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The Role of the N170 in Linking Stimuli to Feedback-Effects of Stimulus Modality and Feedback Delay. N170在刺激与反馈联系中的作用——刺激模态效应和反馈延迟。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-04-01 DOI: 10.1111/psyp.70050
Madita Röhlinger, Christine Albrecht, Christian Bellebaum
{"title":"The Role of the N170 in Linking Stimuli to Feedback-Effects of Stimulus Modality and Feedback Delay.","authors":"Madita Röhlinger, Christine Albrecht, Christian Bellebaum","doi":"10.1111/psyp.70050","DOIUrl":"https://doi.org/10.1111/psyp.70050","url":null,"abstract":"<p><p>With increasing feedback delay, feedback processing appears to shift from the striatum to the hippocampus. In addition, higher-order sensory areas might be involved in bridging a temporal gap between stimulus and feedback by reactivating the representation of the feedback-predicting stimulus during feedback processing. We hypothesized that the feedback-locked N170, an occipito-temporal event-related potential (ERP) component linked to higher-order visual processing, is more pronounced when delayed feedback is provided for choices between visual compared to auditory stimuli. 35 subjects completed a probabilistic feedback learning task with immediate (1 s) and delayed (7 s) monetary feedback for choices between visual or auditory stimuli. Participants successfully learned to choose the more rewarding stimuli irrespective of stimulus modality. For the N170 amplitude over the right hemisphere, we found an interaction between feedback timing and the modality of the chosen stimulus. Only for delayed feedback, the N170 was more pronounced for choices between visual than auditory stimuli. Moreover, in this condition, the N170 amplitude particularly reflected the reward prediction error (PE), with larger amplitudes for positive PEs and lower amplitudes for negative PEs. This suggests that the N170 reflects feedback-locked reactivations in higher-order visual areas mediated by the reward PE. While these effects need to be studied further, we discuss the N170 as a counterpart to the feedback-related negativity (FRN) regarding interacting influences of feedback valence, feedback timing, and PE.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 4","pages":"e70050"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preference for Social Motion in Autistic Adults. 自闭症成人的社会运动偏好。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-04-01 DOI: 10.1111/psyp.70053
Magdalena Matyjek, Nico Bast, Salvador Soto Faraco
{"title":"Preference for Social Motion in Autistic Adults.","authors":"Magdalena Matyjek, Nico Bast, Salvador Soto Faraco","doi":"10.1111/psyp.70053","DOIUrl":"https://doi.org/10.1111/psyp.70053","url":null,"abstract":"<p><p>Autism is often linked to attenuated social attention, including a lowered looking preference for biological motion in autistic compared to non-autistic children. This looking preference has been suggested as an autism marker in childhood. However, few studies have investigated whether this bias persists into adulthood. Furthermore, the underlying cognitive mechanism of this group difference is largely unknown. Pupillary responses have been established as an index of salience processing and are thus a promising measurement of the cognitive bases of looking preference. The present study examined differences in looking preference and pupillary responses to social versus geometric motion between autistic and non-autistic adults (N = 66). In terms of preference, autistic adults demonstrated a reduced spontaneous looking toward social stimuli compared to the non-autistic group. Whereas the former displayed no clear preference for either motion type, the latter showed a strong preference for social motion. In terms of pupillary responses, the autistic group showed faster and larger pupil dilation for social motion compared to the non-autistic group, which indicated heightened cognitive effort and arousal. These results suggest persistent differences in social attention across the developmental lifespan in autism.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 4","pages":"e70053"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of Adolescents With Major Depressive Disorder Using Random Forest Based on Nocturnal Heart Rate Variability. 基于夜间心率变异性的随机森林识别青少年重度抑郁症。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-03-01 DOI: 10.1111/psyp.70049
Wanlin Chen, Haisi Chen, Haoxuan Ruan, Wenchen Jiang, Cheng Chen, Moya Xu, Yifei Xu, Hang Chen, Zhenghe Yu, Shulin Chen
{"title":"Identification of Adolescents With Major Depressive Disorder Using Random Forest Based on Nocturnal Heart Rate Variability.","authors":"Wanlin Chen, Haisi Chen, Haoxuan Ruan, Wenchen Jiang, Cheng Chen, Moya Xu, Yifei Xu, Hang Chen, Zhenghe Yu, Shulin Chen","doi":"10.1111/psyp.70049","DOIUrl":"10.1111/psyp.70049","url":null,"abstract":"<p><p>Major depressive disorder (MDD) in adolescents is often underdiagnosed, with the current diagnosis predominantly relying on subjective assessment. Sleep disturbance and reduced heart rate variability (HRV) have been typically observed in adolescents with MDD. This study aimed to develop an automatic classification model based on nocturnal HRV features to identify adolescent MDD. Sixty-three subjects, including depressed adolescents and healthy controls, participated in the study and completed a three-night sleep electrocardiogram (ECG) monitoring, yielding 160 overnight RR interval time series and 7520 5-min short-term segments for analysis. Nineteen HRV features were extracted from the time domain, frequency domain, and nonlinear dynamics. The Bayesian-optimized random forest (BO-RF) algorithm was applied as the classifier, with performance evaluated using ten-fold cross-validation. The impact of data accumulation on the reliability of identification using short-term data and the importance of features were also examined. The BO-RF classifier based on long-term features achieved a noteworthy predictive accuracy of 80.6%, and the performance of the classifier using short-term data showed a significant improvement when more segment outcomes from the same night were included, ultimately achieving an accuracy of 75.0%. The Poincaré plot-derived features, especially heart rate asymmetry (HRA) features such as C1<sub>d</sub>, significantly contributed to distinguishing depressed adolescents from healthy subjects. Nocturnal HRV features can effectively differentiate adolescents with MDD from healthy controls. This study provides a promising diagnostic approach for adolescent MDD, with the potential to be integrated into wearable devices for broader application.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70049"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpersonal Conversations Are Characterized by Increases in Respiratory Sinus Arrhythmia. 人际交谈以呼吸性窦性心律失常增加为特征。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-03-01 DOI: 10.1111/psyp.70043
Nathan C Stuart, Brett J Peters, Peggy M Zoccola, Ashley Tudder, Jeremy P Jamieson
{"title":"Interpersonal Conversations Are Characterized by Increases in Respiratory Sinus Arrhythmia.","authors":"Nathan C Stuart, Brett J Peters, Peggy M Zoccola, Ashley Tudder, Jeremy P Jamieson","doi":"10.1111/psyp.70043","DOIUrl":"10.1111/psyp.70043","url":null,"abstract":"<p><p>Multiple theoretical perspectives connect vagally mediated heart rate variability, or respiratory sinus arrhythmia (RSA), and self-regulatory and interpersonal processes. Together they suggest that self-regulatory effort and positive social experiences may lead to short-term increases in RSA, which in turn are related to adaptive emotional, social, and physical functioning. However, the extant literature on adult social interactions does not clearly support this premise. To study the connections between dyadic social interactions and phasic changes in RSA, the current research examined 356 dyads (712 adults between 18 and 36 years; 50% males, 50% females) across three studies in which participants engaged in face-to-face social interactions in a laboratory setting. Relationship type and conversation context varied across studies, and high-frequency power was used to estimate RSA across resting baseline, anticipatory periods, and conversation tasks. Analyses indicated that anticipation of and engagement in dyadic social interactions were associated with an increase in RSA from a resting baseline. The mean estimated effect size for anticipation was r = 0.50, and the mean estimated effect size for conversation was r = 0.34. Associations were robust across relationship types, including strangers and romantic couples, conversation context, including topic and valence, and across speaking and listening roles. The present research provides consistent evidence for increased RSA in anticipation of and during in-person social interactions among adults, prompting the need for further investigation into potential underlying mechanisms.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70043"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interplay of Spontaneous Pupil-Size Fluctuations and EEG Power in Near-Threshold Detection. 近阈值检测中瞳孔大小波动与脑电功率的相互作用。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-03-01 DOI: 10.1111/psyp.70035
Veera Ruuskanen, C Nico Boehler, Sebastiaan Mathôt
{"title":"The Interplay of Spontaneous Pupil-Size Fluctuations and EEG Power in Near-Threshold Detection.","authors":"Veera Ruuskanen, C Nico Boehler, Sebastiaan Mathôt","doi":"10.1111/psyp.70035","DOIUrl":"10.1111/psyp.70035","url":null,"abstract":"<p><p>Detection of near-threshold stimuli depends on the properties of the stimulus and the state of the observer. In visual detection tasks, improved accuracy is associated with larger prestimulus pupil size. However, it is still unclear whether this association is due to optical effects (more light entering the eye), correlations with arousal, correlations with cortical excitability (as reflected in alpha power), or a mix of these. To better understand this, we investigated the relative contributions of pupil size and power in the alpha, beta, and theta frequency bands on near-threshold detection. We found that larger prestimulus pupil size is associated with improved accuracy and more stimulus-present responses, and these effects were not mediated by spectral power in the EEG. Pupil size was also positively correlated with power in the beta and alpha bands. Taken together, our results show an independent effect of pupil size on detection performance that is not driven by cortical excitability but may be driven by optical effects, physiological arousal, or a mix of both.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70035"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amygdala Structure and Function: Association With Transdiagnostic Trauma Severity in Anxiety and Mood Disorder Patients. 杏仁核结构和功能:与焦虑和情绪障碍患者的跨诊断性创伤严重程度相关。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-03-01 DOI: 10.1111/psyp.70027
Nicola Sambuco, Margaret M Bradley, Peter J Lang
{"title":"Amygdala Structure and Function: Association With Transdiagnostic Trauma Severity in Anxiety and Mood Disorder Patients.","authors":"Nicola Sambuco, Margaret M Bradley, Peter J Lang","doi":"10.1111/psyp.70027","DOIUrl":"10.1111/psyp.70027","url":null,"abstract":"<p><p>Reductions in both the size of the amygdala and functional activity during emotional processing have been independently associated with trauma exposure and severity, raising the question of whether reduced volume prompts reduced functional activation. In this multimodal assessment, the relationship between amygdala structure and function was investigated in mood and anxiety patients to determine their covariation and their relationship to trauma magnitude. Overall, amygdala volume and functional emotional reactivity were unrelated, with smaller volumes and reduced emotional reactivity each independently predicting trauma magnitude for women, and mediation analysis did not support a hypothesis that the relationship between reduced functional activity and trauma severity depends on amygdala volume. Structural and functional differences were instead separately related to different facets of trauma experience, highlighting the need for longitudinal and multimodal analyses to further elucidate the relationship between brain structure, function, and psychopathology.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70027"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering Distinct Drivers of Covert Attention in Complex Environments With Pupillometry. 用瞳孔测量法揭示复杂环境下隐蔽注意的不同驱动因素。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-03-01 DOI: 10.1111/psyp.70036
Yuqing Cai, Stefan Van der Stigchel, Julia Ganama, Marnix Naber, Christoph Strauch
{"title":"Uncovering Distinct Drivers of Covert Attention in Complex Environments With Pupillometry.","authors":"Yuqing Cai, Stefan Van der Stigchel, Julia Ganama, Marnix Naber, Christoph Strauch","doi":"10.1111/psyp.70036","DOIUrl":"10.1111/psyp.70036","url":null,"abstract":"<p><p>Spatial visual attention prioritizes specific locations while disregarding others. The location of spatial attention can be deployed without overt movements (covertly). Spatial dynamics of covert attention are exceptionally difficult to measure due to the hidden nature of covert attention. One way to implicitly index covert attention is via the pupillary light response (PLR), as the strength of PLR is modulated by where attention is allocated. However, this method has so far necessitated simplistic stimuli and targeted only one driver of covert attention per experiment. Here we report a novel pupillometric method that allows tracking multiple effects on covert attention with highly complex stimuli. Participants watched movie clips while either passively viewing or top-down shifting covert attention to targets on the left, right, or both sides of the visual field. Using a recent toolbox (Open-DPSM), we evaluated whether luminance changes in regions presumably receiving more attention contribute more strongly to the pupillary responses-and thereby reveal covert attention. Three established effects of covert attention on pupil responses were found: (1) a bottom-up effect suggesting more attention drawn to more dynamic regions, (2) a top-down effect suggesting more attention towards the instructed direction, and (3) an overall tendency to attend to the left side (i.e. pseudoneglect). Beyond the successful validation of our method, these drivers of covert attention did not modulate each other's effects, indicating independent contributions of bottom-up, top-down, and pseudoneglect to covert attention in stimuli as dynamic as the present. We further explain how to use Open-DPSM to track covert attention in a brief tutorial.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70036"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parallel Syntactic Processing in the Flankers Task: Insights From ERP Decoding. 侧翼任务中的并行句法处理:ERP解码的启示
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-03-01 DOI: 10.1111/psyp.70019
Aaron Vandendaele, Sofia E Ortega, Katherine J Midgley, Jonathan Grainger, Phillip J Holcomb
{"title":"Parallel Syntactic Processing in the Flankers Task: Insights From ERP Decoding.","authors":"Aaron Vandendaele, Sofia E Ortega, Katherine J Midgley, Jonathan Grainger, Phillip J Holcomb","doi":"10.1111/psyp.70019","DOIUrl":"10.1111/psyp.70019","url":null,"abstract":"<p><p>The current paper reports the results of two ERP experiments that investigated the extent to which syntactic information can be extracted from the parafovea. We used the reading version of the flankers task in which participants had to classify foveal target words as either being a noun or an adjective. In Experiment 1, targets were flanked by either syntactically congruent or incongruent words (e.g., noun noun noun vs. adjective noun adjective), or were embedded in a sequence of words that was either grammatical or ungrammatical (e.g., adjective noun verb vs. verb noun adjective). Experiment 2 employed the same stimuli as the latter condition, with participants now tasked to judge the word sequence as being grammatically correct or not. Results showed a significant reduction in N400 amplitude for both the syntactically congruent and syntactically grammatical conditions in Experiment 1, and for syntactic grammaticality when making sentence judgments in Experiment 2. In the second experiment, a syntactically grammatical word sequence could be reliably decoded starting around 500 ms post-stimulus onset. These results indicate that skilled readers can extract and process syntactic information from multiple words in a short timeframe and that syntactic categories retrieved from individual words (i.e., parts-of-speech) are rapidly integrated into a sentence-level representation.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70019"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Event-Related Potentials to Facial Expressions Are Related to Stimulus-Level Perceived Arousal and Valence. 面部表情的事件相关电位与刺激水平的知觉唤醒和效价有关。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-03-01 DOI: 10.1111/psyp.70045
Amie J Durston, Roxane J Itier
{"title":"Event-Related Potentials to Facial Expressions Are Related to Stimulus-Level Perceived Arousal and Valence.","authors":"Amie J Durston, Roxane J Itier","doi":"10.1111/psyp.70045","DOIUrl":"10.1111/psyp.70045","url":null,"abstract":"<p><p>Facial expressions provide critical details about social partners' inner states. We investigated whether event-related potentials (ERP) related to the visual processing of facial expressions are modulated by participants' perceived arousal and valence at the stimulus level. ERPs were recorded while participants (N = 80) categorized the gender of faces expressing fear, anger, happiness, and no emotion. Participants then viewed each face again and rated them on arousal and valence using 1-9 Likert scales. For each participant, ratings of each unique face were linked back to corresponding ERP trials. ERPs were analyzed at all time points and electrodes using hierarchical mass univariate statistics. Three different ANOVA models were employed: the original emotion model, and models with valence or arousal ratings as trial-level regressors. Results from models with ratings highly overlapped with the original model, although they were more temporally restricted. The N170 component was the most impacted by arousal and valence ratings, with four out of six emotion contrasts revealing significant valence or arousal interactions. Emotion effects on the P2 component were mostly unrelated to ratings. On the EPN component, only two contrasts related to both arousal and valence ratings. Thus, ERP emotion effects are related to participants' perceived arousal and valence of the stimuli, although this association depends on the contrast analyzed. These findings, their limitations, and generalizability are discussed in reference to existing theories and literature.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70045"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Transcutaneous Auricular Vagus Nerve Stimulation Increases Long-Latency Neural Processing in Multiple Sensory Modalities. 连续经皮耳迷走神经刺激增加多种感觉模式的长潜伏期神经加工。
IF 2.9 2区 心理学
Psychophysiology Pub Date : 2025-03-01 DOI: 10.1111/psyp.70048
Valentina Jelinčić, Martina D'Agostini, Carlos Ventura-Bort, Loriss Cascio, Ekaterina Gorianskaia, Mathias Weymar, Diana M Torta, Ilse Van Diest, Andreas von Leupoldt
{"title":"Continuous Transcutaneous Auricular Vagus Nerve Stimulation Increases Long-Latency Neural Processing in Multiple Sensory Modalities.","authors":"Valentina Jelinčić, Martina D'Agostini, Carlos Ventura-Bort, Loriss Cascio, Ekaterina Gorianskaia, Mathias Weymar, Diana M Torta, Ilse Van Diest, Andreas von Leupoldt","doi":"10.1111/psyp.70048","DOIUrl":"10.1111/psyp.70048","url":null,"abstract":"<p><p>Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive technique stimulating vagal afferent fibers, showing promise in treating neurological and mental disorders. taVNS is believed to activate the locus coeruleus (LC), promoting noradrenergic activation (NA), which enhances arousal and attention. However, evidence for the LC-NA hypothesis is mixed, and investigations in different sensory modalities are lacking. This study investigated whether continuous taVNS enhances standard NA markers along with neural processing in three sensory modalities (auditory, respiratory, and somatosensory). In a 2-day Sham-controlled crossover protocol, 45 healthy adults received taVNS at the cymba concha and Sham stimulation at the earlobe. During stimulation, participants experienced paired auditory clicks, inspiratory occlusions, and electrocutaneous stimuli, while EEG was acquired. Salivary alpha-amylase (sAA) and subjective experienced arousal were measured at pre-/end-stimulation. Resting-state EEG was measured pre-/poststimulation to assess alpha-band (8-13 Hz) oscillation power, and participants rated the intensity and unpleasantness of all stimuli. Auditory-, respiratory-related-, and somatosensory evoked potentials were measured, specifically P50, N1, and P2 components, as well as the P50/N1 amplitude difference of the second and the first stimulus in the pair (neural gating; S2-S1). Although no effects in P50 or N1 amplitudes were observed, P2 amplitudes in auditory and somatosensory blocks increased during taVNS. Self-reported arousal increased in the taVNS condition, with no effects on neural gating, sAA concentration, or resting-state alpha power. taVNS had no effect on self-reported intensity/unpleasantness of stimuli. These results highlight certain limitations posed by combining taVNS and EEG and underline the need for further mechanistic taVNS research.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 3","pages":"e70048"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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