Psychoneuroendocrinology最新文献

{"title":"Linking childhood allostatic load, early adversity and the emergence of mental health symptoms in early adulthood: Analysis of the ALSPAC longitudinal birth cohort","authors":"Sabine Finlay ,&nbsp;Oyelola Adegboye ,&nbsp;Brett McDermott ,&nbsp;Donna Rudd ,&nbsp;Zoltán Sarnyai","doi":"10.1016/j.psyneuen.2024.107276","DOIUrl":"10.1016/j.psyneuen.2024.107276","url":null,"abstract":"<div><h3>Background</h3><div>It has been well-established that the allostatic load (AL) index, a cumulative score of multi-system dysregulation in response to chronic stress, is significantly increased at the time of a psychiatric diagnosis. However, no studies have investigated if there is an association between the AL index in childhood and the later development of mental health symptoms in young adults.</div></div><div><h3>Methods</h3><div>Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population cohort from Bristol, United Kingdom, we investigated the AL index at age 9 years and the risks for mental health symptoms at age 24 years. We used multinomial logistic regression analysis to investigate the association between AL threshold (categorised into bottom third: AL index ≤ 7, middle third: AL index = 7.1–9.9, and top third: AL index ≥ 10) and mental health symptoms while adjusting for sex, the age of mother at delivery, and social class. We used a relative risk ratio (RRR) and 95 % confidence interval(CI) for each variable. We further investigated the association between adverse childhood experiences (ACEs) and mental health symptoms.</div></div><div><h3>Results</h3><div>We identified a significant association between sex and mental health symptoms, with more females (59 % vs 41 %) showing mental health symptoms than males. We found no direct association between the AL index at age 9 and the later development of mental health symptoms. However, an RRR analysis showed that individuals in the middle and the top third of the AL index had an RRR of 1.99 and 2.20, respectively, to develop mental health symptoms if they were females. We found that individuals who experienced ACE had a much higher risk of developing mental health symptoms as young adults, with the adjusted RRR of 5.39 (95 % CI: 3.00;9.67), 6.79 (95 % CI: 2.55; 18.1), and 2.10 (95 % CI: 0.37;11.8) for neglect, physical and sexual abuse, respectively, in individuals with mood disorder symptoms. The adjusted RRR for neglect and physical and sexual abuse in individuals with psychotic symptoms was 0.99 (95 % CI: 0.37; 2.59), 2.92 (95 % CI: 0.35; 24.4), and 10.5 (95 % CI: 0.99; 112), respectively.</div></div><div><h3>Conclusion</h3><div>Although the AL index in childhood was not directly associated with the later development of psychotic and mood disorder symptoms in this cohort, females in the higher tertiles of the AL index measured at 9 years of age had an elevated risk of mental health symptoms as young adults. In line with previous work, a strong association was identified between childhood adversity and mental health symptoms in young adulthood. These results highlight the importance of considering the impact of early stress on biological embedding and the later emergence of mental health problems, especially in females.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107276"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of peripheral and cerebral inflammatory markers with suicidal deaths in Indian population","authors":"Ruchika Kaushik ,&nbsp;Baibaswata Nayak ,&nbsp;Sujata Satapathy ,&nbsp;Deepak Ramkumar Bharti ,&nbsp;Shivam Pandey ,&nbsp;Chittaranjan Behera","doi":"10.1016/j.psyneuen.2024.107268","DOIUrl":"10.1016/j.psyneuen.2024.107268","url":null,"abstract":"<div><div>Globally, a suicide occurs every 43 seconds. In India, approximately 465 suicides took place daily in 2022, with a suicide rate of 12.4 per 100,000 population, exceeding the global rate of 9. This study aims to investigate differences in cytokine levels, including vascular endothelial growth factor (VEGF), between individuals who died by suicide and those who did not. Additionally, it aims to explore any pattern between plasma and cerebrospinal fluid (CSF) levels of these analytes. Concentrations of inflammatory cytokines, i.e., Interleukins: IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, Tumor Necrosis Factor-α and VEGF in plasma and CSF were analyzed among suicide death subjects (N = 6, cases) and non-suicidal death subjects (N = 59, controls). All analytes were quantified using a customized multiplex (9-plex) kit, with 50 µl of plasma and CSF in duplicates. Significantly higher levels of IL-6 (p &lt; 0.001) and IL-10 (p &lt; 0.05) were observed in the plasma of the suicidal group. However, no statistically significant changes were found in the rest of the analytes between the two groups. In CSF, only VEGF levels were significantly lower in the suicidal group (p &lt; 0.01). In cases, significant positive correlations were observed between plasma and CSF levels of IL-1β, IL-4, IL-6, and IL-10, whereas in controls, only IL-8 demonstrated a significant positive correlation, indicating a moderate relationship between these cytokines systemic and central concentrations. Dysregulation of inflammatory biomarkers appears to play a crucial role in the pathophysiology of suicide. We conclude that higher levels of IL-6 are present in the plasma of suicide completers compared to non-suicidal deceased individuals.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107268"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-derived appetite regulating hormones across the anorexia nervosa spectrum","authors":"Maged Muhammed ,&nbsp;Helen Burton-Murray ,&nbsp;Franziska Plessow ,&nbsp;Kendra R. Becker ,&nbsp;Lauren Breithaupt ,&nbsp;Meghan Lauze ,&nbsp;Meghan Slattery ,&nbsp;Hang Lee ,&nbsp;Jennifer J. Thomas ,&nbsp;Kamryn T. Eddy ,&nbsp;Elizabeth A. Lawson ,&nbsp;Madhusmita Misra","doi":"10.1016/j.psyneuen.2024.107257","DOIUrl":"10.1016/j.psyneuen.2024.107257","url":null,"abstract":"<div><h3>Background</h3><div>Appetite-regulating hormones are implicated in anorexia nervosa (AN) pathophysiology, however, data are limited for appetite-regulating hormones across the AN weight spectrum. We aimed to investigate fasting and post-prandial concentrations of appetite-regulating hormones — peptide YY (PYY), cholecystokinin (CCK), and ghrelin — among adolescent and young adult females across the AN weight spectrum, specifically those with AN and Atypical AN, and healthy controls (HC).</div></div><div><h3>Methods</h3><div>Participants (<em>N</em> = 95; ages 11–22 years) included 33 with AN, 25 with Atypical AN, and 37 HC. AN was differentiated from Atypical AN by BMI &lt; 10th percentile for age and sex (if &lt;18 years) or &lt; 18.5 kg/m²(if ≥18 years). Blood samples were collected fasting and 30, 60 and 120 minutes following a standardized meal to assess total PYY, CCK, and total ghrelin concentrations.</div></div><div><h3>Results</h3><div>Median fasting and post-prandial PYY concentrations were significantly higher in AN vs. HC with medium differences (<em>p</em> = .001–.006, <em>r</em> = .34–.43). Atypical AN had significantly higher PYY concentrations compared to HC at T-0 (<em>p</em> = .027, <em>r</em> = .29) only, and did not significantly differ from concentrations in AN (<em>p</em> = .105–.413, <em>r</em> = .11–.22). Area under the curve (AUC; <em>p</em> = .001; <em>r</em> = .41) and peak PYY concentrations (<em>p</em> = .003; <em>r</em> = .41) were also significantly higher in AN vs. HC with medium differences. There were no significant differences in fasting (<em>p</em> = .885) or post-prandial (<em>p</em> = .846–.993) CCK concentrations across groups. AN and Atypical AN each had significantly higher ghrelin concentrations than HC with small to medium effect (AN vs HC <em>p</em> = .004–.025, <em>r</em> = .27–.36; Atypical AN vs HC <em>p</em> = .004–.033; <em>r</em> = .28–.28).</div></div><div><h3>Conclusions</h3><div>Higher peak postprandial concentrations of anorexigenic PYY in AN (compared to HC) may facilitate dietary restriction and contribute to maintenance of lower weight. Lack of CCK suppression in AN is maladaptive in the context of undernutrition. Despite continued restriction, ghrelin is adaptively higher in AN overall and may not be differentiated by weight status.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107257"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation 3: The moderating role of the child’s anxiety vulnerability on parent-child cortisol patterns","authors":"M. Arcand ,&nbsp;C. Raymond ,&nbsp;A. Bilodeau-Houle ,&nbsp;M-F. Marin","doi":"10.1016/j.psyneuen.2025.107311","DOIUrl":"10.1016/j.psyneuen.2025.107311","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107311"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation 2: Cortisol regulation in autistic youth: how a stress education program during the pandemic made a difference","authors":"S.-M. Fecteau","doi":"10.1016/j.psyneuen.2025.107303","DOIUrl":"10.1016/j.psyneuen.2025.107303","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107303"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation 2: Brain preparedness: cortisol awakening response proactively affects functional brain network organization in human emotion and cognition","authors":"S. Qin,&nbsp;X. Bingsen,&nbsp;Y. Zen","doi":"10.1016/j.psyneuen.2025.107296","DOIUrl":"10.1016/j.psyneuen.2025.107296","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107296"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Something's buzzing: Recent progress in point of care corticosteroid assessments","authors":"V. Kallen ,&nbsp;R. Montijn","doi":"10.1016/j.psyneuen.2025.107344","DOIUrl":"10.1016/j.psyneuen.2025.107344","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107344"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of hormonal contraceptive type in female intrasexual competition and jealousy","authors":"C. Burns,&nbsp;S. Jimenez-Delgado,&nbsp;A.C. Hahn","doi":"10.1016/j.psyneuen.2025.107353","DOIUrl":"10.1016/j.psyneuen.2025.107353","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107353"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural regulation of stress responses via the ventral subiculum and BNST","authors":"J. Spencer-Segal","doi":"10.1016/j.psyneuen.2025.107286","DOIUrl":"10.1016/j.psyneuen.2025.107286","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107286"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of gestational anxiety and depression with neonatal hair steroid levels","authors":"Arthur Chortatos ,&nbsp;Axel Davies Vittersø ,&nbsp;Lauri Uusitalo ,&nbsp;Marko Lehtonen ,&nbsp;Johanna Huotari ,&nbsp;Seppo Auriola ,&nbsp;Raimo Voutilainen ,&nbsp;Katri Backman ,&nbsp;Leea Keski-Nisula ,&nbsp;Soili M. Lehto","doi":"10.1016/j.psyneuen.2024.107260","DOIUrl":"10.1016/j.psyneuen.2024.107260","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association prenatal maternal depression and anxiety may have on the levels of neonatal hair steroids (i.e. cortisol, cortisone, and the cortisol/cortisone ratio) at birth.</div></div><div><h3>Methods</h3><div>Altogether, 271 mother-infant pairs derived from the Finnish Kuopio Birth Cohort Study were assessed for maternal depression and anxiety using the Edinburgh Postnatal Depression Scale (EPDS: EPDS-10 for depression, EPDS-3A for anxiety) during the first (T1) and third (T3) trimesters. The levels of cortisol and cortisone were determined from neonatal hair samples obtained at birth. Linear mixed models adjusted for sex, preterm birth, smoking during pregnancy, and gestational diabetes were used.</div></div><div><h3>Results</h3><div>Neither T1 nor T3 EPDS-10 predicted the levels of neonatal hair steroids. T3 EPDS-3A (p = 0.012), but not T1 EPDS-3A, was linked to reduced neonatal hair cortisol levels. Neither T1 nor T3 EPDS-3A were significant predictors of neonate cortisone levels or cortisol/cortisone ratios.</div></div><div><h3>Conclusion</h3><div>Prenatal maternal anxiety, but not depression, may lead to pronounced alterations in some markers of fetal stress systems. Future research should further determine whether prenatal maternal symptoms of anxiety would form an optimal intervention target in order to attenuate fetal stress responses.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107260"},"PeriodicalIF":3.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}