Anti-Viral Agents in Neurodegenerative Disorders: New Paradigm for Targeting Alzheimer's Disease.

Q3 Medicine
Khushboo G Faldu, Jigna S Shah, Snehal S Patel
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引用次数: 7

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease affecting geriatric populations for which several causes have been proposed. These include a relationship with known pathogens although the exact nature of such a relationship remains uncertain. Herpes simplex virus-1 has been proposed as potential cause of AD because of its ability to form ß amyloid(Aß) and neurofibrillary tangles due to tau hyperphosphorylation and action of beta & gamma secretase on amyloid precursor protein(APP) together with genetic association with apolipoprotein-E4(ApoE-Ɛ4), which points out to latent Herpes Simplex virus-1 as an agent causing AD. There are numerous studies that linked HSV-1 with AD like anti-HSV-1 IgM antibodies, nectin-2, heme oxygenase-1, phosphorylated eukaryotic initiation factor-2A, caspase-8 and nucleus-specific alteration of raphe neurons. Various possible mechanisms by which HSV-1 might lead to development of AD such as ApoE, ß-amyloid, tau phosphorylation, inflammation and oxidative stress are also discussed. Thus, this review discusses patent information and a strong relationship between latent HSV-1 and AD and also proposes antiviral therapy for AD.

神经退行性疾病的抗病毒药物:针对阿尔茨海默病的新范式。
阿尔茨海默病(AD)是一种影响老年人群的神经退行性疾病,有几种原因被提出。其中包括与已知病原体的关系,尽管这种关系的确切性质仍不确定。单纯疱疹病毒-1由于tau蛋白的过度磷酸化和β & γ分泌酶对淀粉样蛋白前体蛋白(APP)的作用,以及与载脂蛋白e4 (ApoE-Ɛ4)的遗传关联,能够形成ß淀粉样蛋白(asβ)和神经原纤维缠结,这表明潜伏的单纯疱疹病毒-1是导致AD的潜在原因。有许多研究将HSV-1与AD联系起来,如抗HSV-1 IgM抗体、连接素-2、血红素加氧酶-1、磷酸化真核起始因子- 2a、caspase-8和中缝神经元的核特异性改变。还讨论了HSV-1可能导致AD发展的各种可能机制,如ApoE, ß-淀粉样蛋白,tau磷酸化,炎症和氧化应激。因此,本文讨论了专利信息和潜伏性HSV-1与AD之间的密切关系,并提出了针对AD的抗病毒治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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