Marco Cascella, Matteo L G Leoni, Mohammed Naveed Shariff, Giustino Varrassi
{"title":"Towards artificial intelligence application in pain medicine.","authors":"Marco Cascella, Matteo L G Leoni, Mohammed Naveed Shariff, Giustino Varrassi","doi":"10.1701/4460.44555","DOIUrl":"10.1701/4460.44555","url":null,"abstract":"<p><p>Pain is a complex, multidimensional experience involving significant challenges in both diagnosis and management. While acute pain serves as a critical warning mechanism, chronic pain encompasses intricate biological, psychological, and social components, complicating its assessment and treatment. Artificial intelligence (AI) technologies are revolutionizing medicine and healthcare. Here we present an overview of the recent advances in AI for pain medicine. For example, the emergence of automatic pain assessment (APA) methodologies offers promising avenues for more objective pain evaluation. For APA aims, AI technologies, including machine learning algorithms and deep learning architectures such as natural language processing systems, have shown potential in analyzing biosignals, facial expressions, and speech patterns related to pain. However, the integration of these objective measures with traditional self-reporting remains essential for a comprehensive approach to pain diagnosis. Notably, APA models can be implemented for pain diagnosis in newborn and non-communicative patients. Additionally, the application of AI extends beyond pain diagnosis to personalized treatment strategies, predict opioid use disorders, education and training, clinical trajectory definition, and telehealth and real-time. Despite the potential of these innovations, challenges such as validation, parameter selection, and ethical aspects of technical implementation must be addressed.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"156-161"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Carlo Alfredo Clerici, pioniere del legame tra spiritualità e cura.","authors":"Marco Dotti","doi":"10.1701/4460.44565","DOIUrl":"10.1701/4460.44565","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"199-200"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter K Kurotschka, Allen F Shaughnessy, Alice Serafini
{"title":"[In adults with knee osteoarthritis, methotrexate offers minimal pain relief.]","authors":"Peter K Kurotschka, Allen F Shaughnessy, Alice Serafini","doi":"10.1701/4450.44444","DOIUrl":"10.1701/4450.44444","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"120-121"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Successfully treatment with axicabtagene ciloleucel of a female patient with an early relapsed diffuse large B-cell lymphoma.]","authors":"Renato Scalone","doi":"10.1701/4450.44452","DOIUrl":"10.1701/4450.44452","url":null,"abstract":"<p><p>Refractoriness and early relapse after first-line therapy are two high-risk conditions for patients with diffuse large B-cell lymphoma (DLBCL). Nowadays, axicabtagene ciloleucel (axi-cel) is the therapeutic strategy to adopt in these clinical conditions, considering the results obtained in terms of overall survival and progression free survival in the ZUMA-7 trial. In the clinical case here reported, a female patient with an early relapsed triple expressor DLBCL was successfully treated with axi-cel, obtaining the complete remission at one month from therapy. Similarly, the adverse events onset after axi-cel were successfully and quickly treated.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"e33-e35"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Numeri in questo numero<br>2025 Febbraio.","authors":"","doi":"10.1701/4450.44434","DOIUrl":"10.1701/4450.44434","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The first Italian patient affected by diffuse large B-cell lymphoma treated with axi-cel in the second line: innovation and tradition.]","authors":"Stefania Bramanti, Davide Chizzoniti, Daniele Mannina","doi":"10.1701/4450.44450","DOIUrl":"10.1701/4450.44450","url":null,"abstract":"<p><p>CAR-T cell therapy has revolutionized the treatment of refractory or relapsed diffuse large B-cell lymphoma (DLBCL) within 12 months, replacing the use of high-dose chemotherapy with autologous stem cell reinfusion. Primary chemoresistance remains one of the most unfavorable prognostic scenarios for patients with DLBCL, despite the progress made with the introduction of anti-CD20 monoclonal antibodies in first-line treatment. Early identification of prognostic factors associated with clinical presentation represents an integrated approach that ensures rapid access to autologous anti-CD19 CAR-T therapy in selected cases that may benefit from treatment according to current standard indications.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"e24-e27"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viviana Forte, Allen F Shaughnessy, Peter K Kurotschka
{"title":"[Routine Ecg screening: limited value for evaluating cardiovascular risk in working-age adults.]","authors":"Viviana Forte, Allen F Shaughnessy, Peter K Kurotschka","doi":"10.1701/4450.44445","DOIUrl":"10.1701/4450.44445","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"122-123"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[From modern science to open science, publishing in the scientific field: copyright, Creative Commons and… beyond.]","authors":"","doi":"10.1701/4450.44437","DOIUrl":"10.1701/4450.44437","url":null,"abstract":"<p><p>The concept of copyright protection emerged and developed throughout history to promote the widest dissemination of information. After two centuries of its establishment, development, and maturation, the traditional system entered a full-blown crisis, undermined at its foundations by digital innovation and the socio-cultural transformation of the 20th century. This evolution, marked by continuous adaptations, has introduced elements that are currently limiting the free circulation of scientific knowledge and hindering access to information. Creative Commons (CC) licenses offer a more flexible model for managing copyright, allowing authors to reserve some rights while relinquishing others. There are different variants of CC licenses, ranging from simple attribution (CC BY) to restrictions on commercial use and derivative works (CC BY NC ND). These licenses have been used both to promote the openness of resources and to perpetuate their commercial or paid distribution. For a significant shift towards more open science, a rebalancing of power is needed among authors, publishers, and users, with greater awareness of their rights by those who play a key role in scientific production.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ogni maledetta domenica (i bianchi e i verdi).","authors":"Vittorio Fontana","doi":"10.1701/4450.44447","DOIUrl":"10.1701/4450.44447","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"126"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}