生物化学与生物物理进展最新文献_第2页

Neural Mechanisms of Reward Seeking Behavior and Cognitive Control in Individuals With Internet Addiction 网络成瘾个体的奖赏寻求行为和认知控制的神经机制

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1206.2014.00023

Qiran Li, Yue Qi, Mq Tian, K. Zhang, Xian Liu

{"title":"Neural Mechanisms of Reward Seeking Behavior and Cognitive Control in Individuals With Internet Addiction","authors":"Qiran Li, Yue Qi, Mq Tian, K. Zhang, Xian Liu","doi":"10.3724/SP.J.1206.2014.00023","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2014.00023","url":null,"abstract":"Internet addiction(IA) as a behavioral addiction is currently becoming a serious mental health issue around the globe. According to the neurobiological model of brain development, exploring the neural mechanisms of reward seeking behavior and cognitive control in internet addicts may help in developing treatments for individuals with IA. Behavioral research has indicated that IA is commonly associated with enhanced reward sensitivity and decreased inhibitory control. Additionally, research focused on the neural mechanisms of IA indicates that deficits in the reward or cognitive control systems might be a high risk factor for addictive behaviors.Compared with substance addictions, IA, as a kind of psychological addiction, has a specific reward mechanism.While previous research has deepened the understanding of the psychological and neural mechanisms in IA, there still exist many issues surrounding diagnosis and treatment of IA: the screening criteria are not scientific; the classification is ambiguous; the effect of intervention and treatment is controversial; causal research is scarce; and research paradigms are flawed. Substantial future research is needed to explore, fully understand, and treat IA.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"230 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77474686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Progress of Long Noncoding RNA HOTAIR in Human Cancer 长链非编码RNA HOTAIR在人类肿瘤中的研究进展

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2015-01-01 DOI: 10.16476/J.PIBB.2014.0230

Xiaoling Li, P. Xy, Zeng Zy, Strong, Li Gy, W. Xiong, Zhang Xy, M. Zhou, D. Xue, Li Yw, Jing Yz, Wang Ym, B. Kuang

引用次数: 7

Foundation of Biophysics and Establishment of Interdisciplinary Subjects in China 中国生物物理学基础与交叉学科建设

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2014-10-01 DOI: 10.3724/SP.J.1206.2014.00209

Wang Gu-yan

引用次数: 0

Screening and Verifying The Interactive Protein of Selenoprotien W in Human Brain 人脑硒蛋白W相互作用蛋白的筛选与验证

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2014-08-01 DOI: 10.3724/SP.J.1206.2013.00412

Chen Ping, L. Qing, Ma Xiao-Jie, Wang Shi-Jie, L. Qiong, Ni Jiazuan

引用次数: 0

MTOR signaling in aging and aging-associated diseases MTOR信号在衰老和衰老相关疾病中的作用

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2014-03-01 DOI: 10.3724/SP.J.1206.2014.00007

Jie-yu He, Feng Liu

引用次数: 1

Dicer and its miRNAs are necessary gene and regulatory factors for differentiation and proliferation of vascular smooth muscle cell Dicer及其mirna是血管平滑肌细胞分化和增殖的必要基因和调控因子

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2014-01-01 DOI: 10.3724/SP.J.1206.2014.00115

Yaoqian Pan, B. Pan, Xing-you Liu, Ruili Li, J. Yue

引用次数: 1

Negative Regulation of Inflammasome Signaling 炎性小体信号的负向调控

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2014-01-01 DOI: 10.3724/SP.J.1206.2013.00306

Z. Cai, Y. Xin

引用次数: 0

Progress in The Studies on Synaptic and Extrasynaptic NMDA Receptors and The Roles in Alzheimer′s Disease 突触和突触外NMDA受体及其在阿尔茨海默病中的作用研究进展

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2014-01-01 DOI: 10.3724/SP.J.1206.2013.00320

Can Gao, Xing-yu Li

引用次数: 0

Establishment of Cardiomyocyte-specific miR-30b Transgenic Mice and Exploring The Function of miR-30b 心肌细胞特异性miR-30b转基因小鼠的建立及miR-30b功能的探索

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2014-01-01 DOI: 10.3724/SP.J.1206.2013.00206

Yuan-yuan Fan, B. Long, Fang Liu, Luyu Zhou, Kun Wang, Peifeng Li

{"title":"Establishment of Cardiomyocyte-specific miR-30b Transgenic Mice and Exploring The Function of miR-30b","authors":"Yuan-yuan Fan, B. Long, Fang Liu, Luyu Zhou, Kun Wang, Peifeng Li","doi":"10.3724/SP.J.1206.2013.00206","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2013.00206","url":null,"abstract":"MicroRNAs(miRNAs) array results have shown that the expression of miR-30b is downregulated in heart tissues from patients with familial hypertrophic cardiomyopathy who were carriers of missense mutations in the MYH7,and also in a murine heart failure model,implying that miR-30b might play an important role in heart diseases.To study miR-30b in vivo function,we generated a transgenic mouse line overexpressing miR-30b under the control of the 5.5 kb promoter of α-myosin heavy chain(α-MHC).qRT-PCR results demonstrated that miR-30b was significantly increased in the heart tissues of miR-30b transgenic mice(P 0.05).miR-30b transgenic mice did not exhibit significant heart/body weight and left ventricular(LV)/body weight changes and abnormal myocardium structure.At present,little is known about how miR-30b regulates myocardial infarction.We constructed I/R models by the coronary artery ligation method and sham-operated mice were used as controls.Biochemical detection results and TTC-Evans blue results showed that after ischemia-reperfusion,these transgenic mice had lower releases of LDH,CK and cTn玉(P 0.05)and their hearts exhibited a smaller infarct size compared to those from control mice(P 0.05).Echocardiographic results indicated that cardiac function of transgenic mice was markedly improved compared to that of control mice.In conclusion,miR-30b has protective effect upon ischemic-reperfusion injury.And it may provide a new therapeutic approach for preventing and treating myocardial infarction.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"222 1","pages":"575-582"},"PeriodicalIF":0.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85901467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect and Mechanism of PLUNC Protein Family Against Inflammation and Carcinogenesis of Nasopharyngeal Carcinoma PLUNC蛋白家族抗鼻咽癌炎症及癌变的作用及机制

IF 0.3 4区生物学

生物化学与生物物理进展 Pub Date : 2014-01-01 DOI: 10.3724/SP.J.1206.2013.00396

Z. Yong, Zhou Ming, Xia-Yu Li, Zhang Wen-ling, Gong Zhao-Jian, Li Qian-jin, Xiao-Ling Li, Zeng Zhao-yang, Ma Jian, Shen Shou-rong, W. Fang, Xiong Wei

{"title":"The Effect and Mechanism of PLUNC Protein Family Against Inflammation and Carcinogenesis of Nasopharyngeal Carcinoma","authors":"Z. Yong, Zhou Ming, Xia-Yu Li, Zhang Wen-ling, Gong Zhao-Jian, Li Qian-jin, Xiao-Ling Li, Zeng Zhao-yang, Ma Jian, Shen Shou-rong, W. Fang, Xiong Wei","doi":"10.3724/SP.J.1206.2013.00396","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2013.00396","url":null,"abstract":"Secretion on the surface of human nasal mucosa contains many innate proteins,the key factors of which are SPLUNC1 and LPLUNC1,members of the palate,lung and nasal epithelium clone(PLUNC) family.These two proteins are highly expressed in nasopharyngeal epithelium with the relative specificity.Both of them have bacterial/permeability-increasing protein(BPI) domain which can bind to lipopolysaccharide(LPS) to inhibit or kill bacterial growth directly.They also have the immuno defense function to protect nasopharyngeal epithelium from Epstein-Barr virus(EBV) and some other pathogenic microorganism effectively.These proteins play a significant role in the process of chronic inflammation and carcinogenesis of nasopharyngeal epithelium by inhibiting the secretion of inflammatory factors,such as IL-6,through activating NF-κB and STAT3 signaling pathways.In addition,they also can suppress nasopharyngeal carcinoma(NPC) cell growth and induce cell apoptosis through MAPK and miR-141-PTEN-AKT signaling pathways when the PLUNC proteins are re-expressed in NPC cell lines.Further study about the mechanism of PLUNC protein family in pathogenesis of NPC has important significance for the prevention and treatment guidance of NPC.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"26 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88866783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7