Recent developments in materials and applications of triplet dynamic nuclear polarization

IF 7.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Progress in Nuclear Magnetic Resonance Spectroscopy Pub Date : 2024-05-16 DOI:10.1016/j.pnmrs.2024.05.001

Tomoyuki Hamachi , Nobuhiro Yanai

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Abstract

Dynamic nuclear polarization (DNP) is a method for achieving high levels of nuclear spin polarization by transferring spin polarization from electrons to nuclei by microwave irradiation, resulting in higher sensitivity in NMR/MRI. In particular, DNP using photoexcited triplet electron spins (triplet-DNP) can provide a hyperpolarized nuclear spin state at room temperature and in low magnetic field. In this review article, we highlight recent developments in materials and instrumentation for the application of triplet-DNP. First, a brief history and principles of triplet-DNP will be presented. Next, important advances in recent years will be outlined: new materials to hyperpolarize water and biomolecules; high-sensitivity solution NMR by dissolution triplet-DNP; and strategies for further improvement of the polarization. In view of these developments, future directions to widen the range of applications of triplet-DNP will be discussed.

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三重动态核极化材料与应用的最新发展

动态核极化（DNP）是一种通过微波辐照将自旋极化从电子转移到原子核来实现高水平核自旋极化的方法，从而提高核磁共振/核磁共振成像的灵敏度。特别是，使用光激发三重电子自旋的 DNP（三重-DNP）可在室温和低磁场条件下提供超极化核自旋态。在这篇综述文章中，我们将重点介绍应用三重-DNP 的材料和仪器方面的最新进展。首先，我们将简要介绍三重-DNP 的历史和原理。接下来，将概述近年来的重要进展：使水和生物分子超极化的新材料；通过溶解三重-DNP 实现高灵敏度溶液 NMR；以及进一步改进极化的策略。鉴于这些进展，将讨论拓宽三重-DNP 应用范围的未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Nuclear Magnetic Resonance Spectroscopy 物理-光谱学

CiteScore

14.30

自引率

8.20%

发文量

审稿时长

62 days

期刊介绍： Progress in Nuclear Magnetic Resonance Spectroscopy publishes review papers describing research related to the theory and application of NMR spectroscopy. This technique is widely applied in chemistry, physics, biochemistry and materials science, and also in many areas of biology and medicine. The journal publishes review articles covering applications in all of these and in related subjects, as well as in-depth treatments of the fundamental theory of and instrumental developments in NMR spectroscopy.