Peter K Kurotschka, Allen F Shaughnessy, Alice Serafini
{"title":"[In adults with knee osteoarthritis, methotrexate offers minimal pain relief.]","authors":"Peter K Kurotschka, Allen F Shaughnessy, Alice Serafini","doi":"10.1701/4450.44444","DOIUrl":"https://doi.org/10.1701/4450.44444","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"120-121"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Successfully treatment with axicabtagene ciloleucel of a female patient with an early relapsed diffuse large B-cell lymphoma.]","authors":"Renato Scalone","doi":"10.1701/4450.44452","DOIUrl":"https://doi.org/10.1701/4450.44452","url":null,"abstract":"<p><p>Refractoriness and early relapse after first-line therapy are two high-risk conditions for patients with diffuse large B-cell lymphoma (DLBCL). Nowadays, axicabtagene ciloleucel (axi-cel) is the therapeutic strategy to adopt in these clinical conditions, considering the results obtained in terms of overall survival and progression free survival in the ZUMA-7 trial. In the clinical case here reported, a female patient with an early relapsed triple expressor DLBCL was successfully treated with axi-cel, obtaining the complete remission at one month from therapy. Similarly, the adverse events onset after axi-cel were successfully and quickly treated.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"e33-e35"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The first Italian patient affected by diffuse large B-cell lymphoma treated with axi-cel in the second line: innovation and tradition.]","authors":"Stefania Bramanti, Davide Chizzoniti, Daniele Mannina","doi":"10.1701/4450.44450","DOIUrl":"https://doi.org/10.1701/4450.44450","url":null,"abstract":"<p><p>CAR-T cell therapy has revolutionized the treatment of refractory or relapsed diffuse large B-cell lymphoma (DLBCL) within 12 months, replacing the use of high-dose chemotherapy with autologous stem cell reinfusion. Primary chemoresistance remains one of the most unfavorable prognostic scenarios for patients with DLBCL, despite the progress made with the introduction of anti-CD20 monoclonal antibodies in first-line treatment. Early identification of prognostic factors associated with clinical presentation represents an integrated approach that ensures rapid access to autologous anti-CD19 CAR-T therapy in selected cases that may benefit from treatment according to current standard indications.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"e24-e27"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Numeri in questo numero<br>2025 Febbraio.","authors":"","doi":"10.1701/4450.44434","DOIUrl":"https://doi.org/10.1701/4450.44434","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viviana Forte, Allen F Shaughnessy, Peter K Kurotschka
{"title":"[Routine Ecg screening: limited value for evaluating cardiovascular risk in working-age adults.]","authors":"Viviana Forte, Allen F Shaughnessy, Peter K Kurotschka","doi":"10.1701/4450.44445","DOIUrl":"https://doi.org/10.1701/4450.44445","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"122-123"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[From modern science to open science, publishing in the scientific field: copyright, Creative Commons and… beyond.]","authors":"","doi":"10.1701/4450.44437","DOIUrl":"https://doi.org/10.1701/4450.44437","url":null,"abstract":"<p><p>The concept of copyright protection emerged and developed throughout history to promote the widest dissemination of information. After two centuries of its establishment, development, and maturation, the traditional system entered a full-blown crisis, undermined at its foundations by digital innovation and the socio-cultural transformation of the 20th century. This evolution, marked by continuous adaptations, has introduced elements that are currently limiting the free circulation of scientific knowledge and hindering access to information. Creative Commons (CC) licenses offer a more flexible model for managing copyright, allowing authors to reserve some rights while relinquishing others. There are different variants of CC licenses, ranging from simple attribution (CC BY) to restrictions on commercial use and derivative works (CC BY NC ND). These licenses have been used both to promote the openness of resources and to perpetuate their commercial or paid distribution. For a significant shift towards more open science, a rebalancing of power is needed among authors, publishers, and users, with greater awareness of their rights by those who play a key role in scientific production.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ogni maledetta domenica (i bianchi e i verdi).","authors":"Vittorio Fontana","doi":"10.1701/4450.44447","DOIUrl":"https://doi.org/10.1701/4450.44447","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"126"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Beyond quantity: rethinking quality and integrity in scientific research.]","authors":"Luca De Fiore","doi":"10.1701/4450.44436","DOIUrl":"https://doi.org/10.1701/4450.44436","url":null,"abstract":"<p><p>Scientific publications have been suffering from a credibility crisis for years. This is the consequence of an excess of quantity in the production of articles produced for the sole purpose of advancing one's career and acquiring new funding to produce new studies and, consequently, new publications. To the problems of quantity are added those of quality: useless research results in scientific literature of little value. The preventive filter - entrusted to the peer review system - continues to prove insufficient to prevent the publication of useless or, increasingly, fraudulent articles. The method of critical review process should be radically reconsidered, as should the tools for measuring the impact of scientific articles: impact factors and other citation indices have proved incapable of giving an insight into the quality of what is published. The increased attention being paid to the scientific publication crisis can be a useful deterrent to improve quality and limit fraudulent behaviour. New generations of clinicians and researchers must be educated to respect the rules, and stricter and more timely penalties are needed for those who do not meet the standards that the scientific community has established over the years. More generally, the assessment of the quality of scientific production, and not its quantity, should inspire the evaluation of professional profiles when allocating new funding and selecting candidates for academic positions. Finally, journalism schools and masters' degrees in science communication must train new professionals capable of carrying out investigative journalism, which must be intensified in order to bring to light opportunistic and fraudulent behaviour.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"65-68"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Resveratrol= placebo for treating pain associated with degenerative joint disease of the knee.]","authors":"Peter K Kurotschka, Henry Barry, Alice Serafini","doi":"10.1701/4450.44443","DOIUrl":"https://doi.org/10.1701/4450.44443","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 2","pages":"118-119"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}