MTOR信号在衰老和衰老相关疾病中的作用

IF 0.2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

生物化学与生物物理进展 Pub Date : 2014-03-01 DOI:10.3724/SP.J.1206.2014.00007

Jie-yu He, Feng Liu

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引用次数: 1

摘要

衰老导致生理功能的普遍下降，从而导致各种代谢和心血管疾病。衰老与衰老相关疾病之间的联系仍有待完全确定，但最近的研究表明，抑制雷帕霉素(mTOR)信号通路的哺乳动物/机制靶点可以延长寿命，延缓衰老相关的代谢和神经退行性疾病。作为代谢和衰老的关键调节因子，mTOR信号通路目前已成为开发有效治疗衰老和衰老相关疾病的热点。

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MTOR signaling in aging and aging-associated diseases

Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established,but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin(mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging,the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.

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来源期刊

生物化学与生物物理进展生物-生化与分子生物学

CiteScore

0.50

自引率

33.30%

发文量

6805

审稿时长

4 months

期刊介绍： Progress in Biochemistry and Biophysics is a monthly, peer-reviewed journal sponsored by Institute of Biophysics, The Chinese Academy of Sciences together with Biophysical Society of China. It started publication in 1974. It mainly reports on the latest developments in biochemistry, biophysics, molecular biology and neuroscience both in China and abroad. It contains several columns such as "reviews and monographs", "rapid and short communications", "research papers", "techniques and methods" and "academic discussions".