Leptospirosis in an urban setting: cases diagnosed at a private medical center of Western Colombia, 2008-2012.

Q3 Medicine
María M Ramírez-Ramírez, Olga M León-Castañeda, Alfonso J Rodriguez-Morales
{"title":"Leptospirosis in an urban setting: cases diagnosed at a private medical center of Western Colombia, 2008-2012.","authors":"María M Ramírez-Ramírez,&nbsp;Olga M León-Castañeda,&nbsp;Alfonso J Rodriguez-Morales","doi":"10.2174/1574891x10666150414124825","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Leptospirosis has reemerged as significant threat particularly in developing countries, including those in Latin America. Data from Colombia is still limited and there are no published studies in the Western area of the country.</p><p><strong>Methods: </strong>Data on suspected cases were collected over the study period (2008- 2012). Cases were diagnosed clinically and confirmed by ELISA IgG and microscopic agglutination test (MAT) (titers ≥1:400).</p><p><strong>Results: </strong>During the study period 264 suspected cases of leptospirosis were found. From those, 8.33% (22 cases) were microbiologically confirmed. Number of suspected cases increased in the period from 20 (2008) (40 cases/100,000 consultations) to 58 (2012) (120 cases/100,000 consultations). Regard sex distribution, 62.5% were males, 14% in the age group 21-30 y-old, from confirmed cases 95% live in urban areas of Pereira, 25.7% own dogs and 13.2% cats, 32.3% reporting rats at home as well 22.7% at work places. From confirmed cases 72.7% were hospitalized. Clinical findings found were: fever (60.2%), myalgias (47%), and headache (41.9%), among others. All the cases corresponded to Leptospira interrogans. Regard the serovars, in these patients 6 were identified: Australis (54.5%), Icterohaemorrhagiae (45.5%), Canicola (45.5%), Panama (45.5%), Pomona (36.3) and Grippotyphosa (1%). Thirty nine percent of the patients received antimicrobial therapy, 50% ceftriaxone. No deaths occurred.</p><p><strong>Conclusion: </strong>Leptospirosis is an emerging infectious disease that has changed from an occupational disease of veterinarians, farmers, butchers, and other animal handlers to a cause of epidemics in poor and decayed urban communities in developing countries, including those in Latin America such as Colombia.</p>","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574891x10666150414124825","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent patents on anti-infective drug discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1574891x10666150414124825","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 2

Abstract

Introduction: Leptospirosis has reemerged as significant threat particularly in developing countries, including those in Latin America. Data from Colombia is still limited and there are no published studies in the Western area of the country.

Methods: Data on suspected cases were collected over the study period (2008- 2012). Cases were diagnosed clinically and confirmed by ELISA IgG and microscopic agglutination test (MAT) (titers ≥1:400).

Results: During the study period 264 suspected cases of leptospirosis were found. From those, 8.33% (22 cases) were microbiologically confirmed. Number of suspected cases increased in the period from 20 (2008) (40 cases/100,000 consultations) to 58 (2012) (120 cases/100,000 consultations). Regard sex distribution, 62.5% were males, 14% in the age group 21-30 y-old, from confirmed cases 95% live in urban areas of Pereira, 25.7% own dogs and 13.2% cats, 32.3% reporting rats at home as well 22.7% at work places. From confirmed cases 72.7% were hospitalized. Clinical findings found were: fever (60.2%), myalgias (47%), and headache (41.9%), among others. All the cases corresponded to Leptospira interrogans. Regard the serovars, in these patients 6 were identified: Australis (54.5%), Icterohaemorrhagiae (45.5%), Canicola (45.5%), Panama (45.5%), Pomona (36.3) and Grippotyphosa (1%). Thirty nine percent of the patients received antimicrobial therapy, 50% ceftriaxone. No deaths occurred.

Conclusion: Leptospirosis is an emerging infectious disease that has changed from an occupational disease of veterinarians, farmers, butchers, and other animal handlers to a cause of epidemics in poor and decayed urban communities in developing countries, including those in Latin America such as Colombia.

城市环境中的钩端螺旋体病:哥伦比亚西部一家私人医疗中心诊断的病例,2008-2012年。
钩端螺旋体病已重新成为重大威胁,特别是在发展中国家,包括拉丁美洲国家。来自哥伦比亚的数据仍然有限,在该国西部地区没有发表的研究报告。方法:收集研究期间(2008- 2012年)的疑似病例资料。病例经临床诊断并经ELISA IgG和显微镜凝集试验(MAT)(滴度≥1:400)确诊。结果:研究期间共发现疑似钩端螺旋体病病例264例。其中8.33%(22例)为微生物学确诊。在此期间,疑似病例从20例(2008年)(40例/10万次诊治)增加到58例(2012年)(120例/10万次诊治)。在性别分布方面,62.5%为男性,14%为21-30岁年龄组,确诊病例中95%生活在佩雷拉的城市地区,25.7%养狗,13.2%养猫,32.3%报告家中有老鼠,22.7%报告工作场所有老鼠。确诊病例中有72.7%住院。临床表现为:发热(60.2%)、肌痛(47%)、头痛(41.9%)等。所有病例均为钩端螺旋体病例。在这些患者中,共鉴定出6种血清型:Australis(54.5%)、icterohemorrhage(45.5%)、Canicola(45.5%)、Panama(45.5%)、Pomona(36.3)和grippo伤寒(1%)。39%的患者接受抗菌药物治疗,50%接受头孢曲松治疗。没有人员死亡。结论:钩端螺旋体病是一种新出现的传染病,已从兽医、农民、屠夫和其他动物处理者的职业病转变为发展中国家(包括哥伦比亚等拉丁美洲国家)贫困和衰败城市社区的流行病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信