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生物化学与生物物理进展最新文献

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GroEL-Assisted Protein Folding by Utilizing The Energy From ATP 利用ATP能量的groel辅助蛋白质折叠
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2015-01-01 DOI: 10.16476/J.PIBB.2014.0143
Y. Ling, Lin Zong, Fu Zheng-wei
{"title":"GroEL-Assisted Protein Folding by Utilizing The Energy From ATP","authors":"Y. Ling, Lin Zong, Fu Zheng-wei","doi":"10.16476/J.PIBB.2014.0143","DOIUrl":"https://doi.org/10.16476/J.PIBB.2014.0143","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81254779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural and Functional Characterization of Acinetobacter baumannii Nucleoside Diphosphate Kinase 鲍曼不动杆菌核苷二磷酸激酶的结构和功能表征
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2015-01-01 DOI: 10.2210/PDB4WBF/PDB
Y. Hu, F. Feng, Y. Liu
{"title":"Structural and Functional Characterization of Acinetobacter baumannii Nucleoside Diphosphate Kinase","authors":"Y. Hu, F. Feng, Y. Liu","doi":"10.2210/PDB4WBF/PDB","DOIUrl":"https://doi.org/10.2210/PDB4WBF/PDB","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78597988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The visual representation for cellulase degradation velocity and the analysis for limiting factor 纤维素酶降解速度的可视化表示及限制因素分析
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2015-01-01 DOI: 10.16476/J.PIBB.2014.0220
Fanjuan Meng, Xuejuen Jiang, Lin Liu, Huaisong Zhang, P. Gao, L. Wang
{"title":"The visual representation for cellulase degradation velocity and the analysis for limiting factor","authors":"Fanjuan Meng, Xuejuen Jiang, Lin Liu, Huaisong Zhang, P. Gao, L. Wang","doi":"10.16476/J.PIBB.2014.0220","DOIUrl":"https://doi.org/10.16476/J.PIBB.2014.0220","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87804358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Mechanisms of Reward Seeking Behavior and Cognitive Control in Individuals With Internet Addiction 网络成瘾个体的奖赏寻求行为和认知控制的神经机制
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2015-01-01 DOI: 10.3724/SP.J.1206.2014.00023
Qiran Li, Yue Qi, Mq Tian, K. Zhang, Xian Liu
{"title":"Neural Mechanisms of Reward Seeking Behavior and Cognitive Control in Individuals With Internet Addiction","authors":"Qiran Li, Yue Qi, Mq Tian, K. Zhang, Xian Liu","doi":"10.3724/SP.J.1206.2014.00023","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2014.00023","url":null,"abstract":"Internet addiction(IA) as a behavioral addiction is currently becoming a serious mental health issue around the globe. According to the neurobiological model of brain development, exploring the neural mechanisms of reward seeking behavior and cognitive control in internet addicts may help in developing treatments for individuals with IA. Behavioral research has indicated that IA is commonly associated with enhanced reward sensitivity and decreased inhibitory control. Additionally, research focused on the neural mechanisms of IA indicates that deficits in the reward or cognitive control systems might be a high risk factor for addictive behaviors.Compared with substance addictions, IA, as a kind of psychological addiction, has a specific reward mechanism.While previous research has deepened the understanding of the psychological and neural mechanisms in IA, there still exist many issues surrounding diagnosis and treatment of IA: the screening criteria are not scientific; the classification is ambiguous; the effect of intervention and treatment is controversial; causal research is scarce; and research paradigms are flawed. Substantial future research is needed to explore, fully understand, and treat IA.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77474686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Progress of Long Noncoding RNA HOTAIR in Human Cancer 长链非编码RNA HOTAIR在人类肿瘤中的研究进展
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2015-01-01 DOI: 10.16476/J.PIBB.2014.0230
Xiaoling Li, P. Xy, Zeng Zy, Strong, Li Gy, W. Xiong, Zhang Xy, M. Zhou, D. Xue, Li Yw, Jing Yz, Wang Ym, B. Kuang
{"title":"Progress of Long Noncoding RNA HOTAIR in Human Cancer","authors":"Xiaoling Li, P. Xy, Zeng Zy, Strong, Li Gy, W. Xiong, Zhang Xy, M. Zhou, D. Xue, Li Yw, Jing Yz, Wang Ym, B. Kuang","doi":"10.16476/J.PIBB.2014.0230","DOIUrl":"https://doi.org/10.16476/J.PIBB.2014.0230","url":null,"abstract":"Long noncoding RNA(lnc RNA) play important roles in cancer progression. HOX transcript antisense RNA(HOTAIR) was observed upregulated in a variety of tumors. Over-expression of HOTAIR is a poor prognostic factor. HOTAIR interacts with Polycomb Repressive complex 2(PRC2), resulting in histone H3tri-methylated atlysine27(H3K27me3), which silences the expression of some down-stream genes, such as WIF-1,PTEN and p21, then mediated Wnt, Akt and p53 signaling pathways transduction. As a result, the properties of tumor, including invasion and metastasis, evading growth suppressors, resisting apoptosis and inducing angiogenesis would be affected. Thoroughly elucidate mechanisms of HOTAIR in cancer development will have important theoretical significance in cancer etiology and pathogenesis. As an important biomarker and potential target, HOTAIR may also has important clinical application in cancer's early diagnosis, therapeutic evaluation,prognosis, and even potential gene therapy.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72618059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Foundation of Biophysics and Establishment of Interdisciplinary Subjects in China 中国生物物理学基础与交叉学科建设
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2014-10-01 DOI: 10.3724/SP.J.1206.2014.00209
Wang Gu-yan
{"title":"Foundation of Biophysics and Establishment of Interdisciplinary Subjects in China","authors":"Wang Gu-yan","doi":"10.3724/SP.J.1206.2014.00209","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2014.00209","url":null,"abstract":"As a new independent subject, biophysics emerged in the early 1950's. The Institute of Biophysics, Chinese Academy of Sciences, was established in 1958. It was the milestone of the beginning of biophysics in China. This review introduces the foundation and the early development of biophysics in China, and the establishment of the interdisciplinary subjects, including radiation biology, bio-cybernetics, astrobiology, and bionics.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76128232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening and Verifying The Interactive Protein of Selenoprotien W in Human Brain 人脑硒蛋白W相互作用蛋白的筛选与验证
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2014-08-01 DOI: 10.3724/SP.J.1206.2013.00412
Chen Ping, L. Qing, Ma Xiao-Jie, Wang Shi-Jie, L. Qiong, Ni Jiazuan
{"title":"Screening and Verifying The Interactive Protein of Selenoprotien W in Human Brain","authors":"Chen Ping, L. Qing, Ma Xiao-Jie, Wang Shi-Jie, L. Qiong, Ni Jiazuan","doi":"10.3724/SP.J.1206.2013.00412","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2013.00412","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83987426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MTOR signaling in aging and aging-associated diseases MTOR信号在衰老和衰老相关疾病中的作用
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2014-03-01 DOI: 10.3724/SP.J.1206.2014.00007
Jie-yu He, Feng Liu
{"title":"MTOR signaling in aging and aging-associated diseases","authors":"Jie-yu He, Feng Liu","doi":"10.3724/SP.J.1206.2014.00007","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2014.00007","url":null,"abstract":"Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established,but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin(mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging,the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84066058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Negative Regulation of Inflammasome Signaling 炎性小体信号的负向调控
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2014-01-01 DOI: 10.3724/SP.J.1206.2013.00306
Z. Cai, Y. Xin
{"title":"Negative Regulation of Inflammasome Signaling","authors":"Z. Cai, Y. Xin","doi":"10.3724/SP.J.1206.2013.00306","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2013.00306","url":null,"abstract":"Inflammasomes activation is critical for both innate and adaptive immunity through their regulation of interleukin 1β(IL-1β) and IL-18.Prolonged inflammasomes activation can lead to exaggerated expression of signaling components as well as pro-inflammatory cytokines that can damage the host,resulting in chronic inflammatory diseases and autoimmune disorders.Therefore,pathways of deactivation are important to balance the immune responses.However,recent discoveries have uncovered a plethora of pathogenic strategies to inhibit the activation of inflammasome signal pathways and the production of pro-inflammatory cytokines to evade immune responses.Elucidation of these mechanisms might be helpful to the rational design of therapy against infectious diseases and other inflammasome-dependent inflammatory processes.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77582368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in The Studies on Synaptic and Extrasynaptic NMDA Receptors and The Roles in Alzheimer′s Disease 突触和突触外NMDA受体及其在阿尔茨海默病中的作用研究进展
IF 0.3 4区 生物学
生物化学与生物物理进展 Pub Date : 2014-01-01 DOI: 10.3724/SP.J.1206.2013.00320
Can Gao, Xing-yu Li
{"title":"Progress in The Studies on Synaptic and Extrasynaptic NMDA Receptors and The Roles in Alzheimer′s Disease","authors":"Can Gao, Xing-yu Li","doi":"10.3724/SP.J.1206.2013.00320","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2013.00320","url":null,"abstract":"Extrasynaptic NMDA receptors, which locate in the extrasynaptic site rather than synaptic site have shown to mediate cell death pathway, while synaptic NMDA receptors play an important role in learning and memory and mediate cell survival pathway. This review discussed the reasons of their different distribution between synaptic and extrasynaptic sites, the different molecular mechanisms for signaling pathways of cell fate, as well as their roles in Alzheimer's disease(AD) based on the structure and function of NMDA receptors. Finally, we proposed a reasonable outlook on the treatment of AD from the view of extrasynaptic NMDA receptor.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76389648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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