Progress in lipid research最新文献_第6页

Biosynthesis of phosphatidylglycerol in photosynthetic organisms 光合生物中磷脂酰甘油的生物合成。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2024-01-01 Epub Date: 2023-11-29 DOI: 10.1016/j.plipres.2023.101266

Koichi Kobayashi , Haruhiko Jimbo , Yuki Nakamura , Hajime Wada

{"title":"Biosynthesis of phosphatidylglycerol in photosynthetic organisms","authors":"Koichi Kobayashi , Haruhiko Jimbo , Yuki Nakamura , Hajime Wada","doi":"10.1016/j.plipres.2023.101266","DOIUrl":"10.1016/j.plipres.2023.101266","url":null,"abstract":"<div><p>Phosphatidylglycerol (PG) is a unique phospholipid class with its indispensable role in photosynthesis and growth in land plants, algae, and cyanobacteria. PG is the only major phospholipid in the thylakoid membrane of cyanobacteria and plant chloroplasts and a main lipid component in photosynthetic protein-cofactor complexes such as photosystem I and photosystem II. In plants and algae, PG is also essential as a substrate for the biosynthesis of cardiolipin, which is a unique lipid present only in mitochondrial membranes and crucial for the functions of mitochondria. PG biosynthesis pathways in plants include three membranous organelles, plastids, mitochondria, and the endoplasmic reticulum in a complex manner. While the molecular biology underlying the role of PG in photosynthetic functions is well established, many enzymes responsible for the PG biosynthesis are only recently cloned and functionally characterized in the model plant species including <em>Arabidopsis thaliana</em> and <em>Chlamydomonas reinhardtii</em> and cyanobacteria such as <em>Synechocystis</em> sp. PCC 6803. The characterization of those enzymes helps understand not only the metabolic flow for PG production but also the crosstalk of biosynthesis pathways between PG and other lipids. This review aims to summarize recent advances in the understanding of the PG biosynthesis pathway and functions of involved enzymes.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101266"},"PeriodicalIF":13.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000565/pdfft?md5=59eec7a8fe480a879401a444422a47bd&pid=1-s2.0-S0163782723000565-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders 脂蛋白颗粒转运氧脂素及其对心脏代谢和神经系统疾病的功能意义。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2024-01-01 Epub Date: 2023-11-17 DOI: 10.1016/j.plipres.2023.101265

Nuanyi Liang , Brian A. Harsch , Sitong Zhou , Alison Borkowska , Gregory C. Shearer , Rima Kaddurah-Daouk , John W. Newman , Kamil Borkowski

{"title":"Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders","authors":"Nuanyi Liang , Brian A. Harsch , Sitong Zhou , Alison Borkowska , Gregory C. Shearer , Rima Kaddurah-Daouk , John W. Newman , Kamil Borkowski","doi":"10.1016/j.plipres.2023.101265","DOIUrl":"10.1016/j.plipres.2023.101265","url":null,"abstract":"<div><p>Lipoprotein metabolism is critical to inflammation. While the periphery and central nervous system (CNS) have separate yet connected lipoprotein systems, impaired lipoprotein metabolism is implicated in both cardiometabolic and neurological disorders. Despite the substantial investigation into the composition, structure and function of lipoproteins, the lipoprotein oxylipin profiles, their influence on lipoprotein functions, and their potential biological implications are unclear. Lipoproteins carry most of the circulating oxylipins. Importantly, lipoprotein-mediated oxylipin transport allows for endocrine signaling by these lipid mediators, long considered to have only autocrine and paracrine functions. Alterations in plasma lipoprotein oxylipin composition can directly impact inflammatory responses of lipoprotein metabolizing cells. Similar investigations of CNS lipoprotein oxylipins are non-existent to date. However, as APOE4 is associated with Alzheimer's disease-related microglia dysfunction and oxylipin dysregulation, ApoE4-dependent lipoprotein oxylipin modulation in neurological pathologies is suggested. Such investigations are crucial to bridge knowledge gaps linking oxylipin- and lipoprotein-related disorders in both periphery and CNS. Here, after providing a summary of existent literatures on lipoprotein oxylipin analysis methods, we emphasize the importance of lipoproteins in oxylipin transport and argue that understanding the compartmentalization and distribution of lipoprotein oxylipins may fundamentally alter our consideration of the roles of lipoprotein in cardiometabolic and neurological disorders.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101265"},"PeriodicalIF":13.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000553/pdfft?md5=be8e25586ceac1d086f14095d47c4e1e&pid=1-s2.0-S0163782723000553-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphatidic acid signaling and function in nuclei 磷脂酸在细胞核中的信号传递和功能。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2024-01-01 Epub Date: 2023-12-26 DOI: 10.1016/j.plipres.2023.101267

Shuaibing Yao , Sang-Chul Kim , Jianwu Li , Shan Tang , Xuemin Wang

{"title":"Phosphatidic acid signaling and function in nuclei","authors":"Shuaibing Yao , Sang-Chul Kim , Jianwu Li , Shan Tang , Xuemin Wang","doi":"10.1016/j.plipres.2023.101267","DOIUrl":"10.1016/j.plipres.2023.101267","url":null,"abstract":"<div><p>Membrane lipidomes are dynamic and their changes generate lipid mediators affecting various biological processes. Phosphatidic acid (PA) has emerged as an important class of lipid mediators involved in a wide range of cellular and physiological responses in plants, animals, and microbes. The regulatory functions of PA have been studied primarily outside the nuclei, but an increasing number of recent studies indicates that some of the PA effects result from its action in nuclei. PA levels in nuclei are dynamic in response to stimuli. Changes in nuclear PA levels can result from activities of enzymes associated with nuclei and/or from movements of PA generated extranuclearly. PA has also been found to interact with proteins involved in nuclear functions, such as transcription factors and proteins undergoing nuclear translocation in response to stimuli. The nuclear action of PA affects various aspects of plant growth, development, and response to stress and environmental changes.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101267"},"PeriodicalIF":13.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000577/pdfft?md5=b8a95a7e0cf2d7931c42eb46a5f22a93&pid=1-s2.0-S0163782723000577-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in research on microbial conjugated linoleic acid bioconversion 微生物共轭亚油酸生物转化研究进展。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2024-01-01 Epub Date: 2023-10-26 DOI: 10.1016/j.plipres.2023.101257

Chen Wu , Haiqin Chen , Yongchao Mei , Bo Yang , Jianxin Zhao , Catherine Stanton , Wei Chen

{"title":"Advances in research on microbial conjugated linoleic acid bioconversion","authors":"Chen Wu , Haiqin Chen , Yongchao Mei , Bo Yang , Jianxin Zhao , Catherine Stanton , Wei Chen","doi":"10.1016/j.plipres.2023.101257","DOIUrl":"10.1016/j.plipres.2023.101257","url":null,"abstract":"<div><p>Conjugated linoleic acid (CLA) is a functional food ingredient with prebiotic properties that provides health benefits for various human pathologies and disorders. However, limited natural CLA sources in animals and plants have led microorganisms like <em>Lactobacillus</em> and <em>Bifidobacterium</em> to emerge as new CLA sources. Microbial conversion of linoleic acid to CLA is mediated by linoleic acid isomerase and multicomponent enzymatic systems, with CLA production efficiency dependent on microbial species and strains. Additionally, complex factors like LA concentration, growth status, culture substrates, precursor type, prebiotic additives, and co-cultured microbe identity strongly influence CLA production and isomer composition. This review summarizes advances in the past decade regarding microbial CLA production, including bacteria and fungi. We highlight CLA production and potential regulatory mechanisms and discuss using microorganisms to enhance CLA content and nutritional value of fermented products. We also identify primary microbial CLA production bottlenecks and provide strategies to address these challenges and enhance production through functional gene and enzyme mining and downstream processing. This review aims to provide a reference for microbial CLA production and broaden the understanding of the potential probiotic role of microbial CLA producers.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101257"},"PeriodicalIF":13.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000474/pdfft?md5=a9e30a4fa83bcdb6a1b3eaa05560cfef&pid=1-s2.0-S0163782723000474-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The heterogeneity and complexity of skin surface lipids in human skin health and disease 皮肤表面脂质在人类皮肤健康和疾病中的异质性和复杂性

IF 13.6 1区医学

Progress in lipid research Pub Date : 2024-01-01 Epub Date: 2023-11-06 DOI: 10.1016/j.plipres.2023.101264

Dalibor Mijaljica, Joshua P. Townley, Fabrizio Spada, Ian P. Harrison

{"title":"The heterogeneity and complexity of skin surface lipids in human skin health and disease","authors":"Dalibor Mijaljica, Joshua P. Townley, Fabrizio Spada, Ian P. Harrison","doi":"10.1016/j.plipres.2023.101264","DOIUrl":"10.1016/j.plipres.2023.101264","url":null,"abstract":"<div><p>The outermost epidermal layer of the skin, the <em>stratum corneum</em>, is not simply a barrier that safeguards skin integrity from external insults and invaders, it is also a delicately integrated interface composed of firm, essentially dead corneocytes and a distinctive lipid matrix. Together, the <em>stratum corneum</em> lipid matrix and sebum lipids derived from sebaceous glands give rise to a remarkably complex but quite unique blend of skin surface lipids that demonstrates tremendous heterogeneity and provides the skin with its indispensable protective coating. The <em>stratum corneum</em> lipid matrix is composed primarily of three major lipid classes: ceramides, non-esterified fatty acids and cholesterol, whereas sebum is a waxy mixture predominantly composed of acylglycerols, wax esters, non-esterified fatty acids, squalene, cholesterol and cholesterol esters. The balance of these skin surface lipids in terms of their relative abundance, composition, molecular organisation and dynamics, and their intricate interactions play a crucial role in the maintenance of healthy skin. For that reason, even minuscule alterations in skin surface lipid properties or overall lipid profile have been implicated in the aetiology of many common skin diseases including atopic dermatitis, psoriasis, xerosis, ichthyosis and acne. Novel lipid-based interventions aimed at correcting the skin surface lipid abnormalities have the potential to repair skin barrier integrity and the symptoms associated with such skin diseases, even though the exact mechanisms of lipid restoration remain elusive.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101264"},"PeriodicalIF":13.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000541/pdfft?md5=1010c40e6cd9758c917348dc99212284&pid=1-s2.0-S0163782723000541-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71493509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fats of the matter: Lipids in prebiotic chemistry and in origin of life studies 物质的脂肪:益生元化学中的脂质和生命起源的研究

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-11-01 Epub Date: 2023-09-01 DOI: 10.1016/j.plipres.2023.101253

Tania C.B. Santos, Anthony H. Futerman

{"title":"The fats of the matter: Lipids in prebiotic chemistry and in origin of life studies","authors":"Tania C.B. Santos, Anthony H. Futerman","doi":"10.1016/j.plipres.2023.101253","DOIUrl":"10.1016/j.plipres.2023.101253","url":null,"abstract":"<div><p>The unique biophysical and biochemical properties of lipids render them crucial in most models of the origin of life (OoL). Many studies have attempted to delineate the prebiotic pathways by which lipids were formed, how micelles and vesicles were generated, and how these micelles and vesicles became selectively permeable towards the chemical precursors required to initiate and support biochemistry and inheritance. Our analysis of a number of such studies highlights the extremely narrow and limited range of conditions by which an experiment is considered to have successfully modeled a role for lipids in an OoL experiment. This is in line with a recent proposal that bias is introduced into OoL studies by the extent and the kind of human intervention. It is self-evident that OoL studies can only be performed by human intervention, and we now discuss the possibility that some assumptions and simplifications inherent in such experimental approaches do not permit determination of mechanistic insight into the roles of lipids in the OoL. With these limitations in mind, we suggest that more nuanced experimental approaches than those currently pursued may be required to elucidate the generation and function of lipids, micelles and vesicles in the OoL.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101253"},"PeriodicalIF":13.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10283654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triacylglycerol uptake and handling by macrophages: From fatty acids to lipoproteins 巨噬细胞对三酰甘油的摄取和处理:从脂肪酸到脂蛋白

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-11-01 Epub Date: 2023-08-22 DOI: 10.1016/j.plipres.2023.101250

Lei Deng , Sander Kersten , Rinke Stienstra

{"title":"Triacylglycerol uptake and handling by macrophages: From fatty acids to lipoproteins","authors":"Lei Deng , Sander Kersten , Rinke Stienstra","doi":"10.1016/j.plipres.2023.101250","DOIUrl":"10.1016/j.plipres.2023.101250","url":null,"abstract":"<div><p>Macrophages are essential innate immune cells and form our first line of immune defense. Also known as professional phagocytes, macrophages interact and take up various particles, including lipids. Defective lipid handling can drive excessive lipid accumulation leading to foam cell formation, a key feature of various cardiometabolic conditions such as atherosclerosis, non-alcoholic fatty liver disease, and obesity. At the same time, intracellular lipid storage and foam cell formation can also be viewed as a protective and anti-lipotoxic mechanism against a lipid-rich environment and associated elevated lipid uptake. Traditionally, foam cell formation has primarily been linked to cholesterol uptake via native and modified low-density lipoproteins. However, other lipids, including non-esterified fatty acids and triacylglycerol (TAG)-rich lipoproteins (very low-density lipoproteins and chylomicrons), can also interact with macrophages. Recent studies have identified multiple pathways mediating TAG uptake and processing by macrophages, including endocytosis and receptor/transporter-mediated internalization and transport. This review will present the current knowledge of how macrophages take up different lipids and lipoprotein particles and address how TAG-rich lipoproteins are processed intracellularly. Understanding how macrophages take up and process different lipid species such as TAG is necessary to design future therapeutic interventions to correct excessive lipid accumulation and associated co-morbidities.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101250"},"PeriodicalIF":13.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How fish consumption prevents the development of Major Depressive Disorder? A comprehensive review of the interplay between n-3 PUFAs, LTP and BDNF 鱼类消费如何预防严重抑郁症的发展？n-3 PUFA、LTP和BDNF之间相互作用的全面综述。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-11-01 Epub Date: 2023-10-09 DOI: 10.1016/j.plipres.2023.101254

Łukasz Kołodziej , Piotr Lech Czarny , Sylwia Ziółkowska , Katarzyna Białek , Janusz Szemraj , Piotr Gałecki , Kuan-Pin Su , Tomasz Śliwiński

{"title":"How fish consumption prevents the development of Major Depressive Disorder? A comprehensive review of the interplay between n-3 PUFAs, LTP and BDNF","authors":"Łukasz Kołodziej , Piotr Lech Czarny , Sylwia Ziółkowska , Katarzyna Białek , Janusz Szemraj , Piotr Gałecki , Kuan-Pin Su , Tomasz Śliwiński","doi":"10.1016/j.plipres.2023.101254","DOIUrl":"10.1016/j.plipres.2023.101254","url":null,"abstract":"<div><p>MDD (major depressive disorder) is a highly prevalent mental disorder with a complex etiology involving behavioral and neurochemical factors as well as environmental stress. The interindividual variability in response to stress stimuli may be explained by processes such as long-term potentiation (LTP) and long-term depression (LTD). LTP can be described as the strengthening of synaptic transmission, which translates into more efficient cognitive performance and is regulated by brain-derived neurotrophic factor (BDNF), a protein responsible for promoting neural growth. It is found in high concentrations in the hippocampus, a part of the limbic system which is far less active in people with MDD. Omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) not only contribute to structural and antioxidative functions but are essential for the maintenance of LTP and stable BDNF levels. This review explores the mechanisms and potential roles of omega-3 fatty acids in the prevention of MDD.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101254"},"PeriodicalIF":13.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41210683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphingosine 1-phosphate signaling during infection and immunity 鞘氨醇1-磷酸在感染和免疫中的信号传导

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-11-01 Epub Date: 2023-08-24 DOI: 10.1016/j.plipres.2023.101251

Sabira Mohammed , Anu Bindu , Arun Viswanathan , Kuzhuvelil B. Harikumar

引用次数: 1

FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer FADS2在主要癌症热点11q13位点的功能改变了癌症中的脂肪酸代谢

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-11-01 Epub Date: 2023-08-18 DOI: 10.1016/j.plipres.2023.101242

Kumar S.D. Kothapalli , Hui Gyu Park , Niharika S.L. Kothapalli , J. Thomas Brenna

{"title":"FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer","authors":"Kumar S.D. Kothapalli , Hui Gyu Park , Niharika S.L. Kothapalli , J. Thomas Brenna","doi":"10.1016/j.plipres.2023.101242","DOIUrl":"10.1016/j.plipres.2023.101242","url":null,"abstract":"<div><p>Dysregulation of fatty acid metabolism and <em>de novo</em><span><span><span><span> lipogenesis is a key driver of several cancer types through highly </span>unsaturated fatty acid<span> (HUFA) signaling precursors such as arachidonic acid. The </span></span>human chromosome<span> 11q13 locus has long been established as the most frequently amplified in a variety of human cancers. The fatty acid desaturase genes (FADS1, FADS2 and FADS3) responsible for HUFA </span></span>biosynthesis<span> localize to the 11q12-13.1 region. FADS2 activity is promiscuous, catalyzing biosynthesis of several unsaturated fatty acids by Δ6, Δ8, and Δ4 desaturation. Our main aim here is to review known and putative consequences of FADS2 dysregulation due to effects on the 11q13 locus potentially driving various cancer types. FADS2 silencing causes synthesis of sciadonic acid (5Z,11Z,14Z-20:3) in MCF7 cells and breast cancer </span></span><em>in vivo</em><span>. 5Z,11Z,14Z-20:3 is structurally identical to arachidonic acid (5Z,8Z,11Z,14Z–20:4) except it lacks the internal Δ8 double bond required for prostaglandin<span><span> and leukotriene synthesis, among other eicosanoids<span><span>. Palmitic acid has </span>substrate specificity for both </span></span>SCD<span><span><span> and FADS2. Melanoma, prostate, liver and lung cancer cells insensitive to SCD inhibition show increased FADS2 activity and sapienic acid biosynthesis. Elevated serum mead acid levels found in hepatocellular carcinoma patients suggest an unsatisfied demand for arachidonic acid. FADS2 </span>circular RNAs are at high levels in colorectal and lung cancer tissues. FADS2 circular RNAs are associated with shorter overall survival in colorectal cancer patients. The evidence thusfar supports an effort for future research on the role of FADS2 as a </span>tumor suppressor in a range of neoplastic disorders.</span></span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101242"},"PeriodicalIF":13.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10068709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4