Psychoneuroendocrinology最新文献

{"title":"Spousal bereavement enhances proinflammatory cytokine production to acute, psychological stress","authors":"E. Lydia Wu-Chung ,&nbsp;Ryan L. Brown ,&nbsp;Robert Suchting ,&nbsp;Jensine Paoletti-Hatcher ,&nbsp;Michelle A. Chen ,&nbsp;Angie S. LeRoy ,&nbsp;Kyle W. Murdock ,&nbsp;Cobi J. Heijnen ,&nbsp;Christopher P. Fagundes","doi":"10.1016/j.psyneuen.2025.107498","DOIUrl":"10.1016/j.psyneuen.2025.107498","url":null,"abstract":"<div><div>Early widowhood is characterized by chronic stress and is associated with a higher risk of incident depression and cardiovascular-related morbidity and mortality. Peripheral inflammation is involved in the pathogenesis of major depressive disorder and atherothrombosis and may represent a common mechanism underlying widow(er)’s elevated risk for both health conditions. Chronic psychological stress sensitizes the release of proinflammatory cytokines during the peripheral stress response. The present study examined whether recent spousal bereavement enhances the inflammatory response to an acute, psychological stressor. Recently widowed older adults (n = 143) and non-widowed controls (n = 69) participated in a quasi-experimental study, during which they underwent the Trier Social Stress Test, provided multiple blood samples through an intravenous catheter (before stressor, 45 min post-stressor, 120 min post-stressor), and completed self-report questionnaires. Blood samples were assayed for serum Interleukin (IL)-6 levels. Mixed linear modeling was used to test hypotheses. There was a significant time × bereavement status effect on IL-6 after controlling for confounding variables. Widow(er)s showed a steeper increase in IL-6 per hour compared to non-bereaved adults. Findings suggest that the inflammatory stress response is heightened in widow(er)s, which may contribute to the mental and physical health risks associated with early widowhood.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107498"},"PeriodicalIF":3.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortisol dynamics and sleep quality: The role of sex and oral contraceptive use","authors":"Margot W.L. Morssinkhof ,&nbsp;Søren Vinther Larsen ,&nbsp;Brice Ozenne ,&nbsp;Arafat Nasser ,&nbsp;Sofie Hvitved ,&nbsp;Ysbrand D. van der Werf ,&nbsp;Brenda W.J.H. Penninx ,&nbsp;Birit F.P. Broekman ,&nbsp;Vibe G. Frokjaer","doi":"10.1016/j.psyneuen.2025.107497","DOIUrl":"10.1016/j.psyneuen.2025.107497","url":null,"abstract":"<div><div>Women report poorer sleep than men, and oral contraceptive (OC) users appear to experience poorer sleep quality, in particular disrupted sleep, relative to non-users, potentially related to disruption of the circadian rhythm of cortisol. This preregistered study evaluated sleep quality and sleep disruptions and their relationship with cortisol dynamics in naturally cycling (NC) women, OC users and men. In 242 healthy participants from the Cimbi database, we first conducted cross-sectional group comparisons of self-reported sleep quality and sleep disruptions between the groups with linear regression and probabilistic index models, respectively. Second, we examined if the cortisol awakening response (CAR) mediated potential group differences in sleep quality and sleep disruptions. We show no significant differences in sleep disruptions in OC users (n = 31), or in men (n = 124) compared to NC women (n = 87). OC users reported marginally poorer overall sleep quality compared to NC women (p_adjusted=0.042). This difference was not mediated by the CAR. However, a lower CAR was associated with more sleep disruptions within OC users (-0.138 [-0.238; −0.039], p = 0.006) and with poorer sleep quality in men (0.24 [-0.41; −0.07], p = 0.006), but no associations with sleep were seen in NC women. In conclusion, we find modestly poorer sleep in healthy OC users compared to NC women, but no differences in sleep between NC women and men. Further, our data suggest a coupling between cortisol dynamics and sleep in OC users and men. Prospective studies are necessary to further assess the role of sex/gender differences and OC use in cortisol dynamics and sleep.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107497"},"PeriodicalIF":3.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not just for bonding: Nucleus accumbens oxytocin receptors facilitate huddling with strangers and feeding in male spiny mice","authors":"Brandon A. Fricker ,&nbsp;Arjen J. Boender ,&nbsp;Larry J. Young ,&nbsp;Aubrey M. Kelly","doi":"10.1016/j.psyneuen.2025.107496","DOIUrl":"10.1016/j.psyneuen.2025.107496","url":null,"abstract":"<div><div>Although oxytocin receptors (OXTRs) in the nucleus accumbens (NAc) are well known for their contributions to bonding in mating and parental contexts, little is known about how accumbal OT signaling modulates nonreproductive social behavior. Here we used the communal spiny mouse and viral-mediated CRISPR/Cas9 to decrease OXTR expression in the NAc of males to determine the direct contributions of accumbal OXTRs to behavior during interactions with novel, same-sex conspecifics. To determine whether NAc OXTRs specifically regulate social behaviors, feeding behavior was also assessed in a mealworm eating test. Males with reduced NAc OXTR expression exhibited less huddling with novel, same-sex conspecifics and consumed fewer mealworms compared to control males. These findings suggest that accumbal OXTRs do not specifically modulate social behaviors and that there is strong evolutionary conservation of NAc OXTR social function, such that these receptors facilitate prosocial behavior across rodent species that vary in breeding system and group structure.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107496"},"PeriodicalIF":3.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the added value of salivary hormones in the context of menstrual cycle staging: A machine learning approach and app-implementation","authors":"Alexander Rietzler,&nbsp;Tobias Hausinger,&nbsp;Belinda Pletzer","doi":"10.1016/j.psyneuen.2025.107495","DOIUrl":"10.1016/j.psyneuen.2025.107495","url":null,"abstract":"<div><h3>Objective</h3><div>Salivary hormone assessment is commonly used in menstrual cycle studies, but its validity for accurate menstrual cycle staging has been questioned. In the present study, we explore possibilities and limitations of salivary hormone assessment for menstrual cycle staging using a machine-learning approach. Specifically, we determine, how saliva sampling should be scheduled in various scenarios to maximize prediction accuracy of menstrual cycle phases from salivary estradiol and progesterone.</div></div><div><h3>Methods</h3><div>We utilize a data set including daily salivary estradiol and progesterone assessment, urinary ovulation tests, as well as accurate forward and backwards counts of cycle days over 136 cycles from 68 women (age: 18–35 years). A Support Vector Machine (SVM) approach was chosen to evaluate improvements in prediction accuracy for cycle phases due to salivary hormone assessments, using a series of models designed to reflect practical scenarios in menstrual cycle research.</div></div><div><h3>Results</h3><div>A singular salivary hormone assessment does not significantly improve prediction of menstrual cycle phases when adequate counting methods or urinary ovulation kits are available. When no counting method is available, only progesterone, but not estradiol measurements can adequately distinguish between cycle phases, specifically progesterone works best in identifying mid-luteal sessions. However, salivary hormone assessment does significantly improve prediction of cycle phases when more than one time-point is assessed, and values can be referenced against each other. Adding a second assessment timepoint is more informative for estradiol than progesterone values, but most effective when both hormones are combined. Importantly, and contrary to common practice, prediction accuracy is highest when saliva is sampled on days near the transitions between cycle phases when counting methods do not allow for a definitive decision.</div></div><div><h3>Conclusion</h3><div>These results demonstrate that salivary hormone assessments are not necessary in all research designs but are useful when counting methods are inadequate or do not allow for a definitive decision, or when multiple assessment days are included. Results of our models were implemented in a web application to aid researchers in assessing the prediction accuracy of their menstrual cycle staging based on the measures they have available.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107495"},"PeriodicalIF":3.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood violence, hair cortisol, and perceived stress among Black men living in a large urban city","authors":"Sage J. Kim ,&nbsp;Evgenia Karayeva ,&nbsp;Miguel Negrete ,&nbsp;Kestutis Bendinskas ,&nbsp;Robert A. Winn ,&nbsp;Alicia K. Matthews","doi":"10.1016/j.psyneuen.2025.107478","DOIUrl":"10.1016/j.psyneuen.2025.107478","url":null,"abstract":"<div><h3>Background</h3><div>Exposure to social stress, such as neighborhood violence, affects the body’s psychoneuroendocrinology, contributing to multiple chronic diseases. Hair cortisol concentration (HCC) is a novel proxy measure of chronic stress response. While Black Americans are exposed to social stress at a higher level, the association between violence exposure and HCC has not been extensively examined in older Black men. Intersectionality of race, gender, and class may disproportionately affect Black men to exposure to violence, thus, elevated HCC.</div></div><div><h3>Methods</h3><div>Black men aged 45 and older were recruited from four barbershops in predominantly Black communities in Chicago. Hair samples were collected by barbers for HCC, and a set of survey questions concerning perceived stress, exposure to violence, and fear of crime were collected along with demographic characteristics and residential community area. Using the residential community area, the homicide and poverty rates were appended. Descriptive statistics and a two-level hierarchical regression were used to examine the association between HCC and individual- and neighborhood-level factors.</div></div><div><h3>Results</h3><div>A total of 127 participants were included in the final analytic sample. The mean HCC was 22.3 pg/mg for those living in the lowest quartile homicide rates, while the mean HCC was 40.2 pg/mg for participants residing in the highest quartile homicide areas. Log-HCC was significantly correlated with homicide rate (r = .264, P &lt; .01) and perceived violence exposure (r = .195, p = .028) but not with perceived stress (r = .100, p = .508) or fear of crime (r = .124, p = .136). Multilevel regression models showed that log-HCC was significantly higher for those living in the highest homicide quartile compared to HCC in the lowest quartile homicide rate (p &lt; .01), controlling for age, being a current smoker, being married, being unemployed, and perceived stress, violence exposure, and fear of crime measures.</div></div><div><h3>Conclusion</h3><div>HCC was significantly higher for Black men residing in neighborhoods with high violence. The study highlights how Black men, particularly those in segregated urban areas, experience disproportionate exposure to social stressors such as neighborhood violence. The study findings demonstrate that multiple social positions compound exposure to systemic inequities, which results in elevated risk of mental and physical health conditions.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107478"},"PeriodicalIF":3.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement: 55th Annual Meeting of the International Society of Psychoneuroendocrinology (ISPNE)","authors":"","doi":"10.1016/j.psyneuen.2025.107486","DOIUrl":"10.1016/j.psyneuen.2025.107486","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"177 ","pages":"Article 107486"},"PeriodicalIF":3.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low anti-Müllerian hormone mediates the association between childhood trauma and PTSD in women but not in men","authors":"Shane W. Adams ,&nbsp;Richard L. Hauger ,&nbsp;Allison D. Altman ,&nbsp;Sherry Yam ,&nbsp;Shira Maguen ,&nbsp;Sabra S. Inslicht","doi":"10.1016/j.psyneuen.2025.107484","DOIUrl":"10.1016/j.psyneuen.2025.107484","url":null,"abstract":"<div><div>Women experience differential risk for childhood trauma and posttraumatic stress disorder (PTSD) when compared to men. Recent research has indicated lasting effects of childhood trauma across the lifespan and a bidirectional relationship between gonadal hormones like anti-Müllerian hormone (AMH) and PTSD that may help explain sex differences in PTSD. However, there is little data to support this hypothesized relationship, the potential direction of this relationship, or its effect in women <em>and</em> men across a large age range. The current study utilized a lifespan approach to examine the association between childhood trauma exposure and adulthood levels of AMH and PTSD symptoms. The current sample included 68 trauma-exposed veteran and non-veteran women (<em>n</em> = 27) and men (<em>n</em> = 41) aged 18–50 with clinical interview, self-report, and blood serum data, including 31 (47.0 %) participants with subthreshold-to-full PTSD. Adult trauma-exposed women had lower AMH levels (<em>M</em>=3.27 sqrt ng/mL) compared to trauma-exposed men (<em>M</em>=8.64 sqrt ng/mL; Hedge’s g=1.26). Overall, sex was a critical moderator of the association between AMH and PTSD, demonstrating significant AMH-related effects for women but not for men. To evaluate the potential developmental impact of childhood trauma and bidirectional relationship between AMH and lifetime PTSD symptoms, two moderated mediation analyses were conducted, examining sex as the moderator and 1) AMH and 2) PTSD symptoms as alternative mediators. AMH levels (Indirect Effect <em>β</em>=.391) mediated the relationship between childhood trauma and lifetime PTSD symptom severity for women but not for men. Alternatively, lifetime PTSD symptoms did not significantly mediate the relationship between childhood trauma and AMH levels. Findings from this small trauma-exposed cohort offer preliminary evidence that links developmental exposures to premature gonadal dysfunction and stress pathophysiology across the lifespan, revealing a potentially unidirectional relationship in which greater childhood trauma exposure is associated with reduced AMH levels in adult women and may confer greater lifetime PTSD symptom severity.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107484"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone and cortisol jointly mediate and modulate trust behavior in early adolescence","authors":"Rui Su ,&nbsp;Xuting Jiang ,&nbsp;Xiang Ma ,&nbsp;Huagen Wang ,&nbsp;Chao Liu","doi":"10.1016/j.psyneuen.2025.107483","DOIUrl":"10.1016/j.psyneuen.2025.107483","url":null,"abstract":"<div><div>During early adolescence, individuals undergo significant changes in neuroendocrine systems, neurodevelopment, and social sensitivity. Placing trust in the appropriate person becomes especially crucial for adolescents, given their increased peer interaction and heightened susceptibility to peer influence during this period. Adolescents take social distance into account when making trust decisions. However, the biological and cognitive mechanisms involved in trust decision-making towards peers of different social distances remain unclear. The present study investigated the interactions among hormonal (basal cortisol and basal testosterone), cognitive (impulsivity and theory of mind), and contextual (friends and strange peers) factors underlying trust decision-making in a sample of 142 adolescents (45 % females, <em>M</em>_age = 12.32 years, <em>SD</em>_age = 0.60). Using a balloon analog risk task, a cartoon story reasoning task, and a modified version of the trust game, we assessed adolescents’ impulsivity, theory of mind, as well as trust investment and evaluation of return possibility towards their friends and strangers, separately. The results showed a unique hormonal-cognitive-contextual mechanism underlying trust investment, despite adolescents demonstrating a preference for trusting friends over strangers in both trust investment and trust evaluation. Cortisol predominantly influenced adolescents’ general trust, directly and indirectly through impulsivity. Testosterone appeared to modulate the indirect effect of cortisol via impulsivity on general trust and impacted their strategic trust decisions through the theory of mind. These findings highlight the role of cortisol and testosterone in trust and its potential cognitive process and provide guidance for tailored interventions for promoting healthy social development.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107483"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of discrimination during pregnancy predict altered neonatal hair cortisol at birth","authors":"Kimberly D’Anna-Hernandez ,&nbsp;LillyBelle K. Deer ,&nbsp;Özlü Aran ,&nbsp;Kenia M. Rivera ,&nbsp;Melissa Nevarez-Brewster ,&nbsp;Jenalee R. Doom ,&nbsp;Benjamin L. Hankin ,&nbsp;M. Camille Hoffman ,&nbsp;Elysia Poggi Davis","doi":"10.1016/j.psyneuen.2025.107482","DOIUrl":"10.1016/j.psyneuen.2025.107482","url":null,"abstract":"<div><h3>Objective</h3><div>Prenatal glucocorticoids (e.g., cortisol) are a widely proposed prenatal programming mechanism, yet few studies directly measure fetal cortisol. Neonatal hair provides a non-invasive method to assess fetal cortisol. The current studies test the association between maternal exposure to discrimination and fetal cortisol, as measured in neonatal hair, in two cohorts.</div></div><div><h3>Methods</h3><div><strong>Study 1:</strong> Pregnant individuals (<em>N</em> = 65) and their neonates (61.8 % female) participated in study 1 between 2017 and 2021. Participants self-identified as Asian (6.2 %), Black (21.5 %), Latinx (35.4 %), Multiracial or Multiethnic (35.4 %), and Native Hawaiian or Pacific Islander (1.5 %). Experiences of discrimination were measured using the Everyday Discrimination Scale. Neonatal hair samples were collected close to birth (Median_days=1.30, IQR_days=0.96–2.03).</div></div><div><h3>Results</h3><div><strong>Study 1:</strong> Higher experiences of everyday discrimination among pregnant individuals were associated with lower hair cortisol levels in neonates (<em>r</em> = -.28, <em>p</em> = .031).</div></div><div><h3>Methods</h3><div><strong>Study 2:</strong> Pregnant individuals of Mexican descent (<em>N</em> = 73) and their neonates (50.7 % female) participated in study 2 between 2017 and 2020. Participants reported on their exposure to experiences of discrimination using the Discrimination Stress Scale, and neonatal hair samples were collected shortly after birth (Median_days=13.0, IQR_days=11–18).</div></div><div><h3>Results</h3><div><strong>Study 2:</strong> Those who had higher discrimination stress during pregnancy had neonates with higher cortisol than those with low discrimination (<em>F</em>(1,70)= 3.78, <em>p</em> = .03), but this relation did not remain significant after controlling for gestational age.</div></div><div><h3>Conclusion</h3><div>Across two cohorts, higher experiences of discrimination were associated with alterations in neonatal hair cortisol. Both higher and lower neonatal hair cortisol are linked to poorer neonatal development, indicating that experiences of discrimination might be a potential source of health disparities in the next generation.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107482"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of sex and gender role self-concept in stress reactivity: Evidence from the Trier Social Stress Test (TSST)","authors":"Stephanie Zintel ,&nbsp;Laura I. Schmidt ,&nbsp;Andreas B. Neubauer ,&nbsp;Martin Stoffel ,&nbsp;Yasaman Rafiee ,&nbsp;Beate Ditzen ,&nbsp;Monika Sieverding","doi":"10.1016/j.psyneuen.2025.107480","DOIUrl":"10.1016/j.psyneuen.2025.107480","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate biological sex and gender role self-concept in stress reactivity, utilizing the Trier Social Stress Test for Groups (TSST-G).</div></div><div><h3>Method</h3><div>A sample of 175 participants (56 % women, <em>M</em> = 39.2 years, <em>SD</em> = 12.5) underwent the TSST-G. Subjective and biological stress indicators (salivary cortisol sCort) and sex hormones (estradiol, testosterone) were assessed. Gender role self-concept (Bem Sex Role Inventory), in particular agency (stereotypically associated with masculinity), and biological sex were considered.</div></div><div><h3>Results</h3><div>Women reported higher subjective stress, whereas men had a steeper increase in sCort levels throughout the TSST-G. Results suggest lower subjective stress responses in more agentic people, independently of sex. Agency was not associated with sCort levels. Exploratory analyses revealed no interaction between agency and sex hormones.</div></div><div><h3>Conclusion</h3><div>Our study identified correlations between gender role self-concept and subjective stress in a large, non-student sample. The data confirm associations of biological sex with sCort response.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"178 ","pages":"Article 107480"},"PeriodicalIF":3.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}