Recent patents on anti-infective drug discovery最新文献_第10页

Methicillin-Resistant Staphylococcus aureus: Treatment with Cultures of Non Drug-Resistant Staphylococcus epidermidis. 耐甲氧西林金黄色葡萄球菌:非耐药表皮葡萄球菌培养治疗。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150827103448

Felix-Martin Werner, Rafael Covenas

引用次数: 1

Opinion Paper: NANOMACHINES AND "NANOSOLUTIONS": THEY ARE CHANGING THE PERSPECTIVE OF MEDICAL TREATMENTS. 观点论文:纳米机器和“纳米解决方案”:它们正在改变医学治疗的观点。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150529150526

Luiz E da Silva

引用次数: 2

Antiseptic Resistance in Methicillin Sensitive and Methicillin Resistant Staphylococcus aureus Isolates from Some Major Hospitals, Iran. 伊朗一些主要医院对甲氧西林敏感和耐甲氧西林金黄色葡萄球菌的抗菌剂耐药性

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150623093259

Azar Hasanvand, Sobhan Ghafourian, Morovat Taherikalani, Farid A Jalilian, Nourkhoda Sadeghifard, Iraj Pakzad

{"title":"Antiseptic Resistance in Methicillin Sensitive and Methicillin Resistant Staphylococcus aureus Isolates from Some Major Hospitals, Iran.","authors":"Azar Hasanvand, Sobhan Ghafourian, Morovat Taherikalani, Farid A Jalilian, Nourkhoda Sadeghifard, Iraj Pakzad","doi":"10.2174/1574891x10666150623093259","DOIUrl":"https://doi.org/10.2174/1574891x10666150623093259","url":null,"abstract":"Background: Extensive use of antibiotics and biocide in treatment of patients and cleaning of surfaces and medical equipment has led to the emergence of resistant microorganisms. The current research goals to determine the antiseptics Minimum Inhibitory Concentration value in Staphylococcus aureus (methicillin -resistant Staphylococcus aureus and methicillin sensitive Staphylococcus aureus) isolates from some major hospitals in Iran and to detect qacA/B, norA , smr and blaZ genes.Methods: Two hundred isolates of S. aureus including 100 MRSA and 100 MSSA clinical isolates were collected from 4 hospitals in the west of Iran during period 2012 to 2013. Detection of disinfectant resistant genes (qac A/B, smr and norA), antimicrobial resistance genes (mecA and blaZ) and SCCmec typing of MRSA isolates was performed by PCR.Results: MIC of chlorhexidine digluconate (CHX) in 70% of MRSA and 30% of MSSA strains was 8-16 µg/ml. High level of MIC of citrimide (>2 µg/ml) in MRSA and MSSA isolates was 20% and 5% , respectively. MIC of benzalkonium chloride (BC) in 80% of MRSA and 83% of MSSA isolates was less than 2 µg/ml; only 9% of MRSA had MIC higher than 2 µg/ml. Frequency of antiseptic and antibiotic resistance genes norA, blaZ and qacA/B in MRSA isolates were 83%, 98% and 9%, respectively; while this value for MSSA isolates were 62%, 8% and 0%, respectively. The smr gene was not detected in both MRSA and MSSA isolates. In all biocides high MIC were observed in SCCmec type III and IVc. High frequency of qacA/B gene was found in SCCmec type III,Vc and IVb, which were 66.6% ,22% and 11.1% respectively.Conclusion: We found SCCmec types III, Vc was related to high MIC of biocide in MRSA isolates.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33409783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Ocular toxocariasis: new diagnostic and therapeutic perspectives. 眼弓形虫病:新的诊断和治疗观点。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150410125057

Dayron F Martínez-Pulgarín, Marcela Muñoz-Urbano, Luz D Gomez-Suta, Olinda M Delgado, Alfonso J Rodriguez-Morales

{"title":"Ocular toxocariasis: new diagnostic and therapeutic perspectives.","authors":"Dayron F Martínez-Pulgarín, Marcela Muñoz-Urbano, Luz D Gomez-Suta, Olinda M Delgado, Alfonso J Rodriguez-Morales","doi":"10.2174/1574891x10666150410125057","DOIUrl":"https://doi.org/10.2174/1574891x10666150410125057","url":null,"abstract":"Purpose: To provide an updated insight of concepts regarding the overview, epidemiology, risk factors, clinical manifestations, diagnosis, treatment and prevention of ocular toxocariasis.Design: Perspective of literature review.Methods: Review and synthesis of literature about toxocariasis, with interpretation and perspective. A literature search for \"ocular toxocariasis\" was performed using PubMed, ScienceDirect, Scopus, SciELO and LILACS databases.Results: Mild to moderate infections are frequently reported in ocular toxocariasis which usually occurs in children and typically presents as unilateral vision impairment, blindness is common and could present invasion of the retina. There are three groups of presentation of toxocariasis (according to the physical examination): chronic endophthalmitis, posterior granuloma and peripheral granuloma. Standard diagnosis of ocular toxocariasis is based on the identification of clinical signs, supported by additional diagnostic methods. Regarding treatment, there is no commonly accepted regimen but most of the authors prefer to use steroids and anthelminthic agents, but nowadays there are no standardized parameters in terms of dosage, duration and route of administration. Surgery has been recommended in some cases.Conclusion: Toxocariasis is still a problem of public health, particularly in developing countries with an increasing epidemiological burden in terms of morbidity and mortality and most of the authors agree on the utmost relevance of its prevention. Clinical experience and suspicion of ophthalmologists make an important role in its diagnosis, but always with supportive diagnostic methods. Additional studies should explore new therapeutic options for toxocariasis.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574891x10666150410125057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33204675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Leptospirosis in an urban setting: cases diagnosed at a private medical center of Western Colombia, 2008-2012. 城市环境中的钩端螺旋体病:哥伦比亚西部一家私人医疗中心诊断的病例，2008-2012年。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150414124825

María M Ramírez-Ramírez, Olga M León-Castañeda, Alfonso J Rodriguez-Morales

{"title":"Leptospirosis in an urban setting: cases diagnosed at a private medical center of Western Colombia, 2008-2012.","authors":"María M Ramírez-Ramírez, Olga M León-Castañeda, Alfonso J Rodriguez-Morales","doi":"10.2174/1574891x10666150414124825","DOIUrl":"https://doi.org/10.2174/1574891x10666150414124825","url":null,"abstract":"Introduction: Leptospirosis has reemerged as significant threat particularly in developing countries, including those in Latin America. Data from Colombia is still limited and there are no published studies in the Western area of the country.Methods: Data on suspected cases were collected over the study period (2008- 2012). Cases were diagnosed clinically and confirmed by ELISA IgG and microscopic agglutination test (MAT) (titers ≥1:400).Results: During the study period 264 suspected cases of leptospirosis were found. From those, 8.33% (22 cases) were microbiologically confirmed. Number of suspected cases increased in the period from 20 (2008) (40 cases/100,000 consultations) to 58 (2012) (120 cases/100,000 consultations). Regard sex distribution, 62.5% were males, 14% in the age group 21-30 y-old, from confirmed cases 95% live in urban areas of Pereira, 25.7% own dogs and 13.2% cats, 32.3% reporting rats at home as well 22.7% at work places. From confirmed cases 72.7% were hospitalized. Clinical findings found were: fever (60.2%), myalgias (47%), and headache (41.9%), among others. All the cases corresponded to Leptospira interrogans. Regard the serovars, in these patients 6 were identified: Australis (54.5%), Icterohaemorrhagiae (45.5%), Canicola (45.5%), Panama (45.5%), Pomona (36.3) and Grippotyphosa (1%). Thirty nine percent of the patients received antimicrobial therapy, 50% ceftriaxone. No deaths occurred.Conclusion: Leptospirosis is an emerging infectious disease that has changed from an occupational disease of veterinarians, farmers, butchers, and other animal handlers to a cause of epidemics in poor and decayed urban communities in developing countries, including those in Latin America such as Colombia.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574891x10666150414124825","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33215433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

From imported to an endemic disease: impact of Chikungunya virus disease in the hospital epidemiology, Tolima, Colombia, 2014-2015. 从输入性疾病到地方性疾病:基孔肯雅病毒病在医院流行病学中的影响，哥伦比亚托利马，2014-2015年。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150414125124

Carlos E Jimenez-Canizales, David A Medina-Gaitan, Álvaro E Mondragon-Cardona, Alfonso J Rodríguez-Morales

引用次数: 12

In vitro Antimicrobial Study for Biological Evaluation of Clerodendrum infortunatum Linn. 石斛生物评价的体外抗菌研究。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150512104405

Talukdar M Waliullah, Akter M Yeasmin, Ashraful Alam, Wahedul Islam, Parvez Hassan

{"title":"In vitro Antimicrobial Study for Biological Evaluation of Clerodendrum infortunatum Linn.","authors":"Talukdar M Waliullah, Akter M Yeasmin, Ashraful Alam, Wahedul Islam, Parvez Hassan","doi":"10.2174/1574891x10666150512104405","DOIUrl":"https://doi.org/10.2174/1574891x10666150512104405","url":null,"abstract":"Objective: To explore a scientific idea, this study was examined for evaluation of antimicrobial potency using root, leaf and stem of ethyl acetate and chloroform extracts of C. infortunatum (Verbenaceae) due to randomly use in traditional medicine to cure common ailments such as intestinal disorder, diarrhea, tuberculosis and respiratory problems etc.Methods: The in vitro application was carried out by using disc diffusion, micro broth dilution and serial dilution techniques against clinically important life threatening organisms.Results: All the extracts showed significant inhibitory activity over the bacteria and fungus comparable to the standard drug tetracycline and fluconazole. The maximum average diameter zone of inhibition was recorded to bacterial strains against B. megaterium, S. typhi, K. pneumoniae and to fungi against A. niger and C. albicans. The MIC values of ethyl acetate and chloroform root extract were determined 64 µg/ml to B. subtilis, and K. pneumoniae; to S.-β-haemolyticus and S. typhi for ethyl acetate extracts, 128 µg/ml to S. aureus, and E. coli for both ethyl acetate and chloroform root extracts but only S. typhi and S.-β-haemolyticus for chloroform extract.Conclusion: The findings evidently appear promising antibacterial and antifungal properties of C. infortunatum against antagonistic pathogens. Leaf possess quite potent activity than root and stem specially root extract > leaf extract > stem extract. One of the more significant achievements of this study to follows and covers the most recent and important patents WO2009075290 (2009) which deals on yeast having immunopotentiating effect and food or feed. This study serves as basis for further research to lead compounds to be isolated so that may be as a template for the implications of these results for bioactivity and drug discovery potential of herbal products are discussed.","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34181479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Novel Advanced Laboratory Diagnosis to Guide Tuberculosis Drug Therapy. 一种新的先进实验室诊断方法指导结核病药物治疗。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150803153138

Leonard Amaral, Dick van Soolingen

引用次数: 3

Anti-Viral Agents in Neurodegenerative Disorders: New Paradigm for Targeting Alzheimer's Disease. 神经退行性疾病的抗病毒药物:针对阿尔茨海默病的新范式。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150509193236

Khushboo G Faldu, Jigna S Shah, Snehal S Patel

{"title":"Anti-Viral Agents in Neurodegenerative Disorders: New Paradigm for Targeting Alzheimer's Disease.","authors":"Khushboo G Faldu, Jigna S Shah, Snehal S Patel","doi":"10.2174/1574891x10666150509193236","DOIUrl":"https://doi.org/10.2174/1574891x10666150509193236","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative disease affecting geriatric populations for which several causes have been proposed. These include a relationship with known pathogens although the exact nature of such a relationship remains uncertain. Herpes simplex virus-1 has been proposed as potential cause of AD because of its ability to form ß amyloid(Aß) and neurofibrillary tangles due to tau hyperphosphorylation and action of beta & gamma secretase on amyloid precursor protein(APP) together with genetic association with apolipoprotein-E4(ApoE-Ɛ4), which points out to latent Herpes Simplex virus-1 as an agent causing AD. There are numerous studies that linked HSV-1 with AD like anti-HSV-1 IgM antibodies, nectin-2, heme oxygenase-1, phosphorylated eukaryotic initiation factor-2A, caspase-8 and nucleus-specific alteration of raphe neurons. Various possible mechanisms by which HSV-1 might lead to development of AD such as ApoE, ß-amyloid, tau phosphorylation, inflammation and oxidative stress are also discussed. Thus, this review discusses patent information and a strong relationship between latent HSV-1 and AD and also proposes antiviral therapy for AD. ","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33168893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Chloroquine: An Old Drug with New Perspective Against Giardiasis. 氯喹:一种治疗贾第虫病的新药。

Recent patents on anti-infective drug discovery Pub Date : 2015-01-01 DOI: 10.2174/1574891x10666150914122118

Angel A Escobedo, Pedro Almirall, Sérgio Cimerman, Marco Lalle, Frank Pacheco, Carlos Z Acanda, Niurka Sánchez

引用次数: 8