Psychoneuroendocrinology最新文献

{"title":"The effects of single testosterone administration and stress induction on steroid hormone levels in hair","authors":"Hana H. Kutlikova ,&nbsp;Christoph Eisenegger ,&nbsp;Aniko Krumbholz ,&nbsp;Igor Riečanský ,&nbsp;Claus Lamm ,&nbsp;Boris B. Quednow","doi":"10.1016/j.psyneuen.2024.107252","DOIUrl":"10.1016/j.psyneuen.2024.107252","url":null,"abstract":"<div><div>Hair steroid analysis is increasingly recognized for its ability to capture cumulative hormone secretion, thought to reflect an individual’s response to long-term environmental conditions. Despite its growing use, the influence of single, isolated events on hair steroid concentrations remains underexplored. Our study therefore examined the effects of a single-dose transdermal testosterone administration (150 mg) and acute laboratory stress induction on hair testosterone and cortisol levels in a randomized, between-subject, placebo-controlled, and double-blind design. Liquid chromatography-tandem mass spectrometry analysis revealed a significant increase in hair testosterone levels seven weeks post-testosterone administration, underscoring the efficacy of hair analysis in detecting single-use hormone intake. Moreover, we observed a significant elevation in hair cortisol levels seven weeks post-exposure to the laboratory somatic stressor (Cold pressor test), highlighting the efficacy of hair analysis in capturing experimentally induced hormonal responses. The exploration of contextual factors revealed that individuals in committed relationships exhibited lower levels of both hair cortisol and testosterone compared to those who were single or in uncommitted relationships.</div><div>Our study provides new insights into the sensitivity of hair analysis for detecting hormonal changes following single-dose hormone administration and experimentally induced short-term stress events. The exploratory findings emphasize the importance of individual contextual factors in influencing hair hormone concentrations and lay the groundwork for further investigation into the dynamics of cumulative hair hormone measurements.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107252"},"PeriodicalIF":3.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific differences in the relationship between thyroid hormones and neurocognition in schizophrenia: A large-scale cross-sectional study","authors":"Junhao Chen ,&nbsp;Hongmin Ge ,&nbsp;Nannan Liu ,&nbsp;Yanzhe Li ,&nbsp;Yeqing Dong ,&nbsp;Xinxu Wang ,&nbsp;Zhiyuan Xun ,&nbsp;Shen Li","doi":"10.1016/j.psyneuen.2024.107249","DOIUrl":"10.1016/j.psyneuen.2024.107249","url":null,"abstract":"<div><h3>Background</h3><div>Sex differences in thyroid hormones, cognitive function, and psychiatric symptoms in schizophrenia remain underexplored. The study aimed to investigate the cross-sectional relationships between thyroid hormone levels, cognitive impairments, and clinical symptoms in people with chronic schizophrenia, with a focus on sex differences.</div></div><div><h3>Methods</h3><div>We included 1007 people with schizophrenia (602 males and 405 females), and 326 healthy controls (193 males and 133 females). Cognitive function and psychiatric symptoms were assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Positive and Negative Syndrome Scale (PANSS), respectively. Blood samples were collected to measure serum total thyroxine (TT4), total triiodothyronine (TT3), thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3). Analysis of variance (ANOVA) and two-way ANOVA were used to compare clinical characteristics and sex differences. Pearson correlation and hierarchical linear regression were conducted to assess the relationships between thyroid hormone levels, cognitive impairments, and clinical symptoms.</div></div><div><h3>Results</h3><div>People with schizophrenia exhibited lower levels of thyroid hormones compared to the healthy control group (both <em>P</em> &lt; 0.01). Male patients had higher TT3 and FT3 levels than female patients (both <em>P</em> &lt; 0.01). The cognitive scores of the healthy controls were generally higher than those of people with schizophrenia (<em>P</em> &lt; 0.001). Additionally, there were significant sex differences in visuospatial/constructive abilities and language (both <em>P</em> &lt; 0.01) among people with schizophrenia, with males scoring higher than females. The linear regression found that in the cognitive domain, TT4 was negatively associated with Visuospatial/Constructive abilities and RBANS total scores in male patients (both P &lt; 0.05), whereas TT4 was positively associated with these abilities and attention in female patients (all P &lt; 0.05). Additionally, in male patients, TT3 was negatively associated with most of PANSS scale (all P &lt; 0.05). In female, TT3 was only negatively associated with the PANSS Negative scale (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Sex differences exist in thyroid hormone T3 levels in people with schizophrenia. The association between thyroid hormones and cognitive performance varies by sex in chronic schizophrenia.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107249"},"PeriodicalIF":3.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The transition to parenthood: Linking hormones, brain, and behavior","authors":"Susana Carmona,&nbsp;Oscar Vilarroya","doi":"10.1016/j.psyneuen.2024.107247","DOIUrl":"10.1016/j.psyneuen.2024.107247","url":null,"abstract":"<div><div>This Special Issue brings together pioneering research that explores the neurobiological and hormonal underpinnings of parenting, with an important emphasis on translational perspectives that bridge laboratory findings with real-world applications. By integrating evidence from both human and animal studies, this collection sheds light on the biological flexibility that supports adaptive caregiving behaviors, offering insights into the hormonal shifts, neural adaptations, and stress responses that characterize the perinatal and postpartum periods</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107247"},"PeriodicalIF":3.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory signalling during the perinatal period: Implications for short- and long-term disease risk","authors":"Romina Garcia de leon ,&nbsp;Travis E. Hodges ,&nbsp;Hilary K. Brown ,&nbsp;Tamara S. Bodnar ,&nbsp;Liisa A.M. Galea","doi":"10.1016/j.psyneuen.2024.107245","DOIUrl":"10.1016/j.psyneuen.2024.107245","url":null,"abstract":"<div><div>During pregnancy and the postpartum, there are dynamic fluctuations in steroid and peptide hormone levels as well as inflammatory signalling. These changes are required for a healthy pregnancy and can persist well beyond the postpartum. Many of the same hormone and inflammatory signalling changes observed during the perinatal period also play a role in symptoms related to autoimmune disorders, psychiatric disorders, and perhaps neurodegenerative disease later in life. In this review, we outline hormonal and immunological shifts linked to pregnancy and the postpartum and discuss the possible role of these shifts in increasing psychiatric, neurodegenerative disease risk and autoimmune symptoms during and following pregnancy. Furthermore, we discuss how key variables such as the number of births (parity) and sex of the fetus can influence inflammatory signalling, and possibly future disease risk, but are not often studied. We conclude by discussing the importance of studying female experiences such as pregnancy and parenting on physiology and disease.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107245"},"PeriodicalIF":3.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State rumination links major life stressors to acute stressor cortisol response in healthy adults","authors":"Jacqueline Rodriguez-Stanley ,&nbsp;Katherine Knauft ,&nbsp;Samuele Zilioli","doi":"10.1016/j.psyneuen.2024.107234","DOIUrl":"10.1016/j.psyneuen.2024.107234","url":null,"abstract":"<div><div>Experiencing major life stressors is associated with negative health outcomes, yet the mechanisms are not fully understood. Major stressors are threatening, discrete events that can have lingering consequences on emotional and cognitive processes. This can lead to maladaptive coping strategies, such as rumination, that compromise the ability to handle subsequent stressors and disrupt the hypothalamic-pituitary-adrenal (HPA) axis response. Based on the Perseverative Cognition Hypothesis, it was hypothesized that greater exposure to major stressors would be associated with greater rumination during a laboratory stressor, which, in turn, would predict higher cortisol reactivity and peak and delayed recovery. Participants were 211 healthy adults (<em>M</em>_age = 30.2, <em>SD</em> = 10.9, range = 18 – 55) who underwent the Trier Social Stress Test and self-reported rates of major stressors in the past 12 months and stress-related state rumination. Two-piece growth curve modeling with landmark registration was used to calculate peak salivary cortisol levels along with cortisol reactivity and recovery slopes to capture individual differences in the trajectory of cortisol response. Results showed that state rumination significantly mediated the link between more major stressors and elevated peak cortisol levels as well as steeper reactivity and recovery slopes. Interpersonal stressors and non-interpersonal stressors showed similar associations to cortisol response via state rumination. This study enhances our understanding of how stress contributes to HPA axis dysregulation by connecting major stressors with acute stressors, pointing at stress-induced rumination as a plausible mechanism.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107234"},"PeriodicalIF":3.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay of socio-emotional vulnerability and physiological stress response: Unraveling distress patterns amidst the COVID-19 pandemic","authors":"Catherine Raymond ,&nbsp;Alexe Bilodeau-Houle ,&nbsp;Maryse Arcand ,&nbsp;Clémence Peyrot ,&nbsp;Marie-France Marin","doi":"10.1016/j.psyneuen.2024.107233","DOIUrl":"10.1016/j.psyneuen.2024.107233","url":null,"abstract":"<div><div>The COVID-19 pandemic led to increased internalizing symptoms (IS) among adults, with notable interindividual differences. Cross-sectional studies suggest that both biological (physiological stress) and psychological (socio-emotional) factors independently contribute to IS. This longitudinal study examined whether physiological stress during the pandemic moderated the relationship between socio-emotional vulnerability and IS. In June 2020, 94 adults (average age 34.16, SD = 8.86) provided a 6 cm hair sample, allowing the quantification of cumulative hair cortisol concentrations (HCC) during the three months preceding the pandemic (Segment A) and the three months of the first wave of the pandemic in Quebec, Canada (Segment B). We calculated HCC reactivity (rHCC) as the percent change between the two segments. A socio-emotional composite score (SECS) was derived using the Anxiety Sensitivity Index, Intolerance of Uncertainty Scale, and Perseverative Thinking Questionnaire. Every three months from June 2020 to March 2021, participants completed the Depression Anxiety Stress Scales and Impact of Event Scale. Analyses revealed an interaction between Time, SECS, and rHCC on stress, and between SECS and rHCC on depressive symptoms. High rHCC was associated with a stronger correlation between SECS and stress symptoms in September and December 2020 (these months were significant transition periods during the pandemic in Quebec). Additionally, individuals with low rHCC exhibited greater depressive symptoms, regardless of time. Our findings suggest that the activation of the physiological stress system at the beginning of the pandemic was associated with increased stress symptoms during subsequent transition periods. Conversely, lower activation of the stress system contributed to greater depressive symptoms over time, particularly in individuals with heightened socio-emotional vulnerability. This highlights the role of physiological responses in modulating emotional outcomes under prolonged stress and adds to the growing literature on vulnerability factors in response to enduring stressors.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107233"},"PeriodicalIF":3.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal care is associated with neural and behavioral effects of oxytocin administration during empathic accuracy in schizophrenia and controls","authors":"Casey K. Brown ,&nbsp;Lize De Coster ,&nbsp;Junghee Lee ,&nbsp;Lisa Lin ,&nbsp;Daniel H. Mathalon ,&nbsp;Joshua D. Woolley","doi":"10.1016/j.psyneuen.2024.107228","DOIUrl":"10.1016/j.psyneuen.2024.107228","url":null,"abstract":"<div><div>Empathic accuracy, the ability to accurately understand other people’s emotions, is a complex social cognitive skill that is often impaired in schizophrenia and this impairment is associated with poor functional outcomes. Intranasally administered oxytocin, a neuropeptide implicated in social behavior, is thought to improve empathic accuracy for individuals with schizophrenia. However, early experiences related to caregiving may shape the oxytocinergic system and influence individual responses to oxytocin administration. Using a cross-over, double-blind, placebo-controlled design coupled with fMRI, the current study investigated whether administration of oxytocin improves empathic accuracy in schizophrenia compared to a matched placebo, and the moderating role of early maternal care. Results revealed that, compared to controls, individuals with schizophrenia had lower empathic accuracy and recruited a sparser pattern of neural activation to achieve empathic accuracy. Oxytocin administration was not associated with improved empathic accuracy for either group. However, in both groups, individuals reporting higher maternal care demonstrated the greatest improvements in empathic accuracy with oxytocin administration, accompanied by decreased activity in the right dorsolateral prefrontal cortex, a region implicated in selective attention to socioemotional stimuli. Findings highlight the importance of examining individual differences in responses to oxytocin administration and suggest that early social experiences influence later responses to oxytocin administration.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"172 ","pages":"Article 107228"},"PeriodicalIF":3.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated testosterone and prosocial behavior in female patients with borderline personality disorder independent of social exclusion","authors":"Livia Graumann ,&nbsp;Eugenia Kulakova ,&nbsp;An Bin Cho ,&nbsp;Christian Eric Deuter ,&nbsp;Oliver T. Wolf ,&nbsp;Jill Schell ,&nbsp;Julian Hellmann-Regen ,&nbsp;Stefan Roepke ,&nbsp;Christian Otte ,&nbsp;Katja Wingenfeld","doi":"10.1016/j.psyneuen.2024.107232","DOIUrl":"10.1016/j.psyneuen.2024.107232","url":null,"abstract":"<div><h3>Objective</h3><div>Borderline personality disorder (BPD) is marked by unstable relationships and fear of abandonment. Earlier studies suggest that patients with BPD are highly sensitive to social exclusion and show deficits in trust and cooperation. The hormone testosterone influences such prosocial behavior and regulates aggressive and caring behavior. Previous studies show elevated testosterone levels in female patients with BPD at baseline and after psychosocial stress, while results after social exclusion are missing.</div></div><div><h3>Method</h3><div>We investigated the effects of social exclusion on prosocial behavior (sharing and punishment) and salivary testosterone in female patients with BPD. Ninety-eight patients with BPD and 98 healthy females matched for menstrual cycle were randomly assigned to an overinclusion or exclusion condition of the virtual ballgame Cyberball. Afterwards, participants played two games in which they could share money with a fictional player (\"dictator game\") and accept or reject (= punish) offers from a player (\"ultimatum game\").</div></div><div><h3>Results</h3><div>Female patients with BPD displayed higher testosterone levels than the control group before and after Cyberball. Social exclusion did not affect testosterone levels. Patients with BPD exhibited more prosocial behavior by sharing more money than controls and punished co-players for unfair offers equally often.</div></div><div><h3>Conclusion</h3><div>We replicated previous findings of elevated testosterone in female patients with BPD and showed that it is not affected by experimentally induced social exclusion. Regardless of social exclusion, patients with BPD showed more prosocial behavior, which may reflect a status-seeking strategy to secure their social standing.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107232"},"PeriodicalIF":3.4,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term hair cortisone and perceived stress are associated with long-term hedonic eating tendencies in patients with obesity","authors":"Susanne Kuckuck ,&nbsp;Eline S. van der Valk ,&nbsp;Robin Lengton ,&nbsp;Julius März ,&nbsp;Manon H.J. Hillegers ,&nbsp;Brenda W.J.H. Penninx ,&nbsp;Maryam Kavousi ,&nbsp;Mariëtte R. Boon ,&nbsp;Sjoerd A.A. van den Berg ,&nbsp;Elisabeth F.C. van Rossum","doi":"10.1016/j.psyneuen.2024.107224","DOIUrl":"10.1016/j.psyneuen.2024.107224","url":null,"abstract":"<div><h3>Introduction</h3><div>Long-term biological stress, reflected in hair cortisol and cortisone levels, predicts future weight gain and metabolic deterioration. This is likely at least partially mediated by glucocorticoid-induced increases in hedonic overeating. Yet, the relationship between long-term biological stress and long-term hedonic eating tendencies remains to be elucidated.</div></div><div><h3>Methods</h3><div>We included N=108 adults with lifestyle-induced obesity (91 women, median body-mass-index=38.4 kg/m2) for our primary analysis investigating cross-sectional associations between long-term biological stress (hair cortisol and cortisone measured in the first 3 cm of scalp hair using liquid chromatography tandem mass spectrometry) and self-reported long-term hedonic eating tendencies (emotional and external eating, ‘Dutch Eating Behavior Questionnaire’, and trait food craving, ‘Food Craving Questionnaire-Trait’). In secondary analyses, we investigated the moderating role of long-term psychological stress (Perceived Stress Scale-14 score) on the relation between hair glucocorticoid levels and hedonic eating tendencies.</div></div><div><h3>Results</h3><div>Higher hair cortisone levels, but not higher hair cortisol levels, were associated with more food cravings after adjustment for sex and age (p&lt;0.05). The association remained significant after additional adjustment for psychological stress (p&lt;0.05). Psychological stress correlated positively with food craving and hedonic eating (p&lt;0.05), and, in trend, with external eating (p&lt;0.1). Stratification of stress groups (high vs. low psychological stress in addition to high vs. low biological stress) showed food cravings and emotional eating to be highest in the group with both high psychological-stress and high hair-cortisone (p&lt;0.05), suggesting potential additive effects of different stress measures.</div></div><div><h3>Conclusion</h3><div>Long-term psychological and biological stress correlate with hedonic eating tendencies with potentially adverse additive effects on weight management and clinical features of obesity.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107224"},"PeriodicalIF":3.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventral subiculum control of avoidance behavior and hypothalamic-pituitary-adrenal axis reactivity via the bed nucleus of the stria terminalis in male and female mice – ISPNE 2024 Dirk Helhammer Award","authors":"Jena S. Marsh ,&nbsp;Cara Teixeira ,&nbsp;Swapnil Gavade ,&nbsp;Colin Johnston ,&nbsp;Salisha Baranwal ,&nbsp;Christen N. Snyder ,&nbsp;Chih-Lin Chang ,&nbsp;Shany Yang ,&nbsp;Joanna L. Spencer-Segal","doi":"10.1016/j.psyneuen.2024.107229","DOIUrl":"10.1016/j.psyneuen.2024.107229","url":null,"abstract":"<div><div>Avoidance or anxiety-like behavior is accompanied by corresponding changes in hypothalamic-pituitary-adrenal (HPA) axis activation. The underlying neural circuitry for this coordinated behavioral and neuroendocrine control is not well established. Prior studies pointed to a neural projection from the ventral subiculum (vSub) to the bed nucleus of the stria terminalis (BNST) that can inhibit the HPA axis response to stress. Here, we used chemogenetics to investigate the role of vSub neurons and their projection to the anterior BNST (aBNST) in avoidance behavior and the accompanying corticosterone response in male and female mice. Surprisingly, we found that chemogenetic activation of ventral subiculum neurons increased the HPA axis response to an open field test in male and female mice, which was also seen with selective activation of vSub neurons projecting to the anterior BNST (vSub-aBNST neurons). On the other hand, VSub neuron and vSub-aBNST neuron activation had different effects on avoidance behavior, suggesting that the behavioral role of the VSub is variable and is dissociable from its neuroendocrine effects. In conclusion, our results reveal a surprising and novel role for the ventral subiculum in HPA axis activation via the anterior BNST. We also show that, like the ventral hippocampus, ventral subiculum neurons can increase or decrease avoidance behavior depending on their downstream projection.</div></div>","PeriodicalId":20836,"journal":{"name":"Psychoneuroendocrinology","volume":"171 ","pages":"Article 107229"},"PeriodicalIF":3.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}