Recent patents on anti-infective drug discovery最新文献_第6页

Polymyxin Resistance Mechanisms: From Intrinsic Resistance to Mcr Genes. 多粘菌素耐药机制:从内在耐药到Mcr基因。

Recent patents on anti-infective drug discovery Pub Date : 2018-01-01 DOI: 10.2174/1574891X14666181126142704

Georgios Meletis, Lemonia Skoura

引用次数: 19

Current Progress in Synthesis, Characterization and Applications of Silver Nanoparticles: Precepts and Prospects. 纳米银的合成、表征及应用研究进展:展望与展望。

Recent patents on anti-infective drug discovery Pub Date : 2018-01-01 DOI: 10.2174/1574891X12666171006102833

Md Abul Barkat, Harshita, Sarwar Beg, Mohd Javed Naim, Faheem H Pottoo, Satya P Singh, Farhan J Ahmad

{"title":"Current Progress in Synthesis, Characterization and Applications of Silver Nanoparticles: Precepts and Prospects.","authors":"Md Abul Barkat, Harshita, Sarwar Beg, Mohd Javed Naim, Faheem H Pottoo, Satya P Singh, Farhan J Ahmad","doi":"10.2174/1574891X12666171006102833","DOIUrl":"https://doi.org/10.2174/1574891X12666171006102833","url":null,"abstract":"Background: Silver nanoparticles (AgNPs), are amongst the utmost striking nanosized materials that are extensively applied in a variety of biomedical applications which includes diagnostic use, disease management, medical device coating, drug delivery and for personal health care.Discussion: With the growing interest and its application in the health care sector, it is becoming necessary for a better understanding and exploration of AgNPs mechanism of action like biological interaction, their possible toxicity, and safety concern to human exposure. AgNPs have been the subject of researchers attention and interest due to the unique properties and quality such as shape and size depending optical, electrical, and antimicrobial potentials (antibacterial, antifungal, antiviral etc.). In recent times, several studies have been conducted on AgNPs antimicrobial potential and also a number of patents related to its synthesis, clinical role and importance have also been registered. In this review, a short overview of AgNPs synthesis approach is presented (physical, chemical, and biological or green synthesis) and it also delivers a historical outlook of AgNPs application as an antimicrobial agent which includes combined evidence of microbial resistance and safety issues with human exposure.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574891X12666171006102833","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35427048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Evaluation of Fosfomycin Activity Against Extended Spectrum Beta Lactamase (ESBL) Producing Enterobacteriaceae Isolated from Three Centers of Tehran, Iran. 磷霉素对伊朗德黑兰三个中心产肠杆菌科扩展谱β -内酰胺酶(ESBL)的活性评价

Recent patents on anti-infective drug discovery Pub Date : 2018-01-01 DOI: 10.2174/1574891X13666180517075803

Roya Ghanavati, Elnaz Ohadi, Hossein Kazemian, Fateme Yazdani, Alireza Torki, Behrooz S Kalani, Gholamreza Irajian

{"title":"Evaluation of Fosfomycin Activity Against Extended Spectrum Beta Lactamase (ESBL) Producing Enterobacteriaceae Isolated from Three Centers of Tehran, Iran.","authors":"Roya Ghanavati, Elnaz Ohadi, Hossein Kazemian, Fateme Yazdani, Alireza Torki, Behrooz S Kalani, Gholamreza Irajian","doi":"10.2174/1574891X13666180517075803","DOIUrl":"https://doi.org/10.2174/1574891X13666180517075803","url":null,"abstract":"Background: Rising rates of antimicrobial resistance among Enterobacteriaceae limit the use of reliably active forms of available drugs. The aim of this study was to investigate the prevalence of fosfomycin (US6794490B2) resistance gene among ESBL producing isolates in Iran.Method: We tested 355 isolates of Enterobacteriacea collected from various clinical samples including urine, wounds, blood and other sources during June 2016 to July 2017. Antibiotic sensitivity and Extended Spectrum Beta Lactamase (ESBL) production were tested using agar dilution method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. ESBL genes (blaTEM, bla SHV,bla CTX-M), plasmid-encoded fosfomycin resistance genes (fosA, fosB, fosA3 and fosC2) and chromosomal mutations (murA, glpT, uhpT) were detected by Polymerase Chain Reaction (PCR).Results: In this study, 151 of the 355 isolates were ESBL-positive. blaCTX-M (77%) was the most common gene followed by blaSHV (70%) and blaTEM (58%), either alone or in combination. Eighty nine percent (132/151) of the ESBL-positive isolates were MDR. Antimicrobial susceptibility rates were higher for fosfomycin (92.8%) and imipenem (35.5%) among ESBL-positive isolates. None of the ESBL- positive isolates harbored any mutations or plasmid-mediated fosfomycin resistance determinants.Conclusion: In conclusion, fosfomycin showed good antimicrobial activity against multidrug resistance ESBL- positive Enterobacteriaceae.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36104667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In Vitro Anti-mycobacterial Activity of Three Medicinal Plants of Lamiaceae Family. 三种兰科药用植物体外抗分枝杆菌活性的研究。

Recent patents on anti-infective drug discovery Pub Date : 2018-01-01 DOI: 10.2174/1574891X13666180626170155

Hossein Kazemian, Hamid Heidari, Jalil Kardan Yamchi, Hengameh Zandi, Asieh Taji, Fateme Yazdani, Gholamreza Hamzehloo, Roya Ghanavati, Hossein A Rahdar, Mohammad M Feizabadi

{"title":"In Vitro Anti-mycobacterial Activity of Three Medicinal Plants of Lamiaceae Family.","authors":"Hossein Kazemian, Hamid Heidari, Jalil Kardan Yamchi, Hengameh Zandi, Asieh Taji, Fateme Yazdani, Gholamreza Hamzehloo, Roya Ghanavati, Hossein A Rahdar, Mohammad M Feizabadi","doi":"10.2174/1574891X13666180626170155","DOIUrl":"https://doi.org/10.2174/1574891X13666180626170155","url":null,"abstract":"Background: Mycobacterium tuberculosis as an intracellular pathogen causes Tuberculosis (TB). Due to the long time required for treatment, hepatotoxicity of drugs and also emergence of Multidrug-Resistant (MDR) and Extremely Drug Resistant (XDR) strains, TB is currently a major public health problem. Some medicinal plants possess remarkable activity against Mycobacterium. Among them, Lamiaceae family are of pharmaceutical interest because of their potential antimicrobial properties. The aim of the study was to evaluate the in vitro activities of Satureja rechingeri, Satureja khuzestanica and Zataria multiflora against MDR M. tuberculosis and two Non-Tuberculous Mycobacteria (NTM).Methods: The essential oils were prepared by the standard method. The confirmed strains were obtained from the microbial collection of Tehran University of Medical Sciences. Minimum Inhibitory Concentrations (MICs) of essential oils of plants against mycobacterial strains were determined using standard broth microdilution method.Results: MDR M. tuberculosis was completely inhibited by Z. multiflora at 78µg/ml concentration. S. rechingeri and S. khuzestanica also showed same anti-mycobacterial activity against MDR M. tuberculosis with MICs of 156 µg/ml. The MICs of the essential oils against M. tuberculosis H37Rv, M. kansasii and M. fortuitum were in the range from 39 to 156 µg/ml.Conclusion: The studied medicinal plants showed notable effects against mycobacterial strains. Our results indicated that utilization of Lamiaceae family can be helpful for treatment of mycobacterial infections.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36266748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Oral Colonization by Nosocomial Pathogens During Hospitalization in Intensive Care Unit and Prevention Strategies. 重症监护病房住院期间院内病原菌的口腔定植及预防策略。

Recent patents on anti-infective drug discovery Pub Date : 2017-10-02 DOI: 10.2174/1574891X12666170215152854

H. Kazemian, Samaneh Bourbour, M. Beheshti, A. Bahador

引用次数: 10

Nanoemulsion for the Effective Treatment and Management of Anti-tubercular Drug Therapy. 纳米乳剂对抗结核药物治疗的有效治疗和管理。

Recent patents on anti-infective drug discovery Pub Date : 2017-01-01 DOI: 10.2174/1574891X12666170504094330

Sarwar Beg, Sumant Saini, Syed S Imam, Mahfoozur Rahman, Suryakanta Swain, Mohammad S Hasnain

{"title":"Nanoemulsion for the Effective Treatment and Management of Anti-tubercular Drug Therapy.","authors":"Sarwar Beg, Sumant Saini, Syed S Imam, Mahfoozur Rahman, Suryakanta Swain, Mohammad S Hasnain","doi":"10.2174/1574891X12666170504094330","DOIUrl":"https://doi.org/10.2174/1574891X12666170504094330","url":null,"abstract":"Background: Tuberculosis is considered as one of the deadliest diseases of human existence. Since ancient age the treatment of tuberculosis has been highly challenging primarily owing to the pathogenic nature of the Mycobacterium and its diverse spots of localization in human body including lungs, liver, spleen, eye, meninges and lymph nodes.Methods: The conventional drug therapy employed for the treatment of tuberculosis is not highly satisfactorily owing to low oral bioavailability of the drugs. The evolution of nano-technology recently in few decades has completely revolutionized the treatment of diverse diseases and so is the tuberculosis. Nanotechnology not only possesses enormous potential for improving the biopharmaceutical performance, but also allows the delivery of therapeutic molecules to the desired site of action. Diverse types of nanocarriers have been employed for the treatment of tuberculosis infections. In this regard, nanoemulsions are considered as one of the promising alternatives for augmenting the bioavailability of the antitubercular drugs through oral route for improving their therapeutic efficacy.Conclusion: The nanoemulsion loaded with antitubercular drugs can easily cross the biological barriers to reach the systemic circulation and consequently in the target for reducing the load of Mycobacterium tuberculosis. Besides, the lipidic nature of such systems facilitates targeting of the drugs to the lymph nodes, thus improves drug bioavailability and reduction of the dosing frequency. In lieu of this, the present article compiles the basics of nanoemulsions in brief along with an updated account on their applications in delivering antitubercular drugs for enhanced immunization. Moreover, overview of patent literature published in this area has also been included in the manuscript.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34975142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Optimization of Microemulsion Based Transdermal Gel of Triamcinolone. 曲安奈德微乳透皮凝胶的优选。

Recent patents on anti-infective drug discovery Pub Date : 2017-01-01 DOI: 10.2174/1574891X12666170426092911

Swati Jagdale, Bhagyashree Chaudhari

{"title":"Optimization of Microemulsion Based Transdermal Gel of Triamcinolone.","authors":"Swati Jagdale, Bhagyashree Chaudhari","doi":"10.2174/1574891X12666170426092911","DOIUrl":"https://doi.org/10.2174/1574891X12666170426092911","url":null,"abstract":"Background: Triamcinolone is a long acting corticosteroid used in the treatment of arthritis, eczema, psoriasis and similar conditions which cause inflammation. Triamcinolone has half-life of 88min. Prolonged oral use is associated with gastrointestinal adverse effects as peptic ulcer, abdominal distention and ulcerative esophagitis as described in various patents. Microemulgel offers advantage of better stability, better loading capacity and controlled release especially for drug with short half life.Objective: Objective of the present study was to optimize microemulgel based transdermal delivery of triamcinolone.Method: Saturated solubility of triamcinolone in various oils, surfactants and co-surfactants is estimated. Pseudo-ternary phase diagrams were constructed to determine the region of transparent microemulsion. Microemulsion was evaluated for globule size (FE-SEM, zetasizer), % transmittance, pH, viscosity, conductivity etc. Design of experiment was used to optimize microemulsion based gel. Carbopol 971P and HPMC K100M were used as independent variables. Microemulsion based gel was evaluated for in-vitro as well as ex-vivo parameters.Results: Microemulsion was formulated with oleic acid, lauroglycol FCC and propylene glycol. PDI 0.197 indicated microemulsion is mono-disperse. 32 factorial design gave batch F8 as optimized. Design expert suggested drug release; gel viscosity and bio-adhesive strength were three significant dependant factors affecting the transdermal delivery. F8 showed drug release 92.62.16±1.22% through egg membrane, 95.23±1.44% through goat skin after 8hr and Korsmeyer-Peppas release model was followed.Conclusion: It can be concluded that a stable, effective controlled release transdermal microemulgel was optimised for triamcinolone. This would be a promising tool to deliver triamcinolone with enhanced bioavailability and reduced dosing frequency.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34996352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Nano-carriers for the Treatment of Tuberculosis. 治疗肺结核的纳米载体。

Recent patents on anti-infective drug discovery Pub Date : 2017-01-01 DOI: 10.2174/1574891X12666170427120230

Sadaf J Gilani, Ameeduzzafar, Mohammed Jafar, Kashif Shakil, Syed S Imam

{"title":"Nano-carriers for the Treatment of Tuberculosis.","authors":"Sadaf J Gilani, Ameeduzzafar, Mohammed Jafar, Kashif Shakil, Syed S Imam","doi":"10.2174/1574891X12666170427120230","DOIUrl":"https://doi.org/10.2174/1574891X12666170427120230","url":null,"abstract":"Background: Nano size based drug delivery systems are an emerging technique with the potential to develop new strategies involving handling of drugs at the nanometer scale. There are many nano-based drug delivery systems that have been extensively reported as drug carriers for the treatment of tuberculosis.Methods: There are numerous nano sized drug delivery systems like lipid nanoparticles, polymeric micelle, carbon nanotubes and polymeric nanoparticles that have been reported for a long time to treat diseases. There are a number of drawbacks in conventional TB dosage forms such as the development of multiple drug resistance, resulting in intolerable toxicity and high drug dose required. So, to overcome the drawbacks of conventional therapy, there is a need for a new drug delivery system with an aim to reduce the side effects of drug treatment. Nano-sized based drug delivery systems have considerable potential for the treatment of tuberculosis. These delivery systems have several advantages like high stability, high loading capacity, the feasibility of incorporation of both hydrophilic and hydrophobic drugs, and feasibility of variable routes of administration, and prolonged drug release from the matrix. These advantages enable enhanced drug solubility, bioavailability, reduced dosing frequency, high targeting, and may resolve the problem of non adherence to prescribed therapy, which is one of the major obstacles in the control of tuberculosis epidemics.Conclusion: This article gives an exhaustive review of patents and research papers published over the years on the challenges, the current treatment therapy of the disease faces, and potential advantages of nano sized formulations to offer more effective treatment and prevention for tuberculosis.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35072142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recently Patented Viral Nucleotide Sequences and Generation of Virus-Derived Vaccines. 最近获得专利的病毒核苷酸序列和病毒衍生疫苗的产生。

Recent patents on anti-infective drug discovery Pub Date : 2017-01-01 DOI: 10.2174/1574891X12666170619102506

Srividhya Venkataraman, Tauqeer Ahmad, Mounir A Haidar, Kathleen L Hefferon

引用次数: 1

3rd Generation of Cephalosporins and Monobactam Resistant Among Pathogenic Bacteria Collected from Ilam Hospitals During 2008 to 2015: A Systematic Review and Meta-Analysis. 2008 - 2015年伊拉姆医院病原菌对第三代头孢菌素和单巴坦耐药情况的系统回顾和meta分析

Recent patents on anti-infective drug discovery Pub Date : 2017-01-01 DOI: 10.2174/1574891X12666170130101006

S. Hemati, S. Ghafourian, Nourkhoda Sadeghfard, Z. Mahdavi, A. Maleki, Fatemeh Sayehmiri, K. Sayehmiri, L. Bogdanović, M. Taherikalani

引用次数: 0