Psychoneuroendocrinology最新文献

{"title":"Cortisol and C-reactive protein (CRP) regulation in severe mental disorders.","authors":"Amina Inova, Viktoria Birkenæs, Daniel S Quintana, Monica B E G Ormerod, Torill Ueland, Thor Ueland, Srdjan Djurovic, Ole Andreassen, Nils Eiel Steen, Monica Aas","doi":"10.1016/j.psyneuen.2024.107272","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107272","url":null,"abstract":"<p><strong>Background: </strong>People with schizophrenia (SZ) and bipolar disorder (BD) show abnormalities in the biological stress system and low-grade inflammation. However, whether the hypothalamic-pituitary-adrenal (HPA) axis-immune regulation is disrupted in SZ and BD, is yet to be determined.</p><p><strong>Methods: </strong>Cortisol and C-reactive protein (CRP) were measured in blood samples collected at or before 10 am in participants with SZ (N = 257), BD (N = 153), and healthy controls (N = 40). Cortisol/CRP ratio was calculated as an indicator of the balance between HPA axis activity and inflammatory activity, called HPA axis-immune regulation. Global functioning and symptom levels were obtained using the Global Assessment of Functioning (GAF) Scale and Positive and Negative Syndrome Scale (PANSS). Standardized neuropsychological tests were used to assess cognitive function. All analyses were adjusted for demographic variables (age and sex) and the time of blood sampling.</p><p><strong>Results: </strong>Participants with a SZ or BD diagnosis had lower cortisol/CRP ratios (F=5.93, p = 0.003) compared to healthy controls. The difference was no longer statistically significant (p > 0.1) when BMI was added as a covariate to the model. Within patients, those on psychotropic treatment (n = 337) had lower cortisol/CRP ratio than those not taking psychotropic agents (n = 59) (F=4.72, p = 0.03). Compared to HC, only patients on regular psychotropic agents had lower cortisol/CRP ratio (p = 0.02). Within the SZ group, lower cortisol/CRP ratio was associated with having poorer general functioning as measured by GAF (ß=-0.18, p = 0.01), and more severe negative and general symptomatology as measured by PANSS (ß=0.19, p = 0.007 and ß=0.18, p = 0.01, respectively). In SZ, lower cortisol/CRP ratio was also associated with poorer verbal memory, learning, and processing speed (ß=-0.20 p = 0.007, ß=-0.19 p = 0.01, ß=-0.25, p > 0.001, respectively). No associations were observed between cortisol/CRP ratio and clinical and cognitive functioning in the BD group.</p><p><strong>Conclusion: </strong>These findings may indicate HPA axis-immune dysregulation in SZ. Our study further indicates that disrupted HPA axis-immune regulation in people with SZ and BD is associated with psychotropic treatment and fat mass, highlighting the clinical importance of weight control and regular psychotropic treatment follow-ups within this group.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107272"},"PeriodicalIF":3.4,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of a one- vs. two-session online version of the Trier Social Stress Test.","authors":"Bria Gresham, Emma Karras, Bonny Donzella, Megan R Gunnar","doi":"10.1016/j.psyneuen.2024.107271","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107271","url":null,"abstract":"<p><p>In response to the global COVID-19 pandemic, researchers have validated both one-session and two-session online versions of the Trier Social Stress Test (TSST-OL). In a sample of 82 first-generation college students aged 18-25 from across the U.S. (M_age = 22.30; 75.61 % female; 34.15 % White, 15.85 % Black, 30.49 % Asian, 9.76 % Multiracial, 7.32 % other), we investigated the comparative effectiveness of a one-session and two-session version of the TSST-OL at eliciting a biological stress response. We found no significant differences between the one-session and two-session protocol with respect to cortisol reactivity (i.e., change from baseline to peak, area under the curve with respect to increase, sample peak, and likelihood of demonstrating a response) and self-reported stress during the TSST-OL. The findings indicate that both protocols may be effective at eliciting a stress response. Researchers should consider utilizing a one-session TSST-OL protocol to increase researcher feasibility and make participation more accessible, thereby increasing the representativeness of samples.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107271"},"PeriodicalIF":3.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Semi-Virtual Trier Social Stress Test (SV-TSST).","authors":"Melissa Miller, Madeline Divine, Ciara McAfee, Robin Brown, Shelby Sears, Cole Krautkramer, Rhea Gogia, Robert A Josephs, Frances A Champagne","doi":"10.1016/j.psyneuen.2024.107267","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107267","url":null,"abstract":"<p><p>The Trier Social Stress Test (TSST) is a strategy for inducing acute psychological stress and increases in glucocorticoid levels. Here we describe the methodology and implementation of a Semi-Virtual Trier Social Stress Test (SV-TSST) which combines the control of a laboratory environment with reduced need for in-person logistical support and enhanced social distancing without the need for specialized equipment. During the SV-TSST, the participant is guided through the baseline, anticipatory, challenge, and recovery phases of the test by an in-person experimenter. Confederate judges involved in the challenge phase of the protocol connect with the participant via live video teleconference. Fifty-five healthy male and female participants aged 18-25 completed measures of self-report stress and provided saliva samples for cortisol assay throughout the SV-TSST session. The SV-TSST protocol was found to induce a significant acute increase in subjective psychological stress and salivary cortisol, with elevated psychological stress in SV-TSST female compared to male participants. Results indicate that the SV-TSST can be implemented as protocol for acute stress induction in a within-subject design that can serve as an alternative to classic, virtual, and virtual reality adaptations of this methodology.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107267"},"PeriodicalIF":3.4,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of peripheral and cerebral inflammatory markers with suicidal deaths in Indian population.","authors":"Ruchika Kaushik, Baibaswata Nayak, Sujata Satapathy, Deepak Ramkumar Bharti, Shivam Pandey, Chittaranjan Behera","doi":"10.1016/j.psyneuen.2024.107268","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107268","url":null,"abstract":"<p><p>Globally, a suicide occurs every 43 seconds. In India, approximately 465 suicides took place daily in 2022, with a suicide rate of 12.4 per 100,000 population, exceeding the global rate of 9. This study aims to investigate differences in cytokine levels, including vascular endothelial growth factor (VEGF), between individuals who died by suicide and those who did not. Additionally, it aims to explore any pattern between plasma and cerebrospinal fluid (CSF) levels of these analytes. Concentrations of inflammatory cytokines, i.e., Interleukins: IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, Tumor Necrosis Factor-α and VEGF in plasma and CSF were analyzed among suicide death subjects (N = 6, cases) and non-suicidal death subjects (N = 59, controls). All analytes were quantified using a customized multiplex (9-plex) kit, with 50 µl of plasma and CSF in duplicates. Significantly higher levels of IL-6 (p < 0.001) and IL-10 (p < 0.05) were observed in the plasma of the suicidal group. However, no statistically significant changes were found in the rest of the analytes between the two groups. In CSF, only VEGF levels were significantly lower in the suicidal group (p < 0.01). In cases, significant positive correlations were observed between plasma and CSF levels of IL-1β, IL-4, IL-6, and IL-10, whereas in controls, only IL-8 demonstrated a significant positive correlation, indicating a moderate relationship between these cytokines systemic and central concentrations. Dysregulation of inflammatory biomarkers appears to play a crucial role in the pathophysiology of suicide. We conclude that higher levels of IL-6 are present in the plasma of suicide completers compared to non-suicidal deceased individuals.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107268"},"PeriodicalIF":3.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary findings on the association between maternal salivary and hair cortisol and the mother-infant-interaction during the early postpartum period.","authors":"Luisa Ernsten, Sabine Seehagen, Nora Nonnenmacher, Juliane Tautz, Oliver T Wolf, Martin Heil, Nora K Schaal","doi":"10.1016/j.psyneuen.2024.107266","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107266","url":null,"abstract":"<p><p>Maternal capabilities to engage in sensitive caregiving are important for infant development and mother-infant-interaction, however, can be negatively affected by cortisol due to a stress response. Previous research suggested that cortisol possibly impairs cognitive functions important for caregiving behavior, which potentially leads to less maternal sensitivity. However, studies investigating the influence of cortisol using endocrine parameters on the mother-infant-interaction during the early postpartum are lacking. In the current study, fifty-nine mother-infant-dyads participated in a laboratory face-to-face still-face (FFSF) observation when infants were 4 months of age. Maternal and infant positive, negative and matched behavior during the FFSF was microanalytically coded. Cortisol concentrations were obtained using hair and saliva samples. For salivary cortisol, the area under the curve with respect to ground (AUC_G) was calculated using two saliva samples obtained after arrival and after the FFSF. Multiple block-wise hierarchical linear regression models were conducted to incorporate potential confounding factors (maternal age, parity, infant gestational age, infant sex) in a first step and, then, test for the association of hair and salivary cortisol with maternal and infant positive, negative and dyadic behavior in a second step. For both it was hypothesized that cortisol assessed in hair and saliva is negatively associated with positive and matched mother-infant-interaction, and positively associated with negative mother-infant-interaction. It could be shown that salivary but not hair cortisol as well as infant gestational age and infant sex related significantly to infant positive and negative affect as well as matched behavior during the reunion phase of the FFSF. Maternal positive affect was unrelated to any of the variables. The results are discussed in regard to the importance of maternal cortisol levels over a longer period of time and more acute situational levels for the mother-infant-interaction as well as the relevance of included confounding factors.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107266"},"PeriodicalIF":3.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic stress induces depression-like behavior in rats through affecting brain mitochondrial function and inflammation.","authors":"Liyuan Wang, Yongjun Xu, Mengruo Jiang, Mengqi Wang, Meijiao Ji, Xin Xie, Hui Sheng","doi":"10.1016/j.psyneuen.2024.107261","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107261","url":null,"abstract":"<p><p>Chronic stress is involved in pathophysiology of depression, and causes some neurochemical alterations in brain. Both mitochondrial dysfunction and neuroinflammation are implicated in mediating the depression-like behavior. The objectives of present study were, at first, to confirm that chronic unpredictable mild stress (CUMS) induces depression-like behavior and alters mitochondrial function and inflammatory responses within the brain, and then to explore the role of mitochondria in the development of this depression-like behavior. It has been found that CUMS exposure induced depression-like behavior, mitochondrial dysfunction, increased IL-1, IL-6, IFN-γ and TNF-α levels in hippocampus and PFC. Moreover, the level of ATP, the key index of mitochondrial function, was inversely correlated with the levels of proinflammatory cytokine. Intracerebroventricular (ICV) injection of the mitochondrial targeted antioxidant MnTBAP significantly alleviated depression-like behavior in CUMS group. These findings suggested that CUMS results in depression-like behavior, mitochondrial dysfunction as well as neuroinflammation, and mitochondria dysfunction contributes to depression-like behavior caused by CUMS.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107261"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary cortisol and affective responses to acute psychosocial stress among adolescents.","authors":"Haley Dveirin, Victoria Acuna, Mai-Lan Tran, Elizabeth E Antici, Kate Ryan Kuhlman","doi":"10.1016/j.psyneuen.2024.107265","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107265","url":null,"abstract":"<p><strong>Background: </strong>Acute psychosocial stress activates the hypothalamic-pituitary-adrenal (HPA) axis and triggers the release of cortisol, a commonly used biomarker of stress reactivity. Yet only 25 % of studies have reported a correlation between cortisol and affective responses to stress. This study aimed to examine whether cortisol reactivity following an acute psychosocial stressor in the laboratory correlated with concurrent positive and negative affect in adolescents, and whether early life adversity (ELA) moderated this relationship.</p><p><strong>Methods: </strong>The current study examined the salivary cortisol response of 89 adolescents (46.1 % female) following administration of the Trier Social Stress Test for Children (TSST-C). Using 7 simultaneous measurements, changes in cortisol were compared to changes in concurrent affect using the Positive and Negative Affect Schedule (PANAS). Parents reported their child's exposure to ELA.</p><p><strong>Results: </strong>Within-person variability in cortisol was associated with higher negative affect at baseline, b = 1.43 (SE =.41), p < .001, as well as more rapid negative affective recovery following stress, b = -0.003 (SE =.002), p = .04. ELA-exposed participants were not more sensitive to this effect. Within-person variability in cortisol was not associated with positive affect at baseline or following the TSST-C on average, all ps > .27. However, within-person increases in cortisol were associated with decrements in positive affect among ELA-exposed individuals, all ps < .01, suggesting differential sensitivity to anhedonic effects of glucocorticoids.</p><p><strong>Conclusions: </strong>Stress impacts affective states, in part through acute increases in HPA axis activity. The present data show that negative affect is more vulnerable to this than positive affect among adolescents. Further, adolescents with high ELA may be more vulnerable to decrements in positive affect in the acute aftermath of HPA axis activation. Whether this is a modifiable source of vulnerability to stress-related disease in this high-risk population remains to be understood.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107265"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent social isolation induces sex-specific behavioral and neural alterations.","authors":"Naomi Ciano Albanese, Silvia Poggini, Alice Reccagni, Caterina Barezzi, Clara Salciccia, Anna Poleggi, Igor Branchi","doi":"10.1016/j.psyneuen.2024.107264","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107264","url":null,"abstract":"<p><p>Adversities associated with isolation during adolescence, including the lack of appropriate emotional and social experiences, can jeopardize the individual development leading to the onset of mental illnesses such as major depressive disorder. Girls have higher rates of depression compared to boys; however, the relative contribution of biological and cultural factors to such a gender-dependent difference remains unclear. To identify the role of biological factors in this distinct susceptibility, we exposed adolescent C57BL/6 male and female mice (n = 12-14) to social isolation and we evaluated their behavioral responses, investigating both emotional and cognitive competencies during adolescence. In addition, we assessed alterations in immune activation and brain plasticity by measuring the expression levels of several pro- and anti-inflammatory cytokines and neural plasticity markers. Finally, we investigated the hormonal stress response by evaluating the hypothalamic-pituitary-adrenal (HPA) axis reactivity. Our findings indicate that adolescent social isolation leads to the development of depressive- and anxiety-like traits, although it impacts distinct behavioral domains with varying degrees in males and females. Both genders exhibited deficiencies in the emotional realm, displaying enhanced anhedonia and anxiety compared to their respective control groups. Moreover, males exhibited cognitive impairments linked to an altered HPA axis activity. Remarkably, social isolation influenced immune activation in both sexes, resulting in decreased pro-inflammatory markers. Overall, these results affirm the significant impact of social experiences during adolescence on neurodevelopment. Notably, our study reveals that both males and females are equally susceptible to the effects of isolation, although sex-specific differences become apparent in the alterations observed at both behavioral and physiological levels.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107264"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of gestational anxiety and depression with neonatal hair steroid levels.","authors":"Arthur Chortatos, Axel Davies Vittersø, Lauri Uusitalo, Marko Lehtonen, Johanna Huotari, Seppo Auriola, Raimo Voutilainen, Katri Backman, Leea Keski-Nisula, Soili M Lehto","doi":"10.1016/j.psyneuen.2024.107260","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107260","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association prenatal maternal depression and anxiety may have on the levels of neonatal hair steroids (i.e. cortisol, cortisone, and the cortisol/cortisone ratio) at birth.</p><p><strong>Methods: </strong>Altogether, 271 mother-infant pairs derived from the Finnish Kuopio Birth Cohort Study were assessed for maternal depression and anxiety using the Edinburgh Postnatal Depression Scale (EPDS: EPDS-10 for depression, EPDS-3A for anxiety) during the first (T1) and third (T3) trimesters. The levels of cortisol and cortisone were determined from neonatal hair samples obtained at birth. Linear mixed models adjusted for sex, preterm birth, smoking during pregnancy, and gestational diabetes were used.</p><p><strong>Results: </strong>Neither T1 nor T3 EPDS-10 predicted the levels of neonatal hair steroids. T3 EPDS-3A (p = 0.012), but not T1 EPDS-3A, was linked to reduced neonatal hair cortisol levels. Neither T1 nor T3 EPDS-3A were significant predictors of neonate cortisone levels or cortisol/cortisone ratios.</p><p><strong>Conclusion: </strong>Prenatal maternal anxiety, but not depression, may lead to pronounced alterations in some markers of fetal stress systems. Future research should further determine whether prenatal maternal symptoms of anxiety would form an optimal intervention target in order to attenuate fetal stress responses.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107260"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of the hair-based nine hormones from four neuroendocrine systems.","authors":"Xuliang Hou, Xiaoli Ding, Lulu Zhao, Wei Gao, Deyi Qi, Huihua Deng","doi":"10.1016/j.psyneuen.2024.107262","DOIUrl":"https://doi.org/10.1016/j.psyneuen.2024.107262","url":null,"abstract":"<p><strong>Introduction: </strong>The stress response maintains the homeostasis of the body's internal environment and normal physiological activities, involving several neuroendocrine systems, such as the HPA axis, the HPG axis, the endocannabinoid system, and the melatonin system. However, studies on the intricate interactions among the four neuroendocrine systems are lacking, and it is not clear how these interactions are affected by demographic variables. The aim of this study was to investigate the network characteristics of hormonal networks comprising nine hormones from four neuroendocrine systems and how they were affected by demographic variables.</p><p><strong>Methods: </strong>252 healthy current students were recruited from Southeast University, China. The concentrations of nine hormones in their hair were measured by LC/MS methods, and hormonal network was constructed. Network analysis was used to characterize the interrelationships between hormones or neuroendocrine systems, central hormones, bridge hormones, hormonal network characteristics, and their changes in response to demographic variables.</p><p><strong>Results: </strong>Complex interactions between the HPA axis, the HPG axis, the ECS and the melatonin system formed a sparse and stable network, with cortisol and cortisone being the central hormones and melatonin as the bridge hormone. Demographic variables did not affect the overall characteristics of the network or the central hormone, but a number of specific connections in the network changed and the bridge hormones became cortisone and progesterone.</p><p><strong>Conclusion: </strong>The interactions between the four stress-related neuroendocrine systems were relatively stable and were centered and initiated by the HPA axis. Demographic variables did not affect the overall structure of the network, but influenced local features of the network, such as edge weights and bridge centrality.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"107262"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}