Progress in lipid research最新文献_第6页

Corrigendum to “A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis” [Prog Lipid Res. 2023 Jan;89:101197. doi: 10.1016/j.plipres.2022.101197] “高甘油三酯血症的一个新的调控方面:microrna在调节富含甘油三酯的脂蛋白生物合成中的作用”[j] . Prog脂质杂志，2023(1);89:101197。doi: 10.1016 / j.plipres.2022.101197]

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101221

Masoomeh Khalifeh , Raul D. Santos , Reza KazemiOskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar

引用次数: 1

Endoplasmic reticulum stress and lipids in health and diseases 内质网应激和脂质在健康和疾病中的作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101198

Cenk Celik , Stella Yue Ting Lee , Wei Sheng Yap , Guillaume Thibault

{"title":"Endoplasmic reticulum stress and lipids in health and diseases","authors":"Cenk Celik , Stella Yue Ting Lee , Wei Sheng Yap , Guillaume Thibault","doi":"10.1016/j.plipres.2022.101198","DOIUrl":"10.1016/j.plipres.2022.101198","url":null,"abstract":"<div><p>The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER enters a stress state, which, in turn, activates the highly conserved unfolded protein response (UPR). By sensing the accumulation of unfolded proteins or lipid bilayer stress (LBS) at the ER, the UPR triggers pathways to restore ER homeostasis and eventually induces apoptosis if the stress remains unresolved. In recent years, it has emerged that the UPR works intimately with other cellular pathways to maintain lipid homeostasis at the ER, and so does at cellular levels. Lipid distribution, along with lipid anabolism and catabolism, are tightly regulated, in part, by the ER. Dysfunctional and overwhelmed lipid-related pathways, independently or in combination with ER stress, can have reciprocal effects on other cellular functions, contributing to the development of diseases. In this review, we summarize the current understanding of the UPR in response to proteotoxic stress and LBS and the breadth of the functions mitigated by the UPR in different tissues and in the context of diseases.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101198"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10759797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Proteins involved in fat-soluble vitamin and carotenoid transport across the intestinal cells: New insights from the past decade 参与脂溶性维生素和类胡萝卜素在肠细胞运输的蛋白质:过去十年的新见解

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101208

Emmanuelle Reboul

{"title":"Proteins involved in fat-soluble vitamin and carotenoid transport across the intestinal cells: New insights from the past decade","authors":"Emmanuelle Reboul","doi":"10.1016/j.plipres.2022.101208","DOIUrl":"10.1016/j.plipres.2022.101208","url":null,"abstract":"<div><p>It is now well established that vitamins D, E, and K and carotenoids are not absorbed solely through passive diffusion. Broad-specificity membrane transporters such as SR-BI (scavenger receptor class B type I), CD36 (CD36 molecule), NPC1L1 (Niemann Pick C1-like 1) or ABCA1 (ATP-binding cassette A1) are involved in the uptake of these micronutrients from the lumen to the enterocyte cytosol and in their secretion into the bloodstream. Recently, the existence of efflux pathways from the enterocyte back to the lumen or from the bloodstream to the lumen, involving ABCB1 (P-glycoprotein/MDR1) or the ABCG5/ABCG8 complex, has also been evidenced for vitamins D and K. Surprisingly, no membrane proteins have been involved in dietary vitamin A uptake so far. After an overview of the metabolism of fat-soluble vitamins and carotenoids along the gastrointestinal tract (from the mouth to the colon where interactions with microbiota may occur), a focus is placed on the identified and candidate proteins participating in the apical uptake, intracellular transport, basolateral secretion and efflux back to the lumen of fat-soluble vitamins and carotenoids in enterocytes. This review also highlights the mechanisms that remain to be identified to fully unravel the pathways involved in fat-soluble vitamin and carotenoid intestinal absorption.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101208"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10776796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis 高甘油三酯血症的一个新的调控方面:microrna在调节富含甘油三酯的脂蛋白生物合成中的作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101197

Masoumeh Khalifeh , Raul D. Santos , Reza Kazemi Oskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar

{"title":"A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis","authors":"Masoumeh Khalifeh , Raul D. Santos , Reza Kazemi Oskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar","doi":"10.1016/j.plipres.2022.101197","DOIUrl":"10.1016/j.plipres.2022.101197","url":null,"abstract":"<div><p>Atherosclerotic cardiovascular disease (ASCVD) is one of the major leading global causes of death. Genetic and epidemiological studies strongly support the causal association between triacylglycerol-rich lipoproteins (TAGRL) and atherogenesis, even in statin-treated patients. Recent genetic evidence has clarified that variants in several key genes implicated in TAGRL metabolism are strongly linked to the increased ASCVD risk. There are several triacylglycerol-lowering agents; however, new therapeutic options are in development, among which are miRNA-based therapeutic approaches. MicroRNAs (miRNAs) are small non-coding RNAs (18–25 nucleotides) that negatively modulate gene expression through translational repression or degradation of target mRNAs, thereby reducing the levels of functional genes. MiRNAs play a crucial role in the development of hypertriglyceridemia as several miRNAs are dysregulated in both synthesis and clearance of TAGRL particles. MiRNA-based therapies in ASCVD have not yet been applied in human trials but are attractive. This review provides a concise overview of current interventions for hypertriglyceridemia and the development of novel miRNA and siRNA-based drugs. We summarize the miRNAs involved in the regulation of key genes in the TAGRLs synthesis pathway, which has gained attention as a novel target for therapeutic applications in CVD.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101197"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9319585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Corrigendum to “Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials” [Progress in Lipid Research. 2022 Oct 28;88:101196. doi: 10.1016/j.plipres.2022.101196] “omega-3多不饱和脂肪酸对主要心血管事件的比较疗效:随机对照试验的网络荟萃分析”的更正[脂质研究进展，2022年10月28日;88:101196]。doi: 10.1016 / j.plipres.2022.101196]

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101206

Bo Yang , Ping-Tao Tseng , Xiang Hu , Bing-Yan Zeng , Jane Pei-Chen Chang , Yang Liu , Wei-Jie Chu , Shuang-Shuang Zhang , Zhi-Liang Zhou , Chih-Sheng Chu , Cheng-Ho Chang , Yu-Kang Tu , Yi-Cheng Wu , Brendon Stubbs , Andre F. Carvalho , Pao-Yen Lin , Yutaka J. Matsuoka , Mein-Woei Suen , Kuan-Pin Su

引用次数: 0

Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: Plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research 氧化应激和炎症中脂质信号的区隔调节:缩醛原、氧化脂质和铁中毒是生物活性脂质研究的新范式

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101207

Alma M. Astudillo , María A. Balboa , Jesús Balsinde

{"title":"Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: Plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research","authors":"Alma M. Astudillo , María A. Balboa , Jesús Balsinde","doi":"10.1016/j.plipres.2022.101207","DOIUrl":"10.1016/j.plipres.2022.101207","url":null,"abstract":"<div><p>Perturbations in lipid homeostasis combined with conditions favoring oxidative stress constitute a hallmark of the inflammatory response. In this review we focus on the most recent results concerning lipid signaling in various oxidative stress-mediated responses and inflammation. These include phagocytosis and ferroptosis. The best characterized event, common to these responses, is the synthesis of oxygenated metabolites of arachidonic acid and other polyunsaturated fatty acids. Major developments in this area have highlighted the importance of compartmentalization of the enzymes and lipid substrates in shaping the appropriate response. In parallel, other relevant lipid metabolic pathways are also activated and, until recently, there has been a general lack of knowledge on the enzyme regulation and molecular mechanisms operating in these pathways. Specifically, data accumulated in recent years on the regulation and biological significance of plasmalogens and oxidized phospholipids have expanded our knowledge on the involvement of lipid metabolism in the progression of disease and the return to homeostasis. These recent major developments have helped to establish the concept of membrane phospholipids as cellular repositories for the compartmentalized production of bioactive lipids involved in cellular regulation. Importantly, an enzyme classically described as being involved in regulating the homeostatic turnover of phospholipids, namely the group VIA Ca<sup>2+</sup>-independent phospholipase A<sub>2</sub> (iPLA<sub>2</sub>β), has taken center stage in oxidative stress and inflammation research owing to its key involvement in regulating metabolic and ferroptotic signals arising from membrane phospholipids. Understanding the role of iPLA<sub>2</sub>β in ferroptosis and metabolism not only broadens our knowledge of disease but also opens possible new horizons for this enzyme as a target for therapeutic intervention.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101207"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Bile acids and their receptors in regulation of gut health and diseases 胆汁酸及其受体调节肠道健康和疾病

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101210

Sen Lin , Sutian Wang , Peng Wang , Cuiming Tang , Zhenjiang Wang , Lian Chen , Guoqing Luo , Hong Chen , Yuntao Liu , Bin Feng , De Wu , Douglas G. Burrin , Zhengfeng Fang

{"title":"Bile acids and their receptors in regulation of gut health and diseases","authors":"Sen Lin , Sutian Wang , Peng Wang , Cuiming Tang , Zhenjiang Wang , Lian Chen , Guoqing Luo , Hong Chen , Yuntao Liu , Bin Feng , De Wu , Douglas G. Burrin , Zhengfeng Fang","doi":"10.1016/j.plipres.2022.101210","DOIUrl":"10.1016/j.plipres.2022.101210","url":null,"abstract":"<div><p>It is well established that bile acids play important roles in lipid metabolism. In recent decades, bile acids have also been shown to function as signaling molecules via interacting with various receptors. Bile acids circulate continuously through the enterohepatic circulation and go through microbial transformation by gut microbes, and thus bile acids metabolism has profound effects on the liver and intestinal tissues as well as the gut microbiota. Farnesoid X receptor and G protein-coupled bile acid receptor 1 are two pivotal bile acid receptors that highly expressed in the intestinal tissues, and they have emerged as pivotal regulators in bile acids metabolism, innate immunity and inflammatory responses. There is considerable interest in manipulating the metabolism of bile acids and the expression of bile acid receptors as this may be a promising strategy to regulate intestinal health and disease. This review aims to summarize the roles of bile acids and their receptors in regulation of gut health and diseases.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101210"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10760260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The gut microbiota-artery axis: A bridge between dietary lipids and atherosclerosis? 肠道微生物-动脉轴:膳食脂质与动脉粥样硬化之间的桥梁?

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101209

Qinjun Zhang , Liangxiao Zhang , Cheng Chen , Peiwu Li , Baiyi Lu

{"title":"The gut microbiota-artery axis: A bridge between dietary lipids and atherosclerosis?","authors":"Qinjun Zhang , Liangxiao Zhang , Cheng Chen , Peiwu Li , Baiyi Lu","doi":"10.1016/j.plipres.2022.101209","DOIUrl":"10.1016/j.plipres.2022.101209","url":null,"abstract":"<div><p>Atherosclerotic cardiovascular disease is one of the major leading global causes of death. Growing evidence has demonstrated that gut microbiota (GM) and its metabolites play a pivotal role in the onset and progression of atherosclerosis (AS), now known as GM-artery axis. There are interactions between dietary lipids and GM, which ultimately affect GM and its metabolites. Given these two aspects, the GM-artery axis may play a mediating role between dietary lipids and AS. Diets rich in saturated fatty acids (SFAs), omega-6 polyunsaturated fatty acids (n-6 PUFAs), industrial trans fatty acids (TFAs), and cholesterol can increase the levels of atherogenic microbes and metabolites, whereas monounsaturated fatty acids (MUFAs), ruminant TFAs, and phytosterols (PS) can increase the levels of antiatherogenic microbes and metabolites. Actually, dietary phosphatidylcholine (PC), sphingomyelin (SM), and omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been demonstrated to affect AS via the GM-artery axis. Therefore, that GM-artery axis acts as a communication bridge between dietary lipids and AS. Herein, we will describe the molecular mechanism of GM-artery axis in AS and discuss the complex interactions between dietary lipids and GM. In particular, we will highlight the evidence and potential mechanisms of dietary lipids affecting AS via GM-artery axis.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101209"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9319597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

New research development on trans fatty acids in food: Biological effects, analytical methods, formation mechanism, and mitigating measures 食品中反式脂肪酸的研究新进展:生物学效应、分析方法、形成机制和抑制措施

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101199

Qin Guo , Tian Li , Yang Qu , Manzhu Liang , Yiming Ha , Yu Zhang , Qiang Wang

引用次数: 34

Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities 阿南达胺和其他n -酰基乙醇胺:一类具有治疗机会的信号脂质

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101194

Elliot D. Mock , Berend Gagestein, Mario van der Stelt

{"title":"Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities","authors":"Elliot D. Mock , Berend Gagestein, Mario van der Stelt","doi":"10.1016/j.plipres.2022.101194","DOIUrl":"10.1016/j.plipres.2022.101194","url":null,"abstract":"<div><p><em>N</em>-acylethanolamines (NAEs), including <em>N</em>-palmitoylethanolamine (PEA), <em>N</em>-oleoylethanolamine (OEA), <em>N</em>-arachidonoylethanolamine (AEA, anandamide), <em>N</em>-docosahexaenoylethanolamine (DHEA, synaptamide) and their oxygenated metabolites are a lipid messenger family with numerous functions in health and disease, including inflammation, anxiety and energy metabolism. The NAEs exert their signaling role through activation of various G protein-coupled receptors (cannabinoid CB<sub>1</sub> and CB<sub>2</sub> receptors, GPR55, GPR110, GPR119), ion channels (TRPV1) and nuclear receptors (PPAR-α and PPAR-γ) in the brain and periphery. The biological role of the oxygenated NAEs, such as prostamides, hydroxylated anandamide and DHEA derivatives, are less studied. Evidence is accumulating that NAEs and their oxidative metabolites may be aberrantly regulated or are associated with disease severity in obesity, metabolic syndrome, cancer, neuroinflammation and liver cirrhosis. Here, we comprehensively review NAE biosynthesis and degradation, their metabolism by lipoxygenases, cyclooxygenases and cytochrome P450s and the biological functions of these signaling lipids. We discuss the latest findings and therapeutic potential of modulating endogenous NAE levels by inhibition of their degradation, which is currently under clinical evaluation for neuropsychiatric disorders. We also highlight NAE biosynthesis inhibition as an emerging topic with therapeutic opportunities in endocannabinoid and NAE signaling.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101194"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20