Progress in lipid research最新文献_第7页

The gut microbiota-artery axis: A bridge between dietary lipids and atherosclerosis? 肠道微生物-动脉轴:膳食脂质与动脉粥样硬化之间的桥梁?

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101209

Qinjun Zhang , Liangxiao Zhang , Cheng Chen , Peiwu Li , Baiyi Lu

{"title":"The gut microbiota-artery axis: A bridge between dietary lipids and atherosclerosis?","authors":"Qinjun Zhang , Liangxiao Zhang , Cheng Chen , Peiwu Li , Baiyi Lu","doi":"10.1016/j.plipres.2022.101209","DOIUrl":"10.1016/j.plipres.2022.101209","url":null,"abstract":"<div>Atherosclerotic cardiovascular disease is one of the major leading global causes of death. Growing evidence has demonstrated that gut microbiota (GM) and its metabolites play a pivotal role in the onset and progression of atherosclerosis (AS), now known as GM-artery axis. There are interactions between dietary lipids and GM, which ultimately affect GM and its metabolites. Given these two aspects, the GM-artery axis may play a mediating role between dietary lipids and AS. Diets rich in saturated fatty acids (SFAs), omega-6 polyunsaturated fatty acids (n-6 PUFAs), industrial trans fatty acids (TFAs), and cholesterol can increase the levels of atherogenic microbes and metabolites, whereas monounsaturated fatty acids (MUFAs), ruminant TFAs, and phytosterols (PS) can increase the levels of antiatherogenic microbes and metabolites. Actually, dietary phosphatidylcholine (PC), sphingomyelin (SM), and omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been demonstrated to affect AS via the GM-artery axis. Therefore, that GM-artery axis acts as a communication bridge between dietary lipids and AS. Herein, we will describe the molecular mechanism of GM-artery axis in AS and discuss the complex interactions between dietary lipids and GM. In particular, we will highlight the evidence and potential mechanisms of dietary lipids affecting AS via GM-artery axis.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101209"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9319597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

New research development on trans fatty acids in food: Biological effects, analytical methods, formation mechanism, and mitigating measures 食品中反式脂肪酸的研究新进展:生物学效应、分析方法、形成机制和抑制措施

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101199

Qin Guo , Tian Li , Yang Qu , Manzhu Liang , Yiming Ha , Yu Zhang , Qiang Wang

引用次数: 34

Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities 阿南达胺和其他n -酰基乙醇胺:一类具有治疗机会的信号脂质

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101194

Elliot D. Mock , Berend Gagestein, Mario van der Stelt

{"title":"Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities","authors":"Elliot D. Mock , Berend Gagestein, Mario van der Stelt","doi":"10.1016/j.plipres.2022.101194","DOIUrl":"10.1016/j.plipres.2022.101194","url":null,"abstract":"<div>N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N-docosahexaenoylethanolamine (DHEA, synaptamide) and their oxygenated metabolites are a lipid messenger family with numerous functions in health and disease, including inflammation, anxiety and energy metabolism. The NAEs exert their signaling role through activation of various G protein-coupled receptors (cannabinoid CB1 and CB2 receptors, GPR55, GPR110, GPR119), ion channels (TRPV1) and nuclear receptors (PPAR-α and PPAR-γ) in the brain and periphery. The biological role of the oxygenated NAEs, such as prostamides, hydroxylated anandamide and DHEA derivatives, are less studied. Evidence is accumulating that NAEs and their oxidative metabolites may be aberrantly regulated or are associated with disease severity in obesity, metabolic syndrome, cancer, neuroinflammation and liver cirrhosis. Here, we comprehensively review NAE biosynthesis and degradation, their metabolism by lipoxygenases, cyclooxygenases and cytochrome P450s and the biological functions of these signaling lipids. We discuss the latest findings and therapeutic potential of modulating endogenous NAE levels by inhibition of their degradation, which is currently under clinical evaluation for neuropsychiatric disorders. We also highlight NAE biosynthesis inhibition as an emerging topic with therapeutic opportunities in endocannabinoid and NAE signaling.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101194"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials omega-3多不饱和脂肪酸对主要心血管事件的比较疗效:随机对照试验的网络荟萃分析

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101196

Bo Yang , Ping-Tao Tseng , Xiang Hu , Bing-Yan Zeng , Jane Pei-Chen Chang , Yang Liu , Wei-Jie Chu , Shuang-Shuang Zhang , Zhi-Liang Zhou , Chih-Sheng Chu , Cheng-Ho Chang , Yu-Kang Tu , Yi-Cheng Wu , Brendon Stubbs , Andre F. Carvalho , Pao-Yen Lin , Yutaka J. Matsuoka , Mein-Woei Suen , Kuan-Pin Su

{"title":"Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials","authors":"Bo Yang , Ping-Tao Tseng , Xiang Hu , Bing-Yan Zeng , Jane Pei-Chen Chang , Yang Liu , Wei-Jie Chu , Shuang-Shuang Zhang , Zhi-Liang Zhou , Chih-Sheng Chu , Cheng-Ho Chang , Yu-Kang Tu , Yi-Cheng Wu , Brendon Stubbs , Andre F. Carvalho , Pao-Yen Lin , Yutaka J. Matsuoka , Mein-Woei Suen , Kuan-Pin Su","doi":"10.1016/j.plipres.2022.101196","DOIUrl":"10.1016/j.plipres.2022.101196","url":null,"abstract":"<div>The role of omega-3 polyunsaturated fatty acids (PUFAs) in primary and secondary prevention on major cardiovascular events (MCE) is inconclusive due to the potential heterogeneity in study designs of formulas, dosages, and ratios of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from the findings of previous randomized controlled trials (RCTs). Here we conducted a comprehensive narrative review of pre-clinical studies and updated a network meta-analysis (NMA) to determine the comparative efficacy against MCE with different EPA/DHA dosages and formulas. We found that pure EPA was ranked the best option in the secondary prevention (hazard ratio: 0.72, 95% confidence interval: 0.65 to 0.81) from the NMA of 39 RCTs with 88,359 participants. There was no evidence of omega-3 PUFAs' efficacy in primary prevention. The mechanisms of omega-3 PUFAs' cardiovascular protection might link to the effects of anti-inflammation and stabilization of endothelial function from PUFA's derivatives including eicosanoids and the special pre-resolving mediators (SPMs).</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"88 ","pages":"Article 101196"},"PeriodicalIF":13.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10499688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Using molecular simulation to understand the skin barrier 利用分子模拟了解皮肤屏障

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101184

Parashara Shamaprasad , Chloe O. Frame , Timothy C. Moore , Alexander Yang , Christopher R. Iacovella , Joke A. Bouwstra , Annette L. Bunge , Clare McCabe

{"title":"Using molecular simulation to understand the skin barrier","authors":"Parashara Shamaprasad , Chloe O. Frame , Timothy C. Moore , Alexander Yang , Christopher R. Iacovella , Joke A. Bouwstra , Annette L. Bunge , Clare McCabe","doi":"10.1016/j.plipres.2022.101184","DOIUrl":"10.1016/j.plipres.2022.101184","url":null,"abstract":"<div>Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of layers of corneocytes surrounded by highly organized lipid lamellae. As the only continuous path through the SC, transdermal permeation necessarily involves diffusion through these lipid layers. The role of the SC as a protective barrier is supported by its exceptional lipid composition consisting of ceramides (CERs), cholesterol (CHOL), and free fatty acids (FFAs) and the complete absence of phospholipids, which are present in most biological membranes. Molecular simulation, which provides molecular level detail of lipid configurations that can be connected with barrier function, has become a popular tool for studying SC lipid systems. We review this ever-increasing body of literature with the goals of (1) enabling the experimental skin community to understand, interpret and use the information generated from the simulations, (2) providing simulation experts with a solid background in the chemistry of SC lipids including the composition, structure and organization, and barrier function, and (3) presenting a state of the art picture of the field of SC lipid simulations, highlighting the difficulties and best practices for studying these systems, to encourage the generation of robust reproducible studies in the future. This review describes molecular simulation methodology and then critically examines results derived from simulations using atomistic and then coarse-grained models.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"88 ","pages":"Article 101184"},"PeriodicalIF":13.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9328632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

CD36 favours fat sensing and transport to govern lipid metabolism CD36有利于脂肪感知和转运，从而控制脂质代谢

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101193

Yunxia Li , Xingguo Huang , Guan Yang , Kang Xu , Yulong Yin , Gabriele Brecchia , Jie Yin

引用次数: 10

Studies of the cardiolipin interactome 心磷脂相互作用组的研究

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101195

Colin A. Fox , Robert O. Ryan

{"title":"Studies of the cardiolipin interactome","authors":"Colin A. Fox , Robert O. Ryan","doi":"10.1016/j.plipres.2022.101195","DOIUrl":"10.1016/j.plipres.2022.101195","url":null,"abstract":"<div>Cardiolipin (CL) is a unique phospholipid that is fundamental to the structure and function of the highly curved cristae membranes of mitochondria. Given its distinctive cone-shaped molecular architecture, CL induces negative membrane curvature in a bilayer setting. Another key feature of CL is its intrinsic ability to interact with various ligands, including cytochrome c, the anti-neoplastic anthracycline, doxorubicin, and the divalent cation, calcium. Although these, and other, binding interactions exert profound effects on mitochondrial and cellular function, they are difficult to study in intact mitochondria. Whereas liposomes provide a potential model membrane system, their relatively large size, limited ability to accommodate CL and the presence of an inaccessible interior bilayer leaflet, make these structures suboptimal. The discovery that CL can be formulated into aqueous soluble, reconstituted high density lipoprotein particles, termed nanodisks (ND), provides an alternative model membrane system. Comprised solely of CL and an apolipoprotein scaffold, CL-ND exist as a disk-shaped phospholipid bilayer whose perimeter is stabilized by contact with the scaffold protein. In these nanoscale particles, both leaflets of the bilayer are solvent accessible, an advantage for studies of ligand interactions. Recent experiments employing CL-ND have yielded novel insight into apoptosis, cardiotoxicity and CL-dependent bilayer to non-bilayer transitions.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"88 ","pages":"Article 101195"},"PeriodicalIF":13.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10781622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control 酰基辅酶a:二酰基甘油酰基转移酶:性质，生理作用，代谢工程和有意控制

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101181

Guanqun Chen , John L. Harwood , M. Joanne Lemieux , Scot J. Stone , Randall J. Weselake

{"title":"Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control","authors":"Guanqun Chen , John L. Harwood , M. Joanne Lemieux , Scot J. Stone , Randall J. Weselake","doi":"10.1016/j.plipres.2022.101181","DOIUrl":"10.1016/j.plipres.2022.101181","url":null,"abstract":"<div>Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the last reaction in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly in DGAT1 and DGAT2 in eukaryotes and bifunctional wax ester synthase-diacylglycerol acyltransferase (WSD) in bacteria, which are all membrane-bound proteins but exhibit no sequence homology to each other. Recent studies also identified other DGAT enzymes such as the soluble DGAT3 and diacylglycerol acetyltransferase (EaDAcT), as well as enzymes with DGAT activities including defective in cuticular ridges (DCR) and steryl and phytyl ester synthases (PESs). This review comprehensively discusses research advances on DGATs in prokaryotes and eukaryotes with a focus on their biochemical properties, physiological roles, and biotechnological and therapeutic applications. The review begins with a discussion of DGAT assay methods, followed by a systematic discussion of TAG biosynthesis and the properties and physiological role of DGATs. Thereafter, the review discusses the three-dimensional structure and insights into mechanism of action of human DGAT1, and the modeled DGAT1 from Brassica napus. The review then examines metabolic engineering strategies involving manipulation of DGAT, followed by a discussion of its therapeutic applications. DGAT in relation to improvement of traits of farmed animals is also discussed along with DGATs in various other eukaryotic organisms.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"88 ","pages":"Article 101181"},"PeriodicalIF":13.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782722000364/pdfft?md5=0abf0450dec64415ffa3f6bbaa137bbc&pid=1-s2.0-S0163782722000364-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10781103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection 与SARS-CoV-2感染相关的一系列胆固醇依赖过程

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-07-01 DOI: 10.1016/j.plipres.2022.101166

Francisco J. Barrantes

{"title":"The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection","authors":"Francisco J. Barrantes","doi":"10.1016/j.plipres.2022.101166","DOIUrl":"10.1016/j.plipres.2022.101166","url":null,"abstract":"<div>The role of cholesterol in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronavirus-host cell interactions is currently being discussed in the context of two main scenarios: i) the presence of the neutral lipid in cholesterol-rich lipid domains involved in different steps of the viral infection and ii) the alteration of metabolic pathways by the virus over the course of infection. Cholesterol-enriched lipid domains have been reported to occur in the lipid envelope membrane of the virus, in the host-cell plasma membrane, as well as in endosomal and other intracellular membrane cellular compartments. These membrane subdomains, whose chemical and physical properties distinguish them from the bulk lipid bilayer, have been purported to participate in diverse phenomena, from virus-host cell fusion to intracellular trafficking and exit of the virions from the infected cell. SARS-CoV-2 recruits many key proteins that participate under physiological conditions in cholesterol and lipid metabolism in general. This review analyses the status of cholesterol and lipidome proteins in SARS-CoV-2 infection and the new horizons they open for therapeutic intervention.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"87 ","pages":"Article 101166"},"PeriodicalIF":13.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10498057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids 了解硝基脂质体:从化学到质谱分析和修饰复合脂质的生物学意义

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-07-01 DOI: 10.1016/j.plipres.2022.101176

Bruna Neves , Dolores Pérez-Sala , Helena Beatriz Ferreira , Inês M.S. Guerra , Ana S.P. Moreira , Pedro Domingues , M. Rosário Domingues , Tânia Melo

{"title":"Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids","authors":"Bruna Neves , Dolores Pérez-Sala , Helena Beatriz Ferreira , Inês M.S. Guerra , Ana S.P. Moreira , Pedro Domingues , M. Rosário Domingues , Tânia Melo","doi":"10.1016/j.plipres.2022.101176","DOIUrl":"10.1016/j.plipres.2022.101176","url":null,"abstract":"<div>Complex lipids, phospholipids (PLs) and triacylglycerides (TAGs), are prone to modifications induced by reactive nitrated species and reactive oxygen species, generating a range of nitrated, nitrosated or nitroxidized derivatives, as nitro PLs and nitro TAGs. These modified lipids (epilipids) have been reported in vitro and in vivo using lipidomics approaches. However, their detection in living systems remains a challenge hampered by its complexity, high structural diversity, and low abundance. The advances in high-resolution mass spectrometry combined with the higher sensitivity of the instruments like Orbitrap-based mass spectrometers opened new opportunities for the detection of these modified complex lipids. This review summarizes the challenges and findings behind the identification of nitrated, nitrosated and nitroxidized PLs and TAGs fragmentation fingerprints based on collision-induced dissociation (CID) and higher energy CID (HCD) MS/MS approaches. Following what has already been reported for nitrated fatty acids, these complex lipids are found to act as endogenous mediators with potential electrophilic properties and can express bioactivities such as anti-inflammatory and antioxidant actions. This information can be used to design untargeted and targeted lipidomics strategies for these modified complex lipids in biological samples as well as in pathological, food and industrial settings, further unveiling their biological and signalling roles.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"87 ","pages":"Article 101176"},"PeriodicalIF":13.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46877792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5