Angelo D'Ambrosio, Francesco Baglivo, Luigi De Angelis, Federico Tecchio, Caterina Rizzo
{"title":"Performance di large language models su quesiti a risposta multipla per la certificazione in medicina dei viaggi.","authors":"Angelo D'Ambrosio, Francesco Baglivo, Luigi De Angelis, Federico Tecchio, Caterina Rizzo","doi":"10.1701/4573.45796","DOIUrl":"https://doi.org/10.1701/4573.45796","url":null,"abstract":"<p><p>We benchmarked 40 LLMs on a 40 item travel medicine quiz. Bayesian modelling was used to evaluate accuracy, consistency, parsability, and cost metrics. Accuracy spanned 27.9-97.5%; reasoning tuned frontier models (OpenAI o3, Perplexity Sonar Reasoning) topped the benchmark, whereas local small underperformed. Cost accuracy curves revealed five Pareto optimal systems, with o3 being the current best. These findings confirm the performance of current LLMs as public health knowledge support systems.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 10","pages":"603-604"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Ricci, Silvia Capuzzi, Martina Riganati, Alberto Eugenio Tozzi, Marina Vivarelli, Diana Ferro, Manuela Colucci
{"title":"Deep learning su dati clinici longitudinali e immunologici per la stratificazione della sindrome nefrosica.","authors":"Giulia Ricci, Silvia Capuzzi, Martina Riganati, Alberto Eugenio Tozzi, Marina Vivarelli, Diana Ferro, Manuela Colucci","doi":"10.1701/4573.45781","DOIUrl":"https://doi.org/10.1701/4573.45781","url":null,"abstract":"<p><p>This study explores lymphocyte profiles as non-invasive biomarkers for classification of pediatric nephrotic syndrome (NS). Using retrospective clinical and immunological data from 205 patients, the aim is to develop a predictive model based on Long Short-Term Memory to identify NS subtypes. By comparing models with and without immunological data, the study will assess the value of immune profiles. The goal is to support personalized management while reducing the need for invasive procedures.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 10","pages":"573-574"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Ferro, Francesco Baglivo, Luigi De Angelis, Francesco Andrea Causio, Marcello Di Pumpo, Francesca Aurora Sacchi, Giacomo Diedenhofen, Alessio Pivetta, Alessandro Belpiede, Alberto Eugenio Tozzi
{"title":"Making the case for digital twins: Italian healthcare needs AI-driven predictive modeling for personalized medicine.","authors":"Diana Ferro, Francesco Baglivo, Luigi De Angelis, Francesco Andrea Causio, Marcello Di Pumpo, Francesca Aurora Sacchi, Giacomo Diedenhofen, Alessio Pivetta, Alessandro Belpiede, Alberto Eugenio Tozzi","doi":"10.1701/4573.45777","DOIUrl":"https://doi.org/10.1701/4573.45777","url":null,"abstract":"<p><p>Precision medicine seeks to tailor care by integrating genetic, clinical, and environmental data. Digital twins, dynamic, virtual replicas of patients that are updated with longitudinal information, represent a significant step in this direction. Enabled by artificial intelligence, they allow in silico experimentation to simulate therapies, disease trajectories, and adverse events, reducing risk and sharpening personalization. By bridging data and decisions, digital twins can promote earlier diagnosis, targeted treatments, and faster drug discovery, supporting a shift from reactive to predictive and participatory care. Nonetheless, challenges surrounding data integration, privacy, regulation, and equity persist and necessitate collaborative solutions. This viewpoint examines the opportunities and system-level requirements to integrate digital twins into Italian healthcare. Digital twins redefine medicine by turning episodic encounters into continuous, adaptive care. They can anticipate clinical events, simulate individualized treatments, and support shared decision-making, advancing the vision of predictive, preventive, personalized, and participatory medicine. Realizing this potential requires robust governance, interoperable infrastructures, and clinician training, alongside ethical frameworks that protect autonomy and fairness. Public-private partnerships and international collaboration will be crucial for the responsible, inclusive, and transparent adoption of these initiatives. Ultimately, digital twins inaugurate a paradigm in which simulation and clinical reality converge, fostering innovation that is both scientifically rigorous and deeply human.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 10","pages":"561-566"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DermatAI: deep learning per la diagnosi del melanoma.","authors":"Giulia Cartei, Fabrizio di Sciorio","doi":"10.1701/4573.45786","DOIUrl":"https://doi.org/10.1701/4573.45786","url":null,"abstract":"<p><p>DermatAI is the AI-based tool developed for early skin cancer detection, with a focus on Melanoma. Through an ensemble stacking model composed by convolutional neural networks and XGBoost classifier. DermatAI classifies skin lesions with high accuracy, aiding melanoma diagnosis and improving clinical decision support.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 10","pages":"583-584"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvia Capuzzi, Federico Baldisseri, Antonella Cacchione, Andrea Carai, Francesco Fabozzi, Antonio Pietrabissa, Angela Mastronuzzi, Alberto Eugenio Tozzi, Diana Ferro
{"title":"Modello multi-step basato su intelligenza artificiale per il timing chirurgico in oncologia pediatrica.","authors":"Silvia Capuzzi, Federico Baldisseri, Antonella Cacchione, Andrea Carai, Francesco Fabozzi, Antonio Pietrabissa, Angela Mastronuzzi, Alberto Eugenio Tozzi, Diana Ferro","doi":"10.1701/4573.45791","DOIUrl":"https://doi.org/10.1701/4573.45791","url":null,"abstract":"<p><p>This study presents a two-phase AI-based model to predict surgical wait times in paediatric oncology patients. Using real-world data from 1478 patients and 6145 surgeries, the model first classifies surgical urgency, then estimates wait times for urgent cases. Random Forest emerged as the best-performing algorithm in both phases, and SHAP analysis identified similar key predictive features. Results support AI's role in improving surgical planning, resource allocation, and clinical decision-making.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 10","pages":"593-594"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesca Aurora Sacchi, Fidelia Cascini, Noemi Conditi, Alice Ravizza, Margherita Daverio, Francesco Andrea Causio, Vittorio De Vita, Alessio Pivetta, Pierpaolo Maio, Luigi De Angelis, Francesco Baglivo, Giacomo Diedenhofen, Marcello Di Pumpo, Alessandro Belpiede, Diana Ferro, Luca Bolognini
{"title":"The path to trustworthy medical AI: the evolving role of explainability.","authors":"Francesca Aurora Sacchi, Fidelia Cascini, Noemi Conditi, Alice Ravizza, Margherita Daverio, Francesco Andrea Causio, Vittorio De Vita, Alessio Pivetta, Pierpaolo Maio, Luigi De Angelis, Francesco Baglivo, Giacomo Diedenhofen, Marcello Di Pumpo, Alessandro Belpiede, Diana Ferro, Luca Bolognini","doi":"10.1701/4573.45774","DOIUrl":"https://doi.org/10.1701/4573.45774","url":null,"abstract":"<p><p>The integration of artificial intelligence (AI) in medicine has applications across several clinical domains, spanning from disease prevention and diagnosis through treatment and long-term care, as well as remote care. However, many AI systems are inherently characterized by limited explainability, meaning the processes behind their outcomes cannot be clearly understood or communicated to humans, whether developers or end users. This viewpoint explores the importance of AI explainability in medicine by first tracing its evolution from a primarily ethical concern to a legal requirement. It then examines the connection between explainability and the trustworthiness of AI systems. Finally, it considers how explainability is approached from a technical standpoint and its inherent tension with achieving high accuracy.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 10","pages":"546-550"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guido Marchi, Giulia Gambini, Giacomo Guglielmi, Francesco Pistelli, Laura Carrozzi
{"title":"Valutazione comparativa di modelli linguistici di grandi dimensioni per il supporto all’educazione sanitaria del paziente con BPCO: uno studio pneumologico internazionale delle risposte generate da ChatGPT-4, Claude 3.5 Sonnet e Gemini 1.5 Advanced.","authors":"Guido Marchi, Giulia Gambini, Giacomo Guglielmi, Francesco Pistelli, Laura Carrozzi","doi":"10.1701/4573.45780","DOIUrl":"https://doi.org/10.1701/4573.45780","url":null,"abstract":"<p><p>Three LLMs - ChatGPT-4, Claude 3.5 Sonnet and Gemini 1.5 Advanced - were evaluated on COPD questions from the GOLD recommendations. Sixty-one pulmonologists from 6 continents rated 90 AI responses for completeness, accuracy, terminology, accessibility, and safety. Gemini outperformed in completeness, Claude in accuracy and terminology, with no differences in accessibility or safety. While promising, clinical use requires caution and further validation to ensure safe, accurate patient education.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 10","pages":"571-572"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Montomoli, Simone Iannaccone, Sergio Russo, Albenzo Coletta, Onofrio Cappucci, Mariano Folla, Valerio Placidi, Emanuele Frontoni, Francesco Giuliani
{"title":"MedWriter: progettazione di un sistema di intelligenza artificiale per la generazione automatizzata di lettera di dimissione ospedaliera o trasferimento.","authors":"Jonathan Montomoli, Simone Iannaccone, Sergio Russo, Albenzo Coletta, Onofrio Cappucci, Mariano Folla, Valerio Placidi, Emanuele Frontoni, Francesco Giuliani","doi":"10.1701/4573.45785","DOIUrl":"https://doi.org/10.1701/4573.45785","url":null,"abstract":"<p><p>The MedWriter project aims to create an AI-based clinical decision support system for automated discharge letter generation. Co-funded through Italian Sustainable Growth Fund and the EU, the project will utilize 1.3M patient records from HL7/FHIR-compliant SISWEB platform. The system will employ hybrid neural architectures including CNNs, transformers, and reinforcement learning for accurate clinical narrative synthesis.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 10","pages":"581-582"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}