Reproductive Sciences最新文献_第2页

Global Trends in Maternal Mortality and Efforts to Improve Maternal Outcomes Through Sociomedical Interventions. 孕产妇死亡率的全球趋势和通过社会医学干预改善孕产妇结局的努力。

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-05-01 DOI: 10.1007/s43032-026-02086-8

Biraj Sharma, Roger Smith, Craig E Pennell

{"title":"Global Trends in Maternal Mortality and Efforts to Improve Maternal Outcomes Through Sociomedical Interventions.","authors":"Biraj Sharma, Roger Smith, Craig E Pennell","doi":"10.1007/s43032-026-02086-8","DOIUrl":"https://doi.org/10.1007/s43032-026-02086-8","url":null,"abstract":"Maternal mortality continues to be a major global health concern that disproportionately affects low- and middle-income countries (LMICs), with the World Health Organisation (WHO) estimating a maternal death occurring every two minutes. The data-sparse LMICs employ a multitude of estimation approaches to gauge maternal mortality ratios (MMR); however, their classification of deaths and reproducibility of estimates remain open to discussion. Despite a considerable reduction of MMR levels since 2000, more recently, the MMR levels in countries including the US have resurged due to the sociomedical crises brought about by the COVID-19 pandemic. The United Nations' Sustainable Development Goal (SDG) 3.1 aims to achieve global maternal mortality ratios of less than 70 per 100,000 live births and below 140 per 100,000 live births at the national level by 2030. However, recent projections indicate it will remain unmet by a margin of a million maternal deaths. Many LMICs apply the three-delays framework of maternal deaths that requires verbal autopsy to be used in tandem with the identification of maternal deaths. The three-delays model devised in the mid-1990s allows LMICs to gear their resources towards specific intervention points. A significant portion of the existing literature has focused on the description of the magnitude of the issue and the factors precipitating maternal deaths. Innovative solutions have recently been implemented, such as repurposing military helicopters to reduce the delays in managing obstetric complications. Similarly, prospective studies are required to devise ways to address the sociomedical mechanisms underlying maternal deaths.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147820248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal Sperm Morphology in Lodpr/lncRNA-HSVIII Knockout Mice with Advancing Age. 老年Lodpr/lncRNA-HSVIII敲除小鼠精子形态异常

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-04-30 DOI: 10.1007/s43032-026-02103-w

Pummarin Tippramuan, Luo Yujia, Yui Satoh, Kazuhiro Kitada, Chika Fujimori, Atsushi P Kimura

{"title":"Abnormal Sperm Morphology in Lodpr/lncRNA-HSVIII Knockout Mice with Advancing Age.","authors":"Pummarin Tippramuan, Luo Yujia, Yui Satoh, Kazuhiro Kitada, Chika Fujimori, Atsushi P Kimura","doi":"10.1007/s43032-026-02103-w","DOIUrl":"https://doi.org/10.1007/s43032-026-02103-w","url":null,"abstract":"A mouse testis-specific long noncoding RNA, Lodpr/lncRNA-HSVIII, is expressed in germ cells and Leydig cells; however, its functional role remains uncharacterized. To clarify the physiological role, we generated Lodpr/lncRNA-HSVIII knockout (KO) mice using the CRISPR/Cas9 technology. Although Lodpr/lncRNA-HSVIII KO mice did not exhibit infertility, their phenotypic traits were documented at 2 months and 6 months of age. Histological examination of testes revealed alterations in the stages of seminiferous tubules and an increased vascularization within the interstitial tissue in Lodpr/lncRNA-HSVIII KO specimens at both 2 months and 6 months. Notably, certain phenotypes emerged exclusively at 6 months. In the testes of 6-month-old KO mice, an increase in the number of Sertoli cells was noted within the seminiferous tubules, and clusters of germ cell degeneration, potentially resulting in vacuolation, were observed along with enlarged round spermatids. Additionally, in the mediastinum testis of some KO mice, an elongation of the transition zone and fibroblast proliferation within the interstitial tissue were evident at 6 months. In the cauda epididymis, there was a notable increase in extravascular leukocytes at 6 months. Sperm analysis indicated a significant elevation of abnormal sperm, especially bent tails, only in 6-month-old KO mice, despite no significant differences in overall sperm quantity and motility. Collectively, these findings suggest that Lodpr/lncRNA-HSVIII plays a role in modulating the morphology of sperm, testicular tissue, and the epididymis, with effects becoming more pronounced with age.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147820221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Effects of Stromal Stem Cells Derived from Ovarian Tissue in a Cyclophosphamide-Induced Rat Model of Ovarian Failure. 卵巢组织基质干细胞在环磷酰胺诱导的卵巢衰竭大鼠模型中的治疗作用。

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-04-29 DOI: 10.1007/s43032-026-02114-7

Mehpare Akgün, Murat Serkant Ünal, Faruk Altınbaşak, Elif Önder, Semih Tan

{"title":"Therapeutic Effects of Stromal Stem Cells Derived from Ovarian Tissue in a Cyclophosphamide-Induced Rat Model of Ovarian Failure.","authors":"Mehpare Akgün, Murat Serkant Ünal, Faruk Altınbaşak, Elif Önder, Semih Tan","doi":"10.1007/s43032-026-02114-7","DOIUrl":"https://doi.org/10.1007/s43032-026-02114-7","url":null,"abstract":"Chemotherapeutic agents used in cancer treatment cause damage to both oocytes and granulosa cells, resulting in follicle loss and consequently premature ovarian failure. In this study the animals were randomly assigned to three groups: control (n = 6), chemotherapy (n = 6), and stem cell treatment (n = 6). Ovarian failure was induced in the chemotherapy and stem cell groups by intraperitoneal administration of cyclophosphamide (200 mg/kg) on days 1 and 8. Ovarian stromal stem cells (OSSCs) were isolated from the ovaries of 4-week-old donor rats (n = 2) using the explant culture method. On day 9, isolated stromal cells were transplanted bilaterally into the ovaries of rats in the stem cell group. Surface markers were analyzed by flow cytometry in OSSCs, and their adipogenic, osteogenic, and chondrogenic differentiation potentials were evaluated under appropriate in vitro conditions. The number of follicles and the morphological features of the ovarian tissue were histologically examined using hematoxylin and eosin (H&E) staining. Caspase 3 expression in ovarian tissue was analyzed using TUNEL and immunohistochemistry methods. Flow cytometry analysis of isolated ovarian stromal cells showed that CD54, CD90 and CD45 surface markers were expressed, while CD29 was expressed at a lower level. These findings confirmed the ability of OSSCs to differentiate into adipogenic, osteogenic, and chondrogenic lineages in vitro. Follicle counting, TUNEL and immunohistochemical analysis showed that treatment with ovarian stromal stem cells significantly reduced the number of atretic follicles and increased the number of normally developing follicles in the ovaries of chemotherapy-treated rats. Our research demonstrates the therapeutic effects of (allogeneic) ovarian stromal stem cells present in their niche on ovarian toxicity induced by chemotherapy, suggesting an alternative treatment option for approaches aimed at preserving fertility.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Non-Invasive Imaging Tools for Andrological Assessment in Male Reproduction: The Role of Infrared Thermography and Color Doppler Ultrasonography. 新兴的非侵入性成像工具用于男性生殖的男性学评估：红外热成像和彩色多普勒超声的作用。

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-04-29 DOI: 10.1007/s43032-026-02110-x

Divyanshu Lakhanpal, Sushil Kumar, Tushar Kumar Mohanty, Mukesh Bhakat, Anjali Chauhan, Brijesh Kumar, Rubina K Baithalu, Dipti Nain, Varun Kumar

引用次数: 0

Short-Chain Fatty Acids May Promote Regulatory T Cell Induction to Enhance Maternal Immune Tolerance in Early Pregnancy. 短链脂肪酸可能促进调节性T细胞诱导，增强妊娠早期母体免疫耐受。

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-04-28 DOI: 10.1007/s43032-026-02096-6

Kyoko Takahashi, Jun Kawagoe, Isao Takehara, Jun Matsukawa, Yuji Takeda, Tsuyoshi Ohta, Hironobu Asao, Satoru Nagase

引用次数: 0

Insights into Ovarian Cancer: Unraveling the Role of DNA Double-strand Break-related Genes in Pathogenesis and Therapeutic Avenues. 洞察卵巢癌：揭示DNA双链断裂相关基因在发病机制和治疗途径中的作用。

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-04-27 DOI: 10.1007/s43032-026-02082-y

Zihan Zhang, Jingyu Zhao, Zhimin Zhang, Zhuoyan Fu, Xinru Li, Ziming Zhu, Qingxin Li, Xuenan Wang, Jinxiang Yuan, Fei Gao, Xiaomei Wang

引用次数: 0

Decoding Infertility: the Epigenetic Influence of HDACs on Reproductive Function. 解码不孕症：hdac对生殖功能的表观遗传影响。

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-04-24 DOI: 10.1007/s43032-026-02104-9

Annanya Kapur, Yashaswini Reddy, Nanda Rajagopal, Shruthi Nayak, Neil Viren D'Souza, Ipshita Das, Babitha Kampa Sundara

{"title":"Decoding Infertility: the Epigenetic Influence of HDACs on Reproductive Function.","authors":"Annanya Kapur, Yashaswini Reddy, Nanda Rajagopal, Shruthi Nayak, Neil Viren D'Souza, Ipshita Das, Babitha Kampa Sundara","doi":"10.1007/s43032-026-02104-9","DOIUrl":"10.1007/s43032-026-02104-9","url":null,"abstract":"Infertility is a multifactorial condition affecting approximately 10-15% of couples worldwide, with both male and female factors contributing equally. Among the emerging determinants of infertility are epigenetic regulators, particularly histone deacetylases, which modify chromatin structure and influence gene expression by removing acetyl groups from histone tails. Their dysregulation alters gene expression profiles critical for reproductive function. HDACs are classified into four major classes (I-IV) on the basis of their structure and function. A thorough analysis of previous research using animal models, clinical settings, and experiments was performed to investigate how HDACs function in gametogenesis, hormone regulation, and embryonic development, among other areas of reproductive physiology. HDACs play a key role in the epigenetic control of fertility in both sexes. Understanding their isoform-specific functions could help create more focused treatments for infertility and increase the success of reproduction. This review elucidates the mechanisms by which HDACs contribute to infertility and explores their potential as therapeutic targets in reproductive medicine.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD8⁺ T Cells in Association with SCD1 Regulate Cervical Cancer and Tumour Microenvironment Correlation Research. CD8+ T细胞与SCD1相关调控宫颈癌及肿瘤微环境相关性研究

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-04-22 DOI: 10.1007/s43032-026-02070-2

Qi Bao, Zihan Wang, Guanghua Gu, Wei Wang, Shuangyang Qin, Shihui Zhang, Weipei Zhu

引用次数: 0

Blood Clotting as an Unintended Cytokine Stimulus in Pregnancy: Why Serum and Plasma are Non-Equivalent Immune Matrices. 妊娠期凝血作为一种意外的细胞因子刺激：为什么血清和血浆是不等同的免疫基质。

IF 2.5 3区医学

Reproductive Sciences Pub Date : 2026-04-22 DOI: 10.1007/s43032-026-02102-x

Charmi Trivedi, Rohit Jain, Vidhi Vaidya, Ishita Thakkar, Jhanvi Ranpuria, Aarthi Sundararajan

引用次数: 0

Effects of Pre- and Post-treatment of Idebenone on the Side Effects of the Chemotherapy Model with Cyclophosphamide in the Rat Ovary. 依地苯酮前后对环磷酰胺化疗大鼠卵巢毒副反应的影响。