生物化学与生物物理进展Pub Date : 2012-07-30DOI: 10.3724/SP.J.1206.2012.00185
An Yunhe, Zhang Haofeng, S. Min, Z. Jun, Chen Xiuqin, Chen Dong, L. Di, F. Jing, Yang Dongling, S. Lina, Y. Xiyun, 阎锡蕴, J. Zhang
{"title":"sTn is a Novel Biomarker for Type I Endometrial Carcinoma","authors":"An Yunhe, Zhang Haofeng, S. Min, Z. Jun, Chen Xiuqin, Chen Dong, L. Di, F. Jing, Yang Dongling, S. Lina, Y. Xiyun, 阎锡蕴, J. Zhang","doi":"10.3724/SP.J.1206.2012.00185","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00185","url":null,"abstract":"Sialyl-Tn(sTn) is a tumor-associated carbohydrate antigen overexpressed in many carcinomas.But whether it is expressed in neoplastic human endometrium is controversial.Here we screened 111 clinical samples including 82 endometrial cancers,16 atypical hyperplastic and 13 normal endometria,by immunohistochemistry using a novel anti-sTn antibody,namely 3P9.Our results showed that the expression of sTn in the endometrial carcinoma was significantly higher(76%) than that in normal tissues(31%)(P 0.01) and in atypical hyperplasia(44%)(P 0.05).Importantly,we found that sTn expression in typeⅠ carcinoma(80%) was obviously higher than that in typeⅡ(45%)(P 0.05).These results suggested that sTn may be a biomarker for endometrial carcinoma,especially for typeⅠcarcinoma.Moreover,we observed that sTn expression was increased with the decline of tumor histological grade(P 0.05),indicating that sTn was associated with a favorable prognosis in endometrial carcinoma.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87431486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
生物化学与生物物理进展Pub Date : 2012-07-30DOI: 10.3724/SP.J.1206.2012.00236
Yang Xia, Kai Dong, Yongxiu Lai, C. Luo, Lei Lei, D. Yao
{"title":"Study on Resting-State Functional Connectivity of Rat Sensorimotor System*: Study on Resting-State Functional Connectivity of Rat Sensorimotor System*","authors":"Yang Xia, Kai Dong, Yongxiu Lai, C. Luo, Lei Lei, D. Yao","doi":"10.3724/SP.J.1206.2012.00236","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00236","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82283625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
生物化学与生物物理进展Pub Date : 2012-07-30DOI: 10.3724/SP.J.1206.2011.00311
Ming Zheng, Yanxin Huang, Wei-Lun Shen, Yi Zhong, Jianan Wu, Guixia Liu, You Zhou
{"title":"A Novel Scale-free Network Construction Method and Its Application in Gene Expression Profiles Simulation*: A Novel Scale-free Network Construction Method and Its Application in Gene Expression Profiles Simulation*","authors":"Ming Zheng, Yanxin Huang, Wei-Lun Shen, Yi Zhong, Jianan Wu, Guixia Liu, You Zhou","doi":"10.3724/SP.J.1206.2011.00311","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00311","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77725629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
生物化学与生物物理进展Pub Date : 2012-07-24DOI: 10.3724/SP.J.1206.2011.00463
Ming-yan Lei, Jin-Cheng Ma, Hai-Hong Wang
{"title":"Identification of Two Enoyl-ACP Reductase FabI1 and FabI2 in Brucella abortus *: Identification of Two Enoyl-ACP Reductase FabI1 and FabI2 in Brucella abortus *","authors":"Ming-yan Lei, Jin-Cheng Ma, Hai-Hong Wang","doi":"10.3724/SP.J.1206.2011.00463","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00463","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82870852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
生物化学与生物物理进展Pub Date : 2012-07-24DOI: 10.3724/SP.J.1206.2011.00383
Zhilei Liu, Wei Sun, F. He, Xianling Cong, Ying Jiang
{"title":"Status and Development of The Tumor Microenvironment in Hepatocellular Carcinoma*: Status and Development of The Tumor Microenvironment in Hepatocellular Carcinoma*","authors":"Zhilei Liu, Wei Sun, F. He, Xianling Cong, Ying Jiang","doi":"10.3724/SP.J.1206.2011.00383","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00383","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85923366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
生物化学与生物物理进展Pub Date : 2012-07-24DOI: 10.3724/SP.J.1206.2011.00619
Y. Tan, Xingmei Zhang
{"title":"Aptamer Mediated Delivery of Small Interfering RNAs*: Aptamer Mediated Delivery of Small Interfering RNAs*","authors":"Y. Tan, Xingmei Zhang","doi":"10.3724/SP.J.1206.2011.00619","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00619","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76766157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
生物化学与生物物理进展Pub Date : 2012-07-24DOI: 10.3724/SP.J.1206.2011.00370
Gang Qian, Haiyan Wang, Zheng Yuan
{"title":"Using Homology Information From PDB to Improve The Accuracy of Protein β-turn Prediction by NetTurnP*: Using Homology Information From PDB to Improve The Accuracy of Protein β-turn Prediction by NetTurnP*","authors":"Gang Qian, Haiyan Wang, Zheng Yuan","doi":"10.3724/SP.J.1206.2011.00370","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00370","url":null,"abstract":"茁-Turn is a secondary protein structure type that is important in protein folding, protein stability and molecular recognition processes. To date, various methods have been put forward to predict 茁-turns, but none of them have tried directly to map the structures of pre-existing homologues from structural databases like RCSB PDB to the protein to be predicted. Given the large size of PDB (>70 000 structures), it is actually of high possibility to find a structural homologue for a newly identified sequence. In this work, we present a new method that predicts 茁-turns by combining homology information extracted from PDB with the results predicted by NetTurnP. Two datasets, the golden set BT426 and the self-constructed dataset EVA937, are used to assess our method. For each sequence in both datasets, only homologues deposited earlier than the sequence in PDB are employed. We have achieved Matthews correlation coefficients (MCCs) of 0.56, 0.52 respectively, which are higher than those obtained by NetTurnP alone of 0.50, 0.46, and the prediction accuracies (Qtotal) obtained using our method are 81.4% and 80.4% separately, while NetTurnP alone achieves 78.2% and 77.3% . The results confirm that combining the homology information with state-of-the-art 茁-turn predictors like NetTurnP can significantly improve the prediction accuracy. A Java program called BTMapping has been written to implement our method, which is freely available at http://www.bio530.weebly.com together with the related datasets.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84269250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
生物化学与生物物理进展Pub Date : 2012-07-24DOI: 10.3724/SP.J.1206.2011.00324
ZhongFang Wang, Xin-Lu Wang, Guang-Xia Gao
{"title":"PR65A Regulates The Activity of The Zinc-finger Antiviral Protein*: PR65A Regulates The Activity of The Zinc-finger Antiviral Protein*","authors":"ZhongFang Wang, Xin-Lu Wang, Guang-Xia Gao","doi":"10.3724/SP.J.1206.2011.00324","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00324","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74714698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}