Psychoneuroendocrinology最新文献

{"title":"Biomarker profiles of sleep disturbance in adolescence: Results from the National Health and Nutrition Examination Survey 2015–2020","authors":"Jason T. Carbone ,&nbsp;Melynda D. Casement","doi":"10.1016/j.psyneuen.2025.107532","DOIUrl":"10.1016/j.psyneuen.2025.107532","url":null,"abstract":"<div><h3>Objectives</h3><div>Sleep problems are common in adolescence and may be associated with biological dysregulation and related disease risk. This research evaluates profiles of biological dysregulation and their associations with sleep disturbance in a representative sample of United States adolescents.</div></div><div><h3>Methods</h3><div>Biomarker and sleep data were extracted for 16–24-year-olds (N = 2697 weighted to represent 37,292,324) from the 2015–2020 National Health and Nutrition Examination Survey (NHANES). Sex-stratified, bias-adjusted, latent profile analyses were used to identify biomarker profiles and predict multidimensional sleep disturbance and individual sleep outcomes based on profile membership, controlling for sociodemographic characteristics. For comparison, multivariate logistic regression models were also estimated using traditional cumulative scores of dichotomous biomarkers.</div></div><div><h3>Results</h3><div>Three biomarker profiles were identified in both females and males. For females, immuno-metabolic dysregulation was associated with 52 % greater odds of multidimensional sleep disturbance and 5 times greater odds of snoring compared to the low dysregulation group. For males, moderate immuno-metabolic dysregulation was associated with 33 % greater odds of multidimensional sleep disturbance and 3.7 times greater odds of snoring, while high immuno-metabolic dysregulation was associated with 56 % greater odds of multidimensional sleep disturbance, 2.5 times greater odds of snoring, and 2.2 times greater odds of short or long sleep duration.</div></div><div><h3>Conclusions</h3><div>Distinct biomarker profiles can be observed in adolescents. Profiles of high immuno-metabolic dysregulation are associated with multidimensional sleep disturbance and snoring in both sexes, and with short or long sleep duration in males. Longitudinal studies could help evaluate mechanistic relationships between sleep disturbance, biomarker profiles, and disease risk in adolescents.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107532"},"PeriodicalIF":3.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The complex role of oxytocin in fear acquisition and generalization” [Psychoneuroendocrinology 176 (2025), 107421]","authors":"Juntong Liu ,&nbsp;Juan Kou ,&nbsp;Lisha Tan ,&nbsp;Hong Li ,&nbsp;Yi Lei","doi":"10.1016/j.psyneuen.2025.107529","DOIUrl":"10.1016/j.psyneuen.2025.107529","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107529"},"PeriodicalIF":3.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between alexithymia and hypothalamus-pituitary-adrenal axis activity in response to a psychosocial stress in women with eating disorders","authors":"Giammarco Cascino ,&nbsp;Marco Carfagno ,&nbsp;Rossella Ceres ,&nbsp;Eugenia Barone ,&nbsp;Lorenzo Landolfi ,&nbsp;Chiara del Giorno ,&nbsp;Palmiero Monteleone ,&nbsp;Alessio Maria Monteleone","doi":"10.1016/j.psyneuen.2025.107531","DOIUrl":"10.1016/j.psyneuen.2025.107531","url":null,"abstract":"<div><div>Alexithymia is a personality trait that has been defined as a difficulty in identifying, describing, and expressing one’s emotions. Individuals with eating disorders (EDs) exhibit higher prevalence of alexithymia than general population. A prolonged exposure to stress related to alexithymia could affect the functioning of the hypothalamus-pituitary-adrenal (HPA) axis. The aim of this study was to assess the reactivity of HPA axis to the Trier Social Stress Test (TSST) by measuring the cortisol response in women with EDs according to their levels of alexithymia. Eighty-nine women with EDs and 40 healthy women participated into an experimental study. Alexithymia was evaluated by the Toronto Alexithymia Scale-20. Salivary cortisol levels were measured to assess the HPA axis reactivity to TSST. Women with EDs and high levels of alexithymia showed higher salivary cortisol compared to women with EDs and low alexithymia levels and healthy controls, but reduced change in cortisol over time, evaluated by AUCi, compared to healthy controls. In conclusion, our study results show that women with EDs and high levels of alexithymia exhibited higher basal activity and an impaired sensitivity of the HPA axis in response to TSST compared to women with EDs and low levels of alexithymia and healthy women.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107531"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosting oxytocin in postpartum depression: Intranasal oxytocin enhances maternal positive affect and regard for the infant","authors":"Madelon M.E. Riem ,&nbsp;Lisa Loheide-Niesmann ,&nbsp;Roseriet Beijers ,&nbsp;Indira Tendolkar ,&nbsp;Peter C. Mulders","doi":"10.1016/j.psyneuen.2025.107530","DOIUrl":"10.1016/j.psyneuen.2025.107530","url":null,"abstract":"<div><div>Although oxytocin has been recognized for its affiliative and anxiolytic properties, dysregulation of this system may contribute to the link between depressed mood and insensitive maternal care in mothers with postpartum depression (PPD). This double-blind, randomized, within-subject control study investigated the effects of intranasal oxytocin on caregiving behaviors, mood and physiology in mothers with (subclinical) PPD. The study included 45 mothers with 3- to 9-month-old infants who exhibited clinically relevant scores on the Edinburgh Postnatal Depression Scale, with 35 mothers even fulfilling the criteria of a major depressive episode assessed with the SCID-5. We assessed oxytocin’s effects on maternal sensitivity, positive regard toward the infant, self-reported positive and negative mood, and physiological responses, including salivary cortisol, heart rate, and heart rate variability during mother-infant interactions. We found that oxytocin significantly increased maternal positive regard for the child and self-reported positive affect. No effects on maternal sensitivity, negative mood, or physiological responses were found. Our findings suggest that oxytocin may enhance positive maternal emotions in PPD. Future research should explore oxytocin’s therapeutic potential in larger, more diverse populations, considering individual differences such as PPD severity or childhood trauma.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107530"},"PeriodicalIF":3.4,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between brain-gut peptides and depression: A systematic review and meta-analysis","authors":"Yong Wang ,&nbsp;Ying Sun ,&nbsp;Hongxiu Zhang ,&nbsp;Ke Ma","doi":"10.1016/j.psyneuen.2025.107526","DOIUrl":"10.1016/j.psyneuen.2025.107526","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background and objectives&lt;/h3&gt;&lt;div&gt;Depression is a chronic mental disorder that has emerged as one of the most prevalent global public health concerns, with its incidence increasing annually. Brain-gut peptides, various gastrointestinal (GI) hormones secreted by the central nervous system, enteric nervous system, and GI tract, have been demonstrated by numerous studies to play a pivotal role in the pathophysiology of depression. This systematic review and meta-analysis was undertaken to examine the association between brain-gut peptide concentrations and depressive disorders.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;A comprehensive search was conducted across the CNKI, WanFang Database, VIP, PubMed, Embase, Cochrane Library, and Web of Science databases for observational studies investigating the relationship between brain-gut peptide levels and depression. Included studies comprised cross-sectional investigations with clearly defined data collection time points, case-control studies with comparable demographic characteristics across groups, and cohort studies in which participants were initially free of depression and followed longitudinally. Studies were excluded if they were duplicates, non-Chinese/English publications, lacked outcome data or accessible full texts, involved secondary depression (e.g., postpartum, post-stroke), included comorbid depression with other conditions, or did not report extractable corrected effect sizes. The search was limited to articles published up to November 2024. Odds ratios and corresponding 95 % confidence intervals were used to assess risk relationships. Heterogeneity was evaluated using the Q test. When using the fixed effects model, there was statistical homogeneity between studies (P &gt; 0.10, I² &lt; 50 %). Conversely, a random-effects model was utilized in the presence of significant heterogeneity (&lt;em&gt;P&lt;/em&gt; &lt; 0.10, I² &gt; 50 %), with further exploration of potential sources of heterogeneity. Sensitivity analysis was conducted by sequential exclusion of individual studies to evaluate the robustness of the results and to determine whether any single study disproportionately influenced the overall effect size.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 4870 studies were identified, of which 44 met inclusion criteria and were incorporated into the final analysis (inter-rater agreement for the study selection, κ = 0.82; inter-rater agreement for data extraction, ICC=0.91, κ=0.89) involving 4557 participants were included. The meta-analysis revealed that serum levels of substance P (SP), cholecystokinin (CCK), and ghrelin were elevated in the depression group compared to controls. Both the bipolar and unipolar depression subgroups exhibited significantly higher serum SP levels relative to controls. Moreover, no significant differences in serum leptin (LEP) levels were observed between the depression and control groups, nor between male and female subgroups among depressed and no","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107526"},"PeriodicalIF":3.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between cardiac vagal activity and urinary catecholamine: Investigating the effect of race and sex","authors":"Li Shen Chong ,&nbsp;Betty Lin ,&nbsp;Elana B. Gordis ,&nbsp;DeWayne P. Williams ,&nbsp;Julian F. Thayer","doi":"10.1016/j.psyneuen.2025.107527","DOIUrl":"10.1016/j.psyneuen.2025.107527","url":null,"abstract":"<div><div>Black individuals are at greater risk for the development of cardiovascular diseases compared to White individuals. Autonomic nervous system (ANS) dysregulation has been identified as a significant risk factor contributing to racial disparities in cardiovascular disease, yet systematic racial differences that affect the measurement of ANS activity among White and Black participants are likely obscuring understanding about ANS-health disparity links. Moreover, sex differences in ANS activity have been observed. Thus, efforts to elucidate the comparability of ANS indices across race and sex are needed. This study aimed to investigate the effects of race and sex on the associations between two indices of ANS activity—cardiac vagal activity and urinary catecholamines—in a sample of White and Black participants from the MIDUS 2: Biomarker Project (N = 967 adults aged 34 – 84; 81 % White, 57 % female). Participants self-reported their sociodemographic and health information and completed biomarker assessments. Cardiac vagal activity was assessed via heart rate (HR) and heart rate variability (HRV); urinary catecholamines were assessed via epinephrine and norepinephrine. Black participants displayed higher HRV activity and lower levels of urinary catecholamines relative to White participants. Moreover, our results revealed small but significant correlations between urinary catecholamines and cardiac vagal activity across both races, though the nature of these relations varied across race, sex, and ANS index. The correlations between HR and epinephrine and norepinephrine were stronger among Black male participants compared to White male participants. Our results highlight the importance of clarifying the functional equivalence of different ANS indices across race and sex.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107527"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body movements as biomarkers: Machine Learning-based prediction of HPA axis reactivity to stress","authors":"Luca Abel ,&nbsp;Robert Richer ,&nbsp;Felicitas Burkhardt ,&nbsp;Miriam Kurz ,&nbsp;Veronika Ringgold ,&nbsp;Lena Schindler-Gmelch ,&nbsp;Bjoern M. Eskofier ,&nbsp;Nicolas Rohleder","doi":"10.1016/j.psyneuen.2025.107528","DOIUrl":"10.1016/j.psyneuen.2025.107528","url":null,"abstract":"<div><div>Body movements and posture provide valuable insights into stress responses, yet their relationship with endocrine biomarkers of the stress response remains underexplored. This study investigates whether movement patterns during the Trier Social Stress Test (TSST) and the friendly-TSST (f-TSST) can predict cortisol reactivity. Using motion capturing, movement data from 41 participants were analyzed alongside salivary cortisol responses. Machine learning models achieved a classification accuracy of 65.2 % for distinguishing cortisol responders from non-responders and a regression mean absolute error of 2.94 nmol/l for predicting cortisol increase. Findings suggest that movement dynamics can serve as proxies of endocrine stress responses, contributing to objective, non-invasive stress assessment methods.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107528"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone and emotion expression shape social interactions in defection-cooperation conflicts","authors":"Renhui Fang ,&nbsp;Wenbin Pan ,&nbsp;Mei Li ,&nbsp;Zhihao Zhao ,&nbsp;Kaiqiong Yuan ,&nbsp;Ran Zhou ,&nbsp;Benjamin Becker ,&nbsp;Hong Li","doi":"10.1016/j.psyneuen.2025.107525","DOIUrl":"10.1016/j.psyneuen.2025.107525","url":null,"abstract":"<div><div>Emotions and hormones such as testosterone crucially shape social interactions, including cooperation. However, whether testosterone regulates the impact of emotional expressions in defection versus cooperation conflicts remains elusive. The present study determined the effects of single-dose testosterone administration on cooperative behavior and emotional expression in the prisoner’s dilemma game (PDG). Sixty-one healthy young males received either a 125 mg dose of testosterone gel or placebo in a double-blind, placebo-controlled design and subsequently underwent a modified PDG paradigm including emotional expressions. Testosterone increased the likelihood to defect when facing defection, yet enhanced cooperation when both players cooperated. Notably, when exposed to negative emotions from their counterparts, testosterone-treated individuals reacted with a higher proportion of Emoji 4 (commonly conveying strong negative emotions). Findings underscore the crucial interaction between testosterone and emotional cues on social interactions and indicate a social context-specific role of testosterone.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107525"},"PeriodicalIF":3.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences and postoperative cognitive dysfunction: Unveiling biological mechanisms","authors":"Sandra Regina Santana Aguiar Bonfante ,&nbsp;Khiany Mathias ,&nbsp;Taise Petronilho ,&nbsp;Rodrigo Viana ,&nbsp;Richard Simon Machado ,&nbsp;Tatiana Barichello ,&nbsp;Fabricia Petronilho","doi":"10.1016/j.psyneuen.2025.107524","DOIUrl":"10.1016/j.psyneuen.2025.107524","url":null,"abstract":"<div><div>Postoperative cognitive dysfunction (POCD) is a common neurological complication following surgery, particularly in older patients, with significant impacts on recovery, quality of life, and societal burden. As the aging population undergoes more surgical procedures, understanding the multifactorial risks associated with POCD is increasingly critical. While factors such as age, education level, and preexisting cognitive conditions are established risks, the role of biological sex in POCD remains underexplored. Emerging evidence highlights distinct sex differences in brain morphology, hormonal regulation, and neuroinflammatory responses, which may alter susceptibility to POCD. For instance, estrogen has been shown to exert neuroprotective effects under stress, and women may present greater vulnerability to inflammation-driven brain atrophy. Additionally, male carriers of the APOE4 allele exhibit worse postoperative cognitive outcomes, while female carriers appear relatively protected. This review aims to explore the interaction between biological sex and neuroinflammatory processes in the development of POCD. By delving into these mechanisms, the review seeks to shed light on sex-based disparities in POCD incidence and progression, offering new insights into its pathogenesis. Understanding these differences is vital for developing targeted prevention and treatment strategies, ultimately improving outcomes for both male and female patients while alleviating the strain on healthcare systems.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107524"},"PeriodicalIF":3.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heightened risk: Childhood trauma and anticipatory grief exacerbate the impact of loneliness on depressive symptoms and LPS-stimulated cytokines in dementia caregivers","authors":"Kelly N. Brice ,&nbsp;Jensine Paoletti-Hatcher ,&nbsp;E. Lydia Wu-Chung ,&nbsp;Vincent D. Lai ,&nbsp;Daniel L. Argueta ,&nbsp;Michelle A. Chen ,&nbsp;Itee Mahant ,&nbsp;Bryan T. Denny ,&nbsp;Charles Green ,&nbsp;Luis D. Medina ,&nbsp;Paul Schulz ,&nbsp;Jennifer Stinson ,&nbsp;Samantha K. Henry ,&nbsp;Cobi Heijnen ,&nbsp;Christopher P. Fagundes","doi":"10.1016/j.psyneuen.2025.107523","DOIUrl":"10.1016/j.psyneuen.2025.107523","url":null,"abstract":"<div><div>Dementia spousal caregivers are at a disproportionate risk for adverse mental and physical health outcomes. Loneliness is associated with depressive symptoms and proinflammatory cytokine production among caregivers. Additionally, childhood trauma, anticipatory grief, and poor sleep quality are all associated with enhanced stress reactivity. This study used a cross-sectional design to investigate whether loneliness is associated with proinflammatory cytokine production and depressive symptoms in caregivers, and whether these relationships are strongest among caregivers who report high levels of childhood trauma, high amounts of anticipatory grief, or poor sleep quality. A sample of 111 dementia spousal caregivers provided blood samples and completed self-report measures of loneliness, childhood trauma, anticipatory grief, depression, and subjective sleep quality. We measured the ex vivo immune cell proinflammatory cytokine response to whole-blood LPS stimulation. Caregivers who reported greater loneliness exhibited elevated LPS-stimulated proinflammatory cytokine production and more depressive symptoms. The relationship between loneliness and proinflammatory cytokine production was stronger at higher levels of childhood trauma and higher levels of anticipatory grief. The association between loneliness and depressive symptoms was stronger at higher levels of childhood trauma and higher levels of anticipatory grief. These results suggest that loneliness could have more robust effects on adverse health outcomes for caregivers who have experienced more childhood trauma and anticipatory grief. This research contributes to the existing literature investigating the mechanisms that underlie individual differences in health outcomes among dementia spousal caregivers.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107523"},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}