Regenerative Biomaterials最新文献_第10页

3D printing sequentially strengthening high-strength natural polymer hydrogel bilayer scaffold for cornea regeneration 用于角膜再生的三维打印顺序强化高强度天然聚合物水凝胶双层支架

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-02-09 DOI: 10.1093/rb/rbae012

Xiongfeng Nie, Yong Tang, T. Wu, Xinrui Zhao, Ziyang Xu, Rong Yang, Yage Sun, Bin Wu, Quanhong Han, Jingwen Hui, Wenguang Liu

{"title":"3D printing sequentially strengthening high-strength natural polymer hydrogel bilayer scaffold for cornea regeneration","authors":"Xiongfeng Nie, Yong Tang, T. Wu, Xinrui Zhao, Ziyang Xu, Rong Yang, Yage Sun, Bin Wu, Quanhong Han, Jingwen Hui, Wenguang Liu","doi":"10.1093/rb/rbae012","DOIUrl":"https://doi.org/10.1093/rb/rbae012","url":null,"abstract":"\u0000 3D printing of high-strength natural polymer biodegradable hydrogel scaffolds simultaneously resembling the biomechanics of corneal tissue and facilitating tissue regeneration remains a huge challenge due to the inherent brittleness of natural polymer hydrogels and the demanding requirements of printing. Herein, concentrated aqueous solutions of gelatin and carbohydrazide modified alginate (Gel/Alg-CDH) are blended to form a natural polymer hydrogel ink, where the hydrazides in Alg-CDH are found to form strong hydrogen-bonds with the gelatin. The hydrogen-bonding-strengthened Gel/Alg-CDH hydrogel demonstrates an appropriate thickened viscosity and shear-thinning for extrusion printing. The strong hydrogen bonds contribute to remarkably increased mechanical properties of Gel/Alg-CDH hydrogel with a maximum elongation of over 400%. In addition, sequentially Ca2+-physical crosslinking and then moderately chemical crosslinking significantly enhance the mechanical properties of Gel/Alg-CDH hydrogels that ultimately exhibit an intriguing J-shaped stress-strain curve (tensile strength of 1.068 MPa and the toughness of 677.6 kJ/m2). The dually crosslinked Gel-Alg-CDH-Ca2+-EDC hydrogels demonstrate a high transparency, physiological swelling stability and rapid enzymatic degradability, as well as suturability. Growth factor and drug-loaded biomimetic bilayer hydrogel scaffold is customized via a multi-nozzle printing system. This bioactive bilayer hydrogel scaffold considerably promotes regeneration of corneal epithelium and stroma, and inhibits cornea scarring in rabbit cornea keratoplasty.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix 通过对三维非细胞真皮基质进行生物活性和生物力学改性，促进软骨再生和修复

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-02-05 DOI: 10.1093/rb/rbae010

Wei Gao, Tan Cheng, Zhengya Tang, Wenqiang Zhang, Yong Xu, Min Han, Guangdong Zhou, Chunsheng Tao, Xu Ning, Huitang Xia, Weijie Sun

{"title":"Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix","authors":"Wei Gao, Tan Cheng, Zhengya Tang, Wenqiang Zhang, Yong Xu, Min Han, Guangdong Zhou, Chunsheng Tao, Xu Ning, Huitang Xia, Weijie Sun","doi":"10.1093/rb/rbae010","DOIUrl":"https://doi.org/10.1093/rb/rbae010","url":null,"abstract":"\u0000 Acellular dermal matrix (ADM) shows promise for cartilage regeneration and repair. However, an effective decellularization technique that removes cellular components while preserving the extracellular matrix, the transformation of 2D-ADM into a suitable 3D scaffold with porosity, and the enhancement of bioactive and biomechanical properties in the 3D-ADM scaffold are yet to be fully addressed. In this study, we present an innovative decellularization method involving 0.125% trypsin and 0.5% SDS and a 1% Triton X-100 solution for preparing ADM and converting 2D-ADM into 3D-ADM scaffolds. These scaffolds exhibit favorable physicochemical properties, exceptional biocompatibility, and significant potential for driving cartilage regeneration in vitro and in vivo. To further enhance the cartilage regeneration potential of 3D-ADM scaffolds, we incorporated porcine-derived small intestinal submucosa (SIS) for bioactivity and calcium sulfate hemihydrate (CSH) for biomechanical reinforcement. The resulting 3D-ADM+SIS scaffolds displayed heightened biological activity, while the 3D-ADM+CSH scaffolds notably bolstered biomechanical strength. Both scaffold types showed promise for cartilage regeneration and repair in vitro and in vivo, with considerable improvements observed in repairing cartilage defects within a rabbit articular cartilage model. In summary, this research introduces a versatile 3D-ADM scaffold with customizable bioactive and biomechanical properties, poised to revolutionize the field of cartilage regeneration.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139804208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix 通过对三维非细胞真皮基质进行生物活性和生物力学改性，促进软骨再生和修复

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-02-05 DOI: 10.1093/rb/rbae010

Wei Gao, Tan Cheng, Zhengya Tang, Wenqiang Zhang, Yong Xu, Min Han, Guangdong Zhou, Chunsheng Tao, Xu Ning, Huitang Xia, Weijie Sun

{"title":"Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix","authors":"Wei Gao, Tan Cheng, Zhengya Tang, Wenqiang Zhang, Yong Xu, Min Han, Guangdong Zhou, Chunsheng Tao, Xu Ning, Huitang Xia, Weijie Sun","doi":"10.1093/rb/rbae010","DOIUrl":"https://doi.org/10.1093/rb/rbae010","url":null,"abstract":"\u0000 Acellular dermal matrix (ADM) shows promise for cartilage regeneration and repair. However, an effective decellularization technique that removes cellular components while preserving the extracellular matrix, the transformation of 2D-ADM into a suitable 3D scaffold with porosity, and the enhancement of bioactive and biomechanical properties in the 3D-ADM scaffold are yet to be fully addressed. In this study, we present an innovative decellularization method involving 0.125% trypsin and 0.5% SDS and a 1% Triton X-100 solution for preparing ADM and converting 2D-ADM into 3D-ADM scaffolds. These scaffolds exhibit favorable physicochemical properties, exceptional biocompatibility, and significant potential for driving cartilage regeneration in vitro and in vivo. To further enhance the cartilage regeneration potential of 3D-ADM scaffolds, we incorporated porcine-derived small intestinal submucosa (SIS) for bioactivity and calcium sulfate hemihydrate (CSH) for biomechanical reinforcement. The resulting 3D-ADM+SIS scaffolds displayed heightened biological activity, while the 3D-ADM+CSH scaffolds notably bolstered biomechanical strength. Both scaffold types showed promise for cartilage regeneration and repair in vitro and in vivo, with considerable improvements observed in repairing cartilage defects within a rabbit articular cartilage model. In summary, this research introduces a versatile 3D-ADM scaffold with customizable bioactive and biomechanical properties, poised to revolutionize the field of cartilage regeneration.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human extracellular matrix (ECM)-like collagen and its bioactivity 类细胞外基质（ECM）胶原蛋白及其生物活性

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-02-01 DOI: 10.1093/rb/rbae008

Hui Zhou, Wenwei Li, Lixin Pan, Tianci Zhu, Teng Zhou, E. Xiao, Qiang Wei

{"title":"Human extracellular matrix (ECM)-like collagen and its bioactivity","authors":"Hui Zhou, Wenwei Li, Lixin Pan, Tianci Zhu, Teng Zhou, E. Xiao, Qiang Wei","doi":"10.1093/rb/rbae008","DOIUrl":"https://doi.org/10.1093/rb/rbae008","url":null,"abstract":"\u0000 Collagen, the most abundant structural protein in the human extracellular matrix (ECM), provides essential support for tissues and guides tissue development. Despite its widespread use in tissue engineering, there remains uncertainty regarding the optimal selection of collagen sources. Animal-derived sources pose challenges such as immunogenicity, while the recombinant system is hindered by diminished bioactivity. In this study, we hypothesized that human ECM-like collagen (hCol) could offer an alternative for tissue engineering. In this study, a facile platform was provided for generating hCol derived from mesenchymal stem cells (MSCs) with a hierarchical structure and biochemical properties resembling native collagen. Our results further demonstrated that hCol could facilitate basal biological behaviors of human adipose-derived stem cells (hASCs), including viability, proliferation, migration and adipocyte-like phenotype. Additionally, it could promote cutaneous wound closure. Due its high similarity to native collagen and good bioactivity, hCol holds promise as a prospective candidate for in vitro and in vivo applications in tissue engineering.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139892720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human extracellular matrix (ECM)-like collagen and its bioactivity 类细胞外基质（ECM）胶原蛋白及其生物活性

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-02-01 DOI: 10.1093/rb/rbae008

Hui Zhou, Wenwei Li, Lixin Pan, Tianci Zhu, Teng Zhou, E. Xiao, Qiang Wei

{"title":"Human extracellular matrix (ECM)-like collagen and its bioactivity","authors":"Hui Zhou, Wenwei Li, Lixin Pan, Tianci Zhu, Teng Zhou, E. Xiao, Qiang Wei","doi":"10.1093/rb/rbae008","DOIUrl":"https://doi.org/10.1093/rb/rbae008","url":null,"abstract":"\u0000 Collagen, the most abundant structural protein in the human extracellular matrix (ECM), provides essential support for tissues and guides tissue development. Despite its widespread use in tissue engineering, there remains uncertainty regarding the optimal selection of collagen sources. Animal-derived sources pose challenges such as immunogenicity, while the recombinant system is hindered by diminished bioactivity. In this study, we hypothesized that human ECM-like collagen (hCol) could offer an alternative for tissue engineering. In this study, a facile platform was provided for generating hCol derived from mesenchymal stem cells (MSCs) with a hierarchical structure and biochemical properties resembling native collagen. Our results further demonstrated that hCol could facilitate basal biological behaviors of human adipose-derived stem cells (hASCs), including viability, proliferation, migration and adipocyte-like phenotype. Additionally, it could promote cutaneous wound closure. Due its high similarity to native collagen and good bioactivity, hCol holds promise as a prospective candidate for in vitro and in vivo applications in tissue engineering.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of metal organic frameworks-based functional composite scaffolds in tissue engineering 基于金属有机框架的功能复合支架在组织工程中的应用

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-02-01 DOI: 10.1093/rb/rbae009

Xinlei Yao, Xinran Chen, Yu Sun, Pengxiang Yang, Xiaosong Gu, Xiu Dai

{"title":"Application of metal organic frameworks-based functional composite scaffolds in tissue engineering","authors":"Xinlei Yao, Xinran Chen, Yu Sun, Pengxiang Yang, Xiaosong Gu, Xiu Dai","doi":"10.1093/rb/rbae009","DOIUrl":"https://doi.org/10.1093/rb/rbae009","url":null,"abstract":"\u0000 With the rapid development of materials science and tissue engineering, a variety of biomaterials have been used to construct tissue engineering scaffolds. Due to the performance limitations of single materials, functional composite biomaterials have attracted great attention as tools to improve the effectiveness of biological scaffolds for tissue repair. In recent years, metal organic frameworks (MOFs) have shown great promise for application in tissue engineering because of their high specific surface area, high porosity, high biocompatibility, appropriate environmental sensitivities and other advantages. This review introduces methods for the construction of MOFs-based functional composite scaffolds and describes the specific functions and mechanisms of MOFs in repairing damaged tissue. The latest MOFs-based functional composites and their applications in different tissues are discussed. Finally, the challenges and future prospects of using MOFs-based composites in tissue engineering are summarized. The aim of this review is to show the great potential of MOFs-based functional composite materials in the field of tissue engineering and to stimulate further innovation in this promising area.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139888976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of metal organic frameworks-based functional composite scaffolds in tissue engineering 基于金属有机框架的功能复合支架在组织工程中的应用

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-02-01 DOI: 10.1093/rb/rbae009

Xinlei Yao, Xinran Chen, Yu Sun, Pengxiang Yang, Xiaosong Gu, Xiu Dai

{"title":"Application of metal organic frameworks-based functional composite scaffolds in tissue engineering","authors":"Xinlei Yao, Xinran Chen, Yu Sun, Pengxiang Yang, Xiaosong Gu, Xiu Dai","doi":"10.1093/rb/rbae009","DOIUrl":"https://doi.org/10.1093/rb/rbae009","url":null,"abstract":"\u0000 With the rapid development of materials science and tissue engineering, a variety of biomaterials have been used to construct tissue engineering scaffolds. Due to the performance limitations of single materials, functional composite biomaterials have attracted great attention as tools to improve the effectiveness of biological scaffolds for tissue repair. In recent years, metal organic frameworks (MOFs) have shown great promise for application in tissue engineering because of their high specific surface area, high porosity, high biocompatibility, appropriate environmental sensitivities and other advantages. This review introduces methods for the construction of MOFs-based functional composite scaffolds and describes the specific functions and mechanisms of MOFs in repairing damaged tissue. The latest MOFs-based functional composites and their applications in different tissues are discussed. Finally, the challenges and future prospects of using MOFs-based composites in tissue engineering are summarized. The aim of this review is to show the great potential of MOFs-based functional composite materials in the field of tissue engineering and to stimulate further innovation in this promising area.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139829029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A strategy for mechanically integrating robust hydrogel-tissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve. 以机械方式整合坚固的水凝胶-组织混合体以促进生物人工心脏瓣膜抗钙化和内皮化的策略。

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-01-30 eCollection Date: 2024-01-01 DOI: 10.1093/rb/rbae003

Haoshuang Wu, Nuoya Chen, Tiantian Zheng, Li Li, Mengyue Hu, Yumei Qin, Gaoyang Guo, Li Yang, Yunbing Wang

{"title":"A strategy for mechanically integrating robust hydrogel-tissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve.","authors":"Haoshuang Wu, Nuoya Chen, Tiantian Zheng, Li Li, Mengyue Hu, Yumei Qin, Gaoyang Guo, Li Yang, Yunbing Wang","doi":"10.1093/rb/rbae003","DOIUrl":"10.1093/rb/rbae003","url":null,"abstract":"Bioprosthetic heart valve (BHV) replacement has been the predominant treatment for severe heart valve diseases over decades. Most clinically available BHVs are crosslinked by glutaraldehyde (GLUT), while the high toxicity of residual GLUT could initiate calcification, severe thrombosis, and delayed endothelialization. Here, we construed a mechanically integrating robust hydrogel-tissue hybrid to improve the performance of BHVs. In particular, recombinant humanized collagen type III (rhCOLIII), which was precisely customized with anti-coagulant and pro-endothelialization bioactivity, was first incorporated into the polyvinyl alcohol (PVA)-based hydrogel via hydrogen bond interactions. Then, tannic acid was introduced to enhance the mechanical performance of PVA-based hydrogel and interfacial bonding between the hydrogel layer and bio-derived tissue due to the strong affinity for a wide range of substrates. In vitro and in vivo experimental results confirmed that the GLUT-crosslinked BHVs modified by the robust PVA-based hydrogel embedded rhCOLIII and TA possessed long-term anti-coagulant, accelerated endothelialization, mild inflammatory response and anti-calcification properties. Therefore, our mechanically integrating robust hydrogel-tissue hybrid strategy showed the potential to enhance the service function and prolong the service life of the BHVs after implantation.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy. 用于原位治疗肌腱病的抗氧化和消炎注射用水凝胶微球。

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-01-30 eCollection Date: 2024-01-01 DOI: 10.1093/rb/rbae007

Qibin Han, Lang Bai, Yinhua Qian, Xiaoyu Zhang, Juan Wang, Jing Zhou, Wenguo Cui, Yuefeng Hao, Xing Yang

{"title":"Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy.","authors":"Qibin Han, Lang Bai, Yinhua Qian, Xiaoyu Zhang, Juan Wang, Jing Zhou, Wenguo Cui, Yuefeng Hao, Xing Yang","doi":"10.1093/rb/rbae007","DOIUrl":"10.1093/rb/rbae007","url":null,"abstract":"Tendinopathy is a common disorder that causes local dysfunction and reduces quality of life. Recent research has indicated that alterations in the inflammatory microenvironment play a vital role in the pathogenesis of tendinopathy. Herein, injectable methacrylate gelatin (GelMA) microspheres (GM) were fabricated and loaded with heparin-dopamine conjugate (HDC) and hepatocyte growth factor (HGF). GM@HDC@HGF were designed to balance the inflammatory microenvironment by inhibiting oxidative stress and inflammation, thereby regulating extracellular matrix (ECM) metabolism and halting tendon degeneration. Combining growth factors with heparin was expected to improve the encapsulation rate and maintain the long-term efficacy of HGF. In addition, the catechol groups on dopamine have adhesion and antioxidant properties, allowing potential attachment at the injured site, and better function synergized with HGF. GM@HDC@HGF injected in situ in rat Achilles tendinopathy (AT) models significantly down-regulated oxidative stress and inflammation, and ameliorated ECM degradation. In conclusion, the multifunctional platform developed presents a promising alternative for the treatment of tendinopathy.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile synthesis of Nanoparticles-Stacked Co3O4 nanoflakes with catalase-like activity for accelerating wound healing 轻松合成具有类似催化剂活性的纳米颗粒-堆叠 Co3O4 纳米片，加速伤口愈合

IF 6.7 1区医学

Regenerative Biomaterials Pub Date : 2024-01-26 DOI: 10.1093/rb/rbae006

Yanan Huang, Wanyi Liao, Wenxuan Wang, Tingting Zhang, Yan Zhang, Lei Lu

{"title":"Facile synthesis of Nanoparticles-Stacked Co3O4 nanoflakes with catalase-like activity for accelerating wound healing","authors":"Yanan Huang, Wanyi Liao, Wenxuan Wang, Tingting Zhang, Yan Zhang, Lei Lu","doi":"10.1093/rb/rbae006","DOIUrl":"https://doi.org/10.1093/rb/rbae006","url":null,"abstract":"Delayed wound healing caused by excessive reactive oxygen species (ROS) remains a considerable challenge. In recent years, metal oxide nanozymes have gained significant attention in biomedical research. However, a comprehensive investigation of Co3O4 based nanozymes for enhancing wound healing and tissue regeneration is lacking. This study focuses on developing a facile synthesis method to produce high-stability and cost-effective Co3O4 nanoflakes (NFs) with promising catalase (CAT)-like activity to regulate the oxidative microenvironment and accelerate wound healing. The closely arranged Co3O4 nanoparticles (NPs) within the NFs structure result in a significantly larger surface area, thereby amplifying the enzymatic activity compared to commercially available Co3O4 NPs. Under physiological conditions, it was observed that Co3O4 NFs efficiently break down hydrogen peroxide (H2O2) without generating harmful radicals (·OH). Moreover, they exhibit excellent compatibility with various cells involved in wound healing, promoting fibroblast growth and protecting cells from oxidative stress. In a rat model, Co3O4 NFs facilitate both the hemostatic and proliferative phases of wound healing, consequently accelerating the process. Overall, the promising results of Co3O4 NFs highlight their potential in promoting wound healing and tissue regeneration.","PeriodicalId":20929,"journal":{"name":"Regenerative Biomaterials","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139589861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0