Progress in lipid research最新文献_第6页

Systematic review of brain and blood lipidomics in Alzheimer's disease mouse models 阿尔茨海默病小鼠模型脑和血脂组学的系统综述

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101223

Laura Ferré-González , Ana Lloret , Consuelo Cháfer-Pericás

{"title":"Systematic review of brain and blood lipidomics in Alzheimer's disease mouse models","authors":"Laura Ferré-González , Ana Lloret , Consuelo Cháfer-Pericás","doi":"10.1016/j.plipres.2023.101223","DOIUrl":"10.1016/j.plipres.2023.101223","url":null,"abstract":"<div><p><span><span>Alzheimer's disease (AD) diagnosis is based on invasive and expensive biomarkers. Regarding AD pathophysiological mechanisms, there is evidence of a link between AD and aberrant lipid homeostasis. Alterations in </span>lipid composition<span> have been observed in blood and brain samples, and transgenic mouse models represent a promising approach. Nevertheless, there is great variability among studies in mice for the determination of different types of </span></span>lipids in targeted and untargeted methods. It could be explained by the different variables (model, age, sex, analytical technique), and experimental conditions used.</p><p><span>The aim of this work is to review the studies on lipid alteration in brain tissue and blood samples from AD mouse models, focusing on different experimental parameters. As result, great disparity has been observed among the reviewed studies. Brain studies showed an increase in gangliosides, </span>sphingomyelins<span><span>, lysophospholipids and monounsaturated fatty acids and a decrease in </span>sulfatides<span><span>. In contrast, blood studies showed an increase in phosphoglycerides, sterols, diacylglycerols, </span>triacylglycerols<span><span> and polyunsaturated fatty acids, and a decrease in </span>phospholipids<span>, lysophospholipids and monounsaturated fatty acids. Thus, lipids are closely related to AD, and a consensus on lipidomics studies could be used as a diagnostic tool and providing insight into the mechanisms involved in AD.</span></span></span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"90 ","pages":"Article 101223"},"PeriodicalIF":13.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9937319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects 脂溶性维生素和植物化学代谢物:生产、胃肠道吸收和健康影响

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101220

Patrick Borel , Olivier Dangles , Rachel E. Kopec

{"title":"Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects","authors":"Patrick Borel , Olivier Dangles , Rachel E. Kopec","doi":"10.1016/j.plipres.2023.101220","DOIUrl":"10.1016/j.plipres.2023.101220","url":null,"abstract":"<div><p>Consumption of diets rich in fruits and vegetables, which provide some fat-soluble vitamins and many phytochemicals<span><span>, is associated with a lower risk of developing certain degenerative diseases. It is well accepted that not only the parent compounds, but also their derivatives formed upon enzymatic or nonenzymatic transformations, can produce protective biological effects. These derivatives can be formed during food storage, processing, or cooking. They can also be formed in the lumen of the </span>upper digestive tract<span><span> during digestion, or via metabolism by microbiota<span> in the colon. This review compiles the known metabolites of fat-soluble vitamins and fat-soluble phytochemicals (FSV and FSP) that have been identified in food and in the human digestive tract, or could potentially be present based on the known reactivity of the parent compounds in normal or pathological conditions, or following surgical interventions of the digestive tract or consumption of xenobiotics known to impair lipid absorption. It also covers the very limited data available on the bioavailability (absorption, </span></span>intestinal mucosa metabolism) and summarizes their effects on health. Notably, despite great interest in identifying bioactive derivatives of FSV and FSP, studying their absorption, and probing their putative health effects, much research remains to be conducted to understand and capitalize on the potential of these molecules to preserve health.</span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"90 ","pages":"Article 101220"},"PeriodicalIF":13.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9628146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Monomethyl branched-chain fatty acids: Health effects and biological mechanisms 单甲支链脂肪酸:健康效应和生物学机制

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101226

Paulina Gozdzik , Faidon Magkos , Tomasz Sledzinski , Adriana Mika

引用次数: 5

Corrigendum to “A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis” [Prog Lipid Res. 2023 Jan;89:101197. doi: 10.1016/j.plipres.2022.101197] “高甘油三酯血症的一个新的调控方面:microrna在调节富含甘油三酯的脂蛋白生物合成中的作用”[j] . Prog脂质杂志，2023(1);89:101197。doi: 10.1016 / j.plipres.2022.101197]

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101221

Masoomeh Khalifeh , Raul D. Santos , Reza KazemiOskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar

引用次数: 1

Endoplasmic reticulum stress and lipids in health and diseases 内质网应激和脂质在健康和疾病中的作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101198

Cenk Celik , Stella Yue Ting Lee , Wei Sheng Yap , Guillaume Thibault

{"title":"Endoplasmic reticulum stress and lipids in health and diseases","authors":"Cenk Celik , Stella Yue Ting Lee , Wei Sheng Yap , Guillaume Thibault","doi":"10.1016/j.plipres.2022.101198","DOIUrl":"10.1016/j.plipres.2022.101198","url":null,"abstract":"<div><p>The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER enters a stress state, which, in turn, activates the highly conserved unfolded protein response (UPR). By sensing the accumulation of unfolded proteins or lipid bilayer stress (LBS) at the ER, the UPR triggers pathways to restore ER homeostasis and eventually induces apoptosis if the stress remains unresolved. In recent years, it has emerged that the UPR works intimately with other cellular pathways to maintain lipid homeostasis at the ER, and so does at cellular levels. Lipid distribution, along with lipid anabolism and catabolism, are tightly regulated, in part, by the ER. Dysfunctional and overwhelmed lipid-related pathways, independently or in combination with ER stress, can have reciprocal effects on other cellular functions, contributing to the development of diseases. In this review, we summarize the current understanding of the UPR in response to proteotoxic stress and LBS and the breadth of the functions mitigated by the UPR in different tissues and in the context of diseases.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101198"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10759797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Proteins involved in fat-soluble vitamin and carotenoid transport across the intestinal cells: New insights from the past decade 参与脂溶性维生素和类胡萝卜素在肠细胞运输的蛋白质:过去十年的新见解

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101208

Emmanuelle Reboul

{"title":"Proteins involved in fat-soluble vitamin and carotenoid transport across the intestinal cells: New insights from the past decade","authors":"Emmanuelle Reboul","doi":"10.1016/j.plipres.2022.101208","DOIUrl":"10.1016/j.plipres.2022.101208","url":null,"abstract":"<div><p>It is now well established that vitamins D, E, and K and carotenoids are not absorbed solely through passive diffusion. Broad-specificity membrane transporters such as SR-BI (scavenger receptor class B type I), CD36 (CD36 molecule), NPC1L1 (Niemann Pick C1-like 1) or ABCA1 (ATP-binding cassette A1) are involved in the uptake of these micronutrients from the lumen to the enterocyte cytosol and in their secretion into the bloodstream. Recently, the existence of efflux pathways from the enterocyte back to the lumen or from the bloodstream to the lumen, involving ABCB1 (P-glycoprotein/MDR1) or the ABCG5/ABCG8 complex, has also been evidenced for vitamins D and K. Surprisingly, no membrane proteins have been involved in dietary vitamin A uptake so far. After an overview of the metabolism of fat-soluble vitamins and carotenoids along the gastrointestinal tract (from the mouth to the colon where interactions with microbiota may occur), a focus is placed on the identified and candidate proteins participating in the apical uptake, intracellular transport, basolateral secretion and efflux back to the lumen of fat-soluble vitamins and carotenoids in enterocytes. This review also highlights the mechanisms that remain to be identified to fully unravel the pathways involved in fat-soluble vitamin and carotenoid intestinal absorption.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101208"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10776796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis 高甘油三酯血症的一个新的调控方面:microrna在调节富含甘油三酯的脂蛋白生物合成中的作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101197

Masoumeh Khalifeh , Raul D. Santos , Reza Kazemi Oskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar

{"title":"A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis","authors":"Masoumeh Khalifeh , Raul D. Santos , Reza Kazemi Oskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar","doi":"10.1016/j.plipres.2022.101197","DOIUrl":"10.1016/j.plipres.2022.101197","url":null,"abstract":"<div><p>Atherosclerotic cardiovascular disease (ASCVD) is one of the major leading global causes of death. Genetic and epidemiological studies strongly support the causal association between triacylglycerol-rich lipoproteins (TAGRL) and atherogenesis, even in statin-treated patients. Recent genetic evidence has clarified that variants in several key genes implicated in TAGRL metabolism are strongly linked to the increased ASCVD risk. There are several triacylglycerol-lowering agents; however, new therapeutic options are in development, among which are miRNA-based therapeutic approaches. MicroRNAs (miRNAs) are small non-coding RNAs (18–25 nucleotides) that negatively modulate gene expression through translational repression or degradation of target mRNAs, thereby reducing the levels of functional genes. MiRNAs play a crucial role in the development of hypertriglyceridemia as several miRNAs are dysregulated in both synthesis and clearance of TAGRL particles. MiRNA-based therapies in ASCVD have not yet been applied in human trials but are attractive. This review provides a concise overview of current interventions for hypertriglyceridemia and the development of novel miRNA and siRNA-based drugs. We summarize the miRNAs involved in the regulation of key genes in the TAGRLs synthesis pathway, which has gained attention as a novel target for therapeutic applications in CVD.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101197"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9319585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Corrigendum to “Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials” [Progress in Lipid Research. 2022 Oct 28;88:101196. doi: 10.1016/j.plipres.2022.101196] “omega-3多不饱和脂肪酸对主要心血管事件的比较疗效:随机对照试验的网络荟萃分析”的更正[脂质研究进展，2022年10月28日;88:101196]。doi: 10.1016 / j.plipres.2022.101196]

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101206

Bo Yang , Ping-Tao Tseng , Xiang Hu , Bing-Yan Zeng , Jane Pei-Chen Chang , Yang Liu , Wei-Jie Chu , Shuang-Shuang Zhang , Zhi-Liang Zhou , Chih-Sheng Chu , Cheng-Ho Chang , Yu-Kang Tu , Yi-Cheng Wu , Brendon Stubbs , Andre F. Carvalho , Pao-Yen Lin , Yutaka J. Matsuoka , Mein-Woei Suen , Kuan-Pin Su

引用次数: 0

Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: Plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research 氧化应激和炎症中脂质信号的区隔调节:缩醛原、氧化脂质和铁中毒是生物活性脂质研究的新范式

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101207

Alma M. Astudillo , María A. Balboa , Jesús Balsinde

{"title":"Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: Plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research","authors":"Alma M. Astudillo , María A. Balboa , Jesús Balsinde","doi":"10.1016/j.plipres.2022.101207","DOIUrl":"10.1016/j.plipres.2022.101207","url":null,"abstract":"<div><p>Perturbations in lipid homeostasis combined with conditions favoring oxidative stress constitute a hallmark of the inflammatory response. In this review we focus on the most recent results concerning lipid signaling in various oxidative stress-mediated responses and inflammation. These include phagocytosis and ferroptosis. The best characterized event, common to these responses, is the synthesis of oxygenated metabolites of arachidonic acid and other polyunsaturated fatty acids. Major developments in this area have highlighted the importance of compartmentalization of the enzymes and lipid substrates in shaping the appropriate response. In parallel, other relevant lipid metabolic pathways are also activated and, until recently, there has been a general lack of knowledge on the enzyme regulation and molecular mechanisms operating in these pathways. Specifically, data accumulated in recent years on the regulation and biological significance of plasmalogens and oxidized phospholipids have expanded our knowledge on the involvement of lipid metabolism in the progression of disease and the return to homeostasis. These recent major developments have helped to establish the concept of membrane phospholipids as cellular repositories for the compartmentalized production of bioactive lipids involved in cellular regulation. Importantly, an enzyme classically described as being involved in regulating the homeostatic turnover of phospholipids, namely the group VIA Ca<sup>2+</sup>-independent phospholipase A<sub>2</sub> (iPLA<sub>2</sub>β), has taken center stage in oxidative stress and inflammation research owing to its key involvement in regulating metabolic and ferroptotic signals arising from membrane phospholipids. Understanding the role of iPLA<sub>2</sub>β in ferroptosis and metabolism not only broadens our knowledge of disease but also opens possible new horizons for this enzyme as a target for therapeutic intervention.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101207"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Bile acids and their receptors in regulation of gut health and diseases 胆汁酸及其受体调节肠道健康和疾病

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101210

Sen Lin , Sutian Wang , Peng Wang , Cuiming Tang , Zhenjiang Wang , Lian Chen , Guoqing Luo , Hong Chen , Yuntao Liu , Bin Feng , De Wu , Douglas G. Burrin , Zhengfeng Fang

{"title":"Bile acids and their receptors in regulation of gut health and diseases","authors":"Sen Lin , Sutian Wang , Peng Wang , Cuiming Tang , Zhenjiang Wang , Lian Chen , Guoqing Luo , Hong Chen , Yuntao Liu , Bin Feng , De Wu , Douglas G. Burrin , Zhengfeng Fang","doi":"10.1016/j.plipres.2022.101210","DOIUrl":"10.1016/j.plipres.2022.101210","url":null,"abstract":"<div><p>It is well established that bile acids play important roles in lipid metabolism. In recent decades, bile acids have also been shown to function as signaling molecules via interacting with various receptors. Bile acids circulate continuously through the enterohepatic circulation and go through microbial transformation by gut microbes, and thus bile acids metabolism has profound effects on the liver and intestinal tissues as well as the gut microbiota. Farnesoid X receptor and G protein-coupled bile acid receptor 1 are two pivotal bile acid receptors that highly expressed in the intestinal tissues, and they have emerged as pivotal regulators in bile acids metabolism, innate immunity and inflammatory responses. There is considerable interest in manipulating the metabolism of bile acids and the expression of bile acid receptors as this may be a promising strategy to regulate intestinal health and disease. This review aims to summarize the roles of bile acids and their receptors in regulation of gut health and diseases.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101210"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10760260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10