Progress in Nuclear Magnetic Resonance Spectroscopy最新文献_第2页

Glutamine: A key player in human metabolism as revealed by hyperpolarized magnetic resonance 谷氨酰胺：超极化磁共振揭示的人体新陈代谢中的关键角色

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2024-05-31 DOI: 10.1016/j.pnmrs.2024.05.003

Karen Dos Santos , Gildas Bertho , Mathieu Baudin , Nicolas Giraud

{"title":"Glutamine: A key player in human metabolism as revealed by hyperpolarized magnetic resonance","authors":"Karen Dos Santos , Gildas Bertho , Mathieu Baudin , Nicolas Giraud","doi":"10.1016/j.pnmrs.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.pnmrs.2024.05.003","url":null,"abstract":"<div><p>In recent years, there has been remarkable progress in the field of dissolution dynamic nuclear polarization (D-DNP). This method has shown significant potential for enhancing nuclear polarization by over 10,000 times, resulting in a substantial increase in sensitivity. The unprecedented signal enhancements achieved with D-DNP have opened new possibilities for <em>in vitro</em> analysis. This method enables the monitoring of structural and enzymatic kinetics with excellent time resolution at low concentrations. Furthermore, these advances can be straightforwardly translated to <em>in vivo</em> magnetic resonance imaging and magnetic resonance spectroscopy (MRI and MRS) experiments. D-DNP studies have used a range of <sup>13</sup>C labeled molecules to gain deeper insights into the cellular metabolic pathways and disease hallmarks. Over the last 15 years, D-DNP has been used to analyze glutamine, a key player in the cellular metabolism, involved in many diseases including cancer. Glutamine is the most abundant amino acid in blood plasma and the major carrier of nitrogen, and it is converted to glutamate inside the cell, where the latter is the most abundant amino acid. It has been shown that increased glutamine consumption by cells is a hallmark of tumor cancer metabolism. In this review, we first highlight the significance of glutamine in metabolism, providing an in-depth description of its use at the cellular level as well as its specific roles in various organs. Next, we present a comprehensive overview of the principles of D-DNP. Finally, we review the state of the art in D-DNP glutamine analysis and its application in oncology, neurology, and perfusion marker studies.</p></div>","PeriodicalId":20740,"journal":{"name":"Progress in Nuclear Magnetic Resonance Spectroscopy","volume":"144 ","pages":"Pages 15-39"},"PeriodicalIF":6.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0079656524000128/pdfft?md5=8bf86ea44244de6298db1efc4910050a&pid=1-s2.0-S0079656524000128-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141250452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Magnetic resonance elastography in a nutshell: Tomographic imaging of soft tissue viscoelasticity for detecting and staging disease with a focus on inflammation 磁共振弹性成像简述：软组织粘弹性断层成像，用于检测和分期疾病，重点是炎症

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2024-05-29 DOI: 10.1016/j.pnmrs.2024.05.002

Tom Meyer , Johannes Castelein , Jakob Schattenfroh , Anna Sophie Morr , Rafaela Vieira da Silva , Heiko Tzschätzsch , Rolf Reiter , Jing Guo , Ingolf Sack

{"title":"Magnetic resonance elastography in a nutshell: Tomographic imaging of soft tissue viscoelasticity for detecting and staging disease with a focus on inflammation","authors":"Tom Meyer , Johannes Castelein , Jakob Schattenfroh , Anna Sophie Morr , Rafaela Vieira da Silva , Heiko Tzschätzsch , Rolf Reiter , Jing Guo , Ingolf Sack","doi":"10.1016/j.pnmrs.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.pnmrs.2024.05.002","url":null,"abstract":"<div><p>Magnetic resonance elastography (MRE) is an emerging clinical imaging modality for characterizing the viscoelastic properties of soft biological tissues. MRE shows great promise in the noninvasive diagnosis of various diseases, especially those associated with soft tissue changes involving the extracellular matrix, cell density, or fluid turnover including altered blood perfusion – all hallmarks of inflammation from early events to cancer development. This review covers the fundamental principles of measuring tissue viscoelasticity by MRE, which are based on the stimulation and encoding of shear waves and their conversion into parameter maps of mechanical properties by inverse problem solutions of the wave equation. Technical challenges posed by real-world biological tissue properties such as viscosity, heterogeneity, anisotropy, and nonlinear elastic behavior of tissues are discussed. Applications of MRE measurement in both humans and animal models are presented, with emphasis on the detection, characterization, and staging of diseases related to the cascade of biomechanical property changes from early to chronic inflammation in the liver and brain. Overall, MRE provides valuable insights into the biophysics of soft tissues for imaging-based detection and staging of inflammation-associated tissue changes.</p></div>","PeriodicalId":20740,"journal":{"name":"Progress in Nuclear Magnetic Resonance Spectroscopy","volume":"144 ","pages":"Pages 1-14"},"PeriodicalIF":6.1,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0079656524000116/pdfft?md5=aa42014ceffd0d654ee28a00528c7937&pid=1-s2.0-S0079656524000116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141242445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent developments in materials and applications of triplet dynamic nuclear polarization 三重动态核极化材料与应用的最新发展

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2024-05-16 DOI: 10.1016/j.pnmrs.2024.05.001

Tomoyuki Hamachi , Nobuhiro Yanai

引用次数: 0

NMR studies of lithium and sodium battery electrolytes 锂和钠电池电解质的核磁共振研究

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2024-02-09 DOI: 10.1016/j.pnmrs.2024.02.001

Nicole Leifer , Doron Aurbach , Steve G. Greenbaum

{"title":"NMR studies of lithium and sodium battery electrolytes","authors":"Nicole Leifer , Doron Aurbach , Steve G. Greenbaum","doi":"10.1016/j.pnmrs.2024.02.001","DOIUrl":"https://doi.org/10.1016/j.pnmrs.2024.02.001","url":null,"abstract":"<div><p>This review focuses on the application of nuclear magnetic resonance (NMR) spectroscopy in the study of lithium and sodium battery electrolytes. Lithium-ion batteries are widely used in electronic devices, electric vehicles, and renewable energy systems due to their high energy density, long cycle life, and low self-discharge rate. The sodium analog is still in the research phase, but has significant potential for future development. In both cases, the electrolyte plays a critical role in the performance and safety of these batteries. NMR spectroscopy provides a non-invasive and non-destructive method for investigating the structure, dynamics, and interactions of the electrolyte components, including the salts, solvents, and additives, at the molecular level. This work attempts to give a nearly comprehensive overview of the ways that NMR spectroscopy, both liquid and solid state, has been used in past and present studies of various electrolyte systems, including liquid, gel, and solid-state electrolytes, and highlights the insights gained from these studies into the fundamental mechanisms of ion transport, electrolyte stability, and electrode-electrolyte interfaces, including interphase formation and surface microstructure growth. Overviews of the NMR methods used and of the materials covered are presented in the first two chapters. The rest of the review is divided into chapters based on the types of electrolyte materials studied, and discusses representative examples of the types of insights that NMR can provide.</p></div>","PeriodicalId":20740,"journal":{"name":"Progress in Nuclear Magnetic Resonance Spectroscopy","volume":"142 ","pages":"Pages 1-54"},"PeriodicalIF":6.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139744477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling NMR spin systems for quantum computation 为量子计算控制核磁共振自旋系统

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2024-02-09 DOI: 10.1016/j.pnmrs.2024.02.002

Jonathan A. Jones

引用次数: 0

Studying protein stability in crowded environments by NMR 利用核磁共振研究拥挤环境中的蛋白质稳定性

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2024-02-08 DOI: 10.1016/j.pnmrs.2024.01.001

Guohua Xu, Kai Cheng, Maili Liu, Conggang Li

引用次数: 0

Advanced solid-state NMR spectroscopy and its applications in zeolite chemistry 先进固体核磁共振光谱及其在沸石化学中的应用

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2023-11-22 DOI: 10.1016/j.pnmrs.2023.11.001

Mingji Zheng , Yueying Chu , Qiang Wang , Yongxiang Wang , Jun Xu , Feng Deng

{"title":"Advanced solid-state NMR spectroscopy and its applications in zeolite chemistry","authors":"Mingji Zheng , Yueying Chu , Qiang Wang , Yongxiang Wang , Jun Xu , Feng Deng","doi":"10.1016/j.pnmrs.2023.11.001","DOIUrl":"10.1016/j.pnmrs.2023.11.001","url":null,"abstract":"<div><p>Solid-state NMR spectroscopy (ssNMR) can provide details about the structure, host–guest/guest–guest interactions and dynamic behavior of materials at atomic length scales. A crucial use of ssNMR is for the characterization of zeolite catalysts that are extensively employed in industrial catalytic processes. This review aims to spotlight the recent advancements in ssNMR spectroscopy and its application to zeolite chemistry. We first review the current ssNMR methods and techniques that are relevant to characterize zeolite catalysts, including advanced multinuclear and multidimensional experiments, <em>in situ</em> NMR techniques and hyperpolarization methods. Of these, the methodology development on half-integer quadrupolar nuclei is emphasized, which represent about two-thirds of stable NMR-active nuclei and are widely present in catalytic materials. Subsequently, we introduce the recent progress in understanding zeolite chemistry with the aid of these ssNMR methods and techniques, with a specific focus on the investigation of zeolite framework structures, zeolite crystallization mechanisms, surface active/acidic sites, host–guest/guest–guest interactions, and catalytic reaction mechanisms.</p></div>","PeriodicalId":20740,"journal":{"name":"Progress in Nuclear Magnetic Resonance Spectroscopy","volume":"140 ","pages":"Pages 1-41"},"PeriodicalIF":6.1,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0079656523000237/pdfft?md5=30fe7d3a5de7e5c58cd892828ac7c957&pid=1-s2.0-S0079656523000237-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138437332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micron-scale magnetic resonance imaging based on low temperatures and dynamic nuclear polarization 基于低温和动态核极化的微米级磁共振成像

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2023-11-01 DOI: 10.1016/j.pnmrs.2023.10.001

Robert Tycko

引用次数: 0

Fingerprinting and profiling in metabolomics of biosamples 生物样品代谢组学中的指纹图谱和图谱

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2023-11-01 DOI: 10.1016/j.pnmrs.2023.10.002

Veronica Ghini , Gaia Meoni , Alessia Vignoli , Francesca Di Cesare , Leonardo Tenori , Paola Turano , Claudio Luchinat

{"title":"Fingerprinting and profiling in metabolomics of biosamples","authors":"Veronica Ghini , Gaia Meoni , Alessia Vignoli , Francesca Di Cesare , Leonardo Tenori , Paola Turano , Claudio Luchinat","doi":"10.1016/j.pnmrs.2023.10.002","DOIUrl":"10.1016/j.pnmrs.2023.10.002","url":null,"abstract":"<div><p>This review focuses on metabolomics from an NMR point of view. It attempts to cover the broad scope of metabolomics and describes the NMR experiments that are most suitable for each sample type. It is addressed not only to NMR specialists, but to all researchers who wish to approach metabolomics with a clear idea of what they wish to achieve but not necessarily with a deep knowledge of NMR. For this reason, some technical parts may seem a bit naïve to the experts. The review starts by describing standard metabolomics procedures, which imply the use of a dedicated 600 MHz instrument and of four properly standardized 1D experiments. Standardization is a must if one wants to directly compare NMR results obtained in different labs. A brief mention is also made of standardized pre-analytical procedures, which are even more essential. Attention is paid to the distinction between fingerprinting and profiling, and the advantages and disadvantages of fingerprinting are clarified. This aspect is often not fully appreciated. Then profiling, and the associated problems of signal assignment and quantitation, are discussed. We also describe less conventional approaches, such as the use of different magnetic fields, the use of signal enhancement techniques to increase sensitivity, and the potential of field-shuttling NMR. A few examples of biomedical applications are also given, again with the focus on NMR techniques that are most suitable to achieve each particular goal, including a description of the most common heteronuclear experiments. Finally, the growing applications of metabolomics to foodstuffs are described.</p></div>","PeriodicalId":20740,"journal":{"name":"Progress in Nuclear Magnetic Resonance Spectroscopy","volume":"138 ","pages":"Pages 105-135"},"PeriodicalIF":6.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71506518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metal ions based dynamic nuclear polarization: MI-DNP 基于金属离子的动态核极化：MI-DNP

IF 6.1 2区化学

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2023-08-22 DOI: 10.1016/j.pnmrs.2023.08.002

Daniel Jardón-Álvarez, Michal Leskes

{"title":"Metal ions based dynamic nuclear polarization: MI-DNP","authors":"Daniel Jardón-Álvarez, Michal Leskes","doi":"10.1016/j.pnmrs.2023.08.002","DOIUrl":"10.1016/j.pnmrs.2023.08.002","url":null,"abstract":"<div><p>Over the last two decades magic angle spinning dynamic nuclear polarization (MAS DNP) has revolutionized NMR for materials characterization, tackling its main limitation of intrinsically low sensitivity. Progress in theoretical understanding, instrumentation, and sample formulation expanded the range of materials applications and research questions that can benefit from MAS DNP. Currently the most common approach for hyperpolarization under MAS consists in impregnating the sample of interest with a solution containing nitroxide radicals, which upon microwave irradiation serve as exogenous polarizing agents. On the other hand, in metal ion based (MI)-DNP, inorganic materials are doped with paramagnetic metal centres, which then can be used as endogenous polarizing agents. In this work we give an overview of the electron paramagnetic resonance (EPR) concepts required to characterize the metal ions and discuss the expected changes in the NMR response due to the presence of paramagnetic species. We highlight which properties of the electron spins are beneficial for applications as polarizing agents in DNP and how to recognize them, both from the EPR and NMR data. A theoretical description of the main DNP mechanisms is given, employing a quantum mechanical formalism, and these concepts are used to explain the spin dynamics observed in the DNP experiment. In addition, we highlight the main differences between MI-DNP and the more common approaches in MAS DNP, which use organic radicals as exogenous polarizing source. Finally, we review some applications of metal ions as polarizing agents in general and then focus particularly on research questions in materials science that can benefit from MI-DNP.</p></div>","PeriodicalId":20740,"journal":{"name":"Progress in Nuclear Magnetic Resonance Spectroscopy","volume":"138 ","pages":"Pages 70-104"},"PeriodicalIF":6.1,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48724745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0