Psychoneuroendocrinology最新文献

{"title":"Changes in affect variability after starting gender-affirming hormone therapy","authors":"Margot W.L. Morssinkhof ,&nbsp;Marijn Schipper ,&nbsp;Baudewijntje P.C. Kreukels ,&nbsp;Karin van der Tuuk ,&nbsp;Martin den Heijer ,&nbsp;Odile A. van den Heuvel ,&nbsp;David Matthew Doyle ,&nbsp;Birit F.P. Broekman","doi":"10.1016/j.psyneuen.2025.107408","DOIUrl":"10.1016/j.psyneuen.2025.107408","url":null,"abstract":"<div><div>Negative affect variability is determined by how often and how strongly negative affect changes over time. Cisgender women report greater variability in affect than cisgender men. It has been suggested that sex hormone changes may influence affect variability. Transgender people frequently opt to use sex hormones in the form of gender-affirming hormone therapy (GAHT), but the extent to which GAHT can change negative affect variability is not yet clear. Therefore, this study aims to study changes in negative affect variability after starting GAHT.</div><div>We have included data from 92 participants from the RESTED study: 47 persons starting masculinizing hormones (MH), i.e. testosterone, and 45 persons starting feminizing hormones (FH), i.e., estrogens and anti-androgens. Participants completed up to 7 consecutive daily diaries at each of three time points: before starting GAHT, and after 3 and 12 months of GAHT. The daily diaries collected participants’ reports on symptoms related to negative affect: experienced low mood, less interest, tense feelings and restless feelings. We have used linear mixed models to compare negative affect variability during one week, corrected for mean negative affect, between groups (MH versus FH) and measurement time points.</div><div>Results show that in the MH group, variability in tense feelings and restless feelings decreased after 3 and 12 months of GAHT, respectively. In the FH group, variability in low mood increased after 3 months and 12 months of GAHT, as did variability in restless feelings after 12 months of GAHT. Group comparisons indicate significant group differences in changes in variability in low mood and restless feelings, with stronger increases in variability of negative affect in the FH group compared to MH group after 3 and 12 months of GAHT.</div><div>Our findings indicate that variability patterns in negative affect in transgender persons change after starting GAHT, with participants who start masculinizing hormones moving to a profile which more closely resembles that of cisgender men and participants who start feminizing hormones moving to a profile which more closely resembles that of cisgender women. Future studies should focus on measuring both negative and positive affect variability during GAHT, preferably through multiple measurements per day, taking into account diverse social and daily contextual factors during GAHT.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107408"},"PeriodicalIF":3.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forgiveness in the HPA axis: The roles of cumulative genetic effects and cortisol reactivity in trait and situational forgiveness","authors":"Qi Lan ,&nbsp;Yuting Yang ,&nbsp;Yao Xiao ,&nbsp;Min Yang ,&nbsp;Mengying Xue ,&nbsp;Yafang Yang ,&nbsp;XiaoHan Li ,&nbsp;Chunlan Wang ,&nbsp;Wenping Zhao ,&nbsp;Pingyuan Gong","doi":"10.1016/j.psyneuen.2025.107407","DOIUrl":"10.1016/j.psyneuen.2025.107407","url":null,"abstract":"<div><div>Trait and situational forgiveness are vital coping mechanisms and stress responses in the face of interpersonal transgressions. The hypothalamic-pituitary-adrenal (HPA) axis plays a key role in regulating these strategies in response to such transgressions. Building on this foundation, Study 1 examined the impact of cumulative genetic effects of the HPA axis (i.e., a weighted measure of genetic predisposition, calculated by combining the relative contributions of multiple genetic polymorphisms and the number of protective alleles associated with positive psychological traits) on trait forgiveness (<em>N</em> = 852). Study 2 investigated the relationship between these genetic effects, cortisol reactivity, and forgiveness responses following romantic partner conflict (<em>N</em> = 200). Results from Study 1 revealed that higher cumulative genetic scores were associated with stronger trait forgiveness. Study 2 showed that individuals with the higher cumulative genetic scores exhibited more forgiveness responses toward their partners after conflict. Moreover, participants who experienced stronger negative emotions and greater cortisol reactivity were more likely to exhibit forgiveness responses toward their partners. These findings highlight the biological mechanisms underlying forgiveness, emphasizing how genetic and physiological factors of the HPA axis shape adaptive interpersonal coping strategies.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107407"},"PeriodicalIF":3.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily rumination and diurnal cortisol patterns in Latino adolescents: The moderating role of sex","authors":"Kevin Trent ,&nbsp;Michaela S. Gusman ,&nbsp;Skyler H. Mendes ,&nbsp;Leah D. Doane","doi":"10.1016/j.psyneuen.2025.107389","DOIUrl":"10.1016/j.psyneuen.2025.107389","url":null,"abstract":"<div><div>Latinos make up the fastest-growing ethnic minority group in the United States and are at higher risk for the development of internalizing symptoms in adolescence than other ethnic groups. Rumination has been identified as a transdiagnostic risk factor associated with several internalizing disorders such as depression, anxiety, and comorbidities of the two. Indicators of risk for chronic stress and internalizing disorders can also be observed from the hypothalamic-pituitary-adrenal (HPA) axis (e.g., diurnal cortisol slopes [DCS]; cortisol awakening responses [CAR]). Notably, no studies have examined within-group heterogeneity in the association between rumination and the DCS in Latino populations, and literature on the relation between rumination and the CAR is mixed. Leveraging self-reported rumination and gold-standard salivary cortisol collection procedures, the current study elucidated associations between daily rumination and diurnal cortisol in an adolescent Latino sample (<em>N</em> = 209) and examined sex as a potential moderator of this association. Results indicated a significant, small association between night-before rumination on problems/stress and next-day DCS; on days where participants ruminated more than usual regarding their problems/stress, they experienced, on average, a flatter DCS the following day. Sex differences were detected in the effects of same-day rumination and the CAR, such that greater rumination on feelings was associated with a smaller CAR the same day, but only for males. Findings inform future research regarding potential bidirectional relations of daily rumination and the CAR, as well as how different foci of rumination may have differential associations with physiological stress systems of males and females.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107389"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the dissociative subtype of PTSD: The role of early-life trauma, cortisol, and inflammatory profiles","authors":"Dana A. Jarkas ,&nbsp;Rebecca Robillard ,&nbsp;Claude-Richard Malenfant ,&nbsp;Carley Richards ,&nbsp;Malika Lanthier ,&nbsp;Cecile Beaurepaire ,&nbsp;Andrew A. Nicholson ,&nbsp;Natalia Jaworska ,&nbsp;Clifford M. Cassidy ,&nbsp;Jakov Shlik ,&nbsp;Zachary Kaminsky ,&nbsp;Robyn J. McQuaid","doi":"10.1016/j.psyneuen.2025.107406","DOIUrl":"10.1016/j.psyneuen.2025.107406","url":null,"abstract":"<div><div>Post-traumatic stress disorder (PTSD) is a heterogeneous mental health condition, characterized by diverse symptom profiles and biological underpinnings. A dissociative subtype of PTSD has been identified, though the potential risk factors and underlying neurobiology are yet to be understood. The current study comprised Canadian Armed Forces (CAF) members and Veterans with a history of deployment, and with diagnoses of non-dissociative (<em>n</em> = 31) and dissociative subtypes of PTSD (<em>n</em> = 19), in addition to non-deployed healthy controls (<em>n</em> = 14). Participants completed questionnaires assessing clinical symptoms and experiences of trauma, and provided saliva and blood samples for cortisol and inflammatory marker assessments. Individuals with dissociative PTSD displayed elevated PTSD and depression symptom severity, and greater reports of specific forms of childhood trauma compared to individuals with non-dissociative PTSD and controls. Morning cortisol was elevated in both PTSD groups compared to controls, however the PTSD groups did not differ from one another. Evening cortisol concentrations were elevated in both PTSD groups compared to controls, and in the dissociative PTSD subtype compared to the non-dissociative PTSD subtype when controlling for depression symptoms. PTSD diagnostic group moderated the relationship between awakening cortisol levels and PTSD symptom severity, such that the non-dissociative PTSD group displayed a negative correlation between awakening cortisol levels and PTSD symptom severity, while no significant relation was identified in the dissociative PTSD group. C-reactive protein (CRP) levels did not differ across diagnostic groups when accounting for body mass index (BMI). However, CRP positively correlated with depressive symptoms only among individuals with dissociative PTSD. Together, examining PTSD subtypes may help inform more effective and personalized treatment strategies in the future.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107406"},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower levels of positive affect and insomnia are associated with elevated allostatic load among Ukrainian refugees","authors":"Julian Maciaszek,&nbsp;Julia Alejnikowa,&nbsp;Agnieszka Dybek,&nbsp;Marta Błoch,&nbsp;Błażej Misiak","doi":"10.1016/j.psyneuen.2025.107387","DOIUrl":"10.1016/j.psyneuen.2025.107387","url":null,"abstract":"<div><div>To date, several biological alterations associated with the refugee status have been investigated. However, none of them has focused on the allostatic load (AL) index that is a collective measure of biological responses to stress. Therefore, the present study aimed to assess the AL index and its correlates in 60 Ukrainian refugees who migrated to Poland after the Russian invasion. The AL index was measured in 60 Ukrainian refugees and 50 controls matched for age and sex. It was based on sex-specific distributions of 15 biomarkers (cardiovascular markers, anthropometric measures, inflammatory markers, glucose homeostasis parameters, lipids, and steroids). Psychopathological symptoms and behavioral characteristics were assessed using self-reports. Refugees had significantly higher AL index together with higher scores of insomnia, negative affect, depressive and anxiety symptoms, avoidance and hyperarousal symptoms of post-traumatic stress disorder as well as lower levels of positive affect. Similarly, a lifetime exposure to traumatic stressors was significantly higher among Ukrainian refugees. Linear regression analyses demonstrated that lower levels of positive affect (interactive effects with the refugee status but not main associations) and higher levels of insomnia (interactive effects with the refugee status and main associations) were associated with elevated AL index after adjustment for age, education, cigarette smoking status, somatic disease, medication use, and head trauma history. In summary, the findings indicate systemic dysregulations of biological stress responses in Ukrainian refugees that are attributable to higher levels of insomnia and lower levels of positive affect in this population.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107387"},"PeriodicalIF":3.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol” [Psychoneuroendocrinology (2025) 107358]","authors":"Pablo Martino ,&nbsp;Mario Perez-Alarcón ,&nbsp;Luna Deconinck ,&nbsp;Rudi De Raedt ,&nbsp;Marie-Anne Vanderhasselt ,&nbsp;Malgorzata W. Kozusznik ,&nbsp;Frank Kooy ,&nbsp;Vanesa Hidalgo ,&nbsp;César Venero ,&nbsp;Alicia Salvador ,&nbsp;Chris Baeken ,&nbsp;Matias M. Pulopulos","doi":"10.1016/j.psyneuen.2025.107404","DOIUrl":"10.1016/j.psyneuen.2025.107404","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"174 ","pages":"Article 107404"},"PeriodicalIF":3.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory biomarkers and childhood maltreatment: A cluster analysis in patients with eating disorders","authors":"Cristiano Dani ,&nbsp;Livio Tarchi ,&nbsp;Eleonora Rossi ,&nbsp;Emanuele Cassioli ,&nbsp;Francesco Rotella ,&nbsp;Alessandra Fanelli ,&nbsp;Benedetta Salvadori ,&nbsp;Roberta Mannino ,&nbsp;Gian Maria Rossolini ,&nbsp;Stefano Lucarelli ,&nbsp;Valdo Ricca ,&nbsp;Giovanni Castellini","doi":"10.1016/j.psyneuen.2025.107405","DOIUrl":"10.1016/j.psyneuen.2025.107405","url":null,"abstract":"<div><div>Eating Disorders (EDs) are severe psychiatric disorders, with growing evidence pointing towards the role of childhood maltreatment (CM) influencing their onset, severity, and response to treatment. Preliminary evidence showed that CM could be associated with an elevation of inflammatory biomarkers across the different EDs. The objective of the study was to elucidate the interplay between CM, ED-specific psychopathology, and inflammatory biomarkers. The study involved 198 female participants, comprising 70 patients with anorexia nervosa (AN), 56 patients with bulimia nervosa (BN), and 72 healthy controls (HCs). K-means clustering was used to assess the hypothesis that latent clusters could be described between patients affected by EDs based on serum levels of inflammatory biomarkers alone (CRP, IL-6, suPAR). Additionally, the analysis included a comparison between patients with and without history of childhood maltreatment. Patients with AN exhibited significantly higher suPAR levels than HCs, regardless of the severity of psychopathology. A direct association between CM and elevated levels of inflammatory biomarkers, particularly CRP, IL-6, and suPAR were found. Cluster analysis identified two distinct populations among patients with EDs, with the group showing elevated inflammatory biomarkers likely to report more severe CM. Even though preliminary, the results of the present study support the existence of a biologically grounded “maltreated eco-phenotype” in EDs. The present study also reports results on CRP, IL-6 and suPAR, in patients with EDs. These findings might suggest future potential tailored treatments and interventions designed to target specific subgroups of patients, and potentially improving treatment efficacy.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"174 ","pages":"Article 107405"},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study","authors":"Nicole Creasey ,&nbsp;Isabel Schuurmans ,&nbsp;Stella Tsotsi ,&nbsp;Serena Defina ,&nbsp;Vilte Baltramonaityte ,&nbsp;Janine F. Felix ,&nbsp;Alexander Neumann ,&nbsp;Christian M. Page ,&nbsp;Marieke Tollenaar ,&nbsp;Mona Bekkhus ,&nbsp;Esther Walton ,&nbsp;Charlotte Cecil","doi":"10.1016/j.psyneuen.2025.107388","DOIUrl":"10.1016/j.psyneuen.2025.107388","url":null,"abstract":"<div><h3>Background</h3><div>Recent work suggests that DNA methylation can be used as a proxy of fetal glucocorticoid exposure (MPS-GC), showing associations with maternal psychopathology during pregnancy. However, it is unknown whether the MPS-GC may act as a marker for broader prenatal stress and whether it partially mediates associations of prenatal stress with child internalizing and externalizing symptoms.</div></div><div><h3>Methods</h3><div>Using harmonized data from three prospective birth cohorts (N_pooled = 6086), we examined whether a cumulative measure of prenatal stress, and its individual stress domains, associate with the MPS-GC in cord blood at birth. Next, we examined (i) whether the MPS-GC at birth associates with child psychiatric symptoms, (ii) whether this association is moderated by postnatal stress, and (iii) whether the effect of prenatal stress on child psychiatric symptoms is partially mediated by the MPS-GC at birth.</div></div><div><h3>Results</h3><div>Our meta-analysis revealed no significant associations between the MPS-GC at birth and prenatal stress or the individual stress domains. Moreover, the MPS-GC did not significantly associate with later child internalizing or externalizing symptoms, and there were no moderating effects of postnatal stress. Additionally, while prenatal stress significantly associated with child psychiatric symptoms, we found no partial mediation via the MPS-GC at birth.</div></div><div><h3>Conclusions</h3><div>We did not find support that the MPS-GC in cord blood reliably proxies prenatal stress, associates with child psychiatric risk, or partially mediates the associations between prenatal stress and psychiatric risk.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107388"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement: 2025 call for Bruce McEwen lifetime achievement nominations","authors":"","doi":"10.1016/j.psyneuen.2025.107403","DOIUrl":"10.1016/j.psyneuen.2025.107403","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"174 ","pages":"Article 107403"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISPNE New Orleans 2025 September 3–5, 2025 Call for symposia submissions","authors":"","doi":"10.1016/j.psyneuen.2025.107400","DOIUrl":"10.1016/j.psyneuen.2025.107400","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"174 ","pages":"Article 107400"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}