Medicinal Research Reviews最新文献_第7页

Metal complexes bearing EGFR-inhibiting ligands as promising anticancer agents 含有表皮生长因子受体抑制配体的金属复合物是很有前途的抗癌剂。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-27 DOI: 10.1002/med.22021

Xiaoyan Ma, Zhaoran Wang, Yifei Li, Yawen Wang, Wukun Liu

{"title":"Metal complexes bearing EGFR-inhibiting ligands as promising anticancer agents","authors":"Xiaoyan Ma, Zhaoran Wang, Yifei Li, Yawen Wang, Wukun Liu","doi":"10.1002/med.22021","DOIUrl":"10.1002/med.22021","url":null,"abstract":"Overexpression of the epidermal growth factor receptor (EGFR, erbB1) has been observed in a wide range of solid tumors and has frequently been associated with poor prognosis. As a result, EGFR inhibition has become an attractive anticancer drug design strategy, and a large number of small molecular inhibitors have been developed. Despite the widespread clinical use of EGFR tyrosine kinase inhibitors (TKIs), their drug resistance, inadequate accumulation in tumors, and severe side effects have spurred the search for better antitumor drugs. Metal complexes have attracted much attention because of their different mechanisms compared with EGFR-TKIs. Therefore, the combination of metals and inhibitors is a promising anticancer strategy. For example, Ru and Pt centers are introduced to design complexes with double or multiple targets, while Au complexes are combined with inhibitors to overcome drug resistance. Co complexes are designed as prodrugs with weak side effects and enhanced targeting by the hypoxia activation strategy, and other metals such as Rh and Fe enhance the anticancer effect of the complexes. In addition, the introduction of Ga center is beneficial to the development of nuclear imaging tracers. In this paper, metal EGFR-TKI complexes in the last 15 years are reviewed, their mechanisms are briefly introduced, and their advantages are summarized.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 4","pages":"1545-1565"},"PeriodicalIF":13.3,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in dietary androgen receptor inhibitors 饮食雄激素受体抑制剂的最新进展。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-27 DOI: 10.1002/med.22019

Li Ren, Tiehua Zhang, Jie Zhang

{"title":"Recent advances in dietary androgen receptor inhibitors","authors":"Li Ren, Tiehua Zhang, Jie Zhang","doi":"10.1002/med.22019","DOIUrl":"10.1002/med.22019","url":null,"abstract":"As a nuclear transcription factor, the androgen receptor (AR) plays a crucial role not only in normal male sexual differentiation and growth of the prostate, but also in benign prostatic hyperplasia, prostatitis, and prostate cancer. Multiple population-based epidemiological studies demonstrated that prostate cancer risk was inversely associated with increased dietary intakes of green tea, soy products, tomato, and so forth. Therefore, this review aimed to summarize the structure and function of AR, and further illustrate the structural basis for antagonistic mechanisms of the currently clinically available antiandrogens. Due to the limitations of these antiandrogens, a series of natural AR inhibitors have been identified from edible plants such as fruits and vegetables, as well as folk medicines, health foods, and nutritional supplements. Hence, this review mainly focused on recent experimental, epidemiological, and clinical studies about natural AR inhibitors, particularly the association between dietary intake of natural antiandrogens and reduced risk of prostatic diseases. Since natural products offer multiple advantages over synthetic antiandrogens, this review may provide a comprehensive and updated overview of dietary-derived AR inhibitors, as well as their potential for the nutritional intervention against prostatic disorders.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 4","pages":"1446-1500"},"PeriodicalIF":13.3,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies 糖尿病足溃疡辅助治疗的最新进展：关注非侵入性技术。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-27 DOI: 10.1002/med.22020

Fen Wang, Xiaoling Zhang, Jing Zhang, Qinqin Xu, Xuefeng Yu, Anhui Xu, Chengla Yi, Xuna Bian, Shiying Shao

{"title":"Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies","authors":"Fen Wang, Xiaoling Zhang, Jing Zhang, Qinqin Xu, Xuefeng Yu, Anhui Xu, Chengla Yi, Xuna Bian, Shiying Shao","doi":"10.1002/med.22020","DOIUrl":"10.1002/med.22020","url":null,"abstract":"Diabetic foot ulcer (DFU) is one of the most costly and serious complications of diabetes. Treatment of DFU is usually challenging and new approaches are required to improve the therapeutic efficiencies. This review aims to update new and upcoming adjunctive therapies with noninvasive characterization for DFU, focusing on bioactive dressings, bioengineered tissues, mesenchymal stem cell (MSC) based therapy, platelet and cytokine-based therapy, topical oxygen therapy, and some repurposed drugs such as hypoglycemic agents, blood pressure medications, phenytoin, vitamins, and magnesium. Although the mentioned therapies may contribute to the improvement of DFU to a certain extent, most of the evidence come from clinical trials with small sample size and inconsistent selections of DFU patients. Further studies with high design quality and adequate sample sizes are necessitated. In addition, no single approach would completely correct the complex pathogenesis of DFU. Reasonable selection and combination of these techniques should be considered.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 4","pages":"1501-1544"},"PeriodicalIF":13.3,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases 用于治疗神经退行性疾病的新兴磷酸二酯酶抑制剂。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-27 DOI: 10.1002/med.22017

Yu Xiang, Swapna Naik, Liyun Zhao, Jianyou Shi, Hengming Ke

{"title":"Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases","authors":"Yu Xiang, Swapna Naik, Liyun Zhao, Jianyou Shi, Hengming Ke","doi":"10.1002/med.22017","DOIUrl":"10.1002/med.22017","url":null,"abstract":"Neurodegenerative diseases (NDs) cause progressive loss of neuron structure and ultimately lead to neuronal cell death. Since the available drugs show only limited symptomatic relief, NDs are currently considered as incurable. This review will illustrate the principal roles of the signaling systems of cyclic adenosine and guanosine 3′,5′-monophosphates (cAMP and cGMP) in the neuronal functions, and summarize expression/activity changes of the associated enzymes in the ND patients, including cyclases, protein kinases, and phosphodiesterases (PDEs). As the sole enzymes hydrolyzing cAMP and cGMP, PDEs are logical targets for modification of neurodegeneration. We will focus on PDE inhibitors and their potentials as disease-modifying therapeutics for the treatment of Alzheimer's disease, Parkinson's disease, and Huntington's disease. For the overlapped but distinct contributions of cAMP and cGMP to NDs, we hypothesize that dual PDE inhibitors, which simultaneously regulate both cAMP and cGMP signaling pathways, may have complementary and synergistic effects on modifying neurodegeneration and thus represent a new direction on the discovery of ND drugs.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 4","pages":"1404-1445"},"PeriodicalIF":13.3,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GADD45A: With or without you 不管有没有你。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-24 DOI: 10.1002/med.22015

Xavier Palomer, Jesús M. Salvador, Christian Griñán-Ferré, Emma Barroso, Mercè Pallàs, Manuel Vázquez-Carrera

{"title":"GADD45A: With or without you","authors":"Xavier Palomer, Jesús M. Salvador, Christian Griñán-Ferré, Emma Barroso, Mercè Pallàs, Manuel Vázquez-Carrera","doi":"10.1002/med.22015","DOIUrl":"10.1002/med.22015","url":null,"abstract":"The growth arrest and DNA damage inducible (GADD)45 family includes three small and ubiquitously distributed proteins (GADD45A, GADD45B, and GADD45G) that regulate numerous cellular processes associated with stress signaling and injury response. Here, we provide a comprehensive review of the current literature investigating GADD45A, the first discovered member of the family. We first depict how its levels are regulated by a myriad of genotoxic and non-genotoxic stressors, and through the combined action of intricate transcriptional, posttranscriptional, and even, posttranslational mechanisms. GADD45A is a recognized tumor suppressor and, for this reason, we next summarize its role in cancer, as well as the different mechanisms by which it regulates cell cycle, DNA repair, and apoptosis. Beyond these most well-known actions, GADD45A may also influence catabolic and anabolic pathways in the liver, adipose tissue and skeletal muscle, among others. Not surprisingly, GADD45A may trigger AMP-activated protein kinase activity, a master regulator of metabolism, and is known to act as a transcriptional coregulator of numerous nuclear receptors. GADD45A has also been reported to display a cytoprotective role by regulating inflammation, fibrosis and oxidative stress in several organs and tissues, and is regarded an important contributor for the development of heart failure. Overall data point to that GADD45A may play an important role in metabolic, neurodegenerative and cardiovascular diseases, and also autoimmune-related disorders. Thus, the potential mechanisms by which dysregulation of GADD45A activity may contribute to the progression of these diseases are also reviewed below.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 4","pages":"1375-1403"},"PeriodicalIF":13.3,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.22015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139541307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases 使用合成化合物和天然产品的临床前证据表明，AMPK 是治疗肺部疾病的潜在药理靶点。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-16 DOI: 10.1002/med.22014

Chao Yang, Limor Rubin, Xiyong Yu, Philip Lazarovici, Wenhua Zheng

引用次数: 0

The role of Toll-like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management Toll 样受体在神经精神疾病中的作用：免疫病理学、治疗和管理。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-16 DOI: 10.1002/med.22012

Kiarash Saleki, Parsa Alijanizadeh, Nima Javanmehr, Nima Rezaei

{"title":"The role of Toll-like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management","authors":"Kiarash Saleki, Parsa Alijanizadeh, Nima Javanmehr, Nima Rezaei","doi":"10.1002/med.22012","DOIUrl":"10.1002/med.22012","url":null,"abstract":"Neuropsychiatric disorders denote a broad range of illnesses involving neurology and psychiatry. These disorders include depressive disorders, anxiety, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorders, headaches, and epilepsy. In addition to their main neuropathology that lies in the central nervous system (CNS), lately, studies have highlighted the role of immunity and neuroinflammation in neuropsychiatric disorders. Toll-like receptors (TLRs) are innate receptors that act as a bridge between the innate and adaptive immune systems via adaptor proteins (e.g., MYD88) and downstream elements; TLRs are classified into 13 families that are involved in normal function and illnesses of the CNS. TLRs expression affects the course of neuropsychiatric disorders, and is influenced during their pharmacotherapy; For example, the expression of multiple TLRs is normalized during the major depressive disorder pharmacotherapy. Here, the role of TLRs in neuroimmunology, treatment, and management of neuropsychiatric disorders is discussed. We recommend longitudinal studies to comparatively assess the cell-type-specific expression of TLRs during treatment, illness progression, and remission. Also, further research should explore molecular insights into TLRs regulation and related pathways.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 3","pages":"1267-1325"},"PeriodicalIF":13.3,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.22012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139471756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into Ganoderma fungi meroterpenoids opening a new era of racemic natural products in mushrooms 灵芝子实体的新发现开创了蘑菇外消旋天然产品的新纪元。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-10 DOI: 10.1002/med.22006

Jiao-Jiao Zhang, Fu-Ying Qin, Yong-Xian Cheng

引用次数: 0

CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti-inflammatory drug discovery CXCR4/CXCL12 轴：作为抗炎药物发现 "新 "靶点的 "老 "通路。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-04 DOI: 10.1002/med.22011

Liuxin Lu, Junjie Li, Xiaoying Jiang, Renren Bai

{"title":"CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti-inflammatory drug discovery","authors":"Liuxin Lu, Junjie Li, Xiaoying Jiang, Renren Bai","doi":"10.1002/med.22011","DOIUrl":"10.1002/med.22011","url":null,"abstract":"Inflammation is the body's defense response to exogenous or endogenous stimuli, involving complex regulatory mechanisms. Discovering anti-inflammatory drugs with both effectiveness and long-term use safety is still the direction of researchers' efforts. The inflammatory pathway was initially identified to be involved in tumor metastasis and HIV infection. However, research in recent years has proved that the CXC chemokine receptor type 4 (CXCR4)/CXC motif chemokine ligand 12 (CXCL12) axis plays a critical role in the upstream of the inflammatory pathway due to its chemotaxis to inflammatory cells. Blocking the chemotaxis of inflammatory cells by CXCL12 at the inflammatory site may block and alleviate the inflammatory response. Therefore, developing CXCR4 antagonists has become a novel strategy for anti-inflammatory therapy. This review aimed to systematically summarize and analyze the mechanisms of action of the CXCR4/CXCL12 axis in more than 20 inflammatory diseases, highlighting its crucial role in inflammation. Additionally, the anti-inflammatory activities of CXCR4 antagonists were discussed. The findings might help generate new perspectives for developing anti-inflammatory drugs targeting the CXCR4/CXCL12 axis.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 3","pages":"1189-1220"},"PeriodicalIF":13.3,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2024-01-03 DOI: 10.1002/med.22013

Salvatore Nesci, Giovanni Romeo

{"title":"H+-slip correlated to rotor free-wheeling as cause of F1FO-ATPase dysfunction in primary mitochondrial disorders","authors":"Salvatore Nesci, Giovanni Romeo","doi":"10.1002/med.22013","DOIUrl":"10.1002/med.22013","url":null,"abstract":"Inborn errors of metabolism are related to mitochondrial disorders caused by dysfunction of the oxidative phosphorylation (OXPHOS) system. Congenital hypermetabolism in the infant is a rare disease belonging to Luft syndrome, nonthyroidal hypermetabolism, arising from a singular example of a defect in OXPHOS. The mitochondria lose coupling of mitochondrial substrates oxidation from the ADP phosphorylation. Since Luft syndrome is due to uncoupled cell respiration responsible for deficient in ATP production that originates in the respiratory complexes, a de novo heterozygous variant in the catalytic subunit of mitochondrial F1FO-ATPase arises as the main cause of an autosomal dominant syndrome of hypermetabolism associated with dysfunction in ATP production, which does not involve the respiratory complexes. The F1FO-ATPase works as an embedded molecular machine with a rotary action using two different motor engines. The FO, which is an integral domain in the membrane, dissipates the chemical potential difference for H+, a proton motive force (Δp), across the inner membrane to generate a torsion. The F1 domain—the hydrophilic portion responsible for ATP turnover—is powered by the molecular rotary action to synthesize ATP. The structural and functional coupling of F1 and FO domains support the energy transduction for ATP synthesis. The dissipation of Δp by means of an H+ slip correlated to rotor free-wheeling of the F1FO-ATPase has been discovered to cause enzyme dysfunction in primary mitochondrial disorders. In this insight, we try to offer commentary and analysis of the molecular mechanism in these impaired mitochondria.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 3","pages":"1183-1188"},"PeriodicalIF":13.3,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.22013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0