Psychoneuroendocrinology最新文献

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Corrigendum to “Salivary oxytocin and anxiety in older adults during the COVID-19 pandemic: A cross-sectional study” [Psychoneuroendocrinology 179 (2025) 107502] “COVID-19大流行期间老年人唾液催产素与焦虑:一项横断面研究”的勘误表[精神神经内分泌学179 (2025)107502]
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-10 DOI: 10.1016/j.psyneuen.2025.107625
Yutaka Kunitake , Yoshiomi Imamura , Hiroko Kunitake , Junko Ohishi-Fukuchi , Hiroshi Tateishi , Jun Matsushima , Toru Murakawa-Hirachi , Ryohei Kojima , Takumi Shiraishi , Ryuzo Orihashi , Yoshito Mizoguchi
{"title":"Corrigendum to “Salivary oxytocin and anxiety in older adults during the COVID-19 pandemic: A cross-sectional study” [Psychoneuroendocrinology 179 (2025) 107502]","authors":"Yutaka Kunitake , Yoshiomi Imamura , Hiroko Kunitake , Junko Ohishi-Fukuchi , Hiroshi Tateishi , Jun Matsushima , Toru Murakawa-Hirachi , Ryohei Kojima , Takumi Shiraishi , Ryuzo Orihashi , Yoshito Mizoguchi","doi":"10.1016/j.psyneuen.2025.107625","DOIUrl":"10.1016/j.psyneuen.2025.107625","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107625"},"PeriodicalIF":3.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Could intranasal oxytocin enhance the effects of psychotherapy in individuals with mental disorders? A systematic review and meta-analysis” [Psychoneuroendocrinology, vol. 171, (2025), 107206] “鼻内催产素能增强精神障碍患者的心理治疗效果吗?”系统回顾和荟萃分析”[精神神经内分泌学,vol. 171,(2025), 107206]。
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-07 DOI: 10.1016/j.psyneuen.2025.107623
Maria Arqueros , Joaquim Soler , Carlos Schmidt , Daniel Vega , Juan C. Pascual
{"title":"Corrigendum to “Could intranasal oxytocin enhance the effects of psychotherapy in individuals with mental disorders? A systematic review and meta-analysis” [Psychoneuroendocrinology, vol. 171, (2025), 107206]","authors":"Maria Arqueros , Joaquim Soler , Carlos Schmidt , Daniel Vega , Juan C. Pascual","doi":"10.1016/j.psyneuen.2025.107623","DOIUrl":"10.1016/j.psyneuen.2025.107623","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107623"},"PeriodicalIF":3.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social isolation, but not partner separation, lowers hippocampal synaptosome mitochondrial respiration in female California mice (Peromyscus californicus) 社会隔离,而不是伴侣分离,降低了雌性加利福尼亚小鼠的海马突触体线粒体呼吸。
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-04 DOI: 10.1016/j.psyneuen.2025.107647
Amy J. Wegener , Hannah D. Fulenwider , Hannah Stadtler , Paul A. Howell , Nour Abosamak , Susie Turkson , Charlotte A. Ream , Niyomi H. Shah , Erica R. Glasper , Gretchen N. Neigh
{"title":"Social isolation, but not partner separation, lowers hippocampal synaptosome mitochondrial respiration in female California mice (Peromyscus californicus)","authors":"Amy J. Wegener ,&nbsp;Hannah D. Fulenwider ,&nbsp;Hannah Stadtler ,&nbsp;Paul A. Howell ,&nbsp;Nour Abosamak ,&nbsp;Susie Turkson ,&nbsp;Charlotte A. Ream ,&nbsp;Niyomi H. Shah ,&nbsp;Erica R. Glasper ,&nbsp;Gretchen N. Neigh","doi":"10.1016/j.psyneuen.2025.107647","DOIUrl":"10.1016/j.psyneuen.2025.107647","url":null,"abstract":"<div><div>Social isolation, loneliness, and loss profoundly impact health and quality of life, but the complex nature of these constructs can prohibit mechanistic examination in rodent models. Assessment of the peripheral and neural effects of environment manipulations in a social rodent species, such as California mice (<em>Peromyscus californicus</em>), can facilitate inquiry into the biological repercussions of experiencing different types of loss. Stressors can compromise neural function in the hippocampus and a portion of this effect is due to deficits in mitochondrial function at the synapse. Mitochondria at the synapse are essential to facilitate neural transmission and compromise can impair neurotransmission and thereby behavior. In the current study, we used genetically monogamous male and female California mice to evaluate synaptic mitochondrial respiration following removal of a same-sex cage mate for 10- or 30-days (i.e., social isolation; Experiment 1) OR a 10-day separation from an opposite-sex partner following 10-days of cohabitation (i.e., partner separation; Experiment 2). In the social isolation cohort, males, but not females, exhibited physical changes consistent with a prolonged stress response, including reduction in body mass and hypertrophy of the adrenal glands following isolation. In contrast, isolated female mice demonstrated a reduction in hippocampal synaptic mitochondrial respiration at both 10- and 30-days following social isolation, compared to females that remained pair-housed. No effects were observed in males. Social isolation did not alter open field outcomes for either sex. We then investigated the impact of separation from an opposite sex partner on the same metrics. Separation from an opposite sex partner was qualitatively less impactful, such that there were no statistically significant changes observed in body mass, adrenal weight, open field behavior, or mitochondrial respiration following separation from an opposite sex mate. Collectively, these data suggest that males and females differentially manifest the impact of social stress on synaptic mitochondria respiration.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107647"},"PeriodicalIF":3.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A lifespan approach to biological aging: Early adversity, past-year trauma, and telomere length in women 生物学衰老的寿命方法:早期逆境、过去一年的创伤和女性端粒长度。
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-03 DOI: 10.1016/j.psyneuen.2025.107645
Leah Cha , Gabrielle R. Rinne , Judith E. Carroll , Madeleine U. Shalowitz , Sharon Landesman Ramey , Christine Dunkel Schetter , Jennifer A. Sumner
{"title":"A lifespan approach to biological aging: Early adversity, past-year trauma, and telomere length in women","authors":"Leah Cha ,&nbsp;Gabrielle R. Rinne ,&nbsp;Judith E. Carroll ,&nbsp;Madeleine U. Shalowitz ,&nbsp;Sharon Landesman Ramey ,&nbsp;Christine Dunkel Schetter ,&nbsp;Jennifer A. Sumner","doi":"10.1016/j.psyneuen.2025.107645","DOIUrl":"10.1016/j.psyneuen.2025.107645","url":null,"abstract":"<div><div>Adverse experiences over the lifespan can increase risk for poor health outcomes, likely operating in part through accelerated biological aging. From a life course perspective, the extent to which adverse experiences in adulthood predict biological aging will vary as a function of early life adversity, yet few studies have tested this. In this cross-sectional, pre-registered study, we examined associations of early life adversity and past-year potentially traumatic events and their interaction with telomere length in a sample of racially and ethnically diverse and predominantly low-income women (<em>n</em> = 127). We also tested hair cortisol as a potential pathway linking early life adversity and potentially traumatic events with telomere length. Women reported on experiences of early life adversity and the number and negative impact of past-year potentially traumatic events during interviews. Buccal cells and hair samples were collected to assess telomere length and cortisol, respectively. More negative impact of past-year potentially traumatic events was associated with shorter telomere length. However, the strength of this association was conditional on early life adversity and strongest at lower levels of early life adversity. Both greater early life adversity and more negative impact of potentially traumatic events were associated with higher hair cortisol, but hair cortisol was not associated with telomere length. Results suggest that early life adversity modifies the association between subsequent trauma and telomere length and advances understanding of how lifespan adversity shapes biological aging. These findings may inform future research to examine dynamic biological processes linking lifespan adverse experiences to health using longitudinal designs.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107645"},"PeriodicalIF":3.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The short-term impact of music interventions on stress: Results of a multinational cluster-randomized trial using salivary cortisol and alpha-amylase assessments in care home residents with dementia 音乐干预对压力的短期影响:一项多国集群随机试验的结果,使用唾液皮质醇和α -淀粉酶评估痴呆症养老院居民
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-02 DOI: 10.1016/j.psyneuen.2025.107640
Naomi L. Rasing , Sarah I.M. Janus , Annemieke C. Vink , Ulrike A.S. Frischen , Johanna Neuser , Jo Dugstad Wake , Nadine Skoluda , Vigdis Sveinsdottir , Monika Geretsegger , Elias Langeland , Gunter Kreutz , Christian Gold , Urs M. Nater , Sytse U. Zuidema
{"title":"The short-term impact of music interventions on stress: Results of a multinational cluster-randomized trial using salivary cortisol and alpha-amylase assessments in care home residents with dementia","authors":"Naomi L. Rasing ,&nbsp;Sarah I.M. Janus ,&nbsp;Annemieke C. Vink ,&nbsp;Ulrike A.S. Frischen ,&nbsp;Johanna Neuser ,&nbsp;Jo Dugstad Wake ,&nbsp;Nadine Skoluda ,&nbsp;Vigdis Sveinsdottir ,&nbsp;Monika Geretsegger ,&nbsp;Elias Langeland ,&nbsp;Gunter Kreutz ,&nbsp;Christian Gold ,&nbsp;Urs M. Nater ,&nbsp;Sytse U. Zuidema","doi":"10.1016/j.psyneuen.2025.107640","DOIUrl":"10.1016/j.psyneuen.2025.107640","url":null,"abstract":"<div><h3>Objective</h3><div>Stress can have a negative impact on well-being and quality of life in people with dementia. Our study explored the effect of music as a potentially stress-reducing strategy in care home residents with dementia and depression of 25 care home units included in the multinational cluster-randomized controlled trial Music Interventions for Dementia and Depression in Elderly care (MIDDEL). <em>Methods:</em> Group music therapy consisted of singing well-known songs and reminiscence in small groups, optionally improvising on instruments and moving to music. Choir singing consisted of rehearsing well-known and new songs in larger groups of 10 + participants. During month 1, 3, and 6, saliva samples were collected 10 min before and 15 and 60 min after a session of group music therapy (<em>n</em> = 55), recreational choir singing (<em>n</em> = 72) or a book reading (<em>n</em> = 56) in 183 care home residents, along with a stress visual analogue scale. <em>Results:</em> Of 1014 saliva samples collected, 671 (66 %) were valid for alpha-amylase assay and 633 samples (62 %) for cortisol assay. Significant pre/post session changes were found for salivary cortisol, alpha-amylase, and subjective stress within study arms, although no significant difference was found between study arms. <em>Conclusion:</em> Group interventions, including music therapy, can have a positive impact on stress levels in care home residents with dementia. The level or intensity of participation required from the person with dementia may play a role in the impact of music on stress. Findings indicate it is feasible to collect saliva in persons with dementia non-invasively. Future studies in this population should consider strategies to improve validity of data, such as stimulating saliva flow. ClinicalTrials.gov registration NCT03496675.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107640"},"PeriodicalIF":3.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxytocin in prematurely born infants and their parents - A systematic review with clinical implications. 早产婴儿及其父母的催产素-一项具有临床意义的系统综述。
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1016/j.psyneuen.2025.107564
Ulrike Schneider-Schmid, André Morgado, Christine Heim, Heiko Klawitter, Lars Hellmeyer, Sonja Entringer
{"title":"Oxytocin in prematurely born infants and their parents - A systematic review with clinical implications.","authors":"Ulrike Schneider-Schmid, André Morgado, Christine Heim, Heiko Klawitter, Lars Hellmeyer, Sonja Entringer","doi":"10.1016/j.psyneuen.2025.107564","DOIUrl":"10.1016/j.psyneuen.2025.107564","url":null,"abstract":"<p><strong>Introduction: </strong>The neuropeptide oxytocin (OT) is considered an important regulatory factor in mother-child bonding after birth. It is also thought to have neuroprotective effects, which could be particularly important for preterm born (≤ 37 weeks) infants, who are considered a high-risk group for several health issues. They are born when their own and their mother's OT-concentrations have not yet reached their maximum during pregnancy and often require neonatal intensive care, separating them from their parents. This review aims to identify studies on OT-concentration in preterm infants and their parents as well as to investigate possible influences on their OT-secretion.</p><p><strong>Methods: </strong>The systematic literature search was conducted according to PRISMA guidelines, using the keywords \"oxytocin\", \"infants\", \"prematurely\" and synonyms in the PubMed, ScienceDirect, Google Scholar and PsycInfo databases. 15 publications met the criteria. As the studies were very heterogeneous in terms of the methods applied for the analysis of oxytocin concentration, a narrative synthesis and just a partial meta-analysis was performed.</p><p><strong>Results: </strong>The quantification methods of OT were heterogeneous, the reported maternal values ranged from 1 to 4000 pg/ml. The sample sizes were limited (mean n = 31 across all studies) and OT was mostly measured in infant saliva. In the intervention studies, a consistent positive relationship was found between OT-concentration and physical contact, stress reduction and attachment behavior. A meta-analysis was performed for the effect size of bonding interventions like SSC on OT in maternal saliva, revealing a medium effect size (SMD = 0.40, p = 0.002).</p><p><strong>Discussion: </strong>Despite the variance in methods and a certain risk of bias which limits the reliability of the studies, the overall results suggest an increase in oxytocin concentrations in response to bonding interventions like skin contact in preterm infants and their parents. Both appear to benefit from these anxiolytic and stress-reducing measures, supporting the clinical application of Kangaroo care in preterm infants. Methodological issues related to OT assessment in different body fluids of prematurely born infants are critically discussed. Future studies, applying an open-science approach, should focus on longitudinal designs, inclusion of control groups and confounding variables to ensure reliability and comparability.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"107564"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring intersectionality in psychoneuroendocrinology research: A systematic review. 探索精神神经内分泌学研究中的交叉性:系统综述。
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI: 10.1016/j.psyneuen.2025.107536
Natalie A Green, Mariana Rodrigues, Stephanie Espinoza Perez, Annette Milu, Gabrielle Martin, Janice Jachero Caldas, Sabrina Loureiro, Stephanie H Cook
{"title":"Exploring intersectionality in psychoneuroendocrinology research: A systematic review.","authors":"Natalie A Green, Mariana Rodrigues, Stephanie Espinoza Perez, Annette Milu, Gabrielle Martin, Janice Jachero Caldas, Sabrina Loureiro, Stephanie H Cook","doi":"10.1016/j.psyneuen.2025.107536","DOIUrl":"10.1016/j.psyneuen.2025.107536","url":null,"abstract":"<p><strong>Purpose: </strong>While more fields are recognizing the importance of an intersectionality framework and the need to incorporate it into scientific research, conceptual and methodological challenges still arise. Thus, in this review we aim to systematically review the application of the intersectionality framework within the existing psychoneuroendocrinology literature.</p><p><strong>Methods: </strong>A search was conducted on PubMed, APA PsycNet, CINAHL, Web of Science, Scopus, and Google Scholar between July and September of 2024 using specific keywords related to intersectionality and psychoneuroendocrinology.</p><p><strong>Results: </strong>Thirty-two studies proposed intersectionality-related concepts in their study. However, only two-thirds defined intersectionality or integrated such a framework as a part of their methodological strategy. Out of existing psychoneuroendocrinology fields, four topics emerged, including: women's health, mental health, inflammation, and cardiovascular disease (CVD).</p><p><strong>Conclusion: </strong>Studies using an intersectionality framework must move beyond subgroup analysis and examining identities such as race and gender to include other salient aspects such as immigration status, disability or health status. Furthermore, more efforts need to be made to disentangle race and ethnicity as well as gender and sex. Future research priorities were identified, including (1) developing a comprehensive strategy for incorporating an intersectionality framework throughout all the study stages, (2) integrating additional dimensions of identities and power structures, and (3) utilizing different statistical analytical strategies beyond traditional analysis, such as Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA).</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"107536"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal stress assessment: Connecting task-related changes in self-reported stress, salivary biomarkers, heart rate, and facial expressions in the context of the stress response to the Trier Social Stress Test. 多模式压力评估:在特里尔社会压力测试的压力反应背景下,自我报告的压力、唾液生物标志物、心率和面部表情的任务相关变化。
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-01 Epub Date: 2025-07-21 DOI: 10.1016/j.psyneuen.2025.107560
Veronika Ringgold, Felicitas Burkhardt, Luca Abel, Miriam Kurz, Victoria Müller, Robert Richer, Bjoern M Eskofier, Grant S Shields, Nicolas Rohleder
{"title":"Multimodal stress assessment: Connecting task-related changes in self-reported stress, salivary biomarkers, heart rate, and facial expressions in the context of the stress response to the Trier Social Stress Test.","authors":"Veronika Ringgold, Felicitas Burkhardt, Luca Abel, Miriam Kurz, Victoria Müller, Robert Richer, Bjoern M Eskofier, Grant S Shields, Nicolas Rohleder","doi":"10.1016/j.psyneuen.2025.107560","DOIUrl":"10.1016/j.psyneuen.2025.107560","url":null,"abstract":"<p><p>When we are stressed, do we show it? Although the answer to this question may feel intuitive, prior work on the topic does not provide a clear answer. To address this gap, we present the results of the first study that examined physiological and psychological stress responses and facial expressions using a validated acute stress task and control condition in a within-subjects design. Participants (N = 105; 59 women; 22.36 ± 3.52 years of age) underwent the Trier Social Stress Test (TSST) and the friendly TSST (f-TSST) on consecutive days and provided self-reports via the Short Stress State Questionnaire in German (SSSQ-G), saliva samples, and heart rate. Participants were further filmed during both conditions, allowing us to examine their observable emotional displays using their facial muscle movement data (Action Units, AUs). As expected, the TSST elicited higher SSSQ-G scores and greater cortisol and heart rate increases than the f-TSST. Additionally, the trajectory of cortisol was influenced by the order in which the conditions were presented. The total score, along with the Self-evaluation and Worry subscale scores of the SSSQ-G, correlated with the cortisol maximum increase in response to the TSST, as did heart rate. We found no evidence for displays of common emotions during the manipulation, but we did observe more friendly expressions in the f-TSST (compared to the TSST). Individual AUs neither predicted physiological outcomes nor self-reported stress state scores. Together, these results highlight both the complexity of the stress response in relation to observable emotions and the importance of multimodal stress assessment.</p>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"107560"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laboratory stress research in psychiatric and neurological populations: toward a consensus guideline 精神病学和神经学人群的实验室应激研究:走向共识指南
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-10-01 DOI: 10.1016/j.psyneuen.2025.107641
C. Broeder , L. de Nooij , M.J.M. van den Eijnden , E.J. Hermans , D. Hernaus , C.W.E.M. Quaedflieg , F.M. Smits , C.H. Vinkers , M.S.C. Sep
{"title":"Laboratory stress research in psychiatric and neurological populations: toward a consensus guideline","authors":"C. Broeder ,&nbsp;L. de Nooij ,&nbsp;M.J.M. van den Eijnden ,&nbsp;E.J. Hermans ,&nbsp;D. Hernaus ,&nbsp;C.W.E.M. Quaedflieg ,&nbsp;F.M. Smits ,&nbsp;C.H. Vinkers ,&nbsp;M.S.C. Sep","doi":"10.1016/j.psyneuen.2025.107641","DOIUrl":"10.1016/j.psyneuen.2025.107641","url":null,"abstract":"<div><div>Research involving acute laboratory stress induction is essential to understanding the role of stress in human health and disease. However, participant-centered guidelines for stress research involving individuals with psychiatric or neurological disorders are lacking. Using the Delphi method, we established consensus on best practices for research employing stress induction paradigms in these populations. Our panel included up to 179 respondents. In the final round, 173 respondents completed the survey, comprising 22 researchers, 70 stress study participants (acute, chronic, or daily-life), 115 individuals with lived experience, 21 healthcare professionals, and 4 ethicists. In three anonymous online survey rounds, participants rated their agreement with 52 statements on a 5-point Likert scale. Consensus, defined as ≥ 70 % (dis)agreement, was reached for 38 statements (73.1 %). Our findings highlight the importance of carefully balancing effective stress induction with acceptable intensity in studies using stress induction paradigms in clinical populations. We provide recommendations spanning all phases of the research process, including protocol design, recruitment, informed consent procedures, stress induction procedures, debriefing and follow-up. These guidelines serve as a practical framework to support the design of future laboratory stress studies, with the aim of supporting both participant well-being and scientific validity and comparability.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107641"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of HPA-axis polygenic scores in shaping well-being during emerging adulthood: A multi-study approach hpa轴多基因评分在塑造成年初期幸福感中的作用:一项多研究方法。
IF 3.6 2区 医学
Psychoneuroendocrinology Pub Date : 2025-09-30 DOI: 10.1016/j.psyneuen.2025.107639
Chenjin Qiao , Min Yang , Yao Xiao , Han Li , Na Zhao , Yuling Huang , Qi Lan , Wenting Liang , Rong Bao , Jie Ren , Yuting Yang , Wenping Zhao , Pingyuan Gong
{"title":"The role of HPA-axis polygenic scores in shaping well-being during emerging adulthood: A multi-study approach","authors":"Chenjin Qiao ,&nbsp;Min Yang ,&nbsp;Yao Xiao ,&nbsp;Han Li ,&nbsp;Na Zhao ,&nbsp;Yuling Huang ,&nbsp;Qi Lan ,&nbsp;Wenting Liang ,&nbsp;Rong Bao ,&nbsp;Jie Ren ,&nbsp;Yuting Yang ,&nbsp;Wenping Zhao ,&nbsp;Pingyuan Gong","doi":"10.1016/j.psyneuen.2025.107639","DOIUrl":"10.1016/j.psyneuen.2025.107639","url":null,"abstract":"<div><div>Emerging adulthood is a developmental period marked by both opportunity and vulnerability, where well-being depends heavily on effective stress regulation. Given that hypothalamic-pituitary-adrenal (HPA) axis is a key biological system in stress regulation, this multi-study explored how cumulative genetic variations in the HPA axis contribute to well-being during this stage. In Study 1, a cross-sectional analysis of 1318 participants, showed that a higher cumulative genetic score (CGS), reflecting more adaptive HPA-axis functioning, was significantly associated with greater scores on affect balance, life satisfaction, and overall flourishing. Study 2 used a longitudinal design (<em>N</em> = 348) and confirmed that these associations were stable over 12 months. Study 3 explored underlying mechanisms, demonstrating that the higher CGS predicted greater social adaptability and lower perceived stress, which mediated the link between the CGS and well-being. Together, this research indicates that the polygenic sensitivity of the HPA axis supports well-being through modifiable psychological pathways in emerging adulthood.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"182 ","pages":"Article 107639"},"PeriodicalIF":3.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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