Psychoneuroendocrinology最新文献

{"title":"Corrigendum to “Transgenerational transmission of prenatal maternal stress across three generations of male progeny alters inflammatory stress markers in reproductive tissues” [Psychoneuroendocrinology 177 (2025) 107451]","authors":"Nayara A. Lopes , Mirela Ambeskovic , Stephanie E. King , Jamshid Faraji , Nasrin Soltanpour , Wendy Xu , Xin Fang , Gerlinde A.S. Metz , David M. Olson","doi":"10.1016/j.psyneuen.2025.107465","DOIUrl":"10.1016/j.psyneuen.2025.107465","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107465"},"PeriodicalIF":3.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the best sampling region for endocrine hair analysis? A comparison between the posterior vertex and occipital region and recommendation for standardization","authors":"Katharina Huthsteiner ,&nbsp;Johannes B. Finke ,&nbsp;Eva M.J. Peters ,&nbsp;Kristian Kleinke ,&nbsp;Tim Klucken ,&nbsp;Tobias Stalder","doi":"10.1016/j.psyneuen.2025.107457","DOIUrl":"10.1016/j.psyneuen.2025.107457","url":null,"abstract":"<div><h3>Background</h3><div>Hair analysis is increasingly used to index long-term cumulative hormone levels. However, it remains unclear from which scalp region hair should be sampled to yield best results. Here, we conduct an in-depth, systematic investigation into this question, comparing quality characteristics between the two most promising sampling areas, the posterior vertex and the occipital region. To advance standardization in future research, we specify anatomical landmarks to clearly define sampling regions.</div></div><div><h3>Methods</h3><div>Participants (<em>N</em> = 53) provided a total of twelve hair samples across two time points, three months apart. At each time point, six hair samples (three from each region) were analyzed for concentrations of cortisol, cortisone, progesterone, dehydroepiandrosterone and endocannabinoids (AEA, 1/2-AG, OEA, SEA, PEA) via liquid chromatography-tandem mass spectrometry. Patterns of intra-region variability, mean differences, test-retest correlations and associations with external criteria (anthropometrics and perceived stress) were compared between regions.</div></div><div><h3>Results</h3><div>Overall, no consistent differences were found between the posterior vertex and occipital region with regard to intra-region variability, test-retest correlations and external associations. However, significant mean differences in analyte concentrations were observed: hair cortisol and cortisone were higher in the occipital region, while OEA, SEA and PEA were higher at the posterior vertex.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the importance of sampling from a defined scalp region for endocrine hair analyses. While neither scalp region was unequivocally superior, differences in mean concentrations call for increased standardization of methodological practice in future research. We propose anatomical landmarks for precise region localization and offer practical recommendations concerning the choice of sampling region.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107457"},"PeriodicalIF":3.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose intake reduces alcohol craving and amplifies habituation to cue-induced brain activation in male patients with alcohol use disorder: A randomized, placebo-controlled crossover study examining male and female patients with AUD","authors":"Lea Wetzel ,&nbsp;Sabine Hoffmann ,&nbsp;Iris Reinhard ,&nbsp;Alisa Riegler ,&nbsp;Madeleine Pourbaix ,&nbsp;Isabel Ardern ,&nbsp;Tobias Link ,&nbsp;Sabine Vollstädt-Klein ,&nbsp;Bernd Lenz ,&nbsp;Falk Kiefer ,&nbsp;Patrick Bach ,&nbsp;Anne Koopmann","doi":"10.1016/j.psyneuen.2025.107456","DOIUrl":"10.1016/j.psyneuen.2025.107456","url":null,"abstract":"<div><h3>Introduction</h3><div>Evidence suggests a role of appetite-regulating hormones in alcohol use disorder. Reductions in acylated ghrelin levels are associated with reductions in craving and cue-induced brain activity. Ghrelin levels can be physiologically decreased by glucose intake, which therefore could be a treatment reducing craving and cue-induced brain activity in patients with alcohol use disorder, potentially mediated by acylated ghrelin.</div></div><div><h3>Material and methods</h3><div>80 males and females with alcohol use disorder participated in the randomized placebo-controlled crossover study, examining glucose intake as acute treatment to reduce craving. Changes in craving and ghrelin levels were assessed at eight time points. Of these, 43 participants attended fMRI measurements examining habituation to cue-induced brain activation over time. Craving and hormone levels over time were analyzed using linear mixed modeling, brain activation habituation over time using flexible factorial models.</div></div><div><h3>Results</h3><div>Models revealed a significant interaction effect (F(1,474.607)= 13.563, p &lt; .001) between sex and treatment on craving, with lower craving values in males (difference in means=-.540, p = .016, 95 %CI: −.976, −.103) and higher craving in females (difference in means=.815, p = .005, 95 %CI:.243, 1.387) in the glucose compared to the placebo condition. In males, we found a significant effect of treatment (F(1,313.602)= 7.811, p = .006) and a trend, but no significant effect of acylated ghrelin (F(1,301.568)= 3.574, p = .060) on craving as well as greater habituation to cue-induced brain activation after glucose compared to placebo intake in right putamen (T(1,35)= 4.77, p = .019). Individual habituation slopes significantly predicted the difference in craving before and after the alcohol task (F(2,36)= 5.234, p = .010; B= -36.018, p = .027) in males.</div></div><div><h3>Conclusions</h3><div>Glucose intake could be a short-term treatment for males with alcohol use disorder to reduce alcohol craving and cue-induced brain activation. Sex-specific differences should be considered to gain a better understanding of the underlying mechanisms and develop treatment options for females.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107456"},"PeriodicalIF":3.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental stress induction in children and adolescents with the Trier Social Stress Test (TSST): A systematic review and meta-analysis","authors":"Saskia Seel ,&nbsp;Bernhard Pastötter ,&nbsp;Gregor Domes","doi":"10.1016/j.psyneuen.2025.107454","DOIUrl":"10.1016/j.psyneuen.2025.107454","url":null,"abstract":"<div><div>The Trier Social Stress Test (TSST) and its variations for children and adolescents are among the most frequently used laboratory stressors. A previous meta-analysis revealed moderate but robust psychobiological stress responses in children and adolescents. Here, we focused on non-clinical samples and performed both a systematic review as well as a meta-analysis for the following: (a) to provide an overview of study characteristics in children and adolescents, (b) to update the overview of the reported effect sizes, and (c) to identify established and new potential moderators. Reviewing 143 studies, we identified three major variants in practical use: the TSST-C, the TSST-M, and the original TSST. Although the studies were inconsistent in reporting methodological characteristics, the variants did not differ in exclusion criteria, main procedures (administration and preparation time, duration), and composition of the panel. Based on the 92 studies (N = 8291 participants) included in the meta-analysis, we identified an overall publication bias-corrected effect on salivary cortisol stress responses of <em>Hedge’s g</em> = 0.56, p &lt; .0001. Moderation analysis revealed the proportion of girls, number of judges, and total duration of the stress test as significant moderators, all positive. Explorative analysis showed that higher baseline cortisol levels predicted lower baseline-peak reactivity. Overall, variations of the TSST for children and adolescents are suitable for inducing acute psychobiological stress responses in these samples. To promote open and reproducible (meta) science, raising the reporting standards for methods and results in future studies is desirable.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107454"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen receptor alpha (ERα) partially modulates ketamine's sustained anxiolytic effects without altering its antidepressant properties in female rats","authors":"Ece Idil,&nbsp;Bahar Yuksel,&nbsp;Zeynep Sen,&nbsp;Gunes Unal","doi":"10.1016/j.psyneuen.2025.107455","DOIUrl":"10.1016/j.psyneuen.2025.107455","url":null,"abstract":"<div><div>Ketamine is a rapid-acting antidepressant with sexually dimorphic effects. Female animals exhibit a higher sensitivity to its antidepressant properties, which has been associated with their ovarian hormone levels. One factor contributing to this sex difference is the faster rate of ketamine metabolism observed in females, potentially regulated by estrogen receptor alpha (ERα) through modulation of enzymatic activity. In this study, we explored the role of ERα in mediating the therapeutic effects of ketamine in adult female Wistar rats. To inhibit ERα, we administered its antagonist, methyl-piperidino-pyrazole (MPP; 1 mg/kg, IP), 24 h and 1 h prior to a single antidepressant dose of ketamine (10 mg/kg, IP) or saline (vehicle). We tested the animals in the forced swim test (FST), open field test (OFT), elevated plus maze (EPM), and auditory fear conditioning. Ketamine administration ameliorated behavioral despair observed in the vehicle group, and ERα antagonism did not affect this outcome. An interaction between MPP and ketamine was observed in anxiety-like behaviors assessed in the OFT and EPM; however, this effect did not reach significance in post-hoc analyses. Neither MPP nor ketamine affected fear memory, as measured in cued fear conditioning. These findings suggest that the sexually dimorphic antidepressant effects of ketamine occur independently of ERα activity, although ERα may influence neural circuits related to anxiety.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107455"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered circadian pattern of activity in a chronic activity-based anorexia nervosa-like female mouse model deficient for GHSR","authors":"Julia Mattioni ,&nbsp;Philibert Duriez ,&nbsp;Sana Aïdat ,&nbsp;Nicolas Lebrun ,&nbsp;Mohammad Bohlooly-Y ,&nbsp;Philip Gorwood ,&nbsp;Odile Viltart ,&nbsp;Virginie Tolle","doi":"10.1016/j.psyneuen.2025.107453","DOIUrl":"10.1016/j.psyneuen.2025.107453","url":null,"abstract":"<div><div>Anorexia Nervosa (AN) is a psychiatric disorder characterized by voluntary food restriction, resulting in severe undernutrition that has been associated with circadian rhythms alterations. Yet, mechanisms that link circadian rhythm shifts to abnormal eating regulation in AN are poorly understood. Plasma ghrelin concentrations, an orexigenic hormone secreted by the stomach and acting through the GHSR (Growth Hormone Secretagogue Receptor), is elevated in restrictive-type AN. We aimed to test the hypothesis that GHSR signaling contributes to altered circadian pattern observed in AN. For this purpose, we first assessed whether chronotypes (morning, intermediate or evening) were different in patients with AN, bulimia nervosa and healthy controls. We next recorded the pattern of physical activity in young female GHSR deleted (<em>Ghsr-/-</em>) and wild-type (<em>Ghsr+/+</em>) mice housed in cages equipped with running wheels and exposed to quantitative food restriction, mimicking AN metabolic status. We demonstrated that chronotypes were different in the three groups of subjects, a difference mainly driven by an excess of morning chronotype in patients with AN. In mice, the shift toward higher daytime and pre-prandial physical activity and lower night-time and post-prandial physical activity, induced by food restriction, was impaired in <em>Ghsr-/-</em> mice, suggesting a lack of capacity to adapt patterns of circadian activity to chronic food restriction. These data suggest an interaction between altered circadian pattern and AN and indicate that GHSR signaling deficiency may play a critical role in adapting circadian patterns of activity to the undernutrition state in this disorder.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107453"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum scarcity-adversity increases adverse caregiving in the absence of basal corticosterone elevation","authors":"Abishag Porras,&nbsp;Jeffy Jackson,&nbsp;Christine H. Nguyen,&nbsp;Millie Rincón-Cortés","doi":"10.1016/j.psyneuen.2025.107452","DOIUrl":"10.1016/j.psyneuen.2025.107452","url":null,"abstract":"<div><div>Maternal behavior is disturbed by exposure to environmental adversity, including resource scarcity, which can impair maternal care and increase adverse caregiving behaviors like abuse and maltreatment. In rats, exposure to resource scarcity disrupts mother-infant interactions and results in adverse pup-directed maternal behaviors. These changes in maternal behavior are thought to be due to hyperactivity within the hypothalamic-pituitary-adrenal (HPA)-axis, which mediates the stress response. In accordance, upregulation of HPA-axis function is sufficient to drive changes in maternal behavior in rodents. Based on these data, we hypothesized that scarcity-adversity induced changes in maternal behavior would be associated with HPA-axis hyperactivity, as indexed by elevated basal levels of the stress hormone corticosterone (CORT) in rat dams. To test this, we employed a scarcity-adversity paradigm based on creating an impoverished cage environment during postpartum days (PD) 2–9 and examined effects on naturalistic maternal behaviors and basal fecal boli CORT levels (PD 3, PD 5, PD 7) or basal and stress-induced serum CORT levels (PD 9). Surprisingly, rat dams exposed to scarcity-adversity exhibited increases in adverse pup-directed behaviors (e.g., stepping, dragging, shoving) but no elevations in basal or stress-induced CORT levels at any of the time-points assessed. These findings suggest that scarcity-adversity can increase adverse caregiving in a CORT-independent manner. Thus, increases in basal CORT levels are not necessary to induce aberrant maternal behavior in the scarcity-adversity paradigm.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107452"},"PeriodicalIF":3.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgenerational transmission of prenatal maternal stress across three generations of male progeny alters inflammatory stress markers in reproductive tissues","authors":"Nayara A. Lopes ,&nbsp;Mirela Ambeskovic ,&nbsp;Stephanie E. King ,&nbsp;Jamshid Faraji ,&nbsp;Nasrin Soltanpour ,&nbsp;Wendy Xu ,&nbsp;Xin Fang ,&nbsp;Gerlinde A.S. Metz ,&nbsp;David M. Olson","doi":"10.1016/j.psyneuen.2025.107451","DOIUrl":"10.1016/j.psyneuen.2025.107451","url":null,"abstract":"<div><div>Prenatal maternal stress may lead to adverse pregnancy outcomes such as preterm birth and low birth weight. Our team has demonstrated in multiple rat models that prenatal maternal stress modifies the expression of inflammatory and stress regulators in the uterus and that this is transgenerationally passed over multiple generations through the female progeny. In this study, we investigated if male progeny exposed to ancestral prenatal maternal stress could also transmit changes to cause fetal programming of reproductive organs, leading to adverse pregnancy outcomes. We created a paternal transgenerational prenatal stress rat model. Dams (F0) were exposed to chronic variable stress during pregnancy, and their F1 male offspring stressed <em>in utero</em> were bred with control females for two generations. Gestational lengths and litter sizes were unchanged. Elevated gene expression of pro-inflammatory molecules in the uteri of F2 and F3 offspring was observed. Uterine expression of stress markers in the F2 and F3 females also increased even though plasma corticosterone levels were unchanged. Changes in the testicular expression of inflammatory and stress markers were also transmitted through the paternal lineage. These changes, however, tended to bear anti-inflammatory and adaptive functions, indicating compensatory mechanisms at play. These results demonstrate that fetal programming of uterine and testicular gene expression patterns can be transmitted through male progeny exposed to prenatal maternal stress.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107451"},"PeriodicalIF":3.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Share-the-load vs bring-your-own-judge: The effects of friends on social evaluative stress in early adolescence” [Psychoneuroendocrinology 172 (2025) 107254]","authors":"Clarissa R. Filetti,&nbsp;Nikola Tsakonas,&nbsp;Bonny Donzella,&nbsp;Kathleen M. Thomas,&nbsp;Megan R. Gunnar","doi":"10.1016/j.psyneuen.2025.107446","DOIUrl":"10.1016/j.psyneuen.2025.107446","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107446"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and biological pathways between metabolic syndrome and incident Parkinson’s disease: A prospective cohort study of 289,150 participants","authors":"HuiMin Liu ,&nbsp;Tao Peng ,&nbsp;YuDi Xu ,&nbsp;QingSheng Li ,&nbsp;LingFei Yang ,&nbsp;Zhe Gong ,&nbsp;JunFang Teng ,&nbsp;Qiang Zhang ,&nbsp;YanJie Jia","doi":"10.1016/j.psyneuen.2025.107444","DOIUrl":"10.1016/j.psyneuen.2025.107444","url":null,"abstract":"<div><div>The relationship between metabolic syndrome (MetS) and Parkinson’s disease (PD) remains uncertain due to inconsistent findings in previous studies. This prospective cohort study investigated the association between MetS and PD risk, along with potential biological mechanisms, using data from 289,150 PD-free participants in the UK Biobank. MetS was defined by the presence of at least three of the following components, while preMetS included one or two: increased waist circumference, elevated triglycerides (TG), high blood pressure (BP), elevated HbA1c, or reduced high-density lipoprotein cholesterol (HDL-C). Cox proportional hazards models were utilized to assess the risk of PD, and mediation analyses explored the role of blood biomarkers. Over a median follow-up of 13.1 years, 1682 participants developed PD. PreMetS (HR: 1.24, 95 % CI: 1.02–1.51, <em>P</em> = 0.028) and MetS (HR: 1.32, 95 % CI: 1.08–1.61, <em>P</em> = 0.008) were associated with an increased PD risk, with Kaplan-Meier analysis showing risk escalation with more MetS components. Among individual MetS components, increased waist circumference, elevated HbA1c, and reduced HDL-C were significantly associated with higher PD risk, while elevated TG and BP showed no significant association. Mediation analysis indicated that biomarkers of liver function (alkaline phosphatase) and kidney function (cystatin C) partially mediated the MetS-PD relationship. These findings highlight a significant link between MetS and higher PD risk, with possible mediation through specific blood biomarkers, though temporal ambiguity warrants cautious interpretation.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107444"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}