Systematic review of brain and blood lipidomics in Alzheimer's disease mouse models

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in lipid research Pub Date : 2023-04-01 DOI:10.1016/j.plipres.2023.101223

Laura Ferré-González , Ana Lloret , Consuelo Cháfer-Pericás

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引用次数: 0

Abstract

Alzheimer's disease (AD) diagnosis is based on invasive and expensive biomarkers. Regarding AD pathophysiological mechanisms, there is evidence of a link between AD and aberrant lipid homeostasis. Alterations in lipid composition have been observed in blood and brain samples, and transgenic mouse models represent a promising approach. Nevertheless, there is great variability among studies in mice for the determination of different types of lipids in targeted and untargeted methods. It could be explained by the different variables (model, age, sex, analytical technique), and experimental conditions used.

The aim of this work is to review the studies on lipid alteration in brain tissue and blood samples from AD mouse models, focusing on different experimental parameters. As result, great disparity has been observed among the reviewed studies. Brain studies showed an increase in gangliosides, sphingomyelins, lysophospholipids and monounsaturated fatty acids and a decrease in sulfatides. In contrast, blood studies showed an increase in phosphoglycerides, sterols, diacylglycerols, triacylglycerols and polyunsaturated fatty acids, and a decrease in phospholipids, lysophospholipids and monounsaturated fatty acids. Thus, lipids are closely related to AD, and a consensus on lipidomics studies could be used as a diagnostic tool and providing insight into the mechanisms involved in AD.

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阿尔茨海默病小鼠模型脑和血脂组学的系统综述

阿尔茨海默病(AD)的诊断是基于侵入性和昂贵的生物标志物。关于AD的病理生理机制，有证据表明AD与异常脂质稳态之间存在联系。在血液和大脑样本中已经观察到脂质组成的改变，转基因小鼠模型代表了一种很有前途的方法。然而，在小鼠研究中，用靶向和非靶向方法测定不同类型的脂质存在很大的差异。这可以用不同的变量(模型、年龄、性别、分析技术)和使用的实验条件来解释。本文综述了AD小鼠模型脑组织和血液中脂质改变的研究，重点介绍了不同的实验参数。因此，在审查的研究中观察到很大的差异。脑部研究显示神经节苷、鞘磷脂、溶血磷脂和单不饱和脂肪酸增加，而硫脂减少。与此相反，血液研究显示甘油磷脂、甾醇、二酰基甘油、三酰基甘油和多不饱和脂肪酸增加，磷脂、溶血磷脂和单不饱和脂肪酸减少。因此，脂质与阿尔茨海默病密切相关，脂质组学研究的共识可以作为诊断工具，并为阿尔茨海默病的机制提供深入了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.