesized sol-gel derived borate BGs are promising materials for developing advanced wound healing dressing, given their fast ion release behavior and favorable hemostatic, antibacterial and angiogenic activities.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"24 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138531047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exogeneous Metal ions as therapeutic agents in cardiovascular disease and their delivery strategies 异质金属离子作为心血管疾病治疗剂及其递送策略

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-11-21 DOI: 10.1093/rb/rbad103

Xiaoqian Hong, Geer Tian, Yang Zhu, Tanchen Ren

{"title":"Exogeneous Metal ions as therapeutic agents in cardiovascular disease and their delivery strategies","authors":"Xiaoqian Hong, Geer Tian, Yang Zhu, Tanchen Ren","doi":"10.1093/rb/rbad103","DOIUrl":"https://doi.org/10.1093/rb/rbad103","url":null,"abstract":"Metal ions participate in many metabolic processes in the human body, and their homeostasis is crucial for life. In cardiovascular diseases (CVDs), the equilibriums of metal ions are frequently interrupted, which are related with a variety of disturbances of physiological processes leading to abnormal cardiac functions. Exogenous supplement of metal ions has the potential to work as therapeutic strategies for the treatment of CVDs. Compared with other therapeutic drugs, metal ions possess broad availability, good stability and safety, and diverse drug delivery strategies. The delivery strategies of metal ions are important to exert their therapeutic effects and reduce the potential toxic side effects for cardiovascular applications, which are also receiving increasing attentions. Controllable local delivery strategies for metal ions based on various biomaterials are constantly being designed. In this review, we comprehensively summarized the positive roles of metal ions in the treatment of CVDs from three aspects: protecting cells from oxidative stress, inducing angiogenesis, and adjusting the functions of ion-channels. In addition, we introduced the transferability of metal ions in vascular reconstruction and cardiac tissue repair, as well as the currently available engineered strategies for the precise delivery of metal ions, such as integrated with nanoparticles, hydrogels, and scaffolds.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"43 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138531073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue adhesive, ROS-scavenging and injectable PRP-based “plasticine” for promoting cartilage repair 组织胶粘剂，ros清除剂和可注射的prp基“橡皮泥”促进软骨修复

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-11-21 DOI: 10.1093/rb/rbad104

Shiao Li, Dawei Niu, Haowei Fang, Yancheng Chen, Jinyan Li, Kunxi Zhang, Jingbo Yin, Peiliang Fu

{"title":"Tissue adhesive, ROS-scavenging and injectable PRP-based “plasticine” for promoting cartilage repair","authors":"Shiao Li, Dawei Niu, Haowei Fang, Yancheng Chen, Jinyan Li, Kunxi Zhang, Jingbo Yin, Peiliang Fu","doi":"10.1093/rb/rbad104","DOIUrl":"https://doi.org/10.1093/rb/rbad104","url":null,"abstract":"Platelet-rich plasma (PRP) that has various growth factors has been used clinically in cartilage repair. However, the short residence time and release time at the injury site limit its therapeutic effect. The present study fabricated a granular hydrogel that assembled from gelatin microspheres and tannic acid (TA) through their abundant hydrogen bonding. Gelatin microspheres with the gelatin concentration of 10 wt% and the diameter distribution of 1–10 μm were used to assemble by TA to form the granular hydrogel, which exhibited elasticity under low shear strain, but flowability under higher shear strain. The viscosity decreased with increase of shear rate. Meanwhile, the granular hydrogel exhibited self-healing feature during rheology test. Thus, granular hydrogel carrying PRP not only exhibited well-performed injectability, but also performed like a “plasticine” that possessed good plasticity. The granular hydrogel showed tissue adhesion ability and reactive oxygen species (ROS) scavenging ability. Granular hydrogel carrying PRP transplanted to full thickness articular cartilage defects could integrate well with native cartilage, resulting in newly formed cartilage articular fully filled in defects and well-integrated with the native cartilage and subchondral bone. The unique feature of the present granular hydrogel, including injectability, plasticity, porous structure, tissue adhesion, and ROS scavenging provided an ideal PRP-carrier towards cartilage tissue engineering.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"37 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138531037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Citrate-based Polyurethane Tissue Adhesive for Fast Sealing and Promoted Wound Healing 生物活性柠檬酸酯基聚氨酯组织胶，用于快速密封和促进伤口愈合

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-11-20 DOI: 10.1093/rb/rbad101

Yan Li, Jiawei Liu, Chenxi Lian, He Yang, Mingjiang Zhang, Youfa Wang, Honglian Dai

{"title":"Bioactive Citrate-based Polyurethane Tissue Adhesive for Fast Sealing and Promoted Wound Healing","authors":"Yan Li, Jiawei Liu, Chenxi Lian, He Yang, Mingjiang Zhang, Youfa Wang, Honglian Dai","doi":"10.1093/rb/rbad101","DOIUrl":"https://doi.org/10.1093/rb/rbad101","url":null,"abstract":"As a superior alternative to sutures, tissue adhesives have been developed significantly in recent years. However, existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces, bond weakly in wet environments, and lack bioactivity. In this study, a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue adhesion. The hydrophobic layer was created with polycaprolactone to overcome the bonding failure between tissue and adhesion layer in wet environments, which can effectively improve the wet bonding strength. This citrate-based polyurethane adhesive provides rapid, non-invasive, liquid-tight, and seamless closure of skin incisions, overcoming the limitations of sutures and commercial tissue adhesives. In addition, it exhibits biocompatibility, biodegradability, and hemostatic properties. The degradation product citrate could promote the process of angiogenesis and accelerate wound healing. This study provides a novel approach to the development of a fast-adhering wet tissue adhesive and provides a valuable contribution to the development of polyurethane-based tissue adhesives.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"220 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138531045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant 表面脱矿冻干同种异体骨移植后再植失败的下颌牙种植体

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2023-11-17 DOI: 10.1093/rb/rbad102

Jing Zhang, Jie Wang, Jiayi You, Xuan Qin, Huimin Chen, Xiantong Hu, Yantao Zhao, Yang Xia

{"title":"Surface demineralized freeze-dried bone allograft followed by reimplantation in a failed mandibular dental implant","authors":"Jing Zhang, Jie Wang, Jiayi You, Xuan Qin, Huimin Chen, Xiantong Hu, Yantao Zhao, Yang Xia","doi":"10.1093/rb/rbad102","DOIUrl":"https://doi.org/10.1093/rb/rbad102","url":null,"abstract":"The removal of a failed implant with high torque causes significant damage to the surrounding tissue, compromising bone regeneration and subsequent osseointegration in the defect area. Here, we report a case of carrier screw fracture followed by immediate implant removal, bone grafting, and delayed reimplantation. A dental implant with a fractured central carrier screw was removed using the bur-forceps technique. The resulting three-wall bone defect was filled with granular surface demineralized freeze-dried bone allograft (SD-FDBA). Cone-beam computerized tomography was performed at 1 week, 6 months, and 15 months postoperatively, and standardized for quantitative evaluation. The alveolar bone width and height at 15 months post-surgery were about 91% of the original values, with a slightly lower bone density, calculated using the gray value ratio. The graft site was reopened and was found to be completely healed with dense and vascularized bone along with some residual bone graft. Reimplantation followed by restoration was performed 8 months later. The quality of regenerated bone following SD-FDBA grafting was adequate for osseointegration and long-term implant success. The excellent osteogenic properties of SD-FDBA are attributed to its human origin, cortical bone like structure, partly demineralized surfaces, and bone morphogenetic protein-2 containing nature. Further investigation with more cases and longer follow-up was required to confirm the final clinical effect.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138531051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0