Psychoneuroendocrinology最新文献

{"title":"Biological markers of grief in bereaved family members: A systematic review of cortisol, inflammatory and cardiovascular studies.","authors":"Srishruthi Thirumalai, George Hutchings, Holly G Prigerson, Ulrika Kreicbergs","doi":"10.1016/j.psyneuen.2026.108057","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108057","url":null,"abstract":"<p><p>Bereavement is among life's most stressful events, and a minority of mourners develop prolonged and disabling grief. Biological markers have been proposed as signals of this risk, but no systematic review has examined them across bereaved family members or asked how well bereaved parents (parents who have lost a child) are represented. We systematically reviewed observational studies linking a cortisol/HPA-axis, inflammatory/immune, or cardiovascular/autonomic biomarker to a validated measure of coping or grief in bereaved family members of any age or relationship to the deceased (PROSPERO CRD420261446539). Five databases were searched, with citation searching of a related review. Eighteen studies met inclusion criteria across the three domains. More severe grief was linked to blunted or flatter diurnal cortisol in three of five cortisol studies. Bereavement and greater grief were linked to raised inflammatory markers (IL-6, IL-1RA, and related cytokines), although five of seven inflammatory studies appear to come from one research programme, and one study found divergent Type I interferon gene transcription in complicated relative to uncomplicated grief. Cardiovascular and autonomic findings were mixed and depended on moderators such as coping style and childhood adversity. Some cortisol associations weakened with time since loss, so they may not be stable markers of grief severity. Only one participant across all 18 studies was an identifiable bereaved parent. Biological markers show domain-specific associations with grief, but the evidence is exploratory, and bereaved parents are largely absent from it. They should be a priority for future prospective work.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"195 ","pages":"108057"},"PeriodicalIF":3.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149246221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations between plasma oxytocin levels and borderline personality disorder symptoms in adolescents.","authors":"Sibille Steiner, Corinna Reichl, Silvano Sele, Julian Koenig, Thomas Berger, Marialuisa Cavelti, Michael Kaess","doi":"10.1016/j.psyneuen.2026.108047","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108047","url":null,"abstract":"<p><strong>Background: </strong>Borderline personality disorder (BPD) is a complex disorder associated with severe interpersonal instability and common relationship problems. Oxytocin has emerged as a candidate neuropeptide, with cross-sectional studies showing reduced levels in individuals with BPD. Longitudinal data - particularly in adolescents - remain scarce, leaving unresolved whether changes in oxytocin reflect treatment effects, developmental processes, or reciprocal influences with symptom trajectories. The present study examines the longitudinal associations of oxytocin and the number of fulfilled criteria for BPD diagnosis in adolescents.</p><p><strong>Methods: </strong>We examined plasma oxytocin in adolescents who attended a specialized early intervention clinic for BPD. Individuals were assessed at baseline (n = 239) and at one-year follow-up (n = 84). We tested for cross-lagged associations of plasma oxytocin and the number of fulfilled criteria for BPD diagnosis using structural equation modelling (SEM). Age, sex, estradiol levels, and scores of the Symptom Checklist were included as covariates.</p><p><strong>Results: </strong>SEM showed a significant negative cross-lagged effect of oxytocin levels at baseline on BPD criteria at one-year follow-up, but no significant effect of BPD criteria on subsequent oxytocin levels.</p><p><strong>Conclusions: </strong>The exploratory findings suggest that oxytocin may represent a potential biological correlate of future BPD symptom trajectories. A better understanding of the neurobiological processes underlying BPD may inform future treatment development. However, given the exploratory nature and methodological limitations of the present study, any clinical implication including the potential exploration of oxytocin-based lifestyle interventions remain preliminary and require replication before they can be translated into practice.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"195 ","pages":"108047"},"PeriodicalIF":3.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149246247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The transition to fatherhood beyond early infancy: Hormonal, behavioral and psychological changes.","authors":"James K Rilling, Sijia Wu, Esther Jung, Minwoo Lee, Ella J Arrant, Carolyn Zhou, Kelly Ethun","doi":"10.1016/j.psyneuen.2026.108046","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108046","url":null,"abstract":"<p><p>Previous cross-sectional studies have documented hormonal differences between human fathers and nonfathers. However, the timing and persistence of these changes remain unclear. We previously reported that first-time expecting fathers exhibited lower plasma testosterone (T) and arginine vasopressin (AVP), as well as dynamic changes in oxytocin (OT) across portions of the prenatal and early postpartum period compared with partnered nonfather controls. By four months postpartum, however, these group differences were no longer significant. Here, we extend these findings longitudinally into late infancy and early childhood. After controlling for relevant confounds, plasma T, OT, AVP and cortisol levels did not differ significantly between fathers and nonfathers at either one or two years postpartum. Nevertheless, individual differences in paternal hormone levels continued to predict paternal behavior and relationship functioning. At one year postpartum, lower T was associated with greater paternal positive engagement and less frustration with the child, whereas higher cortisol was associated with lower paternal positive engagement. At two years postpartum, higher OT was associated with stronger father-infant attachment. Both fathers and their partners reported declining relationship quality across this period, and mediation analyses suggested that higher T levels mediated the association between reduced time spent with partners and poorer relationship quality. These findings suggest that hormonal changes accompanying the transition to fatherhood may be transient at the group level, while individual variation in paternal hormones continue to relate meaningfully to caregiving, attachment, and relationship functioning into early childhood.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"195 ","pages":"108046"},"PeriodicalIF":3.4,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149246166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the HPA axis in tailoring cognitive remediation therapy in patients with early psychosis: An exploratory randomized clinical trial.","authors":"Francesc Estrada, Josep Maria Crosas, Maribel Ahuir, Juan David Barbero, Itziar Montalvo, Meritxell Tost, Diego J Palao, José Antonio Monreal, Virginia Soria, Roser Nadal, Antonio Armario, Javier Labad","doi":"10.1016/j.psyneuen.2026.108045","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108045","url":null,"abstract":"<p><strong>Background: </strong>Cognitive remediation therapy (CRT) improves cognition in psychosis, yet response variability remains high. The hypothalamic-pituitary-adrenal (HPA) axis may influence cognitive plasticity. This study examined whether the cortisol awakening response (CARi) and diurnal cortisol slope predict cognitive change during CRT in recent-onset psychosis (ROP).</p><p><strong>Methods: </strong>In a randomized, crossover pilot trial (first 12-week phase analyzed), 28 outpatients with ROP were assigned to CRT (n = 14) or treatment as usual (TAU; n = 14). The CRT program (NeuroPersonalTrainer®) consisted of twice-weekly, 90-minute computerized sessions targeting attention, memory, and executive functions. Cognitive performance was assessed with the CANTAB battery at baseline and 12 weeks. Salivary cortisol, collected on two consecutive days, was used to compute CARi (AUCi at awakening, +30, +60 min) and diurnal slope (awakening to 23:00 h). Linear mixed-effects models tested Time × Group × Biomarker interactions for z-scored cognitive outcomes, adjusting for sex and applying false discovery rate (FDR) correction.</p><p><strong>Results: </strong>Groups were comparable at baseline. No domain showed a significant Time × Group × CARi interaction after FDR correction (nominal: Spatial Working Memory - Between Errors, p = .023). In contrast, the diurnal slope significantly moderated change in Rapid Visual Processing Accuracy (RVPA; p = .002, FDR-adjusted p = .04): participants with a steeper (more negative) slope displayed greater gains in sustained attention with CRT versus TAU.</p><p><strong>Conclusions: </strong>A steeper diurnal cortisol slope-but not CARi-predicted greater cognitive improvement following CRT, particularly in sustained attention. The slope may serve as a feasible biomarker to personalize CRT within precision psychiatry.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"195 ","pages":"108045"},"PeriodicalIF":3.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149246170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the variability in HPA-axis reactivity: Quo Vadis.","authors":"Charles B Nemeroff","doi":"10.1016/j.psyneuen.2026.108025","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108025","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":" ","pages":"108025"},"PeriodicalIF":3.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should genetic polymorphism information be incorporated into future salivary cortisol studies: Insights from biological psychiatry.","authors":"Jerrold S Meyer","doi":"10.1016/j.psyneuen.2026.108026","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108026","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":" ","pages":"108026"},"PeriodicalIF":3.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accounting for genetic heterogeneity in salivary cortisol studies: A path forward for Psychoneuroendocrinology?","authors":"Douglas A Granger, Elizabeth A Shirtcliff, Steve W Granger","doi":"10.1016/j.psyneuen.2026.108006","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108006","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":" ","pages":"108006"},"PeriodicalIF":3.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where there's a will, there's a way: How systematically measuring genetic heterogeneity could advance cortisol research.","authors":"Isabelle Ouellet-Morin","doi":"10.1016/j.psyneuen.2026.108039","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108039","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":" ","pages":"108039"},"PeriodicalIF":3.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond candidate genes: Toward phenotype-specific genetics of cortisol.","authors":"Christiaan H Vinkers","doi":"10.1016/j.psyneuen.2026.108019","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2026.108019","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":" ","pages":"108019"},"PeriodicalIF":3.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menstrual cycle estradiol fluctuations predict changes in affect and socioemotional functioning","authors":"Bethany Sander,&nbsp;Duncan Preston,&nbsp;Jennifer L. Gordon","doi":"10.1016/j.psyneuen.2026.107789","DOIUrl":"10.1016/j.psyneuen.2026.107789","url":null,"abstract":"<div><h3>Background</h3><div>Previous research suggests that estradiol (E2) impacts mood as well as socioemotional and stress-related functioning in menstruating individuals. However, research in this area is limited by a preponderance of cross-sectional studies comparing psychological outcomes across menstrual phases that do not allow for conclusions to be made about E2’s effects independent from progesterone.</div></div><div><h3>Methods</h3><div>In the current longitudinal investigation of 23 naturally cycling women, the potential effects of E2 on affect, state self-esteem, irritability, emotion recognition accuracy, and reactivity to both social exclusion (Cyberball) and psychosocial stress (Trier Social Stress Test; TSST) were assessed by comparing outcomes across two times of the menstrual cycle. Specifically, participants completed sessions in the early follicular (EF; cycle days 2–4, when E2 is expected to be low) and late follicular (LF; within the 6 days prior to ovulation, when E2 is expected to be high) phases.</div></div><div><h3>Results</h3><div>Negative affect and irritability were significantly higher in the EF phase, whereas positive affect and state self-esteem were significantly higher in the LF phase. Only recognition accuracy for anger was higher in the EF phase, and this effect did not survive corrections for multiple comparisons. While phase did not impact emotional reactivity to Cyberball or the TSST, rumination in response to Cyberball was significantly increased in the EF compared to LF phase. Main analyses for cortisol and heart rate were not significant; however, exploratory analyses revealed a heightened response for cortisol during stress recovery and a larger increase in heart rate in anticipation of the TSST in the EF phase.</div></div><div><h3>Conclusions</h3><div>A beneficial effect of the high-E2 LF phase was found for general affective variables. Performance on tasks of socioemotional and stress-related functioning suggest that low or declining levels of E2 may enhance sensitivity to perceiving anger in others, ruminating in response to perceived rejection, and physiological activation in anticipation and recovery of psychosocial stress.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"187 ","pages":"Article 107789"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}