A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection.

IF 10.9 1区 医学 Q1 CHEMISTRY, MEDICINAL
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh
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引用次数: 0

Abstract

Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral infections. They can promote or inhibit viral infection and have a pro-viral or antiviral role. Also, viral infections can modulate the expression of host miRNAs. Furthermore, viruses from different families evade the host immune response by producing their own miRNAs called viral miRNAs (v-miRNAs). Understanding the replication cycle of viruses and their relation with host miRNAs and v-miRNAs can help to find new treatments against viral infections. In this review, we aim to outline the structure, genome, and replication cycle of various viruses including hepatitis B, hepatitis C, influenza A virus, coronavirus, human immunodeficiency virus, human papillomavirus, herpes simplex virus, Epstein-Barr virus, Dengue virus, Zika virus, and Ebola virus. We also discuss the role of different host miRNAs and v-miRNAs and their role in the pathogenesis of these viral infections.

全面概述 microRNA 与病毒发病和感染之间的相互关系。
病毒作为最小的传染源,其引起的感染对全球公共卫生构成了重大威胁。病毒感染利用不同的宿主机制来促进自身的传播和致病。微小核糖核酸(miRNA)作为非编码 RNA 小分子,在包括病毒感染在内的各种疾病中发挥着重要的调控作用。它们可以促进或抑制病毒感染,具有促病毒或抗病毒的作用。此外,病毒感染还能调节宿主 miRNA 的表达。此外,不同家族的病毒通过产生自己的 miRNAs(病毒 miRNAs,v-miRNAs)来逃避宿主的免疫反应。了解病毒的复制周期及其与宿主 miRNAs 和 v-miRNAs 的关系,有助于找到抗病毒感染的新疗法。在这篇综述中,我们旨在概述各种病毒的结构、基因组和复制周期,包括乙型肝炎病毒、丙型肝炎病毒、甲型流感病毒、冠状病毒、人类免疫缺陷病毒、人类乳头瘤病毒、单纯疱疹病毒、Epstein-Barr 病毒、登革热病毒、寨卡病毒和埃博拉病毒。我们还讨论了不同宿主 miRNA 和 v-miRNA 的作用及其在这些病毒感染发病机制中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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