Psychoneuroendocrinology最新文献

{"title":"Within-person associations between daily ovarian steroid levels and mood-related symptoms in ovulatory and anovulatory early adolescents","authors":"Allison Stumper ,&nbsp;Hannah Klusmann ,&nbsp;Jessica R. Peters ,&nbsp;Elizabeth H. Andersen","doi":"10.1016/j.psyneuen.2025.107740","DOIUrl":"10.1016/j.psyneuen.2025.107740","url":null,"abstract":"<div><h3>Background</h3><div>Accumulating evidence suggests some adult females experience hormone sensitivity, or neurobehavioral sensitivity to normal fluctuations in ovarian steroid hormones, across the menstrual cycle. However, this work has yet to be adequately extended to adolescent populations, despite the significant increase in risk for affective disorders among females after menarche.</div></div><div><h3>Aims</h3><div>The current study aimed to determine whether hormone sensitivity could be observed in a sample of early adolescent females by examining the within-person associations between daily levels of estrone and progesterone metabolites that are marked for urinary excretion (estrone-3glucuronide or E1G and pregnanediol glucuronide or PdG, respectively) and daily mood symptoms across one menstrual cycle.</div></div><div><h3>Method</h3><div>The current study assessed mood ratings and collected dried urine strips for analysis of E1G and PdG across one full menstrual cycle (up to 48 days) in a sample of peripubertal female adolescents aged 11–14. Within-person multilevel models, run in the full sample and separately for ovulatory cycles (N = 31) and anovulatory cycles (N = 23), evaluated the associations between E1G and PdG and mood symptoms.</div></div><div><h3>Results</h3><div>In the full sample, E1G was negatively associated with mean total symptom score ((b = −.02, 95 % CI = −0.03 – −0.002), irritability (b = −.003, 95 % CI = −0.06 – −0.001), anhedonia (b = −.03, 95 % CI = −0.05 – −0.01), concentration difficulty (b = −.03, 95 % CI = −0.05 – −0.002), and conflicts (b = −.03, 95 % CI = −0.05 – −0.004). In the ovulatory group, E1G was negatively associated with mean total symptom score (<em>b</em> = −.02, 95 % CI = −0.04 – −0.004), hopelessness (<em>b</em> = −0.02, 95 % CI = −0.04 – −0.001), rejection sensitivity (<em>b</em> = −0.03, 95 % CI = −0.06 – −0.001), irritability (<em>b</em> = −0.05, 95 % CI = −0.09 – −0.01), concentration difficulties (<em>b</em> = −0.03, 95 % CI = −0.06 – −0.01), and overwhelm (<em>b</em> = −0.03, 95 % CI = −0.06 – −0.0001). In the anovulatory group, E1G was associated only with anhedonia (<em>b</em> = −0.05, 95 % CI = −0.10 – −0.01).</div></div><div><h3>Conclusions</h3><div>These results demonstrate small associations between normal decreases in E1G and mood symptoms across the menstrual cycle in an adolescent sample, though these effects were largely limited to ovulatory cycles. Results highlight the importance of considering ovulation status in this population and differ from the adult literature in important ways that highlight the need for more work on how hormone sensitivity differs between adolescents and adults.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107740"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of pre-acquisition stress on fear learning and regulation as a function of sex and menstrual-cycle groups","authors":"Jessie Provencher ,&nbsp;Clémence Peyrot ,&nbsp;Marie-Charlotte Beaulieu ,&nbsp;Marie-France Marin","doi":"10.1016/j.psyneuen.2025.107719","DOIUrl":"10.1016/j.psyneuen.2025.107719","url":null,"abstract":"<div><div>Fear conditioning protocols are widely used to investigate fear learning and regulation, with clinical implications for post-traumatic stress and anxiety disorders. In real-world settings, fear learning often occurs under stress, affecting memory strength and regulation. However, laboratory findings on stress effects remain inconsistent, possibly due to the lack of consideration for sex and menstrual-cycle groups, given sex hormones receptors' abundance in fear- and stress-related brain regions. This study examined the impact of 1) pre-acquisition stress and 2) cortisol reactivity on fear processes across sex and menstrual-cycle groups (hormonal data unavailable). A total of 208 participants were exposed to a stressor (men (n = 24), women using oral contraceptives (OCs; n = 25), and women with a menstrual cycle in the early follicular (EF; n = 24) or late follicular phase (LF; n = 26)) or control condition (men (n = 29), OCs (n = 23), EF (n = 26), LF (n = 31)) before undergoing fear acquisition (Context A), where two colors were paired with shock (CS+) and another was not (CS−). On Day 2, one CS+ and the CS− were presented without shock (Context B) for fear extinction learning. On Day 3, extinction recall (Context B) and renewal (Context A) were tested, with all stimuli presented without shock. Fear responses were assessed by skin conductance responses (SCR) and self-reported shock anticipation. Stress-exposed participants showed lower SCR during fear acquisition than controls. During extinction learning, control men exhibited greater SCR reduction than stressed men, whereas LF women showed the opposite pattern. No group differences emerged during extinction recall. During renewal, stressed LF women had lower SCR to the CS+ than their control counterparts. Additional analyses suggested that stressed men with lower cortisol reactivity had higher SCR during fear acquisition and renewal than those with higher cortisol reactivity. These findings indicate that stress exposure and cortisol reactivity differentially influence fear learning and regulation across sex and menstrual-cycle groups, in a context-dependent manner.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107719"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune cell mobilization after exhaustive exercise and its association with subjective mental state in young healthy adults: A randomized cross-over study","authors":"Frederike Adammek ,&nbsp;David Walzik ,&nbsp;Alexander Schenk ,&nbsp;Tobias Esser ,&nbsp;Sina Trebing ,&nbsp;Sarah Valder ,&nbsp;Dennis Dreiskämper ,&nbsp;Philipp Zimmer ,&nbsp;Niklas Joisten","doi":"10.1016/j.psyneuen.2025.107724","DOIUrl":"10.1016/j.psyneuen.2025.107724","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The biological foundation of changes in mental state after acute exercise is not yet understood, but it may be related to immunological alterations. The study investigated the hypothesis that the exercise-induced mobilization in circulating immune cells and cellular inflammation markers are associated with changes in the subjective mental state. As a secondary aim, the study investigated, wether the effects of the circulating immune cells are sex-dependent.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;In a randomized cross-over trial, 24 young healthy adults (eight female; age 25.75 ± 4.35 years) completed a single exercise bout until exhaustion on a cycle ergometer and a passive control session. Outcomes were assessed immediately before, after the session, and 1 h, 3 h, 24 h, and 48 h after the session and comprise cell counts of leukocytes, lymphocytes, neutrophils and platelets, and the inflammation markers neutrophil-to-lymphocyte-ratio, platelet-to-lymphocyte-ratio and systemic-immune-inflammation-index as blood-based parameters, and subjective mental state measured using the Multidimensional-Mood-Questionnaire (MDMQ, subdomains &lt;em&gt;mood&lt;/em&gt;, &lt;em&gt;energetic arousal&lt;/em&gt;, &lt;em&gt;calmness&lt;/em&gt;).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;There were significant time*group effects for all blood-based parameters (p &lt; 0.001) and significant main effects of time for the MDMQ &lt;em&gt;mood&lt;/em&gt; (p &lt; 0.001) and &lt;em&gt;energetic arousal&lt;/em&gt; (p = 0.008). No significant sex-dependent differences were obeserved. Within the intervention group, MDMQ &lt;em&gt;energetic arousal&lt;/em&gt; showed significant correlations with lymphocytes (r&lt;sub&gt;rm&lt;/sub&gt;=-0.41, p &lt; 0.001), platelets (r&lt;sub&gt;rm&lt;/sub&gt;=-0.28, p = 0.002), NLR (r&lt;sub&gt;rm&lt;/sub&gt;=0.28, p = 0.002), PLR (r&lt;sub&gt;rm&lt;/sub&gt;=0.33, p &lt; 0.001), SII (r&lt;sub&gt;rm&lt;/sub&gt;=0.269, p = 0.003) and MDMQ &lt;em&gt;calmness&lt;/em&gt; showed significant correlations with leukocytes (r&lt;sub&gt;rm&lt;/sub&gt;=-0.29, p = 0.002), lymphocytes (r&lt;sub&gt;rm&lt;/sub&gt;=-0.36, p &lt; 0.001), platelets (r&lt;sub&gt;rm&lt;/sub&gt;=-0.30, p = 0.001), and PLR (r&lt;sub&gt;rm&lt;/sub&gt;=0.25, p = 0.007). Within the control group, MDMQ &lt;em&gt;mood&lt;/em&gt; showed significant correlations with lymphocytes (r&lt;sub&gt;rm&lt;/sub&gt;=0.20, p = 0.031, NLR (r&lt;sub&gt;rm&lt;/sub&gt;=-0.28, p = 0.002), PLR (r&lt;sub&gt;rm&lt;/sub&gt;=-0.19, p = 0.033), SII (r&lt;sub&gt;rm&lt;/sub&gt;=-0.24, p = 0.008) and MDMQ &lt;em&gt;calmness&lt;/em&gt; showed significant correlations with PLR (r&lt;sub&gt;rm&lt;/sub&gt;=-0.23, p = 0.011), SII (r&lt;sub&gt;rm&lt;/sub&gt;=-0.20, p = 0.029). Fisher´s z-test revealed no significant difference between the correlations of the groups.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Acute exhaustive exercise affects immune cells, inflammation markers, and the subjective mental state regardless of sex. The correlation between blood-based parameters and the MDMQ appears to be robust and indicates relevant psychoneuroimmune associations in the human body. However, the acute exercise intervention used in this study does not influence this association.&lt;/div&gt;&lt;/div&gt;&lt;","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107724"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145739284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal cortisol cycle and cognitive performance in older people with Type 2 diabetes","authors":"Lorena Vallejo ,&nbsp;Mariola Zapater-Fajarí ,&nbsp;Teresa Montoliu ,&nbsp;Vanesa Hidalgo ,&nbsp;Alicia Salvador","doi":"10.1016/j.psyneuen.2025.107718","DOIUrl":"10.1016/j.psyneuen.2025.107718","url":null,"abstract":"<div><div>In older adults with Type 2 Diabetes (T2D), hypothalamic-pituitary-adrenal (HPA) axis dysregulation accompanied by cognitive impairment has been reported. While the impact of HPA function on declarative memory (DM), working memory (WM), and executive function (EF) has received increased attention in aging research, its role in T2D remains largely unexplored. This study compared diurnal cortisol patterns and cognitive performance between 51 patients with T2D treated with oral antidiabetic medications, injectable therapies, or a combination of both, and 51 healthy controls matched for age, sex, educational level and, body mass index. Participants completed a battery of neuropsychological tests and the Beck Depression Inventory (BDI-II). Additionally, they provided four saliva samples per day across two weekdays to assess the cortisol awakening response (CAR) and the diurnal cortisol slope (DCS). Group comparisons (T2D vs. controls) and moderation analyses were conducted to assess group differences and the associations between cortisol indices and cognitive performance, with group or depression included as moderators. T2D patients showed poorer performance than healthy controls, particularly on DM and WM, but no significant differences in CAR or DCS. In controls, a higher CAR was related to lower Stroop interference, although no significant relationships were found in T2D patients. Across the entire sample, CAR was negatively associated with Stroop interference at low and moderate depression levels, while DCS was positively associated with RAVLT delayed recall at low levels of depression. Our results indicate that medically treated T2D patients show poorer cognitive performance than healthy controls; however, cortisol does not seem to contribute to these cognitive deficits. These findings add to the limited literature on the impact of the HPA on cognitive function in T2D older adults, and they encourage future studies to delve into the mechanisms that could influence cognitive performance in this population, as well the relevance of depression in these cognitive deficits.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107718"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morning cortisol levels and quality of social interactions across the transition to school predict the development of children’s anxious and depressive symptoms in first grade","authors":"Maggy Leblond ,&nbsp;Sophie Parent ,&nbsp;Natalie Castellanos-Ryan ,&nbsp;Sonia J. Lupien ,&nbsp;Catherine M. Herba ,&nbsp;William D. Fraser ,&nbsp;Jean R. Séguin","doi":"10.1016/j.psyneuen.2025.107721","DOIUrl":"10.1016/j.psyneuen.2025.107721","url":null,"abstract":"<div><div>Previous studies spanning the transition from preschool to school (kindergarten) revealed individual differences in children’s stress response, measured by cortisol concentrations. However, whether these represented adaptive cortisol concentration patterns or a risk factor for maladaptation remained unclear because very few studies examined functional correlates of cortisol changes, such as anxious or depressive symptoms. Furthermore, prior research has suggested that social interactions may play a significant role in this association since sensitive stress responses patterns might interact with unsupportive interactions to predict the development of mental health symptoms. For the current study, the pattern of morning cortisol concentration in children was described over 6 time-points before, during and after kindergarten entry. The first objective was to examine the associations between this pattern and the development of anxious or depressive symptoms 18 months later (first grade). The second objective was to examine whether children’s quality of social interactions (i.e., family relational health or peer problems) interacted with these same patterns to predict anxious and depressive symptoms. For this longitudinal study, children and their parents (N = 379) were recruited from the 3D pregnancy study and followed from preschool to first grade. Piecewise latent growth curve models showed that while morning cortisol concentrations increased at a similar rate for all children over the first two weeks of school, children differed from one another in their levels at school entry. During the post-entry period, morning cortisol concentrations showed a U-shaped curve: a decrease during the first two months followed by an increase for the next three to five months. Main and moderation effects suggest that a hypoactivation of the stress response system (i.e., low cortisol levels at school entry or steeper post-entry decrease) during the school transition may be a risk factor for maladaptation in children as it was associated with later increasing anxious and depressive symptoms, especially under specific social environmental conditions. Children exhibiting such hypoactive cortisol patterns appear to be more vulnerable to lower-quality social environment, whether with family or peers, supporting the diathesis-stress model. Results also highlight the potentially protective function of high-quality social interactions in the development of anxious and depressive symptoms for those with hypoactive stress response system.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107721"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersectionality, social stress, and biological embedding: Toward intersectional psychoneuroendocrinology","authors":"Stephanie H. Cook ,&nbsp;Aura A. Mishra","doi":"10.1016/j.psyneuen.2025.107739","DOIUrl":"10.1016/j.psyneuen.2025.107739","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107739"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of glucose administration on stress reactivity and long-term memory in adult men and women","authors":"Maria Meier ,&nbsp;Christian J. Merz ,&nbsp;Tobias Rüttgens ,&nbsp;Oliver T. Wolf ,&nbsp;Jens C. Pruessner","doi":"10.1016/j.psyneuen.2025.107741","DOIUrl":"10.1016/j.psyneuen.2025.107741","url":null,"abstract":"<div><div>Stress and the associated cortisol release have profound effects on long-term memory (LTM). While glucose increases the cortisol stress response and exhibits memory enhancing effects in non-stressful situations, the interaction of glucose and stress on LTM has rarely been studied. The aim of this study was to investigate whether the glucose-related amplification of the cortisol stress response would enhance LTM formation. Overall, <em>N</em> = 62 healthy, fasted adults (age <em>M</em> = 23.13, <em>SD</em> = 3.02; 54.84 % female) participated. They consumed a drink containing water or glucose and underwent a non-stressful control task or the Trier Social Stress Test with Objects, during which panel members interact with certain objects (central) while leaving others untouched (peripheral). At the estimated cortisol peak, they encoded a wordlist. On the next day, they retrieved the objects and the words. We repeatedly assessed subjective stress, salivary cortisol and blood glucose concentrations and recorded an electrocardiogram. Glucose increased blood glucose concentrations, and the stressor led to a significant increase in cortisol as compared with the control task. Changes in cortisol were more pronounced in the glucose as compared with the water groups. Heart rate was elevated in the glucose as compared with the water groups during the recovery. Central objects were better remembered than peripheral objects when encoded during stress. Additionally, emotional words were remembered better as compared with neutral words. These effects were not modulated by glucose. These findings suggest that emotional information is remembered better than neutral information independent of stress and glucose intake. Stress enhances LTM of stressor-relevant information and glucose intake increases the cortisol stress response. However, these factors do not appear to interact. Glucose availability may thus play a less decisive role when memorizing a stressful episode.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"185 ","pages":"Article 107741"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological and immunological benefits of eye movement desensitization and reprocessing in hashimoto thyroiditis: Preliminary findings from a randomized controlled trial","authors":"Maria-Magdalena Macarenco ,&nbsp;Cristian Opariuc-Dan ,&nbsp;Teodora Georgescu ,&nbsp;Livia Căciuloiu","doi":"10.1016/j.psyneuen.2025.107695","DOIUrl":"10.1016/j.psyneuen.2025.107695","url":null,"abstract":"<div><h3>Objective</h3><div>This study examined the effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) in improving psychological functioning and modulating immune markers in adults with Hashimoto’s thyroiditis (HT), a chronic autoimmune disorder increasingly linked to early trauma.</div></div><div><h3>Method</h3><div>In a randomized controlled trial, 91 adults with HT were assigned to EMDR plus treatment-as-usual (TAU), placebo plus TAU, or TAU alone. The EMDR protocol focused on processing ten distressing memories predating illness onset. Outcomes included anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) levels, and measures of depression, anxiety, stress, dissociation, alexithymia, trait anger, emotion regulation, and quality of life, assessed at baseline, posttreatment, and 3-month follow-up.</div></div><div><h3>Results</h3><div>EMDR led to significant improvements in dissociation, alexithymia, depression, anxiety, stress, trait anger, and emotion regulation, along with enhanced quality of life. These effects were maintained at follow-up and generally exceeded those of placebo or TAU. A significant reduction in anti-TPO levels was also observed in the EMDR group, although between-group effects at follow-up did not remain significant after correction for multiple comparisons. No significant differences were found in anti-TG levels.</div></div><div><h3>Conclusion</h3><div>EMDR may offer a clinically relevant adjunctive intervention for individuals with HT, reducing psychological distress and potentially influencing immune activity. Findings on immunomodulation are preliminary and warrant further investigation in larger trials.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107695"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrimination and allostatic load in black middle-aged and older adults: A systematic review and meta-analysis","authors":"Alaa Harb ,&nbsp;Juliana Souza-Talarico ,&nbsp;Peter B. Abad ,&nbsp;Karen Lawrence ,&nbsp;Jihye Lee ,&nbsp;Ana W. Capuano ,&nbsp;Lisa L. Barnes ,&nbsp;Jennifer Deberg","doi":"10.1016/j.psyneuen.2025.107714","DOIUrl":"10.1016/j.psyneuen.2025.107714","url":null,"abstract":"<div><h3>Background</h3><div>Perceived discrimination has been associated with elevated allostatic load (AL), but findings among Black middle-aged and older adults are inconsistent. A focused synthesis is lacking, limiting understanding of how discrimination becomes biologically embedded. This systematic review and meta-analysis aim to clarify the discrimination and AL relationship in Black individuals during aging and highlight key methodological and contextual factors.</div></div><div><h3>Methods</h3><div>A systematic search of seven databases following PRISMA guidelines included studies on discrimination and AL in Black adults aged 40 and older. AL measures were multisystem indexes of stress-related biomarkers. Study quality was assessed using ROBINS-E, and a random-effects meta-analysis estimated the overall effect size.</div></div><div><h3>Results</h3><div>Five studies met the inclusion criteria. Four reported significant associations between discrimination, particularly everyday or adolescent exposure, and higher AL. One study found a negative association moderated by coping mechanisms, while another revealed a significant interaction with hopefulness. Meta-analysis of four studies showed a small, non-significant pooled effect (Hedges’s g = 0.132; 95 % CI: −0.338–0.602; p = 0.582) with high heterogeneity (I² = 94.24 %). Stronger associations appeared in studies using broader biomarker panels and more recent discrimination measures.</div></div><div><h3>Conclusions</h3><div>This study highlights an inconsistent and heterogeneous relationship between discrimination and AL in Black middle-aged and older adults. While evidence suggests a general link, findings remain mixed due to methodological variability. The meta-analysis found no significant pooled effect, reflecting limited and diverse studies. Future research should prioritize longitudinal designs, standardized measures, and consideration of coping and resilience factors.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107714"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High sensitivity C-reactive protein in response to acute stress in healthy men and women","authors":"A-K. Lennartsson ,&nbsp;I.H. Jonsdottir","doi":"10.1016/j.psyneuen.2025.107689","DOIUrl":"10.1016/j.psyneuen.2025.107689","url":null,"abstract":"<div><h3>Background</h3><div>Psychosocial stress has been suggested to contribute to low-grade inflammation, which in turn can, if persisting, increase the risk of developing a wide range of chronic disorders. The aim of this study was to investigate the level of CRP in response to acute psychosocial stress in healthy men and women, whether the responses related to general stress activation. Since it is known that CRP level in general is associated with BMI, we also aimed to investigate whether CRP response during acute stress is related to BMI and overweight.</div></div><div><h3>Method</h3><div>Thirty men and 19 women, aged 30—50 years (mean age 39 years, SD 5.6 years), were included in the study. The participants underwent the Trier Social Stress Test (TSST), and CRP was measured in serum together with measurements of general stress activation.</div></div><div><h3>Results</h3><div>CRP levels slightly and temporarily increased in response to acute psychosocial stress. CRP response was positively related to the response of ACTH and cortisol. The CRP response was also positively associated with BMI and the overweight individuals exhibited a larger stress-induced CRP increase.</div></div><div><h3>Conclusion</h3><div>The results support the idea that stress may contribute to low-grade inflammation, which in turn can constitute one important pathogenic link between stress and adverse health, especially in overweight individuals.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"184 ","pages":"Article 107689"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}