Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future.

IF 10.9 1区医学 Q1 CHEMISTRY, MEDICINAL

Medicinal Research Reviews Pub Date : 2024-08-22 DOI:10.1002/med.22079

Junfang Li, Xiaodong Wang, Honghua Zhang, Xiaoling Hu, Xue Peng, Weifan Jiang, Linsheng Zhuo, Yan Peng, Guo Zeng, Zhen Wang

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引用次数: 0

Abstract

Fenamates as classical nonsteroidal anti-inflammatory agents are widely used for relieving pain. Preclinical studies and epidemiological data highlight their chemo-preventive and chemotherapeutic potential for cancer. However, comprehensive reviews of fenamates in cancer are limited. To accelerate the repurposing of fenamates, this review summarizes the results of fenamates alone or in combination with existing chemotherapeutic agents. This paper also explores targets of fenamates in cancer therapy, including COX, AKR family, AR, gap junction, FTO, TEAD, DHODH, TAS2R14, ion channels, and DNA. Besides, this paper discusses other mechanisms, such as regulating Wnt/β-catenin, TGF-β, p38 MAPK, and NF-κB pathway, and the regulation of the expressions of Sp, EGR-1, NAG-1, ATF-3, ErbB2, AR, as well as the modulation of the tumor immune microenvironment. Furthermore, this paper outlined the structural modifications of fenamates, highlighting their potential as promising leads for anticancer drugs.

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非那明酸盐：被遗忘的癌症治疗和预防宝藏：作用机制、结构改造和光明前景。

非氨酯类药物作为经典的非甾体抗炎药物，被广泛用于缓解疼痛。临床前研究和流行病学数据都强调了它们对癌症的化学预防和化学治疗潜力。然而，有关非那明酸盐在癌症中应用的全面综述却十分有限。为了加快非那明酸盐的再利用，本综述总结了非那明酸盐单独使用或与现有化疗药物联合使用的结果。本文还探讨了非那西丁在癌症治疗中的靶点，包括 COX、AKR 家族、AR、间隙连接、FTO、TEAD、DHODH、TAS2R14、离子通道和 DNA。此外，本文还讨论了其他机制，如调节 Wnt/β-catenin、TGF-β、p38 MAPK 和 NF-κB 通路，调节 Sp、EGR-1、NAG-1、ATF-3、ErbB2、AR 的表达，以及调节肿瘤免疫微环境。此外，本文还概述了非那西丁酸盐的结构修饰，强调了它们作为抗癌药物潜在线索的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinal Research Reviews 医学-药学

CiteScore

29.30

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.