Psychoneuroendocrinology最新文献

{"title":"Neuronal TLR4 overexpression in the medial prefrontal cortex is associated with neuroinflammation and depression-like behaviors in ovariectomized rats","authors":"Xiaolei Huang ,&nbsp;Fangmin Wang ,&nbsp;Yiying Zhou ,&nbsp;Miaojun Lai ,&nbsp;Huizhen Liu ,&nbsp;Yifang Hu ,&nbsp;Wenhua Zhou ,&nbsp;Yisheng Zhang","doi":"10.1016/j.psyneuen.2025.107558","DOIUrl":"10.1016/j.psyneuen.2025.107558","url":null,"abstract":"<div><div>Growing evidence implicates Toll-like receptor 4 (TLR4) expression in neuroinflammatory processes linked to depression pathogenesis, yet its role in perimenopausal depression remains unexplored. This study investigated concurrent changes in TLR4-related inflammatory mechanisms underlying depression-like behaviors following ovariectomy (OVX), focusing on the medial prefrontal cortex (mPFC). Sucrose preference and forced swim tests were used to assess anhedonia and behavioral despair, respectively. Quantitative analysis of TLR4/MyD88/NF-κB/p65 pathway components, pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and apoptosis marker caspase-3 in the mPFC was conducted via Western blotting, whereas dual immunofluorescence staining mapped TLR4 distribution in neurons and microglia. OVX induced depression-like behaviors, along with upregulation of the TLR4-MyD88-NF-κB signalling axis, increased pro-inflammatory cytokines levels, and higher caspase-3 expression in the mPFC. Dual immunofluorescence colocalisation analysis revealed TLR4 expression in both neurons and microglia, with selective neuronal enrichment post-OVX. Notably, the neuronal TLR4 expression profiles showed parallel alterations in apoptosis markers and cytokines. Intraperitoneal administration of ibudilast, a TLR4 inhibitor, significantly ameliorated depression-like behaviors, attenuated upregulation of the TLR4 pathway, and reduced neuroinflammatory markers in OVX rats. These results demonstrate that OVX induces neuronal TLR4 overexpression, which results in concurrent neuroinflammatory and apoptotic processes underlying depressive phenotypes. These findings support the therapeutic potential of TLR4 inhibitors for perimenopausal depression, particularly by targeting neuron-specific inflammatory cascades.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107558"},"PeriodicalIF":3.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining cross-lag associations between perceived stress and hair cortisol from pregnancy to 15 months postpartum","authors":"Jennifer E. Khoury ,&nbsp;Marc Jambon ,&nbsp;Andrea Gonzalez ,&nbsp;Leslie Atkinson","doi":"10.1016/j.psyneuen.2025.107556","DOIUrl":"10.1016/j.psyneuen.2025.107556","url":null,"abstract":"<div><h3>Background</h3><div>The perinatal period is often characterized by heightened psychological and biological stress. While psychological distress and neuroendocrine (hypothalamic pituitary adrenal, HPA) activity are often assumed to be interrelated, perceived stress and hair cortisol concentrations, a marker of longer-term HPA activity, are inconsistently associated during the perinatal period. This longitudinal study investigates the concurrent, prospective, and cross-lagged associations between maternal perceived stress and HCC from pregnancy through 15 months postpartum.</div></div><div><h3>Methods</h3><div>Individuals (n = 304) participated at different points during pregnancy and at 6 weeks, 6 months, and 15 months postpartum. At each time point, self-reported perceived stress and hair samples were collected. Correlational analyses and cross-lagged panel analyses were used to evaluate the stability of perceived stress and hair cortisol over time, as well as the concurrent and cross-lagged associations.</div></div><div><h3>Results</h3><div>Both perceived stress and HCC showed strong stability across time points. The only significant cross-lagged association was between higher HCC at 6 weeks postpartum predicting higher perceived stress at 6 months. No other cross-lagged or concurrent associations between HCC and perceived stress were significant.</div></div><div><h3>Conclusions</h3><div>These findings highlight the stability of maternal perceived stress and HCC from pregnancy to 15 months postpartum. We did not find strong support for concurrent or cross-lagged associations between HCC and perceived stress during the perinatal period, suggesting potential distinct biological and psychosocial contributors to psychological and neuroendocrine markers of stress.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107556"},"PeriodicalIF":3.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood disadvantage and elevated CD14 gene expression among middle-aged adults: Findings from the Midlife in the United States study","authors":"Jemar R. Bather ,&nbsp;Mariana Rodrigues ,&nbsp;Yanping Jiang ,&nbsp;Steven W. Cole ,&nbsp;Adolfo G. Cuevas","doi":"10.1016/j.psyneuen.2025.107553","DOIUrl":"10.1016/j.psyneuen.2025.107553","url":null,"abstract":"<div><div>Social and environmental factors are crucial in health, partly through immune system programming that begins decades before chronic disease onset. This study quantified the associations between neighborhood opportunity and <em>CD14</em> gene expression, a key marker of monocyte abundance and inflammatory potential in the circulating leukocyte pool. Neighborhood opportunity was measured using the Childhood Opportunity Index 3.0 reflecting Overall Neighborhood Opportunity and three subdomains (Education, Health and Environment, and Social and Economic Resources). Multivariable linear regression analyses among 1215 middle-aged adults (57 ± 12 years) from the Midlife in the United States Study revealed that individuals residing in disadvantaged neighborhoods had 36.6 % (95 % CI: 11.7–65.9 % elevation, <em>p</em> = 0.002) higher <em>CD14</em> gene expression levels than those in neighborhoods with high opportunity, even after adjusting for key sociodemographic characteristics and health behaviors. The Education domain (27.5 % elevation, 95 % CI: 5.0–54.8 % elevation, <em>p</em> = 0.015) and Social &amp; Economic Resources domain (32.9 % elevation, 95 % CI: 8.7–62.5 % elevation, <em>p</em> = 0.006) strongly tracked with elevated <em>CD14</em> gene expression levels. These findings extend previous research showing how social factors “get under the skin” through sympathetic nervous system activation and altered myelopoiesis, producing a proinflammatory, glucocorticoid-resistant immune phenotype.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107553"},"PeriodicalIF":3.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of depression in the relationship between allostatic load and mortality","authors":"Yan Huang ,&nbsp;Lin Han ,&nbsp;Yefei Xiao ,&nbsp;Ruiqi Wang ,&nbsp;Dan Liu ,&nbsp;Bing Cao","doi":"10.1016/j.psyneuen.2025.107550","DOIUrl":"10.1016/j.psyneuen.2025.107550","url":null,"abstract":"<div><div>Allostatic load (AL), an indicator of chronic stress that reflects the cumulative cost of repeated environmental stressors on neural and neuroendocrine responses, has been considered as a potential factor in the development of depression and may increase mortality risk. This study aimed to investigate the association between AL, depression, and mortality in the general population and to evaluate the mediating role of depression in the relationship between AL and mortality. Cross-sectional data from 15,571 participants of the US National Health and Nutrition Examination Survey (NHANES) 2009–2016 were analyzed. AL was calculated by summing numerical values for each biomarker based on predefined risk zones, yielding a score from 0 to 11. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9). The results showed a significant association between AL and mortality (HR = 1.16, 95 % CI: 1.09, 1.23, p &lt; 0.001), with larger effects observed in women and participants aged 40–49. Mediation analysis revealed that depression significantly mediated the relationship between AL and mortality (β = 0.0158, p &lt; 0.001), the indirect effect accounting for approximately 10.45 % of the total effect. Overall, our findings underscore the significant link between AL and mortality, with depression playing a notable mediating role. Future research should focus on exploring the vulnerability of elderly females and middle-aged individuals to chronic stress, using larger, more diverse cohorts and longer follow-up periods to better elucidate mechanisms underlying their increased mortality risk.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107550"},"PeriodicalIF":3.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between plasma epidermal growth factor and the progression of anxiety and depressive symptoms in Parkinson's disease","authors":"Xue-Feng Xiang ,&nbsp;Chen-Hong Li ,&nbsp;Jing-Yu Shao ,&nbsp;Rong Li ,&nbsp;Hong-Ju Zhang ,&nbsp;Jie-Wen Zhang ,&nbsp;Shuai Chen","doi":"10.1016/j.psyneuen.2025.107551","DOIUrl":"10.1016/j.psyneuen.2025.107551","url":null,"abstract":"<div><h3>Objective</h3><div>Parkinson's disease (PD) is marked by a high incidence of neuropsychiatric symptoms that significantly impact the patients' quality of life. Biomarkers for monitoring anxiety and depressive symptoms in patients with PD are currently scarce. Epidermal growth factor (EGF), a neuroprotective growth factor, is linked to mood disorders and cognitive decline in patients with PD. This longitudinal study aimed to assess whether baseline plasma EGF levels can forecast the advancement of anxiety and depressive symptoms in patients with PD.</div></div><div><h3>Methods</h3><div>We examined clinical and biomarker data from 154 drug-naïve patients with PD enrolled in the Parkinson's Progression Markers Initiative cohort, with annual follow-up assessments spanning seven years. Baseline plasma EGF concentrations were measured using a sandwich enzyme-linked immunosorbent assay. Participants were categorized into tertiles (low, medium, and high) based on their EGF levels. Linear mixed-effects models (LME) were utilized to investigate the relationships between baseline EGF (evaluated as both continuous and categorical variables) and changes over time in State–Trait Anxiety Inventory (STAI) and Geriatric Depression Scale (GDS) scores.</div></div><div><h3>Results</h3><div>The median age of the cohort was 63.74 years, and the median disease duration at baseline was 0.38 years. No significant differences were observed in the baseline STAI/GDS scores or motor symptom severity among the EGF tertiles. Covariate-adjusted LME analyses indicated that the medium and high EGF groups showed significantly lower annual increases in STAI (β = −0.94 to −1.20, <em>P</em> &lt; 0.05) and GDS (β = −0.14 to −0.22, <em>P</em> &lt; 0.05) scores compared to the low EGF group. Baseline EGF, when considered as a continuous variable, exhibited no correlation with STAI/GDS scores at baseline but displayed significant negative interactions with time for both scales (STAI: β = −0.01, <em>P</em> = 0.017; GDS: β = −0.001, <em>P</em> = 0.020). The sensitivity analyses validated these results.</div></div><div><h3>Conclusions</h3><div>Elevated baseline plasma EGF levels correlate with a decelerated advancement of anxiety and depressive symptoms in PD, supporting EGF's dual potential as a monitoring biomarker and therapeutic target for the neuropsychiatric aspects of PD.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107551"},"PeriodicalIF":3.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fueled and focused: A brief intervention integrating stress reappraisal and achievement goals improves exam performance and reduces cortisol","authors":"Audrey-Ann Journault ,&nbsp;Marisa E. Marotta ,&nbsp;Emily J. Hangen ,&nbsp;Hannah Gravelding ,&nbsp;Andrew J. Elliot ,&nbsp;Jeremy P. Jamieson","doi":"10.1016/j.psyneuen.2025.107544","DOIUrl":"10.1016/j.psyneuen.2025.107544","url":null,"abstract":"<div><div>When taking an exam, experiencing stress is natural, especially for students transitioning to new academic environments. Students who reappraise stress arousal as a functional resource and who adopt approach-oriented achievement goals —focusing on attaining success rather than avoiding failure— may experience healthier biological stress responses and perform better. This study tested whether a short intervention that integrated the stress reappraisal and achievement goal models 1) increased students’ exam scores and 2) decreased their stress hormones during their course exams compared to a control condition. Students in an Introduction to Psychology course (N = 308; <em>M</em>_age = 18.30 years, <em>SD</em>_age = 0.62 years, 59 % Female) were randomly assigned to a short reading-writing intervention or a control condition between their first and second in-class exams. Students provided a saliva sample immediately after each exam to assess the cortisol levels produced while taking the exam, and exam scores were obtained from the course instructor. Results revealed that the intervention increased exam scores and decreased production of salivary cortisol at Exam 2 post-intervention compared to the control intervention. In brief, the short intervention was a successful tool in helping students view their stress responses as additional fuel to focus on the exam and perform.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107544"},"PeriodicalIF":3.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value affirmation or emotional support: The buffering effect of social rewards on psychological stress","authors":"Shuai Wang ,&nbsp;Xiaolin Zhao ,&nbsp;Weiyu Hu ,&nbsp;Meijun Zhou ,&nbsp;Juan Yang","doi":"10.1016/j.psyneuen.2025.107535","DOIUrl":"10.1016/j.psyneuen.2025.107535","url":null,"abstract":"<div><div>Previous studies have demonstrated that social rewards can buffer the stress response. However, little is known about whether different types of social rewards differ in their buffering effects on different psychological stressors. Additionally, since psychological stress usually impairs people's cognitive performance, this study also examined whether social rewards could enhance cognitive abilities after stress. This study used the Trier Social Stress Test (Experiment 1) and Yale Interpersonal Stressor (Experiment 2) to induce performance and interpersonal stress, respectively. Two randomized controlled experiments with Chinese university students (<em>N</em> = 85 in Experiment 1, <em>N</em> = 78 in Experiment 2) compared the buffering effects of value affirmation and emotional support on stress. Furthermore, cognitive ability-enhancing effects were assessed through mental arithmetic performance (Experiment 1) and working memory capacity (Experiment 2). Results showed: 1) only value affirmation, but not emotional support, buffered the performance stress response (lower levels of cortisol, heart rate, and reports of subjective stress) compared to the control condition. 2) while both value affirmation and emotional support buffered interpersonal stress compared to the control condition, emotional support buffered better (lower cortisol and heart rate) than value affirmation. 3) Value affirmation enhanced mental arithmetic accuracy during performance stress and working memory capacity after interpersonal stress, whereas emotional support showed no cognitive benefits. These findings suggest that value affirmation is more effective at buffering performance stress, while emotional support is more effective at buffering interpersonal stress. However, only value affirmation enhances cognitive performance in both performance and interpersonal stress.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107535"},"PeriodicalIF":3.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between lipid parameters and depression with the moderating role of inflammation: Network analyses of 87,636 UK Biobank participants","authors":"Pingan Li ,&nbsp;Haiping Zhang,&nbsp;Jianhua Ma,&nbsp;Jinqi Wang,&nbsp;Shiyun Lv,&nbsp;Xiaoyu Zhao,&nbsp;Xinghua Yang,&nbsp;Yanxia Luo,&nbsp;Lixin Tao,&nbsp;Xiuhua Guo,&nbsp;Bo Gao","doi":"10.1016/j.psyneuen.2025.107543","DOIUrl":"10.1016/j.psyneuen.2025.107543","url":null,"abstract":"<div><h3>Background</h3><div>Studies investigating lipid–depression associations have reported inconsistent findings, and few have considered the interrelationships among lipid parameters. Additionally, the moderating role of inflammation in these associations remains unclear. This study aims to (1) assess lipid–depression associations after controlling for other lipid parameters, and (2) explore the moderating effect of inflammation.</div></div><div><h3>Methods</h3><div>The study included 87,636 participants from the UK Biobank. A pairwise mixed graphical model (MGM) network was constructed in the entire sample to examine the prospective associations between seven lipid parameters and depression. The moderating role of inflammation was explored by: (1) estimating pairwise MGM networks for groups stratified by high-sensitivity C-reactive protein (hs-CRP) levels, (2) conducting network comparison tests (NCTs), and (3) constructing moderated network models (MNMs).</div></div><div><h3>Results</h3><div>In the full-sample network, edges connecting triglycerides (TG, edge weight = 0.034), high-density lipoprotein cholesterol (HDL-C, edge weight = −0.011), low-density lipoprotein cholesterol (LDL-C, edge weight = −0.009), and lipoprotein(a) (Lp(a), edge weight = 0.012) with depression were identified. The non-elevated and elevated hs-CRP networks exhibited opposite signs for the Lp(a)–depression edge. In NCTs, HDL-C–depression and apolipoprotein A1 (Apo A1)–depression showed significant differences in edge weights. hs-CRP moderates the associations of HDL-C, Apo A1, and Lp(a) with depression in MNMs.</div></div><div><h3>Conclusions</h3><div>After controlling for other lipid parameters, TG and Lp(a) are positively, while HDL-C and LDL-C are negatively associated with depression in the overall study population. Inflammation moderates the associations of HDL-C, Apo A1, and Lp(a) with depression. Our study provides further evidence for the lipid–depression associations.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107543"},"PeriodicalIF":3.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Announcement: 55th Annual Meeting of the International Society of Psychoneuroendocrinology (ISPNE)","authors":"","doi":"10.1016/j.psyneuen.2025.107533","DOIUrl":"10.1016/j.psyneuen.2025.107533","url":null,"abstract":"","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"179 ","pages":"Article 107533"},"PeriodicalIF":3.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived discrimination and monocyte abundance in older adults: Findings from the Health and Retirement Study","authors":"A.G. Cuevas ,&nbsp;J.R. Bather ,&nbsp;E. Kranz ,&nbsp;S.W. Cole","doi":"10.1016/j.psyneuen.2025.107534","DOIUrl":"10.1016/j.psyneuen.2025.107534","url":null,"abstract":"<div><div>Perceived discrimination is a pervasive social stressor linked to adverse health outcomes, and these effects appear to be mediated at least in part by immune system alterations that may affect inflammation-related diseases. To determine the cellular mechanisms involved, we investigated the association between everyday perceived discrimination and circulating monocyte counts in data from the 2016 Health and Retirement Study Venous Blood Study (n = 6332). After adjusting for age, sex, race/ethnicity, body mass index, smoking, and alcohol consumption, individuals reporting higher levels of perceived discrimination exhibited increased total monocyte counts, with a 9 % relative increase in total monocyte counts per 4-standard deviation increase in perceived discrimination scores (95 % CI: 0.01, 0.17). These effects stemmed primarily from increased abundance of classical monocytes, with no significant associations for non-classical monocytes. These results suggest that perceived discrimination may contribute to disease at least in part via increased monocyte abundance. These findings underscore the importance of addressing perceived discrimination as a social determinant of health and highlight the need for further research on the immunological pathways involved.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"180 ","pages":"Article 107534"},"PeriodicalIF":3.4,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}