Association and biological pathways between metabolic syndrome and incident Parkinson’s disease: A prospective cohort study of 289,150 participants

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology Pub Date : 2025-03-26 DOI:10.1016/j.psyneuen.2025.107444

HuiMin Liu , Tao Peng , YuDi Xu , QingSheng Li , LingFei Yang , Zhe Gong , JunFang Teng , Qiang Zhang , YanJie Jia

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引用次数: 0

Abstract

The relationship between metabolic syndrome (MetS) and Parkinson’s disease (PD) remains uncertain due to inconsistent findings in previous studies. This prospective cohort study investigated the association between MetS and PD risk, along with potential biological mechanisms, using data from 289,150 PD-free participants in the UK Biobank. MetS was defined by the presence of at least three of the following components, while preMetS included one or two: increased waist circumference, elevated triglycerides (TG), high blood pressure (BP), elevated HbA1c, or reduced high-density lipoprotein cholesterol (HDL-C). Cox proportional hazards models were utilized to assess the risk of PD, and mediation analyses explored the role of blood biomarkers. Over a median follow-up of 13.1 years, 1682 participants developed PD. PreMetS (HR: 1.24, 95 % CI: 1.02–1.51, P = 0.028) and MetS (HR: 1.32, 95 % CI: 1.08–1.61, P = 0.008) were associated with an increased PD risk, with Kaplan-Meier analysis showing risk escalation with more MetS components. Among individual MetS components, increased waist circumference, elevated HbA1c, and reduced HDL-C were significantly associated with higher PD risk, while elevated TG and BP showed no significant association. Mediation analysis indicated that biomarkers of liver function (alkaline phosphatase) and kidney function (cystatin C) partially mediated the MetS-PD relationship. These findings highlight a significant link between MetS and higher PD risk, with possible mediation through specific blood biomarkers, though temporal ambiguity warrants cautious interpretation.

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代谢综合征与帕金森病发病之间的关联和生物学途径：一项289,150名参与者的前瞻性队列研究

代谢综合征（MetS）与帕金森病（PD）之间的关系由于以往的研究结果不一致，仍然不确定。这项前瞻性队列研究调查了met和PD风险之间的关系，以及潜在的生物学机制，使用了来自英国生物银行289,150名无PD参与者的数据。MetS定义为至少存在以下三种成分，而preMetS包括一种或两种：腰围增加，甘油三酯（TG）升高，高血压（BP）， HbA1c升高或高密度脂蛋白胆固醇（HDL-C）降低。采用Cox比例风险模型评估PD的风险，并通过中介分析探讨血液生物标志物的作用。在中位13.1年的随访中，1682名参与者患上了帕金森病。PreMetS （HR: 1.24, 95 % CI: 1.02-1.51, P = 0.028）和MetS （HR: 1.32, 95 % CI: 1.08-1.61, P = 0.008）与PD风险增加相关，Kaplan-Meier分析显示met成分越多，风险增加。在单个MetS成分中，腰围增加、HbA1c升高和HDL-C降低与PD风险升高显著相关，而TG和BP升高无显著关联。中介分析表明，肝功能生物标志物（碱性磷酸酶）和肾功能生物标志物（胱抑素C）部分介导了met - pd关系。这些发现强调了MetS与PD高风险之间的重要联系，可能通过特定的血液生物标志物介导，尽管时间上的模糊性值得谨慎解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.