Psychoneuroendocrinology最新文献

{"title":"Estrogen receptor alpha (ERα) partially modulates ketamine's sustained anxiolytic effects without altering its antidepressant properties in female rats","authors":"Ece Idil,&nbsp;Bahar Yuksel,&nbsp;Zeynep Sen,&nbsp;Gunes Unal","doi":"10.1016/j.psyneuen.2025.107455","DOIUrl":"10.1016/j.psyneuen.2025.107455","url":null,"abstract":"<div><div>Ketamine is a rapid-acting antidepressant with sexually dimorphic effects. Female animals exhibit a higher sensitivity to its antidepressant properties, which has been associated with their ovarian hormone levels. One factor contributing to this sex difference is the faster rate of ketamine metabolism observed in females, potentially regulated by estrogen receptor alpha (ERα) through modulation of enzymatic activity. In this study, we explored the role of ERα in mediating the therapeutic effects of ketamine in adult female Wistar rats. To inhibit ERα, we administered its antagonist, methyl-piperidino-pyrazole (MPP; 1 mg/kg, IP), 24 h and 1 h prior to a single antidepressant dose of ketamine (10 mg/kg, IP) or saline (vehicle). We tested the animals in the forced swim test (FST), open field test (OFT), elevated plus maze (EPM), and auditory fear conditioning. Ketamine administration ameliorated behavioral despair observed in the vehicle group, and ERα antagonism did not affect this outcome. An interaction between MPP and ketamine was observed in anxiety-like behaviors assessed in the OFT and EPM; however, this effect did not reach significance in post-hoc analyses. Neither MPP nor ketamine affected fear memory, as measured in cued fear conditioning. These findings suggest that the sexually dimorphic antidepressant effects of ketamine occur independently of ERα activity, although ERα may influence neural circuits related to anxiety.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107455"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum scarcity-adversity increases adverse caregiving in the absence of basal corticosterone elevation","authors":"Abishag Porras,&nbsp;Jeffy Jackson,&nbsp;Christine H. Nguyen,&nbsp;Millie Rincón-Cortés","doi":"10.1016/j.psyneuen.2025.107452","DOIUrl":"10.1016/j.psyneuen.2025.107452","url":null,"abstract":"<div><div>Maternal behavior is disturbed by exposure to environmental adversity, including resource scarcity, which can impair maternal care and increase adverse caregiving behaviors like abuse and maltreatment. In rats, exposure to resource scarcity disrupts mother-infant interactions and results in adverse pup-directed maternal behaviors. These changes in maternal behavior are thought to be due to hyperactivity within the hypothalamic-pituitary-adrenal (HPA)-axis, which mediates the stress response. In accordance, upregulation of HPA-axis function is sufficient to drive changes in maternal behavior in rodents. Based on these data, we hypothesized that scarcity-adversity induced changes in maternal behavior would be associated with HPA-axis hyperactivity, as indexed by elevated basal levels of the stress hormone corticosterone (CORT) in rat dams. To test this, we employed a scarcity-adversity paradigm based on creating an impoverished cage environment during postpartum days (PD) 2–9 and examined effects on naturalistic maternal behaviors and basal fecal boli CORT levels (PD 3, PD 5, PD 7) or basal and stress-induced serum CORT levels (PD 9). Surprisingly, rat dams exposed to scarcity-adversity exhibited increases in adverse pup-directed behaviors (e.g., stepping, dragging, shoving) but no elevations in basal or stress-induced CORT levels at any of the time-points assessed. These findings suggest that scarcity-adversity can increase adverse caregiving in a CORT-independent manner. Thus, increases in basal CORT levels are not necessary to induce aberrant maternal behavior in the scarcity-adversity paradigm.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107452"},"PeriodicalIF":3.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgenerational transmission of prenatal maternal stress across three generations of male progeny alters inflammatory stress markers in reproductive tissues","authors":"Nayara A. Lopes ,&nbsp;Mirela Ambeskovic ,&nbsp;Stephanie E. King ,&nbsp;Jamshid Faraji ,&nbsp;Nasrin Soltanpour ,&nbsp;Wendy Xu ,&nbsp;Xin Fang ,&nbsp;Gerlinde A.S. Metz ,&nbsp;David M. Olson","doi":"10.1016/j.psyneuen.2025.107451","DOIUrl":"10.1016/j.psyneuen.2025.107451","url":null,"abstract":"<div><div>Prenatal maternal stress may lead to adverse pregnancy outcomes such as preterm birth and low birth weight. Our team has demonstrated in multiple rat models that prenatal maternal stress modifies the expression of inflammatory and stress regulators in the uterus and that this is transgenerationally passed over multiple generations through the female progeny. In this study, we investigated if male progeny exposed to ancestral prenatal maternal stress could also transmit changes to cause fetal programming of reproductive organs, leading to adverse pregnancy outcomes. We created a paternal transgenerational prenatal stress rat model. Dams (F0) were exposed to chronic variable stress during pregnancy, and their F1 male offspring stressed <em>in utero</em> were bred with control females for two generations. Gestational lengths and litter sizes were unchanged. Elevated gene expression of pro-inflammatory molecules in the uteri of F2 and F3 offspring was observed. Uterine expression of stress markers in the F2 and F3 females also increased even though plasma corticosterone levels were unchanged. Changes in the testicular expression of inflammatory and stress markers were also transmitted through the paternal lineage. These changes, however, tended to bear anti-inflammatory and adaptive functions, indicating compensatory mechanisms at play. These results demonstrate that fetal programming of uterine and testicular gene expression patterns can be transmitted through male progeny exposed to prenatal maternal stress.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107451"},"PeriodicalIF":3.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Share-the-load vs bring-your-own-judge: The effects of friends on social evaluative stress in early adolescence” [Psychoneuroendocrinology 172 (2025) 107254]","authors":"Clarissa R. Filetti,&nbsp;Nikola Tsakonas,&nbsp;Bonny Donzella,&nbsp;Kathleen M. Thomas,&nbsp;Megan R. Gunnar","doi":"10.1016/j.psyneuen.2025.107446","DOIUrl":"10.1016/j.psyneuen.2025.107446","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107446"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and biological pathways between metabolic syndrome and incident Parkinson’s disease: A prospective cohort study of 289,150 participants","authors":"HuiMin Liu ,&nbsp;Tao Peng ,&nbsp;YuDi Xu ,&nbsp;QingSheng Li ,&nbsp;LingFei Yang ,&nbsp;Zhe Gong ,&nbsp;JunFang Teng ,&nbsp;Qiang Zhang ,&nbsp;YanJie Jia","doi":"10.1016/j.psyneuen.2025.107444","DOIUrl":"10.1016/j.psyneuen.2025.107444","url":null,"abstract":"<div><div>The relationship between metabolic syndrome (MetS) and Parkinson’s disease (PD) remains uncertain due to inconsistent findings in previous studies. This prospective cohort study investigated the association between MetS and PD risk, along with potential biological mechanisms, using data from 289,150 PD-free participants in the UK Biobank. MetS was defined by the presence of at least three of the following components, while preMetS included one or two: increased waist circumference, elevated triglycerides (TG), high blood pressure (BP), elevated HbA1c, or reduced high-density lipoprotein cholesterol (HDL-C). Cox proportional hazards models were utilized to assess the risk of PD, and mediation analyses explored the role of blood biomarkers. Over a median follow-up of 13.1 years, 1682 participants developed PD. PreMetS (HR: 1.24, 95 % CI: 1.02–1.51, <em>P</em> = 0.028) and MetS (HR: 1.32, 95 % CI: 1.08–1.61, <em>P</em> = 0.008) were associated with an increased PD risk, with Kaplan-Meier analysis showing risk escalation with more MetS components. Among individual MetS components, increased waist circumference, elevated HbA1c, and reduced HDL-C were significantly associated with higher PD risk, while elevated TG and BP showed no significant association. Mediation analysis indicated that biomarkers of liver function (alkaline phosphatase) and kidney function (cystatin C) partially mediated the MetS-PD relationship. These findings highlight a significant link between MetS and higher PD risk, with possible mediation through specific blood biomarkers, though temporal ambiguity warrants cautious interpretation.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107444"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal allostatic load in pregnancy is prospectively associated with child adiposity and metabolic function across infancy and early childhood.","authors":"LE Gyllenhammer ,&nbsp;JM Rasmussen ,&nbsp;KL Lindsay ,&nbsp;W-P Chen ,&nbsp;D Gillen ,&nbsp;KE Boyle ,&nbsp;C Buss ,&nbsp;S Entringer ,&nbsp;PD Wadhwa","doi":"10.1016/j.psyneuen.2025.107450","DOIUrl":"10.1016/j.psyneuen.2025.107450","url":null,"abstract":"<div><h3>Background</h3><div>Empirical evidence suggests that the origins of obesity and metabolic dysfunction can be traced to stress-related exposures in prenatal life. The aim of the present study was to examine the prospective association of a composite, multi-system measure of maternal biological stress in pregnancy -- allostatic load (AL) -- with offspring adiposity and insulin resistance across infancy and early childhood.</div></div><div><h3>Methods</h3><div>In N = 55 mother-child dyads, maternal allostatic load was operationalized as a latent variable representing the following components: pre-pregnancy BMI, cortisol, interleukin-6, C-reactive protein, homeostasis model assessment of insulin resistance (HOMA-IR), free fatty acids, and systolic/diastolic blood pressure. Offspring percent total (%FM) and abdominal (%AbFM) fat were quantified with dual-energy X-ray absorptiometry at birth (newborn), 6-mo, and ∼5 yrs age, and HOMA-IR was quantified at ∼5 yrs age. Generalized estimating equation modeling was used to estimate effects of maternal AL on serial (repeated) measures of child adiposity, and linear regression was used to estimate effects on child HOMA-IR. <em>A priori</em> model covariates included maternal race and ethnicity, socioeconomic status, infant feeding practices, child age, and sex.</div></div><div><h3>Results</h3><div>Maternal AL was positively associated with child %FM and %AbFM before as well as after adjustment for key maternal and offspring covariates (%FM: adjusted β=0.38, p = 0.0074; %AbFM: adjusted β=0.37, p = 0.0013). Maternal AL also was positively associated with child insulin resistance (adjusted β= 0.011, p = 0.0324).</div></div><div><h3>Conclusion</h3><div>Our findings suggest that exposure to a higher biological stress milieu during prenatal development predisposes towards elevated early life adiposity and insulin resistance in early childhood, a proximate cause of type 2 diabetes and cardiometabolic disease. Collectively, these results provide evidence that a multi-systems approach to quantify early life exposures is useful in prospectively predicting variation in childhood adiposity and metabolic function.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107450"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin impairs wound-healing during social isolation but not social living","authors":"Emma Hammond,&nbsp;Patrick Monari,&nbsp;Lila Kilponen,&nbsp;Yiru Chen,&nbsp;Anthony Auger,&nbsp;Catherine Marler","doi":"10.1016/j.psyneuen.2025.107445","DOIUrl":"10.1016/j.psyneuen.2025.107445","url":null,"abstract":"<div><div>Social isolation hampers immune system function, and the biological mechanisms driving this effect remain understudied. We hypothesized that oxytocin (OT), a key neuropeptide involved in social cognition, is a critical mediator of social context on immune function. In the California mouse (<em>Peromyscus californicus)</em>, we examined how female and male immune function is influenced by (1) social isolation from same-sex peers, (2) social peer affiliation, and (3) exogenous OT. We evaluated immune function through wound size progression following a skin biopsy and proinflammatory cytokines in the wound fluid. Unexpectedly, social isolation alone did not influence wound healing, but isolation + OT increased wound size in a dose dependent manner. Wound size progression interacted with sex and OT in socially-housed mice, suggesting that OT increases inflammation in females, while decreasing inflammation in males in a social context-dependent manner. Inflammatory biomarker interleukin-6 (IL-6) mRNA expression correlated with wound size overall, supporting wound healing as an index of inflammatory response. However, isolation + OT mice did not have higher levels of IL-6, suggesting that the mechanism through which isolation + OT influences wound size is not through IL-6 activity. Behaviorally, higher levels of affiliation were negatively associated with wound size, and this effect was diminished by OT treatment. Our results highlight that the anti-inflammatory effects of OT are likely highly dependent on social context.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107445"},"PeriodicalIF":3.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of \"Social\" in the TSST: Social support and Social Motives partly Moderate Psychobiological Stress Responses in Addition to Biological Sex","authors":"Julia Schüler ,&nbsp;Zsuzsanna Zimanyi ,&nbsp;Vanessa Radtke ,&nbsp;Martin Stoffel ,&nbsp;Beate Ditzen","doi":"10.1016/j.psyneuen.2025.107440","DOIUrl":"10.1016/j.psyneuen.2025.107440","url":null,"abstract":"<div><div>Prior research has highlighted sex differences in psychobiological stress responses during the Trier Social Stress Test (TSST). This study expands on these findings by exploring how social motives (affiliation and power motives) and social support, as direct predictors and in interaction with biological sex, influence stress responses and reproductive hormones. A sample of 204 participants (108 women, 96 men) underwent the TSST, with social support being manipulated. The biological and psychological responses followed patterns previously documented in the literature. Linear mixed-effect models indicated that biological sex moderated the trajectories of RMSSD, testosterone, progesterone, and well-being across the TSST phases. Additionally, cortisol responses were more pronounced in men, particularly those with strong power motives. Participants receiving social support exhibited lower estradiol levels during the TSST recovery phase compared to the control group. These findings suggest that the impacts of social stress are shaped by complex interactions between biological and social factors, which could be considered in tailored stress interventions.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107440"},"PeriodicalIF":3.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress arousal reappraisal and worked example effects on the neuroendocrine stress response during breaking bad news in medical education","authors":"Michel Bosshard ,&nbsp;Urs Markus Nater ,&nbsp;Sissel Guttormsen ,&nbsp;Felix Schmitz ,&nbsp;Patrick Gomez ,&nbsp;Christoph Berendonk","doi":"10.1016/j.psyneuen.2025.107439","DOIUrl":"10.1016/j.psyneuen.2025.107439","url":null,"abstract":"<div><div>Breaking bad news (BBN; i.e., the disclosure of a serious diagnosis) is a necessary but challenging task in the medical field, often raising stress levels among physicians. According to the biopsychosocial model of challenge and threat, stress responses can manifest as adaptive challenge states or maladaptive threat states. Prior research has proposed that specific patterns in neuroendocrine responses may signal challenge and threat. In this study, we employed a 2 × 2 design to examine the effects of stress arousal reappraisal (SAR; i.e., reframing bodily arousal as a functional response) and worked example (WE; i.e., stepwise demonstration of BBN) interventions on salivary cortisol, dehydroepiandrosterone, and alpha-amylase responses. A total of 229 third-year medical students participated in a BBN simulation. While significant activation (rise) and regulation (decline) of neuroendocrine markers were observed in response to the BBN encounter, neither the SAR nor the WE intervention affected their peak levels or the magnitude (area under the curve) of the response. Only the WE intervention decelerated the rise and decline in dehydroepiandrosterone levels around individual peaks, potentially indicating an attenuated stress response. These findings suggest that neither of the interventions induced the expected challenge pattern in neuroendocrine activity. However, due to the low temporal resolution of salivary measurements and the dynamic process of challenge and threat orientations, we propose that the neuroendocrine responses may have limitations in distinguishing between challenge and threat.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107439"},"PeriodicalIF":3.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between C-reactive protein-albumin-lymphocyte index and depression in adults with type 2 diabetes mellitus: A cross-sectional study from NHANES","authors":"Wei Hu ,&nbsp;Qian Yuan ,&nbsp;Jie Hu ,&nbsp;Mingzi Li ,&nbsp;Yue Xi ,&nbsp;Ling Luo","doi":"10.1016/j.psyneuen.2025.107442","DOIUrl":"10.1016/j.psyneuen.2025.107442","url":null,"abstract":"<div><h3>Objective</h3><div>Inflammation and nutrition are interrelated, and both are related to depression. This study explored the association between the C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index, a novel immunonutrition scoring system, and depression in patients with type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>We included 3517 patients with T2DM from the National Health and Nutrition Examination Survey 2005–2010 and 2015–2018. The Patient Health Questionnaire-9 was used to evaluate depression. The CALLY index was based on a comprehensive assessment of serum CRP, serum albumin, and the lymphocyte counts from whole blood. Weighted multivariate logistic regression models were used to examine the relationship between the CALLY index and depression. The restricted cubic spline was applied to explore the nonlinear relationship.</div></div><div><h3>Results</h3><div>Compared with the non-depressed group, CALLY index and albumin in the depressed group were significantly reduced, while CRP and lymphocytes were significantly increased (<em>P</em> &lt; 0.05). After adjusting for covariates, only the CALLY index significantly decreased (the highest quartile vs the lowest quartile, odds ratio = 0.58, 95 % confidence interval: 0.38–0.89, <em>P</em> = 0.014). The non-linear association between the CALLY index and depression was not significant (<em>P</em> for nonlinear=0.69). The results of subgroup analysis were basically consistent (<em>P</em> for interaction &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The CALLY index was significantly negatively correlated with depression in American patients with diabetes and served as a potential marker for early identification.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"176 ","pages":"Article 107442"},"PeriodicalIF":3.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}