Recenti progressi in medicina最新文献

[The evolution of a luminal breast cancer to a triple-negative and its impact on disease control with sacituzumab govitecan.] [腔隙性乳腺癌向三阴性乳腺癌的演变及其对萨库珠单抗-戈维替康治疗疾病控制效果的影响]

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43479

Federica Cicchiello, Francesca Riva, Francesca Corti, Claudia Maggioni

{"title":"[The evolution of a luminal breast cancer to a triple-negative and its impact on disease control with sacituzumab govitecan.]","authors":"Federica Cicchiello, Francesca Riva, Francesca Corti, Claudia Maggioni","doi":"10.1701/4357.43479","DOIUrl":"https://doi.org/10.1701/4357.43479","url":null,"abstract":"Triple negative breast cancer (TNBC) represents 15% of invasive breast cancer cases and is an aggressive subtype. Patients with metastatic TNBC have a poor prognosis. Efforts have been made to develop new therapeutic options and identify molecular biomarkers to improve overall survival and quality of life for TNBC patients. Immunotherapy has shown promising frontline clinical activity. To determine which patients will derive the most benefit from a combination of immune checkpoint inhibitors and chemotherapy in metastatic disease, it is essential to evaluate PD-L1 expression. Approximately 15% of TNBC patients have a germline mutation in BRCA1 and/or BRCA2, and for these patients, innovative therapeutic options such as olaparib and talazoparib, which are PARP inhibitors, are available. Sacituzumab govitecan (SG) is a humanized monoclonal antibody-drug conjugate directed against the surface antigen of human trophoblastic cells (Trop-2) expressed in approximately 90% of TNBC, coupled with SN-38, the active metabolite of irinotecan, a topoisomerase I inhibitor. Here, we present the case of a woman who was initially diagnosed with localized luminal B breast cancer (ER-positive; HER2-negative) and was treated with curative therapy. However, she later experienced a recurrence with metastatic TNBC (ER-negative/HER2-negative) and received treatment with sacituzumab govitecan, which resulted in prolonged disease control.","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ritratto di Paolo Vineis: a cena con Taylor Swift. 保罗-维尼斯肖像：与泰勒-斯威夫特共进晚餐。

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43472

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Sacituzumab govitecan nel trattamento delle pazienti con tumore mammario avanzato o metastatico non triplo negativo all’esordio. 萨妥珠单抗戈维替康用于治疗晚期或转移性非三阴性乳腺癌患者。

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43478

Marta Perachino, Matteo Lambertini

引用次数: 0

[Unlikely any benefit from population wide case-finding strategies to identify people with undiagnosed asthma or chronic obstructive pulmonary disease.] [通过全民病例调查战略来发现未确诊的哮喘或慢性阻塞性肺病患者不太可能带来任何益处]。

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43466

Peter K Kurotschka, Mark H Ebell

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La grande fuga: il pronto soccorso come spia dell’avaria del sistema sanitario nazionale. 大逃亡：急诊室是国家医疗系统失败的标志。

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43470

Michela Chiarlo

引用次数: 0

Marisa Cantarelli: un’eredità di luce per la professione infermieristica. 玛丽莎-坎塔雷利：护理行业的光辉遗产。

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43471

Paola Arcadi

引用次数: 0

[Effectiveness and tolerability of sacituzumab govitecan in elderly patient with advanced triple negative breast cancer.] [萨希珠单抗戈维替康对晚期三阴性乳腺癌老年患者的有效性和耐受性]

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43485

Martina Nunzi

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[Tirbanibulin in large field of cancerization: new approach for sequential treatment of contiguous areas.] [替巴尼布林在大面积癌变中的应用：连续治疗毗连区的新方法]

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43476

Gianluca Nazzaro

{"title":"[Tirbanibulin in large field of cancerization: new approach for sequential treatment of contiguous areas.]","authors":"Gianluca Nazzaro","doi":"10.1701/4357.43476","DOIUrl":"https://doi.org/10.1701/4357.43476","url":null,"abstract":"Actinic keratosis (AK) is a common cutaneous keratinocyte dysplasia characterized by the abnormal proliferation of atypical epidermal keratinocytes; an area that presents photoinduced subclinical changes, similar to those found in AKs, on the periphery of clinically visible AKs is defined as a field of cancerization. Its treatment, rather than a treatment aimed at the single lesion, is more recommended as it manages the subclinical damage and prevents the onset of a possible squamous cell carcinoma. Among the field therapies, tirbanibulin has recently been introduced with an innovative mechanism of action that determines cellular apoptosis and consequently a poor local inflammatory reaction. We present the case of an 82-year-old patient, known for previous removals of squamous cell carcinomas at the vertex and currently suffering from a large field of cancerization in the nose and scalp, to whom we proposed a sequential treatment with three cycles of tirbanibulin in contiguous areas. The treatment was well tolerated and allowed complete clearance to be obtained on the nose and > 95% on the scalp, with a reduction of the Actinic Keratosis Area and Severity Index (AKASI) from 9.4 to 1.4.","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Promoting peace in the healthcare sector. What obstacles to overcome?] [促进医疗保健领域的和平：需要克服哪些障碍？］

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43461

Pirous Fateh-Moghadam

{"title":"[Promoting peace in the healthcare sector. What obstacles to overcome?]","authors":"Pirous Fateh-Moghadam","doi":"10.1701/4357.43461","DOIUrl":"https://doi.org/10.1701/4357.43461","url":null,"abstract":"Modern military strategies, armaments and technologies imply that every war today has a deleterious impact on all determinants of health, with direct and indirect effects that cause physical, mental and social suffering of the exposed population, that extends far beyond the duration of the conflict. The promotion of peace and the prevention of war is therefore clearly one of the professional tasks of health professionals, at least as much as the prevention of other public health risks. Nevertheless, peace promotion and anti-war activities are struggling to take off and spread in the health sector. The article examines two possible factors that stand as obstacles between the realisation of the evil of war, shared by all, and the actual commitment to disarmament and peace, practised by a few. The first of these obstacles is the divergence of views on the methods to choose to prevent conflict. Nonviolence and disarmament or military deterrence? The hypothesis discussed is that the deterrence theory still enjoys a certain credibility even in the medical scientific world although it is far from being an evidence-based strategy. The second obstacle examined is the fear of professionals and their associations of being accused of 'playing politics'. Since war is always a public health catastrophe, when health professionals oppose war, they are only doing their job. However, it is undoubtedly true that preventing war also involves political choices, but this is the case in every other area of public health, which without the use of political and regulatory instruments could not fulfil its task. Lastly, a concrete example of an intervention to promote peace is presented, promoted by several Italian scientific societies in the health field who have succeeded in drawing up a joint declaration in favour of peace and against war, open for subscription also by other scientific societies, journals, associations and foundations in the health sector.","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Urgenze ed emergenze in cardiologia”. 心脏病学中的急诊和急症"。

Recenti progressi in medicina Pub Date : 2024-10-01 DOI: 10.1701/4357.43474

引用次数: 0