Reproductive Sciences最新文献_第2页

Correction: Retrospective Analysis of Meiotic Segregation Pattern and Reproductive Outcomes in Blastocysts from Robertsonian Preimplantation Genetic Testing Cycles. 更正：来自罗伯逊着床前基因检测周期的囊胚减数分裂分离模式和生殖结果的回顾性分析。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 DOI: 10.1007/s43032-025-01855-1

Miaomiao Jia, Juanzi Shi, Xia Xue

引用次数: 0

Comparison of GLP-1 Receptor Agonists Combined with Metformin Versus Metformin Alone in the Management of PCOS: A Comprehensive Meta-Analysis. GLP-1受体激动剂联合二甲双胍与单用二甲双胍治疗PCOS的比较：一项综合荟萃分析。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2025-01-29 DOI: 10.1007/s43032-025-01788-9

Yuzi Zhao, Li Jiang, Na Li, Jing Cao, Jie Pi

{"title":"Comparison of GLP-1 Receptor Agonists Combined with Metformin Versus Metformin Alone in the Management of PCOS: A Comprehensive Meta-Analysis.","authors":"Yuzi Zhao, Li Jiang, Na Li, Jing Cao, Jie Pi","doi":"10.1007/s43032-025-01788-9","DOIUrl":"10.1007/s43032-025-01788-9","url":null,"abstract":"This study compared the efficacy and safety of glucogan-like peptide-1 receptor agonists (GLP1RAs) combined with metformin versus metformin alone in women with polycystic ovary syndrome (PCOS). A systematic search of \"PubMed\", \"EMBASE\", \"Cochrane Library\", and \"Web of Science\", \"Google Scholar\" was conducted up to September 2024. Studies were included if they were RCTs investigating the combination of GLP1RAs and metformin in women diagnosed with PCOS. Eligible studies compared this combination therapy to metformin alone. Primary outcomes included changes in body weight, BMI, waist circumference, fasting glucose, HOMA-IR, androgen levels, and sex hormone-binding globulin (SHBG). Meta-analysis was performed using RevMan 5.4 software. Eight RCTs with a total of 337 participants were included. The combination of GLP1RAs and metformin resulted in significant reductions in body weight (mean difference [MD]=-1.37 kg, 95% CI [-2.07, -0.67]; P = 0.0001), BMI (MD= -0.88 kg/m², 95% CI [-1.37, -0.39]; P = 0.0005), waist circumference (MD= -2.46 cm, 95% CI [-3.59,-1.33]; P < 0.0001), fasting glucose level (MD= -0.30, 95% CI [-0.42,-0.17]; P < 0.0001), and glucose level at 2 h after OGTT (MD= -1.58, 95% CI [-2.10,-1.06]; P < 0.0001) compared to metformin alone. Improvements in insulin sensitivity (HOMA-IR) in GLP1RA + Met group were also observed (MD=-1.58, 95% CI [-2.10, -1.06]; P < 0.0001) comparing to Met group. Hormonal outcomes demonstrated an increase in SHBG (MD = 10.04, 95% CI [7.06, 13.01]; P < 0.0001). Adverse events were not different between GLP1RA + Met and Met groups. Collectivley, combination of GLP1RAs and metformin provides superior benefits over metformin alone in reducing body weight, improving insulin sensitivity, and regulating hormonal imbalances in women with PCOS.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1661-1675"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Expression of Programmed Cell Death Ligand-1 and its Relationship with Infiltration, Metastasis and Prognosis in Cervical Squamous Cell Carcinoma. 细胞程序性死亡配体-1在宫颈鳞癌中的表达及其与浸润、转移和预后的关系

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2025-01-30 DOI: 10.1007/s43032-024-01784-5

Juyan Ge, Xiujuan Xu

{"title":"The Expression of Programmed Cell Death Ligand-1 and its Relationship with Infiltration, Metastasis and Prognosis in Cervical Squamous Cell Carcinoma.","authors":"Juyan Ge, Xiujuan Xu","doi":"10.1007/s43032-024-01784-5","DOIUrl":"10.1007/s43032-024-01784-5","url":null,"abstract":"Cervical cancer (CC) represents a major gynecologic health problem. Respecting the role of programmed cell death ligand-1 (PDL-1) in cancer prognosis, we investigated its relationship with cervical squamous cell carcinoma (CSCC) invasion, metastasis and prognosis. A total of 184 CSCC patients were retrospectively selected, with normal paracarcinoma tissues as the Control group. PDL-1 expression was assessed, and its relationship with CSCC prognosis and clinical value on predicting CSCC invasion/metastasis and poor prognosis were determined. PDL-1 was up-regulated in CSCC. CSCC patients at International Federation of Gynecology and Obstetrics stage II/III, and with lymph node metastasis (LNM), parauterine/vascular infiltration, and history of sexually transmitted diseases exhibited up-regulated PDL-1. The areas under the curve of PDL-1 on predicting the invasion and metastasis/poor prognosis of CSCC patients were 0.930 (95%Cl: 0.883-0.962)/0.935 (95%Cl: 0.886-0.967), with cut-off values of 23.27/24.86 (86.76%/80.95% sensitivity, 95.69%/92.68% specificity). The CSCC patients with highly-expressed PDL-1 showed increased cumulative incidence of poor prognosis. Additionally, occurence of vascular infiltration/LNM, and up-regulated PDL-1 were independent risk factors for poor prognosis in CSCC patients. Briefly, PDL-1 expression rised in CSCC. High PDL-1 expression might promote tumor infiltration and LNM, while close monitoring of its expression contributed to evaluating prognosis of CSCC patients.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1676-1684"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Thyroid Hormones on Cellular Development in Human Ovarian Granulosa Tumor Cells (KGN). 甲状腺激素对人类卵巢颗粒细胞（KGN）细胞发育的影响

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2024-10-15 DOI: 10.1007/s43032-024-01721-6

Yakun Yu, Yilin Yao, Yan Liu, Ying Sun, Haoyuan Feng, Nana Kong, Rui Chen, Mingqi Wu, Shuaitian Guo, Shen Tian, Cheng Zhang

{"title":"Effects of Thyroid Hormones on Cellular Development in Human Ovarian Granulosa Tumor Cells (KGN).","authors":"Yakun Yu, Yilin Yao, Yan Liu, Ying Sun, Haoyuan Feng, Nana Kong, Rui Chen, Mingqi Wu, Shuaitian Guo, Shen Tian, Cheng Zhang","doi":"10.1007/s43032-024-01721-6","DOIUrl":"10.1007/s43032-024-01721-6","url":null,"abstract":"Ovarian cancer is a common malignant tumor in the female reproductive system, and Granulosa cell tumor (GCT) of the ovary is a rare type of ovarian cancer, which significantly threatens women's reproductive health. It has been reported that dysregulation of thyroid hormones (THs) may be closely related to the progression and prognosis of ovarian cancer. Moreover, THs regulate phosphorylation of signal transducer and activator of transcription (STAT3) and Octamer-binding transcription factor 4 (OCT4) expression. It has been reported that STAT3 and OCT4 play important roles in cellular development and tumorigenesis. However, the mechanisms by which THs affect the development of GCT are still remained unclear. To evaluate the effect of THs on human ovarian granulosa tumor cells (KGN), cells were treated with 3,5,3' -triiodothyronine (T3). Oct4 small interfering (Oct4 siRNA) or STAT3 inhibitor C188-9 was also co-cultured with cells in some experiments, respectively. The cell viability, proliferation, and proteins content were detected by CCK-8, EdU, and Western Blotting, respectively. The results showed that T3 enhanced cell viability and proliferation. Moreover, T3 also increased the expression of thyroid hormone receptor (TR), p-STAT3, and OCT4 proteins. The effects of T3 on both p-STAT3 and OCT4 expression were blocked by TR antagonist 1-850. Meanwhile, C188-9, an inhibitor of STAT3, decreased T3-induced cellular viability, proliferation, and OCT4 expression, highlighting that p-STAT3 can regulate the expression of OCT4 and affect cellular viability, and proliferation. Furthermore, T3-induced cellular growth was reduced by Oct4 siRNA, which indicates that T3 regulates cellular development through OCT4. These findings suggest that T3 increases cellular development via OCT4, which is mediated by phosphorylation of STAT3, and TR is also involved in these processes.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1545-1556"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Quality Control in Ovarian Function: From Mechanisms to Therapeutic Strategies. 卵巢功能中的线粒体质量控制：从机制到治疗策略

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2024-07-09 DOI: 10.1007/s43032-024-01634-4

Xiaomei Wang, Yuxin Liu, Jinzheng Wang, Xueyi Lu, Zhipeng Guo, Shenmin Lv, Zhenyu Sun, Tan Gao, Fei Gao, Jinxiang Yuan

{"title":"Mitochondrial Quality Control in Ovarian Function: From Mechanisms to Therapeutic Strategies.","authors":"Xiaomei Wang, Yuxin Liu, Jinzheng Wang, Xueyi Lu, Zhipeng Guo, Shenmin Lv, Zhenyu Sun, Tan Gao, Fei Gao, Jinxiang Yuan","doi":"10.1007/s43032-024-01634-4","DOIUrl":"10.1007/s43032-024-01634-4","url":null,"abstract":"Mitochondrial quality control plays a critical role in cytogenetic development by regulating various cell-death pathways and modulating the release of reactive oxygen species (ROS). Dysregulated mitochondrial quality control can lead to a broad spectrum of diseases, including reproductive disorders, particularly female infertility. Ovarian insufficiency is a significant contributor to female infertility, given its high prevalence, complex pathogenesis, and profound impact on women's health. Understanding the pathogenesis of ovarian insufficiency and devising treatment strategies based on this understanding are crucial. Oocytes and granulosa cells (GCs) are the primary ovarian cell types, with GCs regulated by oocytes, fulfilling their specific energy requirements prior to ovulation. Dysregulation of mitochondrial quality control through gene knockout or external stimuli can precipitate apoptosis, inflammatory responses, or ferroptosis in both oocytes and GCs, exacerbating ovarian insufficiency. This review aimed to delineate the regulatory mechanisms of mitochondrial quality control in GCs and oocytes during ovarian development. This study highlights the adverse consequences of dysregulated mitochondrial quality control on GCs and oocyte development and proposes therapeutic interventions for ovarian insufficiency based on mitochondrial quality control. These insights provide a foundation for future clinical approaches for treating ovarian insufficiency.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1399-1413"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential Transfer of Blastocysts on Day 5 and Day 6 in Patients with Repeated Implantation Failure in Frozen Embryo Transfer Cycle. 在冷冻胚胎移植周期中反复移植失败患者的第 5 天和第 6 天连续移植囊胚。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2024-11-25 DOI: 10.1007/s43032-024-01734-1

Qi Jin, Xiaohua Jiang, Lu Zong, Tong Wu, Shengxia Zheng, Limin Wu, Bo Xu

{"title":"Sequential Transfer of Blastocysts on Day 5 and Day 6 in Patients with Repeated Implantation Failure in Frozen Embryo Transfer Cycle.","authors":"Qi Jin, Xiaohua Jiang, Lu Zong, Tong Wu, Shengxia Zheng, Limin Wu, Bo Xu","doi":"10.1007/s43032-024-01734-1","DOIUrl":"10.1007/s43032-024-01734-1","url":null,"abstract":"The aim of this study was to evaluate which frozen embryo transfer (FET) strategy benefits the recurrent implantation failure (RIF) population. A retrospective study of 336 women with RIF was performed from July 2020 to October 2023. The patients were divided into three groups according to the FET protocol. The three FET protocols included transferring a blastocyst on both days 5 and 6 (Group 1, n = 138); transferring a cleavage-stage embryo on day 3 and a blastocyst on day 5 (Group 2, n = 55); and transferring double blastocysts on day 5 (Group 3, n = 143).The sequential day 5 and day 6 blastocyst ET strategy significantly improved in vitro fertilization success rates compared with those of both the traditional double-blastocyst day 5 transfer strategy and the strategy involving one cleavage-stage embryo transfer on day 3 and one blastocyst transfer on day 5 in RIF patients. Compared with those observed in Day 5 double-blastocyst transfer, the rates of clinical pregnancy and implantation increased (51.75% vs. 64.49%, P < 0.001 and 37.06% vs. 41.3%, P = 0.005, respectively), while the rates of biochemical pregnancy and multiple gestation decreased (18.18% vs. 12.32%, P = 0.006 and 43.24% vs. 28.09%, P = 0.044, respectively) with the new protocol.Blastocysts from sequential embryo transfer on day 5 and day 6 were more effective than those from the traditional FET protocol at improving pregnancy outcomes and lowering the multiple pregnancy rate in RIF patients. When only one or zero good-quality blastocysts are available, sequential blastocyst ET on days 5 and 6 should be considered.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1580-1588"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Granulocyte Colony Stimulating Factor in Mitigating the Risk of Recurrent Miscarriages: A Comprehensive Review and Meta-Analysis. 粒细胞集落刺激因子在降低复发性流产风险中的作用：一项综合综述和荟萃分析。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2024-12-02 DOI: 10.1007/s43032-024-01736-z

Biyun Zhang, Jianying Xu, Xiangcai Wei, Xingming Zhong

{"title":"The Role of Granulocyte Colony Stimulating Factor in Mitigating the Risk of Recurrent Miscarriages: A Comprehensive Review and Meta-Analysis.","authors":"Biyun Zhang, Jianying Xu, Xiangcai Wei, Xingming Zhong","doi":"10.1007/s43032-024-01736-z","DOIUrl":"10.1007/s43032-024-01736-z","url":null,"abstract":"Granulocyte colony-stimulating factor (G-CSF), a pivotal hematopoietic cytokine, has been noted for its potential to bolster embryo implantation and augment endometrial receptivity. The present meta-analysis endeavors to evaluate the therapeutic efficacy of G-CSF in mitigating the incidence of recurrent miscarriages, thereby enriching the clinical evidence supporting its use in treatment protocols. Our exhaustive literature search, concluded on August 25, 2024, spanned across various databases including PubMed, Medline, Cochrane Library, Web of Science, ClinicalTrials, China National Knowledge Infrastructure (CNKI), Weipu, and Wanfang, to identify and analyze randomized controlled trials (RCTs) that assessed the impact of G-CSF on recurrent miscarriage. Our review incorporated 7 RCTs. The application of G-CSF was linked to a marked reduction in the rate of miscarriage [RR = 0.48, 95% CI (0.27, 0.86), P = 0.01]. Subgroup analysis indicated that the intra-uterine infusion of G-CSF was notably effective in diminishing the miscarriage rate (RR = 0.35, 95% CI (0.18, 0.68), P = 0.002), while subcutaneous administration did not exhibit a significant impact (RR = 0.55, 95% CI (0.26, 1.20), P = 0.13). Moreover, the administration of G-CSF during the ovulatory phase was identified as particularly efficacious in reducing the miscarriage rate (RR = 0.33, 95% CI (0.18, 0.63), P < 0.001). Intrauterine administration of G-CSF, particularly during the ovulatory phase, is associated with a significant decrease in miscarriage risk and an enhancement in the likelihood of a successful pregnancy outcome in patients with a history of recurrent miscarriages. These findings highlight G-CSF's promise as a valuable therapeutic intervention in this medical scenario.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1379-1387"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circ_0008440 Inhibits Proliferation and Promotes Apoptosis of Trophoblast Cells through the miR-194-5p/PFKFB2 Axis. Circ_0008440通过miR-194-5p/PFKFB2轴抑制滋养细胞增殖并促进细胞凋亡

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2024-12-11 DOI: 10.1007/s43032-024-01757-8

Linqiong Guo, Ting Ji, Xiaoyan Xu, Xing Liu, Yanping Cui

{"title":"Circ_0008440 Inhibits Proliferation and Promotes Apoptosis of Trophoblast Cells through the miR-194-5p/PFKFB2 Axis.","authors":"Linqiong Guo, Ting Ji, Xiaoyan Xu, Xing Liu, Yanping Cui","doi":"10.1007/s43032-024-01757-8","DOIUrl":"10.1007/s43032-024-01757-8","url":null,"abstract":"Preeclampsia (PE), an idiopathic hypertensive disorder that arises during pregnancy, poses a serious threat to the health of expectant mothers. Human chorionic trophoblast cells (HTR-8/SVneo) are associated with the development of PE. It has been reported that circ_0008440 expression is abnormally increased in the placental tissues of PE patients. However, the function of circ_0008440 within HTR-8/SVneo cells during PE has yet to be fully elucidated. The study used RT-qPCR and western blot assay to evaluate the expression levels of 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2 (PFKFB2), circ_0008440, and miR-942-5p in PE patients. Cells viability was measured using cell counting kit-8 (CCK-8) assay. Cell cycle assay and 5-ethynyl-2'-deoxyuridine (EDU) assay were used to measure cell proliferation. Cell apoptosis was assessed using flow cytometry assay. Western blot assay was used to detect protein expression. Dual-luciferase reporter assay and RNA pull-down assay were used to assess the interactions among circ_0008440, miR-942-5p, and PFKFB2 in HTR-8/SVneo cells. The study showed that the expression levels of circ_0008440 and PFKFB2 were significantly increased, while the expression of miR-942-5p was significantly decreased in the placental tissues of PE patients. Silencing of circ_0008440 promoted proliferation and tube formation and inhibited apoptosis of HTR-8/SVneo cells. In terms of molecular mechanism, miR-942-5p inhibitor or overexpression of PFKFB2 could partially reverse the effects of circ_0008440 silencing on the biological characteristics of HTR-8/SVneo cells. Collectively, circ_0008440 could act as a sponge of miR-942-5p to regulate the expression of PFKFB2, which further inhibited viability and proliferation of HTR-8/SVneo cells and promoted cell apoptosis.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1600-1611"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Vitamin D Level and Clinical Outcomes of Assisted Reproductive Treatment: A Systematic Review and Dose-Response Meta-Analysis. 维生素 D 水平与辅助生殖治疗临床结果之间的关系：系统回顾与剂量反应荟萃分析》（A Systematic Review and Dose-Response Meta-Analysis）。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2024-05-22 DOI: 10.1007/s43032-024-01578-9

Chenhao Xu, Xinqi An, Xiumei Tang, Yunxiao Yang, Qi Deng, Quanling Kong, Ying Hu, Dongzhi Yuan

{"title":"Association Between Vitamin D Level and Clinical Outcomes of Assisted Reproductive Treatment: A Systematic Review and Dose-Response Meta-Analysis.","authors":"Chenhao Xu, Xinqi An, Xiumei Tang, Yunxiao Yang, Qi Deng, Quanling Kong, Ying Hu, Dongzhi Yuan","doi":"10.1007/s43032-024-01578-9","DOIUrl":"10.1007/s43032-024-01578-9","url":null,"abstract":"The investigation about association between vitamin D level and clinical outcomes of assisted reproductive treatment showed various outcomes. This study aimed to review the correlation between vitamin D and outcomes of assisted reproductive treatment. The search was registered on the PROSPERO database (CRD42023458040). PubMed, Embase, Medline, ClinicalTrials.gov, and Cochrane databases were searched up to July 2023. Twenty-three observational studies were selected for meta-analysis. Comparing groups with deficient and 'insufficient + sufficient' vitamin D level, meta-analysis showed positive correlation between clinical pregnancy rate and vitamin D (OR 0.81, 95%CI: 0.70, 0.95, P = 0.0001). Comparing groups with 'deficient + insufficient' and sufficient vitamin D level, meta-analysis showed positive correlation between vitamin D and clinical pregnancy rate (OR 0.71, 95%CI: 0.55, 0.91, P = 0.006), vitamin D and live birth rate (OR 0.69, 95%CI: 0.54, 0.89, P = 0.003). Subgroup analysis did not show the source of high heterogeneity. No correlation was found in biochemical pregnancy rate, ongoing pregnancy rate, miscarriage rate and implantation rate. In dose-response meta-analysis, a nonlinear association was found between vitamin D levels and outcomes when levels are below approximately 24 ng/L. The study shows that vitamin D level is associated with clinical pregnancy rate and live birth rate. Low vitamin D level does not influence biochemical pregnancy rate, ongoing pregnancy rate, miscarriage rate and implantation rate. Furthermore, 24 ng/L may be a possible threshold of vitamin D concentration in assisted reproduction therapy.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1446-1458"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth Hormone Improves Ovarian Follicle Health in Premature Ovarian Failure Mice by Reducing Apoptosis : (GH Improves Ovarian Follicle Health in POF Mice by Reducing Apoptosis). 生长激素通过减少细胞凋亡改善卵巢早衰小鼠的卵泡健康：（GH Improves Ovarian Follicle Health in POF Mice by Reducing Apoptosis）。

IF 2.6 3区医学

Reproductive Sciences Pub Date : 2025-05-01 Epub Date: 2025-03-03 DOI: 10.1007/s43032-025-01822-w

Ziwei Hong, Xinyi Ni, Liying Zhou, Hong Ji, Daowei Yang, Hongshu Sui, Hailong Wang

{"title":"Growth Hormone Improves Ovarian Follicle Health in Premature Ovarian Failure Mice by Reducing Apoptosis : (GH Improves Ovarian Follicle Health in POF Mice by Reducing Apoptosis).","authors":"Ziwei Hong, Xinyi Ni, Liying Zhou, Hong Ji, Daowei Yang, Hongshu Sui, Hailong Wang","doi":"10.1007/s43032-025-01822-w","DOIUrl":"10.1007/s43032-025-01822-w","url":null,"abstract":"Premature ovarian failure (POF) is a perplexing condition in women characterized by cessation of oocyte production in the ovaries. Despite numerous proposed causes for the development of POF, the actual cause of the most POF cases remains unknown. Given that POF significantly affects fertility and is a devastating diagnosis for women, there is an urgent need for the development of new therapies aimed at reducing the long-term health consequences associated with POF. To explore the functions and potential mechanisms of growth hormone (GH) in ovarian development, follicle formation, and oocyte production, we created a mouse model of premature ovarian failure (POF) by administering cisplatin via intraperitoneal injection. Subsequently, we investigated the role of GH in attenuating the POF-induced effects. Our findings demonstrate that GH effectively improves the ovarian coefficient, promotes follicular development, and increases the quantity of oocytes. To explore the functions and potential mechanisms of growth hormone (GH) in ovarian development, follicle formation, and oocyte production, we created a mouse model of premature ovarian failure (POF) by administering cisplatin via intraperitoneal injection. Subsequently, we investigated the role of GH in attenuating the POF-induced effects. Our findings demonstrate that GH effectively improves the ovarian coefficient, promotes follicular development, and increases the quantity of oocytes.","PeriodicalId":20920,"journal":{"name":"Reproductive Sciences","volume":" ","pages":"1730-1742"},"PeriodicalIF":2.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0