长链非编码RNA HOTAIR在人类肿瘤中的研究进展

IF 0.2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

生物化学与生物物理进展 Pub Date : 2015-01-01 DOI:10.16476/J.PIBB.2014.0230

Xiaoling Li, P. Xy, Zeng Zy, Strong, Li Gy, W. Xiong, Zhang Xy, M. Zhou, D. Xue, Li Yw, Jing Yz, Wang Ym, B. Kuang

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引用次数: 7

摘要

长链非编码RNA(lnc RNA)在肿瘤进展中起重要作用。HOX转录反义RNA(HOTAIR)在多种肿瘤中表达上调。HOTAIR过表达是不良预后因素。HOTAIR与Polycomb suppression complex 2(PRC2)相互作用，产生组蛋白h3三甲基化分析氨酸27(H3K27me3)，沉默下游部分基因如wi -1、PTEN、p21的表达，进而介导Wnt、Akt、p53信号通路转导。从而影响肿瘤的侵袭转移、躲避生长抑制因子、抵抗细胞凋亡、诱导血管生成等特性。深入阐明HOTAIR在肿瘤发生发展中的作用机制，对研究肿瘤病因病机具有重要的理论意义。HOTAIR作为一种重要的生物标志物和潜在靶点，在癌症的早期诊断、治疗评价、预后甚至潜在的基因治疗方面也有重要的临床应用。

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Progress of Long Noncoding RNA HOTAIR in Human Cancer

Long noncoding RNA(lnc RNA) play important roles in cancer progression. HOX transcript antisense RNA(HOTAIR) was observed upregulated in a variety of tumors. Over-expression of HOTAIR is a poor prognostic factor. HOTAIR interacts with Polycomb Repressive complex 2(PRC2), resulting in histone H3tri-methylated atlysine27(H3K27me3), which silences the expression of some down-stream genes, such as WIF-1,PTEN and p21, then mediated Wnt, Akt and p53 signaling pathways transduction. As a result, the properties of tumor, including invasion and metastasis, evading growth suppressors, resisting apoptosis and inducing angiogenesis would be affected. Thoroughly elucidate mechanisms of HOTAIR in cancer development will have important theoretical significance in cancer etiology and pathogenesis. As an important biomarker and potential target, HOTAIR may also has important clinical application in cancer's early diagnosis, therapeutic evaluation,prognosis, and even potential gene therapy.

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来源期刊

生物化学与生物物理进展生物-生化与分子生物学

CiteScore

0.50

自引率

33.30%

发文量

6805

审稿时长

4 months

期刊介绍： Progress in Biochemistry and Biophysics is a monthly, peer-reviewed journal sponsored by Institute of Biophysics, The Chinese Academy of Sciences together with Biophysical Society of China. It started publication in 1974. It mainly reports on the latest developments in biochemistry, biophysics, molecular biology and neuroscience both in China and abroad. It contains several columns such as "reviews and monographs", "rapid and short communications", "research papers", "techniques and methods" and "academic discussions".