Nanoemulsion for the Effective Treatment and Management of Anti-tubercular Drug Therapy.

Q3 Medicine
Sarwar Beg, Sumant Saini, Syed S Imam, Mahfoozur Rahman, Suryakanta Swain, Mohammad S Hasnain
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引用次数: 7

Abstract

Background: Tuberculosis is considered as one of the deadliest diseases of human existence. Since ancient age the treatment of tuberculosis has been highly challenging primarily owing to the pathogenic nature of the Mycobacterium and its diverse spots of localization in human body including lungs, liver, spleen, eye, meninges and lymph nodes.

Methods: The conventional drug therapy employed for the treatment of tuberculosis is not highly satisfactorily owing to low oral bioavailability of the drugs. The evolution of nano-technology recently in few decades has completely revolutionized the treatment of diverse diseases and so is the tuberculosis. Nanotechnology not only possesses enormous potential for improving the biopharmaceutical performance, but also allows the delivery of therapeutic molecules to the desired site of action. Diverse types of nanocarriers have been employed for the treatment of tuberculosis infections. In this regard, nanoemulsions are considered as one of the promising alternatives for augmenting the bioavailability of the antitubercular drugs through oral route for improving their therapeutic efficacy.

Conclusion: The nanoemulsion loaded with antitubercular drugs can easily cross the biological barriers to reach the systemic circulation and consequently in the target for reducing the load of Mycobacterium tuberculosis. Besides, the lipidic nature of such systems facilitates targeting of the drugs to the lymph nodes, thus improves drug bioavailability and reduction of the dosing frequency. In lieu of this, the present article compiles the basics of nanoemulsions in brief along with an updated account on their applications in delivering antitubercular drugs for enhanced immunization. Moreover, overview of patent literature published in this area has also been included in the manuscript.

纳米乳剂对抗结核药物治疗的有效治疗和管理。
背景:结核病被认为是人类最致命的疾病之一。自古以来,结核病的治疗一直极具挑战性,主要是由于分枝杆菌的致病性及其在人体中的多种定位点,包括肺、肝、脾、眼、脑膜和淋巴结。方法:常规药物治疗结核病,由于口服生物利用度低,治疗效果不理想。近几十年来,纳米技术的发展彻底改变了各种疾病的治疗,结核病也是如此。纳米技术不仅在提高生物制药性能方面具有巨大的潜力,而且还可以将治疗分子运送到所需的作用部位。不同类型的纳米载体已被用于结核病感染的治疗。在这方面,纳米乳剂被认为是通过口服途径增加抗结核药物的生物利用度以提高其治疗效果的有希望的替代方案之一。结论:负载抗结核药物的纳米乳可以很容易地越过生物屏障进入体循环,从而成为减少结核分枝杆菌负荷的靶点。此外,这种系统的脂质特性有助于药物靶向淋巴结,从而提高药物的生物利用度,降低给药频率。本文简要介绍了纳米乳剂的基本原理,并介绍了纳米乳剂在提供抗结核药物以增强免疫方面的最新应用。此外,在该领域发表的专利文献综述也包括在手稿中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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