{"title":"MTOR信号在衰老和衰老相关疾病中的作用","authors":"Jie-yu He, Feng Liu","doi":"10.3724/SP.J.1206.2014.00007","DOIUrl":null,"url":null,"abstract":"Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established,but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin(mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging,the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"MTOR signaling in aging and aging-associated diseases\",\"authors\":\"Jie-yu He, Feng Liu\",\"doi\":\"10.3724/SP.J.1206.2014.00007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established,but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin(mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging,the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.\",\"PeriodicalId\":0,\"journal\":{\"name\":\"\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0,\"publicationDate\":\"2014-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3724/SP.J.1206.2014.00007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3724/SP.J.1206.2014.00007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
MTOR signaling in aging and aging-associated diseases
Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established,but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin(mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging,the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.
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