Ocular toxocariasis: new diagnostic and therapeutic perspectives.

Q3 Medicine
Dayron F Martínez-Pulgarín, Marcela Muñoz-Urbano, Luz D Gomez-Suta, Olinda M Delgado, Alfonso J Rodriguez-Morales
{"title":"Ocular toxocariasis: new diagnostic and therapeutic perspectives.","authors":"Dayron F Martínez-Pulgarín,&nbsp;Marcela Muñoz-Urbano,&nbsp;Luz D Gomez-Suta,&nbsp;Olinda M Delgado,&nbsp;Alfonso J Rodriguez-Morales","doi":"10.2174/1574891x10666150410125057","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To provide an updated insight of concepts regarding the overview, epidemiology, risk factors, clinical manifestations, diagnosis, treatment and prevention of ocular toxocariasis.</p><p><strong>Design: </strong>Perspective of literature review.</p><p><strong>Methods: </strong>Review and synthesis of literature about toxocariasis, with interpretation and perspective. A literature search for \"ocular toxocariasis\" was performed using PubMed, ScienceDirect, Scopus, SciELO and LILACS databases.</p><p><strong>Results: </strong>Mild to moderate infections are frequently reported in ocular toxocariasis which usually occurs in children and typically presents as unilateral vision impairment, blindness is common and could present invasion of the retina. There are three groups of presentation of toxocariasis (according to the physical examination): chronic endophthalmitis, posterior granuloma and peripheral granuloma. Standard diagnosis of ocular toxocariasis is based on the identification of clinical signs, supported by additional diagnostic methods. Regarding treatment, there is no commonly accepted regimen but most of the authors prefer to use steroids and anthelminthic agents, but nowadays there are no standardized parameters in terms of dosage, duration and route of administration. Surgery has been recommended in some cases.</p><p><strong>Conclusion: </strong>Toxocariasis is still a problem of public health, particularly in developing countries with an increasing epidemiological burden in terms of morbidity and mortality and most of the authors agree on the utmost relevance of its prevention. Clinical experience and suspicion of ophthalmologists make an important role in its diagnosis, but always with supportive diagnostic methods. Additional studies should explore new therapeutic options for toxocariasis.</p>","PeriodicalId":20909,"journal":{"name":"Recent patents on anti-infective drug discovery","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1574891x10666150410125057","citationCount":"26","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent patents on anti-infective drug discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1574891x10666150410125057","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 26

Abstract

Purpose: To provide an updated insight of concepts regarding the overview, epidemiology, risk factors, clinical manifestations, diagnosis, treatment and prevention of ocular toxocariasis.

Design: Perspective of literature review.

Methods: Review and synthesis of literature about toxocariasis, with interpretation and perspective. A literature search for "ocular toxocariasis" was performed using PubMed, ScienceDirect, Scopus, SciELO and LILACS databases.

Results: Mild to moderate infections are frequently reported in ocular toxocariasis which usually occurs in children and typically presents as unilateral vision impairment, blindness is common and could present invasion of the retina. There are three groups of presentation of toxocariasis (according to the physical examination): chronic endophthalmitis, posterior granuloma and peripheral granuloma. Standard diagnosis of ocular toxocariasis is based on the identification of clinical signs, supported by additional diagnostic methods. Regarding treatment, there is no commonly accepted regimen but most of the authors prefer to use steroids and anthelminthic agents, but nowadays there are no standardized parameters in terms of dosage, duration and route of administration. Surgery has been recommended in some cases.

Conclusion: Toxocariasis is still a problem of public health, particularly in developing countries with an increasing epidemiological burden in terms of morbidity and mortality and most of the authors agree on the utmost relevance of its prevention. Clinical experience and suspicion of ophthalmologists make an important role in its diagnosis, but always with supportive diagnostic methods. Additional studies should explore new therapeutic options for toxocariasis.

眼弓形虫病:新的诊断和治疗观点。
目的:介绍眼弓形虫病的概况、流行病学、危险因素、临床表现、诊断、治疗和预防等方面的最新概念。设计:文献综述视角。方法:回顾和综合有关弓形虫病的文献,并进行解释和展望。使用PubMed、ScienceDirect、Scopus、SciELO和LILACS数据库对“眼部弓形虫病”进行文献检索。结果:轻至中度感染经常报告在眼部弓形虫病,通常发生在儿童和典型表现为单侧视力损害,失明是常见的,并可表现为视网膜的侵犯。弓形虫病的表现有三组(根据体格检查):慢性眼内炎、眼后肉芽肿和外周肉芽肿。眼弓形虫病的标准诊断是基于临床症状的识别,并辅以其他诊断方法。在治疗方面,目前尚无普遍接受的治疗方案,但大多数作者倾向于使用类固醇和驱虫药,但目前在剂量、持续时间和给药途径方面没有标准化的参数。在某些情况下,建议进行手术。结论:弓形虫病仍然是一个公共卫生问题,特别是在发病率和死亡率日益增加的流行病学负担的发展中国家,大多数作者都认为预防弓形虫病至关重要。临床经验和眼科医生的怀疑对其诊断有重要作用,但往往缺乏支持性的诊断方法。进一步的研究应探索新的弓形虫病治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信