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Role of the medial septum neurotensin receptor 1 in anxiety-like behaviors evoked by emotional stress 内隔神经紧张素受体1在情绪压力诱发的焦虑样行为中的作用。
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2024.107275
Leilei Chang , Yecheng He , Bin Li
{"title":"Role of the medial septum neurotensin receptor 1 in anxiety-like behaviors evoked by emotional stress","authors":"Leilei Chang ,&nbsp;Yecheng He ,&nbsp;Bin Li","doi":"10.1016/j.psyneuen.2024.107275","DOIUrl":"10.1016/j.psyneuen.2024.107275","url":null,"abstract":"<div><div>Anxiety is one of the most common mental disorders. Neurotensin (NT) is a neuropeptide widely distributed in the central nervous system, involved in the pathophysiology of many neural and psychiatric disorders such as anxiety. However, the neural substrates mediating NT’s effect on the regulation of anxiety have not been fully identified. The medial septum (MS) is a crucial brain region in regulating anxiety and expresses neurotensin receptor 1 (NTS1). In the current study, we examined the role of NT/NTS1 in the MS on the anxiety-like behaviors of rats in non-stress and acute stress conditions. We reported that intra-MS infusion of NT produced remarkable anxiogenic effect in behavioral tests. The anxiogenic effect could be blocked by NTS1 antagonist SR48692 pretreatment. Microinjection of NTS1 antagonist to block endogenously released NT in the MS had no effect on anxiety-like behaviors in non-stressed rats, but significantly reduced anxiety in acute restraint stressed rats. Moreover, molecular knockdown of NTS1 in the MS ameliorated anxiety induced by acute restraint stress, also confirming the pharmacological results. Our study implicates NT and its receptors as potential targets for therapeutic interventions of psychiatric diseases, such as anxiety.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107275"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific associations between loneliness and hair cortisol among older african american adults
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107343
K.M. Knauft , K.M. Davis , L.M. Rappaport , S. Zilioli
{"title":"Sex-specific associations between loneliness and hair cortisol among older african american adults","authors":"K.M. Knauft ,&nbsp;K.M. Davis ,&nbsp;L.M. Rappaport ,&nbsp;S. Zilioli","doi":"10.1016/j.psyneuen.2025.107343","DOIUrl":"10.1016/j.psyneuen.2025.107343","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107343"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New methods for exploring the correspondence between cortisol and brain activity during social stress
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107337
K. Casto , D. Cohen
{"title":"New methods for exploring the correspondence between cortisol and brain activity during social stress","authors":"K. Casto ,&nbsp;D. Cohen","doi":"10.1016/j.psyneuen.2025.107337","DOIUrl":"10.1016/j.psyneuen.2025.107337","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107337"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does hair cortisol concentration reflect saliva cortisol levels and/or the regulatory biology of the HPA axis that shapes them in healthy humans?
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107321
G Liberzon , S.L. Clark , J.L. Abelson
{"title":"Does hair cortisol concentration reflect saliva cortisol levels and/or the regulatory biology of the HPA axis that shapes them in healthy humans?","authors":"G Liberzon ,&nbsp;S.L. Clark ,&nbsp;J.L. Abelson","doi":"10.1016/j.psyneuen.2025.107321","DOIUrl":"10.1016/j.psyneuen.2025.107321","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107321"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presentation 1: Childhood adversity and adult depressive symptoms: body mass index and interleukin-6 as sequential mediators in a structural equation modeling meta-analysis
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107299
A. Zagaria , V Fiori , M. Vacca , C. Lombardo , C.M. Pariante , A. Ballesio
{"title":"Presentation 1: Childhood adversity and adult depressive symptoms: body mass index and interleukin-6 as sequential mediators in a structural equation modeling meta-analysis","authors":"A. Zagaria ,&nbsp;V Fiori ,&nbsp;M. Vacca ,&nbsp;C. Lombardo ,&nbsp;C.M. Pariante ,&nbsp;A. Ballesio","doi":"10.1016/j.psyneuen.2025.107299","DOIUrl":"10.1016/j.psyneuen.2025.107299","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107299"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The healing power of love: The oxytocin-sociostasis hypothesis
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107288
C.S. Carter
{"title":"The healing power of love: The oxytocin-sociostasis hypothesis","authors":"C.S. Carter","doi":"10.1016/j.psyneuen.2025.107288","DOIUrl":"10.1016/j.psyneuen.2025.107288","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107288"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of adolescent depression from demographic, clinical, and survey data from ALSPAC using machine learning
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107293
C.E. Hostinar , A. Yoo, F. Li, J. Youn, J. Guan, A. E. Guyer, I. Tagkopoulos
{"title":"Prediction of adolescent depression from demographic, clinical, and survey data from ALSPAC using machine learning","authors":"C.E. Hostinar ,&nbsp;A. Yoo,&nbsp;F. Li,&nbsp;J. Youn,&nbsp;J. Guan,&nbsp;A. E. Guyer,&nbsp;I. Tagkopoulos","doi":"10.1016/j.psyneuen.2025.107293","DOIUrl":"10.1016/j.psyneuen.2025.107293","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107293"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
History of sexual abuse predicts distinct diurnal cortisol slopes in incarcerated girls and boys
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107328
C. Lavassani , M. Johnson , P. Ruttle , A. Dismukes , O. Miočević , E. Shirtcliff
{"title":"History of sexual abuse predicts distinct diurnal cortisol slopes in incarcerated girls and boys","authors":"C. Lavassani ,&nbsp;M. Johnson ,&nbsp;P. Ruttle ,&nbsp;A. Dismukes ,&nbsp;O. Miočević ,&nbsp;E. Shirtcliff","doi":"10.1016/j.psyneuen.2025.107328","DOIUrl":"10.1016/j.psyneuen.2025.107328","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107328"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of objective and subjective socioeconomic status on prenatal sleep: cross-cultural findings from birth cohorts in the us and turkey
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107350
S. Muftareviç , Ö. Aran , M. Nevarez-Brewster , B.L. Hankin , E.P. Davis , E.A. Duman
{"title":"The impact of objective and subjective socioeconomic status on prenatal sleep: cross-cultural findings from birth cohorts in the us and turkey","authors":"S. Muftareviç ,&nbsp;Ö. Aran ,&nbsp;M. Nevarez-Brewster ,&nbsp;B.L. Hankin ,&nbsp;E.P. Davis ,&nbsp;E.A. Duman","doi":"10.1016/j.psyneuen.2025.107350","DOIUrl":"10.1016/j.psyneuen.2025.107350","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107350"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of extracellular vesicle miR-16-5p in mediating long-term effects of childhood trauma
IF 3.4 2区 医学
Psychoneuroendocrinology Pub Date : 2025-02-01 DOI: 10.1016/j.psyneuen.2025.107352
Yangyang He , Karin Wuertz-Kozak , Sanne Houtenbos , Pia-Maria Wippert
{"title":"The role of extracellular vesicle miR-16-5p in mediating long-term effects of childhood trauma","authors":"Yangyang He ,&nbsp;Karin Wuertz-Kozak ,&nbsp;Sanne Houtenbos ,&nbsp;Pia-Maria Wippert","doi":"10.1016/j.psyneuen.2025.107352","DOIUrl":"10.1016/j.psyneuen.2025.107352","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107352"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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