Recenti progressi in medicina最新文献

{"title":"[The current role of CAR-T cell treatment in lymphoma therapy: focus on diffuse large cell lymphoma and mantle cell lymphoma.]","authors":"Alessandro Broccoli, Pier Luigi Zinzani","doi":"10.1701/4495.44947","DOIUrl":"https://doi.org/10.1701/4495.44947","url":null,"abstract":"<p><p>The aim of this work is to provide the information needed to adequately apply chimeric antigen receptor T-cell (CAR-T) therapy in real clinical practice in outpatient, day hospital and ward settings, with a particular focus on patients with diffuse large cell lymphoma and mantle cell lymphoma, which currently represent the main area of use of anti-CD19 CAR-T treatment. The currently approved indications in both contexts are reviewed and the fundamental steps to follow in starting CAR-T cell therapy are described, as well as the data available in the literature regarding each previously presented indication.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"272-284"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Intensive blood pressure targets significantly reduce stroke and cardiovascular outcomes in patients with type 2 diabetes.]","authors":"Viviana Forte, Allen F Shaughnessy","doi":"10.1701/4495.44953","DOIUrl":"https://doi.org/10.1701/4495.44953","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"324-325"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large language models in answering mammography screening questions in Italian and English: Comment.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1701/4495.44956","DOIUrl":"https://doi.org/10.1701/4495.44956","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"330"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recensione<br>“Corpo, umano”.","authors":"","doi":"10.1701/4495.44958","DOIUrl":"https://doi.org/10.1701/4495.44958","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"334"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Antiviral drugs for influenza shorten symptoms by 24 hours or less and don't reduce hospitalizations or deaths.]","authors":"Alice Serafini, Mark H Ebell","doi":"10.1701/4495.44952","DOIUrl":"https://doi.org/10.1701/4495.44952","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"322-323"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The challenges for global health.]","authors":"Massimo Sartelli","doi":"10.1701/4495.44946","DOIUrl":"https://doi.org/10.1701/4495.44946","url":null,"abstract":"<p><p>The world is facing an unprecedented moment of destabilization, where multiple, interconnected challenges threaten public health with the potential to exacerbate existing inequalities and jeopardize global health security. In an era of profound changes, health workers must understand the challenges facing global health to respond with cohesion and determination. Global collaboration represents a beacon of hope and success and can foster unified efforts to address complex challenges for a healthier and more equitable global future.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"269-271"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Uncomplicated urinary tract infections: the new antibiotic gepotidacin is at least as effective as nitrofurantoin.]","authors":"Peter K Kurotschka, Henry Barry","doi":"10.1701/4495.44954","DOIUrl":"https://doi.org/10.1701/4495.44954","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"326-327"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamification in medical sciences education: a scoping review.","authors":"Mohammad Rasool Khazaei, Mohammad Ali Hosseini, Ghobad Ramezani","doi":"10.1701/4495.44949","DOIUrl":"https://doi.org/10.1701/4495.44949","url":null,"abstract":"<p><strong>Background & objective: </strong>Recently, the use of educational games in teach has received the attention of medical education experts. There is a belief that educational games can be used in line with the individual characteristics and diverse learning styles of students. Games in medical education are presented in different forms, including simulation, virtual environments, collaborative and social games, and virtual reality alternative games. A more detailed understanding of the impact of this new method requires more extensive studies. The current research was conducted with the aim to explain the elements affecting the implementation of gamification in medical science education with a scoping review approach.</p><p><strong>Methods: </strong>A scoping review was conducted in Irandoc, SID, and Magiran, Scopus, Science Direct, PubMed, Eric, MEDLINE, PsycINFO, Google Scholar and resources available in the library, theses, research plans between October 2012 and May 2024. Seventy-eight articles met the inclusion criteria. CASP checklists and AMSTAR was used to assess the quality of the articles.</p><p><strong>Results: </strong>Out of a total of 44,165 primary articles, 47 articles remained in the study for the final synthesis. The effective components in gamification included: educational design, virtual awards and points, scoreboards, learner characteristics, interaction with the learning environment, information context, game mechanics and reinforcements. The strategies used in the implementation of gamification included: use challenge, imagination, curiosity, visualization, game dynamics, role-playing and aesthetic. Effective variables of gamification including: increasing students' participation, increasing learning, increasing motivation, reducing anxiety, improving academic performance, reducing professors' workload, increasing satisfaction, active participation in discussion, attractiveness of education, social skills, role playing, self-efficacy, knowledge, skill. The elements of gamification are: goals, rules, feedback, challenge, valuable results, scoreboard and medals.</p><p><strong>Conclusions: </strong>Today, using the existing potential of gamification in medical education curriculum as an effective approach plays a significant role in improving the teaching-learning process of students in this field.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"291-301"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical trials on weight loss drugs do not represent one-third of people eligible for treatment.]","authors":"Daniele Ferrari, Allen F Shaughnessy","doi":"10.1701/4495.44955","DOIUrl":"https://doi.org/10.1701/4495.44955","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"328-329"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Experiences of patients and operators involved in the transition process from pediatric services to adult centers for young people with type 1 diabetes in Italy: the TransiDEA study (2nd phase).]","authors":"Vanna Graziani, Tosca Suprani, Paolo Di Bartolo, Ivana Rabbone, Simonetta Bellone, Riccardo Foglino, Andrea Laurenzi, Marco Marigliano, Maddalena Trombetta, Carlo Ripoli, Rosangela Maria Pilosu, Enza Mozzillo, Lutgarda Bozzetto, Antonio Clavenna, Maurizio Bonati, Federico Marchetti","doi":"10.1701/4495.44950","DOIUrl":"https://doi.org/10.1701/4495.44950","url":null,"abstract":"<p><strong>Introduction: </strong>Type 1 diabetes mellitus (T1D) is a common chronic condition in children and adolescents, with increasing incidence. Adequate management is crucial for glycemic control and the prevention of complications. The transition from pediatric care centers to adult care centers is a critical phase, and its effectiveness varies among different countries and even within different areas of the same country.</p><p><strong>Materials and methods: </strong>In this qualitative study conducted in 2023, at least 30 patients with T1D who had undergone the transition between 2017 and 2022 were invited to participate by completing an online semi-structured questionnaire regarding their transition experiences. Additional questionnaires were administered to healthcare professionals to gather information on organizational barriers and patient expectations.</p><p><strong>Results: </strong>The survey conducted on 52 young adults with T1D from 5 Italian diabetes centers revealed that the transition to adult care typically occurs at an average age of 19.6 years. At the time of the survey, 73% of participants had not experienced acute complications, and 55.7% had optimal metabolic control prior to the transition. However, many patients encountered issues in the operational management of the transition, with about 40% describing the process as difficult, highlighting in some cases a feeling of \"abandonment\" and a desire for greater support and communication between pediatric and adult services. The majority of respondents reported an increase in autonomy in managing their diabetes.</p><p><strong>Discussion and conclusions: </strong>Although the transition process for patients with T1D is structured, the study reveals some gaps in communication and support between pediatric and adult care centers. A well-coordinated pathway is essential, considering the individual needs of patients and strengthening collaboration between care teams.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 5","pages":"302-309"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}