Viviana Forte, Allen F Shaughnessy, Peter K Kurotschka
{"title":"[In patients with opioid addiction: frequent acupuncture sessions may reduce withdrawal symptoms and methadone dosage.]","authors":"Viviana Forte, Allen F Shaughnessy, Peter K Kurotschka","doi":"10.1701/4365.43589","DOIUrl":"https://doi.org/10.1701/4365.43589","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"523-524"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Activity of sacituzumab govitecan in skin metastases: description of a case.]","authors":"Giandomenico Di Menna","doi":"10.1701/4365.43612","DOIUrl":"10.1701/4365.43612","url":null,"abstract":"<p><p>Advanced triple-negative breast cancer is characterized by a severe prognosis, poor response to conventional therapies and poses multiple challenges for the medical oncologist. However, recent developments in molecular research and targeted therapy are opening up new perspectives with encouraging results for the treatment of this aggressive disease. The shared case wants to be an example: we will discuss the story of a 54 years old woman with extensive metastatic localizations in the skin that has obtained an important clinical response to therapy with sacituzumab govitecan, a conjugate antibody approved for the treatment of adult patients with metastatic triple negative breast cancer.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"90e-93e"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Fattirolli, Angela Sciacqua, Alessandra Pratesi, Claudio de Lucia, Dario Leosco, Enrico Occhiuzzi, Angelo Scuteri, Andrea Ungar, Carlo Vigorito
{"title":"[ITACARE-P/SIGG/SIGOT/SICGE position paper: referral of elderly cardiac patient from geriatrics to cardiac rehabilitation.]","authors":"Francesco Fattirolli, Angela Sciacqua, Alessandra Pratesi, Claudio de Lucia, Dario Leosco, Enrico Occhiuzzi, Angelo Scuteri, Andrea Ungar, Carlo Vigorito","doi":"10.1701/4365.43591","DOIUrl":"10.1701/4365.43591","url":null,"abstract":"<p><p>Cardiac rehabilitation (CR) is Class IA indication in patients after an acute cardiovascular (CV) event, with efficacy confirmed even in elderly or frail CV patients CV and geriatric outcomes. However, rate of referral and admission to CR of elderly CV patients remains very low. CV patients admitted in geriatric wards are often complex, multimorbid and frail. Therefore, the present position paper addressees their possible referral to CR, since many have various forms of CV diseases amenable to improve with CR. The multidisciplinary and comprehensive model of CR is applicable to these patients where evaluation and interventions should be tailored to the patient functional and clinical status, aiming to appropriate targets. Cardiologist, Geriatrician and other professionals, should synergistically integrate their competences, thus outlining also the new paradigm of \"Cardiogeriatric Rehabilitation and Prevention\", possibly leading to an increased awareness of the beneficial effect of CR and to an increased referral to CR from Geriatric departments. Operative recommendations are given, based on appropriateness and priority of indications, clinical risk and frailty level, integrating different expertise to reach more effective programs of care.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"527-537"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariasilvia Como, Mariateresa Dacquino, Gabriele De Giovanni, Antonio Maconi
{"title":"Le parole della ricerca.","authors":"Mariasilvia Como, Mariateresa Dacquino, Gabriele De Giovanni, Antonio Maconi","doi":"10.1701/4365.43603","DOIUrl":"https://doi.org/10.1701/4365.43603","url":null,"abstract":"<p><p>The initiative \"Le parole della ricerca,\" launched in 2021, aims to enhance public understanding of health research through digital communication, using visual storytelling and local influencers. The project simplified complex research terms, linked to the DAIRI's activities, into 20 key concepts, illustrated by Gastini, and shared through social media. This campaign involved professionals explaining their work with the support of art, increasing public engagement. This campaign led to an increase in local knowledge of research-related topics, thanks to the increase in specifically dedicated posts on Facebook and their engagement.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"562-563"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recensioni.<br>\"Curarsi con l'intelligenza artificiale\"<br>\"100 volte Scalfari\".","authors":"","doi":"10.1701/4365.43609","DOIUrl":"https://doi.org/10.1701/4365.43609","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"575"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[TNBC, stage IV: a patient's journey, from standard options to the new era of ADC.]","authors":"Laura Iezzi","doi":"10.1701/4365.43616","DOIUrl":"10.1701/4365.43616","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) continues to be the most aggressive molecular subtype of breast cancer and the optimal therapeutic management is still a challenge. Due to the lack of \"traditional\" molecular targets, for decades, systemic treatment has been characterized by the use of classic cytotoxic drugs. In recent years, it has been proved that TNBC is not represented by a single pathology lack of specific features, but of different entities with distinct genetic, histological and clinical alterations. This allowed to optimize and improve the therapeutic management of the disease, with the approval of multiple anti-tumor agents, including antibody-drug conjugates (ADC). The clinical case we present illustrates the \"journey\" of a patient affected by metastatic TNBC, of the therapeutic choices made among the options available over the years, from the standard options to the innovative strategies.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"105e-109e"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Angelini, Emma Maria Ugolini, Alessandro Elias Dimitrio
{"title":"ChatGPT: una risorsa formativa per gli studenti di medicina italiani?","authors":"Matteo Angelini, Emma Maria Ugolini, Alessandro Elias Dimitrio","doi":"10.1701/4365.43600","DOIUrl":"https://doi.org/10.1701/4365.43600","url":null,"abstract":"<p><p>This study evaluated the use of ChatGPT among current and former medical students enrolled at Italian universities. The primary goal was to assess its usage and applications in education. Secondary objectives included gathering opinions and satisfaction levels with ChatGPT for educational purposes. The survey included 208 participants, mainly Italian (95%) and aged 18-23 (76%). Most students were from public universities (62%). Nearly all respondents (99%) knew ChatGPT, and 79% used it for study support. Additionally, 81% consider AI suitable for educational purposes, and 39% positively changed their opinion after using it. While 78% found ChatGPT helpful, limitations like confusion (25%) and accuracy concerns (18%) were noted. Still, 85% found responses accurate, and 89% planned to keep using it, with 81% recommending it to peers. Our findings show ChatGPT is widely used by Italian medical students, despite concerns about accuracy and over-reliance. As we witness the rapid advent and evolution of these tools, it is crucial to consider their attentive and deliberate integration into various aspects of our lives.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"556-557"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felice Musicco, Ruggero Lasala, Fiorenzo Santoleri, Alberto Costantini, Paolo Abrate, Alessia Romagnoli, Irene Terrenato
{"title":"Aderenza e persistenza come indicatori di esito in tempo reale dei trattamenti farmacologici oncoematologici e il caso degli anti-EGFR in prima linea nello NSCLC.","authors":"Felice Musicco, Ruggero Lasala, Fiorenzo Santoleri, Alberto Costantini, Paolo Abrate, Alessia Romagnoli, Irene Terrenato","doi":"10.1701/4365.43596","DOIUrl":"https://doi.org/10.1701/4365.43596","url":null,"abstract":"<p><p>For many new oncological drugs, including target therapy and immunotherapy, the treatment should be continued as long as the patient is deriving clinical benefit from therapy or until unacceptable toxicity occurs. Drug survival or Time to treatment discontinuation (Ttd) or persistence have become important intermediate efficacy endpoints, especially in real-world settings due to their strong correlation with endpoints such as Time to treatment failure (Ttf) and Progression free survival (Pfs). Our methodology is based on validated indicators and information technology tools, to develop continuous and updated oncology drug utilization reports in hospital setting which include data about enrolment curves, Ttd, adherence, dose intensity, dose changes and budget impact. We present, as real-world example, the case of anti-EGFR in first line NSCLC. We analysed data of first and second generation drugs (afatinib, gefitinib, erlotinib) and the new third generation drug (osimertinib). Median Ttd and adherence as Proportion of days covered (Pdc) were respectively 11.6 versus 23.4 months and 0.92 versus 0.95.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"547-549"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diego Sabbi, Angelica Salvadori, Francesco Del Zotti
{"title":"Tecniche di scavo: audit sugli esiti in medicina generale.","authors":"Diego Sabbi, Angelica Salvadori, Francesco Del Zotti","doi":"10.1701/4365.43598","DOIUrl":"10.1701/4365.43598","url":null,"abstract":"<p><p>Netaudit is a unique, voluntary network of general practitioners in Italy dedicated to conducting audits and research on their clinical practice. Unlike traditional academic research, Netaudit is driven by the grassroots efforts of primary care physicians. The project aims to provide practical tools and support for GPs seeking to improve their clinical practice through data-driven insights. Since its start in 2001, Netaudit has fostered a collaborative community of 150 Italian GPs who share a common interest in Audit and Evidence-based medicine. Members conduct a variety of audits, from monitoring laboratory results to evaluating medication use. Research findings are disseminated through the group's website and a dedicated journal. The project has faced challenges related to data standardization due to the diversity of electronic health record systems used by participating GPs. Despite these challenges, Netaudit has successfully conducted numerous audits over the past two decades, contributing to the evidence base for primary care in Italy. Netaudit has demonstrated the value of peer-led research in improving the quality of care. By empowering GPs to conduct their own research, the project has fostered a culture of continuous learning and quality improvement. Moreover, Netaudit has played a pivotal role in advocating for the academic recognition of general practice in Italy.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"115 11","pages":"552-553"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}