Reproductive Sciences最新文献_第4页

Azurocidin is Associated with Dienogest-resistance in Ovarian Endometriotic Cysts.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1007/s43032-025-01795-w

Momoe Watanabe, Yoichi Kobayashi, Manami Ishida, Atsushi Tajima, Shinji Tanigaki, Tohru Morisada

{"title":"Azurocidin is Associated with Dienogest-resistance in Ovarian Endometriotic Cysts.","authors":"Momoe Watanabe, Yoichi Kobayashi, Manami Ishida, Atsushi Tajima, Shinji Tanigaki, Tohru Morisada","doi":"10.1007/s43032-025-01795-w","DOIUrl":"10.1007/s43032-025-01795-w","url":null,"abstract":"Endometriosis and ovarian endometrioma (OMA) cause dysmenorrhea and infertility. Current hormonal therapies for OMA treatment, may exhibit limited effectiveness. Hormonal treatments function by downregulate estrogen receptors (ERs) via progesterone receptor (PR) signaling; therefore, progestins are used for the treatment of endometriosis. Dienogest (DNG), an oral progestin, is highly selective for PRs. Previously we identified the association of azurocidin with DNG resistance. Herein, we aimed to examine the effect of azurocidin on OMAs and its clinical significance. We examined the effect of azurocidin on PR or ER and the action of DNG on the inflammatory cytokines IL-6 and IL-8 in OMAs used the human immortalized endometriotic epithelial Emosis-CC/TERT1 cell line, and measured azurocidin levels in human biological samples. DNG inhibited IL-6 and IL-8 production in vitro, which was suppressed in the presence of azurocidin. Additionally, the inflammatory cytokines IL-6 and IL-8 enhanced azurocidin production. Furthermore, azurocidin induced ER expression; the proliferation of EMosis-CC/TERT1 cells increased significantly upon incubation with 17β-estradiol and azurocidin. Overall, azurocidin inhibits the action of DNG by increasing estrogen sensitivity via promoting ER expression and endometriosis. Azurocidin concentrations in the blood and urine were higher in patients resistant to DNG therapy than in other patients. Thus, azurocidin may be associated with DNG resistance in OMAs.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"702-715"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical-flow Analysis of the Relationship Between Ooplasmic Fluidity and Oocyte Degeneration During Piezo-intracytoplasmic Sperm Injection.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.1007/s43032-025-01807-9

Takashi Morimoto, Hidehiko Matsubayashi, Takumi Takeuchi, Tomomoto Ishikawa, Ryo Haraguchi

{"title":"Optical-flow Analysis of the Relationship Between Ooplasmic Fluidity and Oocyte Degeneration During Piezo-intracytoplasmic Sperm Injection.","authors":"Takashi Morimoto, Hidehiko Matsubayashi, Takumi Takeuchi, Tomomoto Ishikawa, Ryo Haraguchi","doi":"10.1007/s43032-025-01807-9","DOIUrl":"10.1007/s43032-025-01807-9","url":null,"abstract":"To evaluate the predictive ability of ooplasmic fluidity assessment during piezo-intracytoplasmic sperm injection (ICSI) for unintentional membrane rupture (UMR) and oocyte degeneration.We established an optical-flow analysis method that detects ooplasm movement in piezo-ICSI videos. Videos of 104 oocytes recorded during piezo-ICSI at our institute between January 2020 and January 2024 were retrospectively analyzed.To evaluate the apparent velocities in the ooplasmic region, we analyzed the vertical velocity component of the obtained optical flow between the start of puncture and the rupture of the oolemma (1st period) and between sperm injection and pipette withdrawal (2nd period). The velocity distributions between groups were compared using the 95th, 99th, and 99.5th percentiles. The 95th, 99th, and 99.5th percentiles of the survival group (n = 76) were significantly higher than those of the degeneration group (n = 28) during the 1st period (P < 0.001). Similarly, the 95th, 99th, and 99.5th percentiles of the survival group were significantly higher than those of the degenerative group during the 2nd period (P < 0.05). The 95th, 99th, and 99.5th percentiles without UMR (n = 52) were significantly higher than those with UMR (n = 50) during the 1st period (P < 0.001). Similarly, the 95th, 99th, and 99.5th percentiles without UMR were significantly higher than those with UMR during the 2nd period (P < 0.001). Greater ooplasmic fluidity was correlated with lower incidence of UMR and oocyte degeneration. Elucidation of the mechanisms underlying this phenomenon may help reduce UMR and oocyte degeneration.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"684-692"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Therapeutic Potential of Terminalia chebula Retz. in Alleviating the Complications of Letrozole-Induced PCOS in Rat Model.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-12 DOI: 10.1007/s43032-025-01813-x

Vignesh Kalimuthu, Swathi Chandran Manimegalai, Ramya Venkatesan, Sathiya Priya Krishnamoorthy, Nigamananda Dey, Thiyagarajan Ramesh, Kadalmani Balamuthu

{"title":"Exploring the Therapeutic Potential of Terminalia chebula Retz. in Alleviating the Complications of Letrozole-Induced PCOS in Rat Model.","authors":"Vignesh Kalimuthu, Swathi Chandran Manimegalai, Ramya Venkatesan, Sathiya Priya Krishnamoorthy, Nigamananda Dey, Thiyagarajan Ramesh, Kadalmani Balamuthu","doi":"10.1007/s43032-025-01813-x","DOIUrl":"10.1007/s43032-025-01813-x","url":null,"abstract":"Polycystic Ovarian Syndrome is a leading gynecological condition that is being known to affect women fertility irrespective of their reproductive age. Though its prevalency and adverse effects in causing the female infertility is know to be reported worldwide, it has the steroidal pills having remarkable side effects as their effective medication to treat and manage its symptoms. Inorder to find a novel curative plant besed therapy, this study investigates the therapeutic potential of Terminalia chebula Retz. to manage the complications of PCOS. In this present study, the bioactive compounds of Terminalia chebula Retz. fruit extract were identified by GC-MS and the experimental animals (female Wistar rats) were categorized into six groups including control, letrozole-induced PCOS group, metformine treated as standard control, along with the groups orally treated with T. chebula fruit extracts at various concentrations. As a result of PCOS induction, the level of LPx got increased evidencing the increased lipid metabolism where the other antioxidant levels were decreased. The serum hormonal profile revealed a considerable decrease in estrogen and progesterone levels while the levels of LH, FSH, testosterone, and insulin were increased. The mRNA and protein expressions of CYP17A1, was upregulated whereas the CYP19A1 and PPAR-γ found to have lower expression on concerning the control group. These entire physiological, and biochemical observed during the successful induction of PCOS got restored to normal after being treated with the fruit extract of T. chebula in the experimental animals and implied its potentiality in managing the complications of PCOS.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"836-853"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonography Findings in Ovarian Hemangiomas: Report of Three Cases and Review of the Literature. 卵巢血管瘤的超声波检查结果：三例病例报告及文献综述。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-07-17 DOI: 10.1007/s43032-024-01656-y

Yue Qi, Lianting Zhuang, Tiantong Zhu

引用次数: 0

Piceatannol Protects Sperm from Cryopreservation Damage by Modulating the Keap1-Nrf2/ARE Signaling Pathway. 皮夏单酚通过调节 Keap1-Nrf2/ARE 信号通路保护精子免受冷冻损伤

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-10-24 DOI: 10.1007/s43032-024-01723-4

Lijie Fu, Chao Wang, Wenfu Li, Hao Dong, Qian Yang, Guilin Chang, Jianping Liu

{"title":"Piceatannol Protects Sperm from Cryopreservation Damage by Modulating the Keap1-Nrf2/ARE Signaling Pathway.","authors":"Lijie Fu, Chao Wang, Wenfu Li, Hao Dong, Qian Yang, Guilin Chang, Jianping Liu","doi":"10.1007/s43032-024-01723-4","DOIUrl":"10.1007/s43032-024-01723-4","url":null,"abstract":"The purpose of this study was to explore the mechanism of action of Piceatannol (PIC) in attenuating oxidative damage to sperm during cryopreservation. Semen samples were collected and homogenized into six equal parts for freeze-thawing experiments. Four different concentrations of PIC were utilized as cryoprotectants during the freeze-thawing process, maintaing a semen to PIC ratio of 1:1, while sperm motility after freezing and thawing was analyzed using computer-assisted sperm analysis (CASA). Sperm plasma membrane integrity was assessed via the hypo-osmotic swelling (HOS) test. The levels of reactive oxygen species (ROS), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) activities, long with the ability to scavenge sperm malondialdehyde (MDA), were examined in sperm following the addition of PIC. Quantitative real-time PCR (qRT-PCR) was performed to detect the expression levels of Keap1, Nrf2, GCLC, GCLM, and HMOX1 in sperm. The mechanism by which PIC protects sperm during cryopreservation from oxidative stress damage was further verified. Treatment with PIC at a dose of 5.0 μmol/L significantly improved both sperm motility and viability while effectively reducing ROS levels in frozen sperm. Additionally, the integrity of the sperm plasma membrane was significantly enhanced. Furthermore, the expression level of Keap1 was significantly reduced, whereas the expression levels of GCLC, GCLM, HMOX1, and Nrf2 were significantly increased (p < 0.05) after the addition of PIC. Notably, a significant attenuation of sperm motility and viability was observed in this treatment group when PIC treatment was accompanied by the addition of an Nrf2 inhibitor, resulting in a significant elevation of ROS levels. The finding that PIC modulates ROS in frozen sperm via the Keap1-Nrf2/ARE pathway thereby enhancing sperm viability levels after freezing and thawing provides a novel approach to optimize semen cryopreservation.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"783-791"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polycystic Ovarian Syndrome: A Review of Multi-omics Analyses.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-28 DOI: 10.1007/s43032-025-01789-8

Ilmas Naqvi, Anannya Bandyopadhyay, Amisha Panda, B Hareramadas

{"title":"Polycystic Ovarian Syndrome: A Review of Multi-omics Analyses.","authors":"Ilmas Naqvi, Anannya Bandyopadhyay, Amisha Panda, B Hareramadas","doi":"10.1007/s43032-025-01789-8","DOIUrl":"10.1007/s43032-025-01789-8","url":null,"abstract":"Polycystic Ovary Syndrome (PCOS) is among the most prevalent endocrinological abnormalities of young females, posing a grave public health challenge to the society. The objective of the present literature review is to analyze the enormous amount of information available by way of numerous multi-omic studies, and to explore a meaningful relationship between various factors such as genetic, proteomic, environmental etc. to understand the multifactorial metabolic disorder in a proper manner. Detailed literature search was done in various science article repositories and biomedical databases such as PubMed, Google Scholar, BioMed Central, Embase etc. by using several keywords in whole gamut of combinations. PCOS is a heritable disease. It manifests as a result of a combination of several intricately inter-linked symptoms such as anovulation, obesity, type II diabetes, hyperandrogenism, polycystic ovaries etc., the last one being the main manifestation of the disease, thus leading to infertility among several other complications. Such a multifactorial metabolic disorder with extreme symptomatic heterogeneity cannot be fully explained solely based on symptoms or genetic variations; thus, giving some space of thought to other factors such as epigenetic, microbiomic factors etc. playing a role in the causation of the disease. The present scientific survey of literature extensively reviews various aspects of PCOS by critically looking into the vast multi-omic data, and concluded with suggesting treatment options as well as lifestyle changes required to deal with the psychological/ emotional impacts of the condition on affected women.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"618-646"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenesis, Diagnosis, and Management of Inguinal Endometriosis: A Case Series of Six Patients.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-24 DOI: 10.1007/s43032-025-01796-9

Saki Takatsuka, Hisashi Kataoka, Fumitake Ito, Koki Shimura, Taisuke Mori

引用次数: 0

Hypermethylation of Klotho and Peroxisome Proliferator-Activated Receptor γ Concomitant with Overexpression of DNA Methyltransferase 1 in Adenomyosis. 在子宫腺肌病中，Klotho和过氧化物酶体激活受体γ的超甲基化与DNA甲基转移酶1的过度表达同时存在。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-05-30 DOI: 10.1007/s43032-024-01599-4

Jiao Fan, Xishi Liu, Sun-Wei Guo

{"title":"Hypermethylation of Klotho and Peroxisome Proliferator-Activated Receptor γ Concomitant with Overexpression of DNA Methyltransferase 1 in Adenomyosis.","authors":"Jiao Fan, Xishi Liu, Sun-Wei Guo","doi":"10.1007/s43032-024-01599-4","DOIUrl":"10.1007/s43032-024-01599-4","url":null,"abstract":"Cellular senescence is known to be involved in tissue repair, but its role in adenomyosis remains unclear. This study was tasked to evaluate the expression of Klotho, a well-known aging-suppressing protein, as well as PPARγ and DNMT1 in adenomyotic lesions (AD) in comparison with that of control endometrium (CT). We performed immunohistochemistry analysis of markers of cellular senescence p16 and p21, along with Klotho, PPARγ and DNMT1 in CT and AD samples, followed by the quantification of gene expression of Klotho, PPARγ and DNMT1 in epithelial organoids derived from AD and CT samples and methylation-specific PCR to evaluate promoter methylation status. The effect of forced expression and knockdown of DNMT1 on Klotho and PPARγ expression in ectopic endometrial epithelial cells was evaluated. We found that both p16 and p21 immunoreactivity in AD was significantly higher while that of Klotho and PPARγ was significantly lower than CT samples, which was concomitant with elevated immunoexpression of DNMT1. The results were confirmed by transcriptional analysis using epithelial organoids derived from AD and CT samples. In addition, the promoter regions of both Klotho and PPARγ genes were hypermethylated in AD as compared with CT, and treatment with HDAC and DNMT inhibitors reactivated the expression of both Klotho and PPARγ. Forced expression of DNMT1 resulted in downregulation of both Klotho and PPARγ but its knockdown increased their expression. Thus, overexpression of DNMT1 seems to facilitate the promoter hypermethylation of both Klotho and PPARγ in AD, resulting in their reduced expression that is suggestive of the role of senescence in adenomyosis.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"668-683"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Hotspots and Thematic Trends in the Management of Preeclampsia: A Bibliometric Analysis from 2000 to 2022. 子痫前期治疗的研究热点与主题趋势：2000 - 2022年文献计量学分析

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-12-31 DOI: 10.1007/s43032-024-01773-8

Xiao Shen, Yuchen Tao, Yixiao Wang, Nathan Obore, Hong Yu

{"title":"Research Hotspots and Thematic Trends in the Management of Preeclampsia: A Bibliometric Analysis from 2000 to 2022.","authors":"Xiao Shen, Yuchen Tao, Yixiao Wang, Nathan Obore, Hong Yu","doi":"10.1007/s43032-024-01773-8","DOIUrl":"10.1007/s43032-024-01773-8","url":null,"abstract":"Preeclampsia (PE) is one of the serious complications of pregnancy, and the management of PE remains an important problem for obstetricians. This study aims to identify the characteristics and trends of published articles on PE management through bibliometric analysis. We searched the Web of Science database for articles related to PE management from 2000 to 2022. Metadata was obtained, including the titles, publication dates, authors, institutions, countries, and keywords of all articles, and then network visualization and burst keyword analysis were performed using Citespace and VOSviewer software. A total of 5190 articles were included in the analysis. The number of publications in the field of PE management has steadily increased over the years, and a visual analysis of collaborative networks of authors, institutions, and countries revealed that the United States, United Kingdom, Australia, and Canada have contributed the most to the field and formed extensive collaborations. The Journal of maternal-fetal & neonatal medicine has the most publications in this field, and the Journal of Obstetrics and gynecology has not only more publications but also 64.75 citations per article. The keywords mainly focused on prevention, diagnosis, risk factors, and outcome of PE. In addition, hypertensive disorders of pregnancy and fetal growth restriction have received a lot of attention in this field in recent years. We analyzed the partnerships in the field of PE management through bibliometrics and showed trends and developments in the field. The available results suggest that PE management will continue to be a focus of attention for obstetricians and researchers.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"815-824"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Inflammatory Cytokines on Recurrent Pregnancy Loss: A Preliminary Investigation.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-22 DOI: 10.1007/s43032-025-01786-x

Shivani Mishra, Ashish Ashish, Sangeeta Rai, Chetan Sahni, Shivam Tiwari, Bhupendra Kumar, Royana Singh

{"title":"The Impact of Inflammatory Cytokines on Recurrent Pregnancy Loss: A Preliminary Investigation.","authors":"Shivani Mishra, Ashish Ashish, Sangeeta Rai, Chetan Sahni, Shivam Tiwari, Bhupendra Kumar, Royana Singh","doi":"10.1007/s43032-025-01786-x","DOIUrl":"10.1007/s43032-025-01786-x","url":null,"abstract":"Recurrent pregnancy loss (RPL), defined as two or more consecutive miscarriages before 20 weeks of gestation, affects 1-2% of couples worldwide. Pro-inflammatory cytokines, such as TNF-α, IL-1β and IL-6 play critical roles in early pregnancy, while anti-inflammatory cytokines like TGF-β and IL-10 promote immune tolerance to prevent harmful inflammatory responses that play important role in placental and fetal development. This aim of the study is to analyse the levels of inflammatory cytokines in blood serum from RPL patients and healthy women (control). The measured cytokines included TNF-α, IL-6, IL-10, TGF-β, CRP, ferritin, IL-1β and IL-4, IFN-γ and IL-17. Using an unpaired t-test and Pearson correlation, significant difference observed between the groups. The results had significantly elevated CRP levels with decreased levels of TGF-β and ferritin (p < 0.05), whereas, IL-1β and IL-4 also found raised indicating a link between systemic inflammation and recurrent miscarriages. IL-4 and CRP increase further suggest potential oxidative stress role in RPL cases. However, no significant differences observed in IL-10, IL-6, or TNF-α level between the groups. This study highlights immune dysregulation as possible contributors to early pregnancy loss, with significant increases in CRP, IL-1β, and IL-4 levels indicating an imbalanced immune response at the maternal-fetal interface. These cytokine elevations may disrupt immune tolerance, suggesting the need for further exploration into cytokine interactions in pregnancy and their potential as an investigatory biomarker and therapeutic target in RPL.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"804-814"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0