Psychoneuroendocrinology最新文献

{"title":"Racism and hypothalamic-pituitary-adrenal axis functioning in childhood as risks for health disparities across the lifespan","authors":"Akira J. Isaac,&nbsp;Sara J. Bufferd,&nbsp;Yara Mekawi","doi":"10.1016/j.psyneuen.2025.107416","DOIUrl":"10.1016/j.psyneuen.2025.107416","url":null,"abstract":"<div><div>Racism is a primary social determinant of health and chronic stressor that affects the physical and mental health of People of Color and Indigenous Individuals (POCI) and perpetuates racial and ethnic health disparities. Despite the impact of racism on POCI, the mechanisms through which experiences of racism result in negative health outcomes remain understudied, in particular among children. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is one of the possible mechanisms. Frequent and prolonged exposure to chronic stressors may result in dysregulation of the HPA axis, and in turn cause adverse physical and psychological health outcomes for POCI children. This paper argues for the importance of examining HPA axis dysregulation as a mechanism that links racism during early childhood to negative health outcomes over the lifespan. Several studies have explored the relationship between racism and HPA axis dysregulation during adulthood and adolescence and have found associations between racism and salivary and hair cortisol. Recent studies have identified racial and ethnic differences in cortisol levels during early childhood, but only one study, to our knowledge, explored whether the differences are attributed to racism. In this paper, we conduct a review of the existing literature on the links between racism and HPA axis dysregulation during adulthood and adolescence given the dearth of studies exploring this relationship during early childhood. We also highlight the importance of utilizing an intersectionality framework in the study of racism and health to provide a more comprehensive and nuanced understanding of health disparities among and within racial/ethnic groups. Using this evidence along with consideration of relevant models, we propose how HPA axis dysregulation identified early in life may foreshadow children’s increased risk for negative health outcomes from racism and other systems of oppression and signal the need for prevention and intervention.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107416"},"PeriodicalIF":3.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of neighborhood contexts and family-level hair cortisol concentration within Mexican immigrant families","authors":"Shanting Chen ,&nbsp;Yongyong Xu ,&nbsp;Lester Sim ,&nbsp;Wen Wen ,&nbsp;Ka Ip ,&nbsp;Cherita Antonia Clendinen ,&nbsp;Su Yeong Kim","doi":"10.1016/j.psyneuen.2025.107426","DOIUrl":"10.1016/j.psyneuen.2025.107426","url":null,"abstract":"<div><div>Many Mexican American immigrant families live in socioeconomically disadvantaged neighborhoods, which are recognized as risk factors influencing residents’ stress. However, how neighborhood contexts can impact physiological stress at the family level, as indicated by hair cortisol concentration (HCC), particularly among Mexican immigrant family members remains unclear. Using a person-centered approach, the current study identified distinct patterns of family-level HCC and examined their associations with neighborhood contexts (i.e., Hispanic/immigrant concentration, socioeconomic disadvantage, affluence). Participants included 398 adolescents (56.5 % female, <em>M</em>_age = 13.26) and their mothers and fathers. Two profiles emerged and suggested that families living in neighborhoods with higher Hispanic/immigrant concentration and lower affluence were more likely to be in the <em>high family-level HCC</em> group compared to the <em>low family-level HCC</em> group. No group differences were found for neighborhood socioeconomic disadvantage. These results highlight the importance of including multiple family members (child and parents) to provide a more comprehensive understanding of how biological stress crossover within families. Our findings also emphasize the importance of integrating neighborhood contexts in shaping the physiological stress levels of Mexican American immigrant families.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107426"},"PeriodicalIF":3.4,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement: 2025 Call for Bruce McEwen Lifetime Achievement Nominations","authors":"","doi":"10.1016/j.psyneuen.2025.107425","DOIUrl":"10.1016/j.psyneuen.2025.107425","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107425"},"PeriodicalIF":3.4,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement: 55th annual meeting of the international society of psychoneuroendocrinology (ISPNE)","authors":"","doi":"10.1016/j.psyneuen.2025.107420","DOIUrl":"10.1016/j.psyneuen.2025.107420","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107420"},"PeriodicalIF":3.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement: 2025 Call for Dirk Hellhammer Award nominations","authors":"","doi":"10.1016/j.psyneuen.2025.107424","DOIUrl":"10.1016/j.psyneuen.2025.107424","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107424"},"PeriodicalIF":3.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISPNE New Orleans 2025 September 3–5, 2025 call for abstracts: Posters and data blitz","authors":"","doi":"10.1016/j.psyneuen.2025.107423","DOIUrl":"10.1016/j.psyneuen.2025.107423","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107423"},"PeriodicalIF":3.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143611644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The complex role of oxytocin in fear acquisition and generalization","authors":"Juntong Liu ,&nbsp;Juan Kou ,&nbsp;Lisha Tan ,&nbsp;Hong Li ,&nbsp;Yi Lei","doi":"10.1016/j.psyneuen.2025.107421","DOIUrl":"10.1016/j.psyneuen.2025.107421","url":null,"abstract":"<div><div>Fear is an adaptive response that protects individuals from potential threats, but when excessive, it can lead to mental health disorders such as generalized anxiety disorder. Oxytocin is a neuromodulator whose effects on fear processing have been explored, although research results are inconsistent. Previous research indicates that administering oxytocin before fear acquisition can enhance fear learning, while studies have suggested a potential for reducing fear generalization when oxytocin is given after fear acquisition. However, few studies have explored the interplay between oxytocin-induced enhanced fear learning and its drug impact on fear generalization afterwards. To investigate this interaction, a double-blind, placebo-controlled study was conducted where oxytocin was administered before fear acquisition to assess its influence on fear generalization during the drug's effect. A total of 54 healthy male participants were recruited, with 29 in the experimental group and 25 in the control group. Participants received intranasal oxytocin 30 minutes before the fear acquisition phase, with the generalization phase occurring 45 minutes after the intranasal oxytocin. Results revealed that oxytocin increased shock expectancy ratings for fear stimuli (compared with safe stimuli) during acquisition and elevated shock expectancy for generalization stimuli in the generalization phase. These findings suggested that oxytocin may increase vigilance towards safe stimuli and contribute to maladaptive generalization when intranasal oxytocin was administered prior to fear acquisition. This study provides new insights into the potential clinical applications of oxytocin for interaction effect of oxytocin-induced enhanced fear learning to both fear acquisition and fear generalization fear-related disorders.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107421"},"PeriodicalIF":3.4,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational perspectives of endocrine alterations in psychosis: Are we there yet?","authors":"Błażej Misiak,&nbsp;Javier Labad","doi":"10.1016/j.psyneuen.2025.107419","DOIUrl":"10.1016/j.psyneuen.2025.107419","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107419"},"PeriodicalIF":3.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen sulfide improves depression-like behaviors in CUMS-induced mice by regulating autophagy","authors":"Zhaoke Ling ,&nbsp;Qingqing Kong ,&nbsp;Zhiqiang He ,&nbsp;Xin Hao ,&nbsp;Ruiyao Liu ,&nbsp;Jie Liu ,&nbsp;Yushi Wang ,&nbsp;Jiao Liu ,&nbsp;Wenlong Du ,&nbsp;Yi Liu","doi":"10.1016/j.psyneuen.2025.107418","DOIUrl":"10.1016/j.psyneuen.2025.107418","url":null,"abstract":"<div><div>The pathogenesis of depression is associated with synaptic impairment and dysfunction in autophagy processes. Mendelian randomization (MR) analysis revealed that six GWAS IDs revealed a significant association between Beclin-1 levels and depression risk. Besides, all SNPs had a positive effect on depression risk. Analyzing neurons from depressed individuals using single-cell RNA sequencing (scRNA-seq) uncovered decreased expression of AKT, mTOR, and genes linked to synaptic plasticity. The activation of the PI3K/AKT/mTOR signaling has been demonstrated to control autophagy and have a protective effect on the nervous system. Hydrogen sulfide (H₂S) is an endogenous gasotransmitter that can potentially treat various neurological disorders by improving neuronal synaptic plasticity. However, whether H₂S regulates autophagy through PI3K/AKT/mTOR signaling, improves neuronal synaptic plasticity damage, and plays an antidepressant role is unclear. Our current research revealed that the reduction in the expression of p-PI3K, p-AKT, and p-mTOR proteins increase in neuronal autophagy activity and decline synaptic plasticity in mice with depression induced by chronic unpredictable mild stress (CUMS). Treatment with the exogenous hydrogen sulfide donor NaHS for one day and continuous treatment for one week improved the depression-like behaviors in the mice. Compared with those after one day of NaHS treatment, the above protein expression levels were restored and maintained, and the antidepressant effect was more significant after one week of continuous treatment with NaHS. Moreover, the PI3K inhibitor LY294002 was used to demonstrate that NaHS suppresses autophagy through activating the PI3K/AKT/mTOR signaling and ameliorates synaptic plasticity impairments. This study provides novel insights into the antidepressant mechanisms of H₂S, highlighting its antidepressant therapeutic potential.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107418"},"PeriodicalIF":3.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do not exclude your observations: Negative cortisol awakening responses (CAR) may be biologically relevant","authors":"Jose F. Herrera-Moreno ,&nbsp;Belem Trejo-Valdivia ,&nbsp;Maricruz Tolentino ,&nbsp;Robert O. Wright ,&nbsp;Andrea A. Baccarelli ,&nbsp;Rosalind J. Wright ,&nbsp;Megan M. Niedzwieck ,&nbsp;Martha M. Téllez-Rojo ,&nbsp;Marcela Tamayo-Ortiz","doi":"10.1016/j.psyneuen.2025.107417","DOIUrl":"10.1016/j.psyneuen.2025.107417","url":null,"abstract":"<div><div>The Cortisol Awakening Response (CAR) is the change in cortisol concentrations within 30–40 minutes after waking from sleep and is frequently used in stress research. Since a positive CAR is expected, we hypothesized that negative values could be associated to an underlying health condition (reflected in hematological parameters) or to environmental exposures such as lead (Pb), which has neuroendocrine effects including altered cortisol diurnal rhythms. Our aim was to analyze the prevalence of negative CAR values and their association with hematological parameters and blood Pb (BPb) levels in pregnant women (n = 900). Cortisol was measured by luminescence immunoassay in two-day saliva samples. CAR was estimated as the difference between the first (time of awakening) and second (45 min after) cortisol concentrations for each collection day and was operationalized as: both days positive (CAR-PP, 23 %), either day with a negative (CAR-NP/PN, 40 %), and both negative (CAR-NN, 37 %). A complete blood count was done using a coulter hematology analyzer. BPb was analyzed by inductively coupled plasma-mass spectrometry. Associations between hematological variables and CAR groups were analyzed using adjusted multinomial logistic regression models. Probabilities were estimated to assess the influence of BPb and hematological variables between CAR groups. The median (25th, 75th) CAR for the first collection day was −2.76 nmol/L (-16.55, 14.62) and −4.14 nmol/L (-17.66, 13.24) for the second day. Women with higher concentrations of leukocytes, eosinophils, basophils, and BPb were more likely to belong to CAR-NN or CAR-NP/PN groups. Compared to women with CAR-PP, those with CAR-NP/PN and CAR-NN had inverse associations for leukocyte levels and higher BPb concentrations. We conclude that negative CAR values could be an indicator of an underlying health condition or associated with environmental exposures such as Pb. Research should consider a thorough assessment of negative CAR values before excluding them from analyses.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"175 ","pages":"Article 107417"},"PeriodicalIF":3.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}