Progress in lipid research最新文献_第5页

Endocannabinoid signaling in adult hippocampal neurogenesis: A mechanistic and integrated perspective 内源性大麻素信号在成人海马神经发生:一个机制和综合的观点

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101239

Sergio Oddi , Maria Teresa Fiorenza , Mauro Maccarrone

{"title":"Endocannabinoid signaling in adult hippocampal neurogenesis: A mechanistic and integrated perspective","authors":"Sergio Oddi , Maria Teresa Fiorenza , Mauro Maccarrone","doi":"10.1016/j.plipres.2023.101239","DOIUrl":"10.1016/j.plipres.2023.101239","url":null,"abstract":"<div><p>Dentate gyrus of the hippocampus continuously gives rise to new neurons, namely, adult-born granule cells, which contribute to conferring plasticity to the mature brain throughout life. Within this neurogenic region, the fate and behavior of neural stem cells (NSCs) and their progeny result from a complex balance and integration of a variety of cell-autonomous and cell-to-cell-interaction signals and underlying pathways. Among these structurally and functionally diverse signals, there are endocannabinoids (eCBs), the main brain retrograde messengers. These pleiotropic bioactive lipids can directly and/or indirectly influence adult hippocampal neurogenesis (AHN) by modulating, both positively and negatively, multiple molecular and cellular processes in the hippocampal niche, depending on the cell type or stage of differentiation. Firstly, eCBs act directly as cell-intrinsic factors, cell-autonomously produced by NSCs following their stimulation. Secondly, in many, if not all, niche-associated cells, including some local neuronal and nonneuronal elements, the eCB system indirectly modulates the neurogenesis, linking neuronal and glial activity to regulating distinct stages of AHN. Herein, we discuss the crosstalk of the eCB system with other neurogenesis-relevant signal pathways and speculate how the hippocampus-dependent neurobehavioral effects elicited by (endo)cannabinergic medications are interpretable in light of the key regulatory role that eCBs play on AHN.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101239"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10256909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sphingolipids and impaired hypoxic stress responses in Huntington disease 亨廷顿病的鞘脂和缺氧应激反应受损

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101224

Johannes Burtscher , Giuseppe Pepe , Niran Maharjan , Nathan Riguet , Alba Di Pardo , Vittorio Maglione , Grégoire P. Millet

{"title":"Sphingolipids and impaired hypoxic stress responses in Huntington disease","authors":"Johannes Burtscher , Giuseppe Pepe , Niran Maharjan , Nathan Riguet , Alba Di Pardo , Vittorio Maglione , Grégoire P. Millet","doi":"10.1016/j.plipres.2023.101224","DOIUrl":"10.1016/j.plipres.2023.101224","url":null,"abstract":"<div><p>Huntington disease (HD) is a debilitating, currently incurable disease. Protein aggregation and metabolic deficits are pathological hallmarks but their link to neurodegeneration and symptoms remains debated.</p><p>Here, we summarize alterations in the levels of different sphingolipids in an attempt to characterize sphingolipid patterns specific to HD, an additional molecular hallmark of the disease. Based on the crucial role of sphingolipids in maintaining cellular homeostasis, the dynamic regulation of sphingolipids upon insults and their involvement in cellular stress responses, we hypothesize that maladaptations or blunted adaptations, especially following cellular stress due to reduced oxygen supply (hypoxia) contribute to the development of pathology in HD. We review how sphingolipids shape cellular energy metabolism and control proteostasis and suggest how these functions may fail in HD and in combination with additional insults. Finally, we evaluate the potential of improving cellular resilience in HD by conditioning approaches (improving the efficiency of cellular stress responses) and the role of sphingolipids therein.</p><p>Sphingolipid metabolism is crucial for cellular homeostasis and for adaptations following cellular stress, including hypoxia. Inadequate cellular management of hypoxic stress likely contributes to HD progression, and sphingolipids are potential mediators. Targeting sphingolipids and the hypoxic stress response are novel treatment strategies for HD.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"90 ","pages":"Article 101224"},"PeriodicalIF":13.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9632526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Niemann-Pick type diseases – A synopsis of inborn errors in sphingolipid and cholesterol metabolism 尼曼-匹克型疾病-鞘脂和胆固醇代谢先天性错误的概述

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101225

Frank W. Pfrieger

{"title":"The Niemann-Pick type diseases – A synopsis of inborn errors in sphingolipid and cholesterol metabolism","authors":"Frank W. Pfrieger","doi":"10.1016/j.plipres.2023.101225","DOIUrl":"10.1016/j.plipres.2023.101225","url":null,"abstract":"<div><p>Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the underlying mechanisms and the development of efficient therapies represent formidable challenges for biomedical research. Exemplary cases are two rare, autosomal recessive, and ultimately fatal lysosomal diseases historically named \"Niemann-Pick\" honoring the physicians, whose pioneering observations led to their discovery. Acid sphingomyelinase deficiency (ASMD) and Niemann-Pick type C disease (NPCD) are caused by specific variants of the <em>sphingomyelin phosphodiesterase 1</em> (<em>SMPD1</em>) and <em>NPC intracellular cholesterol transporter 1</em> (<em>NPC1</em>) or <em>NPC intracellular cholesterol transporter 2</em> (<em>NPC2</em>) genes that perturb homeostasis of two key membrane components, sphingomyelin and cholesterol, respectively. Patients with severe forms of these diseases present visceral and neurologic symptoms and succumb to premature death. This synopsis traces the tortuous discovery of the Niemann-Pick diseases, highlights important advances with respect to genetic culprits and cellular mechanisms, and exposes efforts to improve diagnosis and to explore new therapeutic approaches.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"90 ","pages":"Article 101225"},"PeriodicalIF":13.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9683084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Systematic review of brain and blood lipidomics in Alzheimer's disease mouse models 阿尔茨海默病小鼠模型脑和血脂组学的系统综述

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101223

Laura Ferré-González , Ana Lloret , Consuelo Cháfer-Pericás

{"title":"Systematic review of brain and blood lipidomics in Alzheimer's disease mouse models","authors":"Laura Ferré-González , Ana Lloret , Consuelo Cháfer-Pericás","doi":"10.1016/j.plipres.2023.101223","DOIUrl":"10.1016/j.plipres.2023.101223","url":null,"abstract":"<div><p><span><span>Alzheimer's disease (AD) diagnosis is based on invasive and expensive biomarkers. Regarding AD pathophysiological mechanisms, there is evidence of a link between AD and aberrant lipid homeostasis. Alterations in </span>lipid composition<span> have been observed in blood and brain samples, and transgenic mouse models represent a promising approach. Nevertheless, there is great variability among studies in mice for the determination of different types of </span></span>lipids in targeted and untargeted methods. It could be explained by the different variables (model, age, sex, analytical technique), and experimental conditions used.</p><p><span>The aim of this work is to review the studies on lipid alteration in brain tissue and blood samples from AD mouse models, focusing on different experimental parameters. As result, great disparity has been observed among the reviewed studies. Brain studies showed an increase in gangliosides, </span>sphingomyelins<span><span>, lysophospholipids and monounsaturated fatty acids and a decrease in </span>sulfatides<span><span>. In contrast, blood studies showed an increase in phosphoglycerides, sterols, diacylglycerols, </span>triacylglycerols<span><span> and polyunsaturated fatty acids, and a decrease in </span>phospholipids<span>, lysophospholipids and monounsaturated fatty acids. Thus, lipids are closely related to AD, and a consensus on lipidomics studies could be used as a diagnostic tool and providing insight into the mechanisms involved in AD.</span></span></span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"90 ","pages":"Article 101223"},"PeriodicalIF":13.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9937319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects 脂溶性维生素和植物化学代谢物:生产、胃肠道吸收和健康影响

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101220

Patrick Borel , Olivier Dangles , Rachel E. Kopec

{"title":"Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects","authors":"Patrick Borel , Olivier Dangles , Rachel E. Kopec","doi":"10.1016/j.plipres.2023.101220","DOIUrl":"10.1016/j.plipres.2023.101220","url":null,"abstract":"<div><p>Consumption of diets rich in fruits and vegetables, which provide some fat-soluble vitamins and many phytochemicals<span><span>, is associated with a lower risk of developing certain degenerative diseases. It is well accepted that not only the parent compounds, but also their derivatives formed upon enzymatic or nonenzymatic transformations, can produce protective biological effects. These derivatives can be formed during food storage, processing, or cooking. They can also be formed in the lumen of the </span>upper digestive tract<span><span> during digestion, or via metabolism by microbiota<span> in the colon. This review compiles the known metabolites of fat-soluble vitamins and fat-soluble phytochemicals (FSV and FSP) that have been identified in food and in the human digestive tract, or could potentially be present based on the known reactivity of the parent compounds in normal or pathological conditions, or following surgical interventions of the digestive tract or consumption of xenobiotics known to impair lipid absorption. It also covers the very limited data available on the bioavailability (absorption, </span></span>intestinal mucosa metabolism) and summarizes their effects on health. Notably, despite great interest in identifying bioactive derivatives of FSV and FSP, studying their absorption, and probing their putative health effects, much research remains to be conducted to understand and capitalize on the potential of these molecules to preserve health.</span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"90 ","pages":"Article 101220"},"PeriodicalIF":13.6,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9628146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Monomethyl branched-chain fatty acids: Health effects and biological mechanisms 单甲支链脂肪酸:健康效应和生物学机制

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101226

Paulina Gozdzik , Faidon Magkos , Tomasz Sledzinski , Adriana Mika

引用次数: 5

Corrigendum to “A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis” [Prog Lipid Res. 2023 Jan;89:101197. doi: 10.1016/j.plipres.2022.101197] “高甘油三酯血症的一个新的调控方面:microrna在调节富含甘油三酯的脂蛋白生物合成中的作用”[j] . Prog脂质杂志，2023(1);89:101197。doi: 10.1016 / j.plipres.2022.101197]

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-04-01 DOI: 10.1016/j.plipres.2023.101221

Masoomeh Khalifeh , Raul D. Santos , Reza KazemiOskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar

引用次数: 1

Endoplasmic reticulum stress and lipids in health and diseases 内质网应激和脂质在健康和疾病中的作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101198

Cenk Celik , Stella Yue Ting Lee , Wei Sheng Yap , Guillaume Thibault

{"title":"Endoplasmic reticulum stress and lipids in health and diseases","authors":"Cenk Celik , Stella Yue Ting Lee , Wei Sheng Yap , Guillaume Thibault","doi":"10.1016/j.plipres.2022.101198","DOIUrl":"10.1016/j.plipres.2022.101198","url":null,"abstract":"<div><p>The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many cellular pathways, including protein synthesis, protein quality control, and lipid synthesis. When one or multiple ER roles are dysregulated and saturated, the ER enters a stress state, which, in turn, activates the highly conserved unfolded protein response (UPR). By sensing the accumulation of unfolded proteins or lipid bilayer stress (LBS) at the ER, the UPR triggers pathways to restore ER homeostasis and eventually induces apoptosis if the stress remains unresolved. In recent years, it has emerged that the UPR works intimately with other cellular pathways to maintain lipid homeostasis at the ER, and so does at cellular levels. Lipid distribution, along with lipid anabolism and catabolism, are tightly regulated, in part, by the ER. Dysfunctional and overwhelmed lipid-related pathways, independently or in combination with ER stress, can have reciprocal effects on other cellular functions, contributing to the development of diseases. In this review, we summarize the current understanding of the UPR in response to proteotoxic stress and LBS and the breadth of the functions mitigated by the UPR in different tissues and in the context of diseases.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101198"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10759797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Proteins involved in fat-soluble vitamin and carotenoid transport across the intestinal cells: New insights from the past decade 参与脂溶性维生素和类胡萝卜素在肠细胞运输的蛋白质:过去十年的新见解

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101208

Emmanuelle Reboul

{"title":"Proteins involved in fat-soluble vitamin and carotenoid transport across the intestinal cells: New insights from the past decade","authors":"Emmanuelle Reboul","doi":"10.1016/j.plipres.2022.101208","DOIUrl":"10.1016/j.plipres.2022.101208","url":null,"abstract":"<div><p>It is now well established that vitamins D, E, and K and carotenoids are not absorbed solely through passive diffusion. Broad-specificity membrane transporters such as SR-BI (scavenger receptor class B type I), CD36 (CD36 molecule), NPC1L1 (Niemann Pick C1-like 1) or ABCA1 (ATP-binding cassette A1) are involved in the uptake of these micronutrients from the lumen to the enterocyte cytosol and in their secretion into the bloodstream. Recently, the existence of efflux pathways from the enterocyte back to the lumen or from the bloodstream to the lumen, involving ABCB1 (P-glycoprotein/MDR1) or the ABCG5/ABCG8 complex, has also been evidenced for vitamins D and K. Surprisingly, no membrane proteins have been involved in dietary vitamin A uptake so far. After an overview of the metabolism of fat-soluble vitamins and carotenoids along the gastrointestinal tract (from the mouth to the colon where interactions with microbiota may occur), a focus is placed on the identified and candidate proteins participating in the apical uptake, intracellular transport, basolateral secretion and efflux back to the lumen of fat-soluble vitamins and carotenoids in enterocytes. This review also highlights the mechanisms that remain to be identified to fully unravel the pathways involved in fat-soluble vitamin and carotenoid intestinal absorption.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101208"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10776796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis 高甘油三酯血症的一个新的调控方面:microrna在调节富含甘油三酯的脂蛋白生物合成中的作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-01-01 DOI: 10.1016/j.plipres.2022.101197

Masoumeh Khalifeh , Raul D. Santos , Reza Kazemi Oskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar

{"title":"A novel regulatory facet for hypertriglyceridemia: The role of microRNAs in the regulation of triglyceride-rich lipoprotein biosynthesis","authors":"Masoumeh Khalifeh , Raul D. Santos , Reza Kazemi Oskuee , Ali Badiee , Seyed Hamid Aghaee-Bakhtiari , Amirhossein Sahebkar","doi":"10.1016/j.plipres.2022.101197","DOIUrl":"10.1016/j.plipres.2022.101197","url":null,"abstract":"<div><p>Atherosclerotic cardiovascular disease (ASCVD) is one of the major leading global causes of death. Genetic and epidemiological studies strongly support the causal association between triacylglycerol-rich lipoproteins (TAGRL) and atherogenesis, even in statin-treated patients. Recent genetic evidence has clarified that variants in several key genes implicated in TAGRL metabolism are strongly linked to the increased ASCVD risk. There are several triacylglycerol-lowering agents; however, new therapeutic options are in development, among which are miRNA-based therapeutic approaches. MicroRNAs (miRNAs) are small non-coding RNAs (18–25 nucleotides) that negatively modulate gene expression through translational repression or degradation of target mRNAs, thereby reducing the levels of functional genes. MiRNAs play a crucial role in the development of hypertriglyceridemia as several miRNAs are dysregulated in both synthesis and clearance of TAGRL particles. MiRNA-based therapies in ASCVD have not yet been applied in human trials but are attractive. This review provides a concise overview of current interventions for hypertriglyceridemia and the development of novel miRNA and siRNA-based drugs. We summarize the miRNAs involved in the regulation of key genes in the TAGRLs synthesis pathway, which has gained attention as a novel target for therapeutic applications in CVD.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"89 ","pages":"Article 101197"},"PeriodicalIF":13.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9319585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1