Progress in lipid research最新文献_第7页

Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials omega-3多不饱和脂肪酸对主要心血管事件的比较疗效:随机对照试验的网络荟萃分析

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101196

Bo Yang , Ping-Tao Tseng , Xiang Hu , Bing-Yan Zeng , Jane Pei-Chen Chang , Yang Liu , Wei-Jie Chu , Shuang-Shuang Zhang , Zhi-Liang Zhou , Chih-Sheng Chu , Cheng-Ho Chang , Yu-Kang Tu , Yi-Cheng Wu , Brendon Stubbs , Andre F. Carvalho , Pao-Yen Lin , Yutaka J. Matsuoka , Mein-Woei Suen , Kuan-Pin Su

{"title":"Comparative efficacy of omega-3 polyunsaturated fatty acids on major cardiovascular events: A network meta-analysis of randomized controlled trials","authors":"Bo Yang , Ping-Tao Tseng , Xiang Hu , Bing-Yan Zeng , Jane Pei-Chen Chang , Yang Liu , Wei-Jie Chu , Shuang-Shuang Zhang , Zhi-Liang Zhou , Chih-Sheng Chu , Cheng-Ho Chang , Yu-Kang Tu , Yi-Cheng Wu , Brendon Stubbs , Andre F. Carvalho , Pao-Yen Lin , Yutaka J. Matsuoka , Mein-Woei Suen , Kuan-Pin Su","doi":"10.1016/j.plipres.2022.101196","DOIUrl":"10.1016/j.plipres.2022.101196","url":null,"abstract":"<div>The role of omega-3 polyunsaturated fatty acids (PUFAs) in primary and secondary prevention on major cardiovascular events (MCE) is inconclusive due to the potential heterogeneity in study designs of formulas, dosages, and ratios of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from the findings of previous randomized controlled trials (RCTs). Here we conducted a comprehensive narrative review of pre-clinical studies and updated a network meta-analysis (NMA) to determine the comparative efficacy against MCE with different EPA/DHA dosages and formulas. We found that pure EPA was ranked the best option in the secondary prevention (hazard ratio: 0.72, 95% confidence interval: 0.65 to 0.81) from the NMA of 39 RCTs with 88,359 participants. There was no evidence of omega-3 PUFAs' efficacy in primary prevention. The mechanisms of omega-3 PUFAs' cardiovascular protection might link to the effects of anti-inflammation and stabilization of endothelial function from PUFA's derivatives including eicosanoids and the special pre-resolving mediators (SPMs).</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"88 ","pages":"Article 101196"},"PeriodicalIF":13.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10499688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Using molecular simulation to understand the skin barrier 利用分子模拟了解皮肤屏障

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101184

Parashara Shamaprasad , Chloe O. Frame , Timothy C. Moore , Alexander Yang , Christopher R. Iacovella , Joke A. Bouwstra , Annette L. Bunge , Clare McCabe

{"title":"Using molecular simulation to understand the skin barrier","authors":"Parashara Shamaprasad , Chloe O. Frame , Timothy C. Moore , Alexander Yang , Christopher R. Iacovella , Joke A. Bouwstra , Annette L. Bunge , Clare McCabe","doi":"10.1016/j.plipres.2022.101184","DOIUrl":"10.1016/j.plipres.2022.101184","url":null,"abstract":"<div>Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of layers of corneocytes surrounded by highly organized lipid lamellae. As the only continuous path through the SC, transdermal permeation necessarily involves diffusion through these lipid layers. The role of the SC as a protective barrier is supported by its exceptional lipid composition consisting of ceramides (CERs), cholesterol (CHOL), and free fatty acids (FFAs) and the complete absence of phospholipids, which are present in most biological membranes. Molecular simulation, which provides molecular level detail of lipid configurations that can be connected with barrier function, has become a popular tool for studying SC lipid systems. We review this ever-increasing body of literature with the goals of (1) enabling the experimental skin community to understand, interpret and use the information generated from the simulations, (2) providing simulation experts with a solid background in the chemistry of SC lipids including the composition, structure and organization, and barrier function, and (3) presenting a state of the art picture of the field of SC lipid simulations, highlighting the difficulties and best practices for studying these systems, to encourage the generation of robust reproducible studies in the future. This review describes molecular simulation methodology and then critically examines results derived from simulations using atomistic and then coarse-grained models.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"88 ","pages":"Article 101184"},"PeriodicalIF":13.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10116345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9328632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

CD36 favours fat sensing and transport to govern lipid metabolism CD36有利于脂肪感知和转运，从而控制脂质代谢

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101193

Yunxia Li , Xingguo Huang , Guan Yang , Kang Xu , Yulong Yin , Gabriele Brecchia , Jie Yin

引用次数: 10

Studies of the cardiolipin interactome 心磷脂相互作用组的研究

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101195

Colin A. Fox , Robert O. Ryan

{"title":"Studies of the cardiolipin interactome","authors":"Colin A. Fox , Robert O. Ryan","doi":"10.1016/j.plipres.2022.101195","DOIUrl":"10.1016/j.plipres.2022.101195","url":null,"abstract":"<div>Cardiolipin (CL) is a unique phospholipid that is fundamental to the structure and function of the highly curved cristae membranes of mitochondria. Given its distinctive cone-shaped molecular architecture, CL induces negative membrane curvature in a bilayer setting. Another key feature of CL is its intrinsic ability to interact with various ligands, including cytochrome c, the anti-neoplastic anthracycline, doxorubicin, and the divalent cation, calcium. Although these, and other, binding interactions exert profound effects on mitochondrial and cellular function, they are difficult to study in intact mitochondria. Whereas liposomes provide a potential model membrane system, their relatively large size, limited ability to accommodate CL and the presence of an inaccessible interior bilayer leaflet, make these structures suboptimal. The discovery that CL can be formulated into aqueous soluble, reconstituted high density lipoprotein particles, termed nanodisks (ND), provides an alternative model membrane system. Comprised solely of CL and an apolipoprotein scaffold, CL-ND exist as a disk-shaped phospholipid bilayer whose perimeter is stabilized by contact with the scaffold protein. In these nanoscale particles, both leaflets of the bilayer are solvent accessible, an advantage for studies of ligand interactions. Recent experiments employing CL-ND have yielded novel insight into apoptosis, cardiotoxicity and CL-dependent bilayer to non-bilayer transitions.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"88 ","pages":"Article 101195"},"PeriodicalIF":13.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10781622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control 酰基辅酶a:二酰基甘油酰基转移酶:性质，生理作用，代谢工程和有意控制

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-11-01 DOI: 10.1016/j.plipres.2022.101181

Guanqun Chen , John L. Harwood , M. Joanne Lemieux , Scot J. Stone , Randall J. Weselake

{"title":"Acyl-CoA:diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control","authors":"Guanqun Chen , John L. Harwood , M. Joanne Lemieux , Scot J. Stone , Randall J. Weselake","doi":"10.1016/j.plipres.2022.101181","DOIUrl":"10.1016/j.plipres.2022.101181","url":null,"abstract":"<div>Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the last reaction in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly in DGAT1 and DGAT2 in eukaryotes and bifunctional wax ester synthase-diacylglycerol acyltransferase (WSD) in bacteria, which are all membrane-bound proteins but exhibit no sequence homology to each other. Recent studies also identified other DGAT enzymes such as the soluble DGAT3 and diacylglycerol acetyltransferase (EaDAcT), as well as enzymes with DGAT activities including defective in cuticular ridges (DCR) and steryl and phytyl ester synthases (PESs). This review comprehensively discusses research advances on DGATs in prokaryotes and eukaryotes with a focus on their biochemical properties, physiological roles, and biotechnological and therapeutic applications. The review begins with a discussion of DGAT assay methods, followed by a systematic discussion of TAG biosynthesis and the properties and physiological role of DGATs. Thereafter, the review discusses the three-dimensional structure and insights into mechanism of action of human DGAT1, and the modeled DGAT1 from Brassica napus. The review then examines metabolic engineering strategies involving manipulation of DGAT, followed by a discussion of its therapeutic applications. DGAT in relation to improvement of traits of farmed animals is also discussed along with DGATs in various other eukaryotic organisms.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"88 ","pages":"Article 101181"},"PeriodicalIF":13.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782722000364/pdfft?md5=0abf0450dec64415ffa3f6bbaa137bbc&pid=1-s2.0-S0163782722000364-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10781103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection 与SARS-CoV-2感染相关的一系列胆固醇依赖过程

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-07-01 DOI: 10.1016/j.plipres.2022.101166

Francisco J. Barrantes

{"title":"The constellation of cholesterol-dependent processes associated with SARS-CoV-2 infection","authors":"Francisco J. Barrantes","doi":"10.1016/j.plipres.2022.101166","DOIUrl":"10.1016/j.plipres.2022.101166","url":null,"abstract":"<div>The role of cholesterol in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronavirus-host cell interactions is currently being discussed in the context of two main scenarios: i) the presence of the neutral lipid in cholesterol-rich lipid domains involved in different steps of the viral infection and ii) the alteration of metabolic pathways by the virus over the course of infection. Cholesterol-enriched lipid domains have been reported to occur in the lipid envelope membrane of the virus, in the host-cell plasma membrane, as well as in endosomal and other intracellular membrane cellular compartments. These membrane subdomains, whose chemical and physical properties distinguish them from the bulk lipid bilayer, have been purported to participate in diverse phenomena, from virus-host cell fusion to intracellular trafficking and exit of the virions from the infected cell. SARS-CoV-2 recruits many key proteins that participate under physiological conditions in cholesterol and lipid metabolism in general. This review analyses the status of cholesterol and lipidome proteins in SARS-CoV-2 infection and the new horizons they open for therapeutic intervention.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"87 ","pages":"Article 101166"},"PeriodicalIF":13.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10498057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids 了解硝基脂质体:从化学到质谱分析和修饰复合脂质的生物学意义

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-07-01 DOI: 10.1016/j.plipres.2022.101176

Bruna Neves , Dolores Pérez-Sala , Helena Beatriz Ferreira , Inês M.S. Guerra , Ana S.P. Moreira , Pedro Domingues , M. Rosário Domingues , Tânia Melo

{"title":"Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids","authors":"Bruna Neves , Dolores Pérez-Sala , Helena Beatriz Ferreira , Inês M.S. Guerra , Ana S.P. Moreira , Pedro Domingues , M. Rosário Domingues , Tânia Melo","doi":"10.1016/j.plipres.2022.101176","DOIUrl":"10.1016/j.plipres.2022.101176","url":null,"abstract":"<div>Complex lipids, phospholipids (PLs) and triacylglycerides (TAGs), are prone to modifications induced by reactive nitrated species and reactive oxygen species, generating a range of nitrated, nitrosated or nitroxidized derivatives, as nitro PLs and nitro TAGs. These modified lipids (epilipids) have been reported in vitro and in vivo using lipidomics approaches. However, their detection in living systems remains a challenge hampered by its complexity, high structural diversity, and low abundance. The advances in high-resolution mass spectrometry combined with the higher sensitivity of the instruments like Orbitrap-based mass spectrometers opened new opportunities for the detection of these modified complex lipids. This review summarizes the challenges and findings behind the identification of nitrated, nitrosated and nitroxidized PLs and TAGs fragmentation fingerprints based on collision-induced dissociation (CID) and higher energy CID (HCD) MS/MS approaches. Following what has already been reported for nitrated fatty acids, these complex lipids are found to act as endogenous mediators with potential electrophilic properties and can express bioactivities such as anti-inflammatory and antioxidant actions. This information can be used to design untargeted and targeted lipidomics strategies for these modified complex lipids in biological samples as well as in pathological, food and industrial settings, further unveiling their biological and signalling roles.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"87 ","pages":"Article 101176"},"PeriodicalIF":13.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46877792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome 调节典型和非典型NLRP3炎性体的脂蛋白相互作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-07-01 DOI: 10.1016/j.plipres.2022.101182

Malvina Pizzuto , Pablo Pelegrin , Jean-Marie Ruysschaert

{"title":"Lipid-protein interactions regulating the canonical and the non-canonical NLRP3 inflammasome","authors":"Malvina Pizzuto , Pablo Pelegrin , Jean-Marie Ruysschaert","doi":"10.1016/j.plipres.2022.101182","DOIUrl":"10.1016/j.plipres.2022.101182","url":null,"abstract":"<div>The inflammatory response is a complex regulated effector mechanism of the innate immune system that is initiated after tissue injury or infection. The NLRP3 inflammasome is an important initiator of inflammation by regulating the activation of caspase-1, the maturation of pro-inflammatory cytokines and the induction of pyroptotic cell death. Numerous studies demonstrate that the NLRP3 inflammasome could be modulated by lipids, existing a relation between lipids and the activation of different inflammatory processes. In this review we will summarize how the mechanism of NLRP3 inflammasome activation is regulated by different lipids and how these lipids control specific cellular localization of NLRP3 during activation. Although being a cytosolic protein, NLRP3 interacts with lipids accessible in neighbor membranes. Also, the modulation of NLRP3 by endogenous lipids has been found causative of different metabolic diseases and bacterial-pathogenic lipids lead to NLRP3 activation during infection. The understanding of the modulation of the NLRP3 inflammasome by lipids has resulted not only in a better knowledge about the mechanism of NLRP3 activation and its implication in disease, but also opens a new avenue for the development of novel therapeutics and vaccines, as NLRP3 could be modulated by synthetic lipids used as adjuvants.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"87 ","pages":"Article 101182"},"PeriodicalIF":13.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10091283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Intestinal fatty acid binding protein: A rising therapeutic target in lipid metabolism 肠道脂肪酸结合蛋白:脂质代谢的新治疗靶点

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-07-01 DOI: 10.1016/j.plipres.2022.101178

Xi Huang, Youci Zhou, Yunwei Sun, Qijun Wang

{"title":"Intestinal fatty acid binding protein: A rising therapeutic target in lipid metabolism","authors":"Xi Huang, Youci Zhou, Yunwei Sun, Qijun Wang","doi":"10.1016/j.plipres.2022.101178","DOIUrl":"10.1016/j.plipres.2022.101178","url":null,"abstract":"<div>Fatty acid binding proteins (FABPs) are key proteins in lipid transport, and the isoforms are segregated according to their tissue origins. Several isoforms, such as adipose-FABP and epidermal-FABP, have been shown to participate in multiple pathologic processes due to their ubiquitous expression. Intestinal fatty acid binding protein, also termed FABP2 or I-FABP, is specifically expressed in the small intestine. FABP2 can traffic lipids from the intestinal lumen to enterocytes and bind superfluous fatty acids to maintain a steady pool of fatty acids in the epithelium. As a lipid chaperone, FABP2 can also carry lipophilic drugs to facilitate targeted transport. When the integrity of the intestinal epithelium is disrupted, FABP2 is released into the circulation. Thus, it can potentially serve as a clinical biomarker. In this review, we discuss the pivotal role of FABP2 in intestinal lipid metabolism. We also summarize the molecular interactions that have been reported to date, highlighting the clinical prospects of FABP2 research.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"87 ","pages":"Article 101178"},"PeriodicalIF":13.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies 脂质组学研究中预防和消除不必要变异的挑战和机遇

IF 13.6 1区医学

Progress in lipid research Pub Date : 2022-07-01 DOI: 10.1016/j.plipres.2022.101177

Gavriel Olshansky , Corey Giles , Agus Salim , Peter J. Meikle

{"title":"Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies","authors":"Gavriel Olshansky , Corey Giles , Agus Salim , Peter J. Meikle","doi":"10.1016/j.plipres.2022.101177","DOIUrl":"10.1016/j.plipres.2022.101177","url":null,"abstract":"<div>Large ‘omics studies are of particular interest to population and clinical research as they allow elucidation of biological pathways that are often out of reach of other methodologies. Typically, these information rich datasets are produced from multiple coordinated profiling studies that may include lipidomics, metabolomics, proteomics or other strategies to generate high dimensional data. In lipidomics, the generation of such data presents a series of unique technological and logistical challenges; to maximize the power (number of samples) and coverage (number of analytes) of the dataset while minimizing the sources of unwanted variation. Technological advances in analytical platforms, as well as computational approaches, have led to improvement of data quality – especially with regard to instrumental variation. In the small scale, it is possible to control systematic bias from beginning to end. However, as the size and complexity of datasets grow, it is inevitable that unwanted variation arises from multiple sources, some potentially unknown and out of the investigators control. Increases in cohort size and complexity have led to new challenges in sample collection, handling, storage, and preparation. If not considered and dealt with appropriately, this unwanted variation may undermine the quality of the data and reliability of any subsequent analysis. Here we review the various experimental phases where unwanted variation may be introduced and review general strategies and approaches to handle this variation, specifically addressing issues relevant to lipidomics studies.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"87 ","pages":"Article 101177"},"PeriodicalIF":13.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7