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Recenti progressi in medicina最新文献

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Linfoma mantellare.
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44567
Alessandro Broccoli, Pier Luigi Zinzani
{"title":"Linfoma mantellare.","authors":"Alessandro Broccoli, Pier Luigi Zinzani","doi":"10.1701/4460.44567","DOIUrl":"10.1701/4460.44567","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"e37-e39"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The INNOVATE framework to foster ethics of artificial intelligence.
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44558
Russell Franco D'Souza, Krishna Mohan Surapaneni, Mary Mathew, Shabbir Amanullah, Joseph Edward Thornton, Rajiv Tandon
{"title":"The INNOVATE framework to foster ethics of artificial intelligence.","authors":"Russell Franco D'Souza, Krishna Mohan Surapaneni, Mary Mathew, Shabbir Amanullah, Joseph Edward Thornton, Rajiv Tandon","doi":"10.1701/4460.44558","DOIUrl":"10.1701/4460.44558","url":null,"abstract":"<p><p>ChatGPT, the latest advancement in Artificial Intelligence (AI), represents one of the most advanced and rapidly evolving chatbot technologies to date. Its capability to provide swift and intelligent responses has garnered admiration from scientists and educators globally. Particularly, the healthcare sector stands to gain significantly from the integration of systems like ChatGPT, with benefits including enhanced productivity, reduced expenses, and improved patient outcomes. However, to ensure their equitable and appropriate implementation, it is crucial to address the ethical challenges associated with these technologies. While numerous studies have highlighted these ethical quandaries, there lacks a comprehensive discussion and resolution framework. This review aims to fill this gap by offering a detailed exploration of the ethical concerns associated with using AI tools like ChatGPT in healthcare. This exploration is structured into five main categories: Bias and discrimination, privacy and data security, disinformation and misinformation, autonomy and human interaction, and accountability and responsibility. Additionally, this review discusses the necessity of establishing a clear ethical framework for deploying AI tools in healthcare, introducing the INNOVATE framework. The detailed description and application of the INNOVATE framework aim to promote ethical practices in AI, ensuring a responsible and beneficial integration into healthcare, thereby addressing the identified ethical concerns.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"175-186"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Efficacy and toxicity of brexucabtagene autoleucel in the treatment of high-risk mantle cell lymphoma: description of a clinical case.]
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44569
Mattia Novo, Corrado Benevolo Savelli, Barbara Botto, Roberto Freilone
{"title":"[Efficacy and toxicity of brexucabtagene autoleucel in the treatment of high-risk mantle cell lymphoma: description of a clinical case.]","authors":"Mattia Novo, Corrado Benevolo Savelli, Barbara Botto, Roberto Freilone","doi":"10.1701/4460.44569","DOIUrl":"10.1701/4460.44569","url":null,"abstract":"<p><strong>Introduction: </strong>Relapsed or refractory (R/R) mantle cell lymphoma (MCL) represent a setting at unfavourable prognosis. Chimeric antigen receptor T-cells (CAR-T) are recently introduced in clinical practice as a new therapeutic option for this setting.</p><p><strong>Clinical case: </strong>61-year-old man with MCL pleomorphic variant, TP53 mutated with high risk MIPI-c early relapsed after frontline immunochemotherapy and ibrutinib. It has treated with brexucabtagene autoleucel (brexu-cel) as third line. A complete remission (CR) is obtained at 1 moth post infusion but the patient developed a severe and prolonged hematological toxicity: anemia G4, thrombocytopenia G4, neutropenia G4. Three months post-CAR-T infusion eltrombopag is introduced with rapid hemoglobin and platelet count recovery and an improvement in neutrophil count but persistent G3 neutropenia at 2 years of follow up. The bone marrow biopsy revealed a granulocytic hypoplasia with a clonal hemopoiesis (ASLX1 and DNMT3A mutations encountered) at the next generation sequencing test (NGS). The patient is in persistent CR at 2 years post brexu-cel infusion without major infection encountered.</p><p><strong>Conclusions: </strong>Brexu-cel represents an effective treatment option even in R/R MCL with high-risk features but can be associated with prolonged toxicities. An accurate patient selection and a close monitoring during post-CAR-T follow-up is crucial in order to prolong survival of these patients.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"e45-e49"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Successful CAR-T cell therapy in a refractory mcl patient with rapidly progressive disease: a case report.]
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44568
Mirko Farina, Alessandro Re
{"title":"[Successful CAR-T cell therapy in a refractory mcl patient with rapidly progressive disease: a case report.]","authors":"Mirko Farina, Alessandro Re","doi":"10.1701/4460.44568","DOIUrl":"10.1701/4460.44568","url":null,"abstract":"<p><p>Mantle cell lymphoma is a rare and aggressive hematologic malignancy characterized by frequent relapses and poor prognosis. Recently, the approval of CAR-T cell therapy has transformed the treatment landscape for relapsed/refractory patients. We report the case of a 52-year-old patient with mantle cell lymphoma who experienced multiple disease relapses. Specifically, the patient showed a rapid and severe progression after treatment with BTK inhibitors in the second line of therapy and was subsequently evaluated for a CAR-T cell therapy program. This case highlights the importance of a multidisciplinary approach, with efficient collaboration optimizing timelines for treatment eligibility, leukapheresis planning, bridge therapy, and CAR-T cell infusion (brexu-cel). The CAR-T treatment was well tolerated, although it was associated with a rare cardiovascular complication, sinus bradycardia, and subsequently, a deep vein thrombosis. Thanks to close collaboration with cardiology specialists, these complications were resolved without sequelae. Post CAR-T cell therapy, the patient achieved complete remission, sustained at 15 months of follow-up.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"e40-e44"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual reality and artificial intelligence: the future of mental health. A narrative review.
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44554
Federica Fiaschè, Andrea Steven Barbetti, Lorenzo Di Natale, Salvatore Cappello, Giulia Sarnataro, Giuseppe Ducci
{"title":"Virtual reality and artificial intelligence: the future of mental health. A narrative review.","authors":"Federica Fiaschè, Andrea Steven Barbetti, Lorenzo Di Natale, Salvatore Cappello, Giulia Sarnataro, Giuseppe Ducci","doi":"10.1701/4460.44554","DOIUrl":"10.1701/4460.44554","url":null,"abstract":"<p><p>In recent years, the use of artificial intelligence (AI) and virtual reality (VR) in the psychiatric field has been rapidly developing. This narrative review seeks to provide insight into how these technologies may be used in psychiatric disorders. VR is used above all to analyze symptoms in detail and personalize therapy. AI is used above all to make early diagnosis and accurate diagnosis. We conducted a search on PubMed and found 18 relevant studies. Most were reviews that focused on the effectiveness of AI and VR in early diagnosis, personalization of treatment, and accurate monitoring of symptoms with more targeted interventions. Despite many limitations, AI and VR could revolutionize psychiatry in the future.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Can large language models answer clinical questions?]
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44551
Eugenio Santoro
{"title":"[Can large language models answer clinical questions?]","authors":"Eugenio Santoro","doi":"10.1701/4460.44551","DOIUrl":"10.1701/4460.44551","url":null,"abstract":"<p><p>With the advancement of large language models (LLMs) such as ChatGPT, their application in medicine is growing, but it is crucial that the responses are aligned with international guidelines. Recent studies have shown that LLMs can be useful in the medical field, providing correct answers to questions about the management and treatment of specific diseases. However, the accuracy of these models must also include readability and thoroughness of the answers and consistency with guidelines. In addition to these characteristics, relevance, pertinence, and up-to-date nature of the sources used by the LLMs to answer questions must be ensured. Furthermore, studies are needed to investigate the consistency of responses across different LLMs and languages used by them, as well as training processes that ensure greater reliability, especially when dealing with rare or complex diseases. Although LLMs can support medical education and decision-making, their integration into clinical practice requires further validation and comparison with international guidelines.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"137-138"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Combining acetaminophen and ibuprofen is more effective for reducing fever in children than using a single drug.]
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44561
Viviana Forte, Allen F Shaughnessy
{"title":"[Combining acetaminophen and ibuprofen is more effective for reducing fever in children than using a single drug.]","authors":"Viviana Forte, Allen F Shaughnessy","doi":"10.1701/4460.44561","DOIUrl":"10.1701/4460.44561","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"191-192"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Exercise, especially resistance and mind-body exercise, improves symptoms of depression in older adults.]
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44559
Mario Luciano, Henry Barry, Alice Serafini
{"title":"[Exercise, especially resistance and mind-body exercise, improves symptoms of depression in older adults.]","authors":"Mario Luciano, Henry Barry, Alice Serafini","doi":"10.1701/4460.44559","DOIUrl":"10.1701/4460.44559","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"187-188"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recensione
“Salute per tutti”. 回顾 "全民健康"。
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44566
{"title":"Recensione<br>“Salute per tutti”.","authors":"","doi":"10.1701/4460.44566","DOIUrl":"10.1701/4460.44566","url":null,"abstract":"","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"201"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Patient-centered medicine in the era of artificial intelligence: what are the possible implications and risks?]
Recenti progressi in medicina Pub Date : 2025-03-01 DOI: 10.1701/4460.44553
Lidia Borghi, Alberto Giovanni Gerli, Elena Vegni
{"title":"[Patient-centered medicine in the era of artificial intelligence: what are the possible implications and risks?]","authors":"Lidia Borghi, Alberto Giovanni Gerli, Elena Vegni","doi":"10.1701/4460.44553","DOIUrl":"10.1701/4460.44553","url":null,"abstract":"<p><p>Patient-Centered Care (PCC) is currently recognized as the gold standard for the doctor-patient relationship, and numerous studies associate it with the improvement of various outcomes. However, the advent of artificial intelligence (AI) technologies in the healthcare field challenges doctor-patient interactions as conceived within the PCC. This article proposes a critical and open reflection on the impact of integrating AI into healthcare systems. It will discuss how the advent of AI can be integrated within a PCC paradigm and its role in decision-making processes, outlining its benefits but also potential critical issues from the perspective of patients, doctors, and the doctor-patient relationship. The available evidence indicates the need for a re-examination of the doctor-patient relationship paradigm that incorporates AI as a third party in the relationship. Furthermore, such incorporation will increasingly impact key dimensions of PCC: empathy, trust, and communication. Therefore, it is suggested to improve the educational training of doctors, who must be trained in the use of soft skills and prepared for a work environment assisted by AI.</p>","PeriodicalId":20887,"journal":{"name":"Recenti progressi in medicina","volume":"116 3","pages":"142-149"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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