Reproductive Sciences最新文献

Correction: Chronic Endometritis and Endometriosis: Two Sides of the Same Coin?

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 DOI: 10.1007/s43032-025-01805-x

Dimitrios Rafail Kalaitzopoulos, Ursula Catena, Alexandra Kohl Schwartz, Georgios Schoretsanitis, Brigitte Leeners, Panagiotis Drakopoulos, Nicolas Samartzis

引用次数: 0

Identification of YBX2 and TSKS As STK33 Interacting Proteins in Testicular Germ Cells.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1007/s43032-025-01798-7

Ying Cai, Jing Ma, Shusong Wang, Huaibiao Li

{"title":"Identification of YBX2 and TSKS As STK33 Interacting Proteins in Testicular Germ Cells.","authors":"Ying Cai, Jing Ma, Shusong Wang, Huaibiao Li","doi":"10.1007/s43032-025-01798-7","DOIUrl":"10.1007/s43032-025-01798-7","url":null,"abstract":"Spermiogenesis is a unique process, in which round spermatids undergo morphological changes to form spermatozoa. Serine/Threonine Kinase 33 (STK33), a member of the serine/threonine protein kinase family, plays a pivotal role in spermiogenesis, manifested by the infertile phenotype of Stk33 knockout mice and patients carrying STK33 mutations. To date, the mechanism by which STK33 promotes spermiogenesis is not fully understood. Here we aimed to identify germ cell-specific proteins that interact with STK33. Using immunoprecipitation and mass spectrometry, 13 proteins were identified that potentially interact with STK33 in testicular germ cells. By comparing the expression patterns of the candidate genes in testicular germ cells, we selected Y-Box Binding Protein 2 (YBX2) and Testis Specific Serine Kinase Substrate (TSKS) for validation. When co-expressed in cultured cells, TSKS was immunoprecipitated by STK33, and vice versa. Furthermore, STK33 was recruited to the TSKS foci, likely through interaction with TSKS. Although proximity ligation assay demonstrated that STK33 and YBX2 form the complex in germ cells, their interaction was not recapitulated in cultured cells. Phosphorylation assays showed that STK33 was unable to phosphorylate both YBX2 and TSKS in vitro. Overall, these results suggest that STK33 regulates spermiogenesis through TSKS and YBX2, which warrants further investigation in vivo.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"769-782"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating microRNAs in Body Fluid: "Fingerprint" RNA Snippets Deeply Impact Reproductive Biology. 体液中循环的microRNAs：“指纹”RNA片段深刻影响生殖生物学。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-12-10 DOI: 10.1007/s43032-024-01753-y

Ayan Mukherjee, Arpana Verma, Troyee Das, Byapti Ghosh, Zhumur Ghosh

{"title":"Circulating microRNAs in Body Fluid: \"Fingerprint\" RNA Snippets Deeply Impact Reproductive Biology.","authors":"Ayan Mukherjee, Arpana Verma, Troyee Das, Byapti Ghosh, Zhumur Ghosh","doi":"10.1007/s43032-024-01753-y","DOIUrl":"10.1007/s43032-024-01753-y","url":null,"abstract":"Circulating miRNAs (C-miRNAs) occuring in a cell-free form within body fluids and other extracellular environments have garnered attention in recent times. They offer deeper insight into various physiological and pathological processes which include reproductive health. This review delves into their diagnostic potential across a spectrum of reproductive disorders, including conditions affecting ovarian function, male infertility and post pregnancy issues. Through analysis of C-miRNA profiles in bodily fluids, researchers uncover crucial markers indicative of reproductive challenges. Dysregulated C-miRNAs emerge as important players in the progression of several reproductive disorders which is the main focus of this review. Advancements in technology, facilitate precise detection and quantification of C-miRNAs, paving the way for innovative diagnostic approaches. Challenges in studying C-miRNAs, such as their low abundance and variability in expression levels, underscore the need for standardized protocols and rigorous validation methods. Despite these challenges, ongoing research endeavors aim to unravel the complex regulatory roles of C-miRNAs in reproductive biology, with potential implications for clinical practice and therapeutic interventions.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"555-574"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Live Birth Outcome in A Patient with Empty Follicle Syndrome: A Case Report and Literature Review. 空卵泡综合征患者的成功活产：病例报告与文献综述

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-11-20 DOI: 10.1007/s43032-024-01738-x

Fang Hong, Bin Chen, Liu Liu, Xiaomei Tong

{"title":"Successful Live Birth Outcome in A Patient with Empty Follicle Syndrome: A Case Report and Literature Review.","authors":"Fang Hong, Bin Chen, Liu Liu, Xiaomei Tong","doi":"10.1007/s43032-024-01738-x","DOIUrl":"10.1007/s43032-024-01738-x","url":null,"abstract":"Here, we report on a rare case of a successful live birth in a patient with empty follicle syndrome. A 35-year-old woman with ovulatory disorder and a 4-year history of primary infertility conducted in vitro fertilization-embryo transfer (IVF-ET) treatment in our hospital. The patient experienced six controlled ovarian stimulation cycles. In the first two cycles, despite adequate ovarian response, normal development of multiple follicles, and normal serum estradiol (E2) levels, no oocytes were retrieved from these mature follicles during the aspiration procedure. The patient was diagnosed with \"empty follicle syndrome\". Whole exome sequencing (WES) identified a missense mutation in the luteinizing hormone/chorionic gonadotropin receptor (LHCGR). In subsequent cycles, we try to increase the trigger dosage, combine gonadotropin-releasing hormone agonists (GnRH agonist) with human chorionic gonadotropin (HCG) for a dual trigger, supplement with luteinizing hormone (LH)-like active substances during the stimulation process, and extend the time between triggering and oocyte retrieval. In the end, successful oocyte retrieval and pregnancy were achieved.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"660-667"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Life's Essential 8 and Infertility as Well as the Mediating Effects of Oxidative Stress and Inflammatory Factors Among U.S. Women Aged 18-45 Years. 美国 18-45 岁女性中生活必需品 8 与不孕不育之间的关系以及氧化应激和炎症因子的调节作用。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-07-08 DOI: 10.1007/s43032-024-01635-3

Yan Zhuang, Laifu Li, Yanqi Zhang, Xuna Liu, Beibei Zeng, Boxu Zhu, Fei Dai

{"title":"Association between Life's Essential 8 and Infertility as Well as the Mediating Effects of Oxidative Stress and Inflammatory Factors Among U.S. Women Aged 18-45 Years.","authors":"Yan Zhuang, Laifu Li, Yanqi Zhang, Xuna Liu, Beibei Zeng, Boxu Zhu, Fei Dai","doi":"10.1007/s43032-024-01635-3","DOIUrl":"10.1007/s43032-024-01635-3","url":null,"abstract":"Management of cardiovascular disease in pregnancy is important, yet the association between cardiovascular health and infertility is rarely reported. In this study, we aimed to explore the association between Life's Essential 8 (LE8), a novel cardiovascular health (CVH) measure, and infertility, and to investigate potential mediating mechanisms. This study investigated cross-sectional data from the 2013-2018 National Health and Nutrition Examination Survey. LE8 score (ranging from 0 to 100) was calculated as the unweighted average of eight CVH metrics. The association between LE8 and infertility was explored through weighted multiple logistic regression. Restricted cubic splines were used to explore nonlinear correlation. In addition, mediation analysis was conducted to investigate the role of oxidative stress and inflammatory markers systematically. After strict exclusion criteria, 1703 American women aged 18-45 years were included. After full adjustment, the LE8 score showed a negative correlation with infertility [per 1 SD increase, OR = 0.675, 95% CI: 0.553-0.824], with a linear dose-response relationship (non-linear P = 0.122). Similar linear negative correlations were found between health factor scores and infertility, with higher body mass index and glucose scores having a significantly lower risk of infertility. Stratified analyses showed a stronger inversed relationship between LE8 and infertility in younger populations. Moreover, mediation analysis revealed that uric acid concentration and lymphocyte count mediated the effect of LE8 on infertility (P < 0.05). LE8 and its subscale scores were linearly and negatively associated with infertility, which may be mediated in part through uric acid and lymphocyte count. Focusing on weight management and glycemic control can effectively reduce the risk of infertility.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"738-747"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beneficial Effects of Pomegranate Extracts for Benign Gynecologic Disorders. 石榴提取物对良性妇科疾病的有益作用。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-12-28 DOI: 10.1007/s43032-024-01776-5

Samya El Sayed, Valeria I Macri, Bhuchitra Singh, James H Segars, Md Soriful Islam

{"title":"Beneficial Effects of Pomegranate Extracts for Benign Gynecologic Disorders.","authors":"Samya El Sayed, Valeria I Macri, Bhuchitra Singh, James H Segars, Md Soriful Islam","doi":"10.1007/s43032-024-01776-5","DOIUrl":"10.1007/s43032-024-01776-5","url":null,"abstract":"Pomegranate (Punica granatum) is a widely cultivated fruit historically recognized for its health benefits and is regarded as a nutritional powerhouse. Pomegranate has a unique composition of bioactive compounds including hydrolysable tannins, anthocyanins, and other polyphenolic components. Of those, punicalagin and its subsequent metabolites are the most extensively studied, demonstrating antioxidant, anti-inflammatory, anti-cancer, and anti-nociceptive activity. The compounds possess promising therapeutic potential for many diseases, including conditions affecting the female reproductive system. This scoping review examines the pharmacodynamics of pomegranate's bioactive compounds and synthesizes the current literature concerning the role in benign gynecological disorders. Pomegranate extract decreased testosterone levels, levels of oxidative stress and inflammation biomarkers in women with polycystic ovary syndrome, erstwhile favorably impacting some cardiovascular risk factors in women. Pomegranate supplementation improved menopause specific health-related quality of life in women. In a pre-clinical murine model following ovariectomy, improved bone formation and reduced vaginal atrophy were associated with pomegranate treatment. Existing data suggests that additional research on the beneficial antioxidant, anti-inflammatory, anti-proliferative, and anti-nociceptive effects of pomegranate extracts for benign gynecologic conditions is warranted.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"600-617"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Kisspeptin and KISS₁ Gene Polymorphism (rs35431622) with Circulating Sex Hormones and Male Infertility.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1007/s43032-025-01803-z

N Prasath, K A Arul Senghor, V M Vinodhini, M Anuradha

{"title":"Association of Kisspeptin and KISS1 Gene Polymorphism (rs35431622) with Circulating Sex Hormones and Male Infertility.","authors":"N Prasath, K A Arul Senghor, V M Vinodhini, M Anuradha","doi":"10.1007/s43032-025-01803-z","DOIUrl":"10.1007/s43032-025-01803-z","url":null,"abstract":"This research delves into the association of Kisspeptin and the KISS1 gene (rs35431622) single nucleotide polymorphism with circulating sex hormones and semen parameters in males diagnosed with infertility. Eighty male participants were recruited from fertility clinic, were divided into two groups: Group A, characterized by normal sperm count and Group B, exhibiting low count. The analysis involved assessing hormone levels Kisspeptin, follicle stimulating hormone, luteinizing hormone, total testosterone and sex hormone binding globulin by utilizing ELISA, investigating the association of the KISS1 gene SNP with these variables through Tetra amplification refractory mutation system-PCR and Gel Electrophoresis. The findings revealed that males a low sperm count displayed notably reduced levels of Kisspeptin and free testosterone, accompanied by increased luteinizing hormone and follicle stimulating hormone. The KISS1 gene SNP rs35431622 (Q36R) demonstrated a 53.3% frequency of the heterozygous mutant TA genotype and OR 0.19 (CI 0.05-0.71) among infertile males, indicating its potential implications a risk factor for male infertility. This study emphasizes the significance of Kisspeptin in overseeing male reproductive health and highlights its potential as a marker for hormonal dysregulation in male infertility.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"748-756"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium.

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1007/s43032-025-01802-0

Gürkan Özbey, Görkem Tuncay, Senem Arda Düz, Yılmaz Çiğremiş, Abdullah Karaer

{"title":"The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium.","authors":"Gürkan Özbey, Görkem Tuncay, Senem Arda Düz, Yılmaz Çiğremiş, Abdullah Karaer","doi":"10.1007/s43032-025-01802-0","DOIUrl":"10.1007/s43032-025-01802-0","url":null,"abstract":"Endometrial polyps are hyperplastic overgrowths of the endometrium that contain both glands and stroma. Myoma uteri is the most common benign tumor of the female pelvis and uterus. HOXA10, which is involved during the organogenesis of the uterus in the embryonic period. The aim of this study was to compare the expression levels of infertility-related genes in endometrial tissue obtained from patients with endometrial polyp and myoma uteri and from healthy controls. A total of 36 patients, including 15 women with endometrial polyp and 21 women with myoma uteri, and 23 healthy controls were enrolled in the study. All patients were evaluated using transvaginal ultrasonography. Endometrial tissue samples were collected from the patient and control groups between the 19th and 21st days of the menstrual cycle. Expression levels of the receptivity markers PROK1, PROKR1, PROK2, PROKR2 and HOXA10 genes were determined by RT- PCR. When the patients diagnosed with endometrial polyp and the healthy controls were compared, it was observed statistically significantly that the expression of PROKR1 increased in endometrium tissue of patients with endometrial polyp (p < 0.05). In patients diagnosed with myoma uteri, gene expression levels of endometrial PROKR1 was statistically significant increased and gene expression levels of PROK1, PROKR2, HOXA10 were found to be statistically significantly decreased compared to the controls (p < 0.05). Changes in the endometrial expression of the HOXA10 and prokineticin gene family in patients with myoma uteri and endometrial polyps may explain certain aspects of infertility in these patients.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"728-737"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143365799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

25-hydroxyvitamin D and Endometriosis: A bidirectional Mendelian randomization study. 25- 羟维生素 D 与子宫内膜异位症：双向孟德尔随机研究

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2024-03-21 DOI: 10.1007/s43032-024-01517-8

Di Pan, Pan Li, Xiaoling Dai, Shiyun Xie

{"title":"25-hydroxyvitamin D and Endometriosis: A bidirectional Mendelian randomization study.","authors":"Di Pan, Pan Li, Xiaoling Dai, Shiyun Xie","doi":"10.1007/s43032-024-01517-8","DOIUrl":"10.1007/s43032-024-01517-8","url":null,"abstract":"Numerous studies have demonstrated a correlation between serum 25-hydroxyvitamin D (25OHD) and endometriosis. However, the precise nature of this association remains elusive. The causal connection between 25OHD and endometriosis remains uncertain, as it is yet to be determined whether one directly influences the other. The objective of our research was to investigate the cause-and-effect connection between 25OHD and endometriosis. The study employed Mendelian randomization (MR) in a bidirectional two-sample investigation to examine the causal relationship between 25OHD and endometriosis. The analysis utilized the most recent publicly accessible statistics from the genome-wide association study (GWAS) encompassing 25OHD, endometriosis, and its five subtypes. The primary analytical approach employed was Inverse-Variance Weighting (IVW), accompanied by supplementary analysis methods including weighted median, MR-Egger, simple mode, and weighted mode. Furthermore, sensitivity analyses were conducted to assess the potential influence of heterogeneity and pleiotropy on the MR outcomes. MR primary analysis showed no significant causal effect of 25OHD on endometriosis (OR = 0.892, 95%CI = 0.745 ~ 1.068, P = 0.213). Similarly, there was no evidence to support a causal relationship of endometriosis on 25OHD (IVW Beta = 0.005, 95%CI = 0.993 ~ 1.018, P = 0.406). However, when conducting MR analysis on different subtypes of endometriosis and 25OHD, we found a positive correlation between endometriosis of ovary and 25OHD level (IVW Beta = 0.012, 95%CI = 1.002 ~ 1.022, P = 0.024). This study indicates that there is no causal relationship between serum 25OHD and endometriosis. However, it is important to note that serum 25OHD levels will increase in patients with endometriosis of the ovary. Further observational studies and clinical trials are indispensable.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"693-701"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MT1/cAMP/PKA Pathway in Melatonin-Regulated Sperm Capacitation. 褪黑激素调控精子获能的MT1/cAMP/PKA通路

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-03-01 Epub Date: 2025-01-21 DOI: 10.1007/s43032-024-01782-7

Tongjuan Niu, Di Zhang, Guobin Qiu, Bin Li, Sheng Cui

{"title":"MT1/cAMP/PKA Pathway in Melatonin-Regulated Sperm Capacitation.","authors":"Tongjuan Niu, Di Zhang, Guobin Qiu, Bin Li, Sheng Cui","doi":"10.1007/s43032-024-01782-7","DOIUrl":"10.1007/s43032-024-01782-7","url":null,"abstract":"Melatonin is mainly synthesized and secreted by pineal gland, and plays multiple functions, including its regulating effects on reproductive processes. Sperm capacitation is necessary for fertilization, but the effect of melatonin on mouse sperm capacitation remains to be elucidated. We thus investigated the roles of melatonin on capacitation by culturing the sperms from mouse cauda epididymis in the medium with different doses of melatonin. The results showed that 10-7 mol/L melatonin significantly enhanced the sperm capacitation by increasing the sperm tyrosine phosphorylation level, percentage of the capacitated sperms and intracellular calcium concentration. In addition, our in vitro and in vivo results showed that melatonin enhanced the fertilizing capacity by increasing the percentage of oocyte cleavage and the number of the fetuses from receptive females which were mated with melatonin-treated males. Mechanically, melatonin activated cyclic adenosine monophosphate (cAMP)/p-Protein kinase A (p-PKA) pathway. Furthermore, the melatonin-induced tyrosine phosphorylation of sperms was decreased by treatment of MT1 or PKA inhibitor. And the same result was found in the sperms cultured in non-capacitating medium (without bicarbonate and bovine serum albumin). Therefore, all those results indicate that MT1/cAMP/PKA pathway is one of key regulatory factors in melatonin-mediated sperm capacitation. The results here are crucial for understanding the molecular mechanisms by which melatonin regulates sperm capacitation, and providing theoretical support for controlling sperm capacitation during artificial insemination procedures.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"792-803"},"PeriodicalIF":2.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0