Progress in lipid research最新文献

{"title":"An update of isoprostanoid nomenclature","authors":"Camille Oger ,&nbsp;Tereza Pavlíčková ,&nbsp;Valérie Bultel-Poncé ,&nbsp;Alexandre Guy ,&nbsp;Jean-Marie Galano ,&nbsp;Ullrich Jahn ,&nbsp;Thierry Durand","doi":"10.1016/j.plipres.2024.101301","DOIUrl":"10.1016/j.plipres.2024.101301","url":null,"abstract":"<div><p>Polyunsaturated fatty acids (PUFAs) play numerous roles in living organisms but are also prone to rapid aerobic oxidation, resulting in the production of a wide range of isomeric metabolites called oxylipins. Among these, isoprostanes, discovered in the 1990s, are formed non-enzymatically from ω–3 and ω–6 PUFAs with 16 to 22 carbon atoms. Over nearly 35 years of research, two nomenclature systems for isoprostanes have been proposed and have evolved. However, as research progresses, certain aspects of the current nomenclature remain unclear and require further clarification to ensure precise identification of each metabolite and its corresponding parent PUFA. Therefore, we propose an update to the current nomenclature system, along with practical guidelines for assessing isoprostanoid diversity and identifying their PUFA origins.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"96 ","pages":"Article 101301"},"PeriodicalIF":14.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000341/pdfft?md5=e8fbece4968164131730ac5196e58dd6&pid=1-s2.0-S0163782724000341-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142242692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of dietary n-6/n-3 fatty acid ratio of atherosclerosis risk: A review","authors":"","doi":"10.1016/j.plipres.2024.101289","DOIUrl":"10.1016/j.plipres.2024.101289","url":null,"abstract":"<div><p>Atherosclerosis is a causative factor associated with cardiovascular disease (CVD). Over the past few decades, extensive research has been carried out on the relationship between the n-6/n-3 fatty acid ratio of ingested lipids and the progression of atherosclerosis. However, there are still many uncertainties regarding the precise nature of this relationship, which has led to challenges in providing sound dietary advice to the general public. There is therefore a pressing need to review our current understanding of the relationship between the dietary n-6/n-3 fatty acid ratio and atherosclerosis, and to summarize the underlying factors contributing to the current uncertainties.</p><p>Initially, this article reviews the association between the n-6/n-3 fatty acid ratio and CVDs in different countries. A summary of the current understanding of the molecular mechanisms of n-6/n-3 fatty acid ratio on atherosclerosis is then given, including inflammatory responses, lipid metabolism, low-density lipoprotein cholesterol oxidation, and vascular function. Possible reasons behind the current controversies on the relationship between the n-6/n-3 fatty acid ratio and atherosclerosis are then provided, including the precise molecular structures of the fatty acids, diet-gene interactions, the role of fat-soluble phytochemicals, and the impact of other nutritional factors. An important objective of this article is to highlight areas where further research is needed to clarify the role of n-6/n-3 fatty acid ratio on atherosclerosis.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101289"},"PeriodicalIF":14.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 world map: 2024 update","authors":"Jan Philipp Schuchardt ,&nbsp;Philine Beinhorn ,&nbsp;Xue Feng Hu ,&nbsp;Hing Man Chan ,&nbsp;Kaitlin Roke ,&nbsp;Aldo Bernasconi ,&nbsp;Andreas Hahn ,&nbsp;Aleix Sala-Vila ,&nbsp;Ken D. Stark ,&nbsp;William S. Harris","doi":"10.1016/j.plipres.2024.101286","DOIUrl":"10.1016/j.plipres.2024.101286","url":null,"abstract":"<div><p>In 2016, the first worldwide n3 PUFA status map was published using the Omega-3 Index (O3I) as standard biomarker. The O3I is defined as the percentage of EPA + DHA in red blood cell (RBC) membrane FAs. The purpose of the present study was to update the 2016 map with new data. In order to be included, studies had to report O3I and/or blood EPA + DHA levels in metrics convertible into an estimated O3I, in samples drawn after 1999. To convert the non-RBC-based EPA + DHA metrics into RBC we used newly developed equations. Baseline data from clinical trials and observational studies were acceptable. A literature search identified 328 studies meeting inclusion criteria encompassing 342,864 subjects from 48 countries/regions. Weighted mean country O3I levels were categorized into very low ≤4%, low &gt;4–6%, moderate &gt;6–8%, and desirable &gt;8%. We found that the O3I in most countries was low to very low. Notable differences between the current and 2016 map were 1) USA, Canada, Italy, Turkey, UK, Ireland and Greece (moving from the very low to low category); 2) France, Spain and New Zealand (low to moderate); and 3) Finland and Iceland (moderate to desirable). Countries such as Iran, Egypt, and India exhibited particularly poor O3I levels.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101286"},"PeriodicalIF":14.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000195/pdfft?md5=6eb90aec0819836d74000ea0a4a726fe&pid=1-s2.0-S0163782724000195-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunology of bile acids regulated receptors","authors":"Stefano Fiorucci ,&nbsp;Silvia Marchianò ,&nbsp;Ginevra Urbani ,&nbsp;Cristina Di Giorgio ,&nbsp;Eleonora Distrutti ,&nbsp;Angela Zampella ,&nbsp;Michele Biagioli","doi":"10.1016/j.plipres.2024.101291","DOIUrl":"10.1016/j.plipres.2024.101291","url":null,"abstract":"<div><p>Bile acids are steroids formed at the interface of host metabolism and intestinal microbiota. While primary bile acids are generated in the liver from cholesterol metabolism, secondary bile acids represent the products of microbial enzymes. Close to 100 different enzymatic modifications of bile acids structures occur in the human intestine and clinically guided metagenomic and metabolomic analyses have led to the identification of an extraordinary number of novel metabolites. These chemical mediators make an essential contribution to the composition and function of the postbiota, participating to the bidirectional communications of the intestinal microbiota with the host and contributing to the architecture of intestinal-liver and -brain and -endocrine axes. Bile acids exert their function by binding to a group of cell membrane and nuclear receptors collectively known as bile acid-regulated receptors (BARRs), expressed in monocytes, tissue-resident macrophages, CD4+ T effector cells, including Th17, T regulatory cells, dendritic cells and type 3 of intestinal lymphoid cells and NKT cells, highlighting their role in immune regulation. In this review we report on how bile acids and their metabolitesmodulate the immune system in inflammations and cancers and could be exploiting for developing novel therapeutic approaches in these disorders.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101291"},"PeriodicalIF":14.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant terpenoid biosynthetic network and its multiple layers of regulation","authors":"Matthew E. Bergman ,&nbsp;Ruy W.J. Kortbeek ,&nbsp;Michael Gutensohn ,&nbsp;Natalia Dudareva","doi":"10.1016/j.plipres.2024.101287","DOIUrl":"10.1016/j.plipres.2024.101287","url":null,"abstract":"<div><p>Terpenoids constitute one of the largest and most chemically diverse classes of primary and secondary metabolites in nature with an exceptional breadth of functional roles in plants. Biosynthesis of all terpenoids begins with the universal five‑carbon building blocks, isopentenyl diphosphate (IPP) and its allylic isomer dimethylallyl diphosphate (DMAPP), which in plants are derived from two compartmentally separated but metabolically crosstalking routes, the mevalonic acid (MVA) and methylerythritol phosphate (MEP) pathways. Here, we review the current knowledge on the terpenoid precursor pathways and highlight the critical hidden constraints as well as multiple regulatory mechanisms that coordinate and homeostatically govern carbon flux through the terpenoid biosynthetic network in plants.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101287"},"PeriodicalIF":14.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxylipin profiling for clinical research: Current status and future perspectives","authors":"Karol Parchem ,&nbsp;Sophia Letsiou ,&nbsp;Toni Petan ,&nbsp;Olga Oskolkova ,&nbsp;Isabel Medina ,&nbsp;Ondrej Kuda ,&nbsp;Valerie B. O'Donnell ,&nbsp;Anna Nicolaou ,&nbsp;Maria Fedorova ,&nbsp;Valery Bochkov ,&nbsp;Cécile Gladine","doi":"10.1016/j.plipres.2024.101276","DOIUrl":"10.1016/j.plipres.2024.101276","url":null,"abstract":"<div><p>Oxylipins are potent lipid mediators with increasing interest in clinical research. They are usually measured in systemic circulation and can provide a wealth of information regarding key biological processes such as inflammation, vascular tone, or blood coagulation. Although procedures still require harmonization to generate comparable oxylipin datasets, performing comprehensive profiling of circulating oxylipins in large studies is feasible and no longer restricted by technical barriers. However, it is essential to improve and facilitate the biological interpretation of complex oxylipin profiles to truly leverage their potential in clinical research. This requires regular updating of our knowledge about the metabolism and the mode of action of oxylipins, and consideration of all factors that may influence circulating oxylipin profiles independently of the studied disease or condition. This review aims to provide the readers with updated and necessary information regarding oxylipin metabolism, their different forms in systemic circulation, the current limitations in deducing oxylipin cellular effects from in vitro bioactivity studies, the biological and technical confounding factors needed to consider for a proper interpretation of oxylipin profiles.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101276"},"PeriodicalIF":13.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000092/pdfft?md5=619145ecf36daed6b2120ba73986df02&pid=1-s2.0-S0163782724000092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging altered lipid metabolism in treating B cell malignancies","authors":"Jaewoong Lee ,&nbsp;Arya Mani ,&nbsp;Min-Jeong Shin ,&nbsp;Ronald M. Krauss","doi":"10.1016/j.plipres.2024.101288","DOIUrl":"10.1016/j.plipres.2024.101288","url":null,"abstract":"<div><p>B cell malignancies, comprising over 80 heterogeneous blood cancers, pose significant prognostic challenges due to intricate oncogenic signaling. Emerging evidence emphasizes the pivotal role of disrupted lipid metabolism in the development of these malignancies. Variations in lipid species, such as phospholipids, cholesterol, sphingolipids, and fatty acids, are widespread across B cell malignancies, contributing to uncontrolled cell proliferation and survival.</p><p>Phospholipids play a crucial role in initial signaling cascades leading to B cell activation and malignant transformation through constitutive B cell receptor (BCR) signaling. Dysregulated cholesterol and sphingolipid homeostasis support lipid raft integrity, crucial for propagating oncogenic signals. Sphingolipids impact malignant B cell stemness, proliferation, and survival, while glycosphingolipids in lipid rafts modulate BCR activation. Additionally, cancer cells enhance fatty acid-related processes to meet heightened metabolic demands. In obese individuals, the obesity-derived lipids and adipokines surrounding adipocytes rewire lipid metabolism in malignant B cells, evading cytotoxic therapies. Genetic drivers such as MYC translocations also intrinsically alter lipid metabolism in malignant B cells.</p><p>In summary, intrinsic and extrinsic factors converge to reprogram lipid metabolism, fostering aggressive phenotypes in B cell malignancies. Therefore, targeting altered lipid metabolism has translational potential for improving risk stratification and clinical management of diverse B cell malignancy subtypes.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101288"},"PeriodicalIF":14.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000213/pdfft?md5=03464b63a3a9a1b370e073b24162c6bc&pid=1-s2.0-S0163782724000213-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid oxidation in emulsions: New insights from the past two decades","authors":"Marie Hennebelle ,&nbsp;Pierre Villeneuve ,&nbsp;Erwann Durand ,&nbsp;Jérôme Lecomte ,&nbsp;John van Duynhoven ,&nbsp;Anne Meynier ,&nbsp;Betül Yesiltas ,&nbsp;Charlotte Jacobsen ,&nbsp;Claire Berton-Carabin","doi":"10.1016/j.plipres.2024.101275","DOIUrl":"10.1016/j.plipres.2024.101275","url":null,"abstract":"<div><p>Lipid oxidation constitutes the main source of degradation of lipid-rich foods, including food emulsions. The complexity of the reactions at play combined with the increased demand from consumers for less processed and more natural foods result in additional challenges in controlling this phenomenon. This review provides an overview of the insights acquired over the past two decades on the understanding of lipid oxidation in oil-in-water (O/W) emulsions. After introducing the general structure of O/W emulsions and the classical mechanisms of lipid oxidation, the contribution of less studied oxidation products and the spatiotemporal resolution of these reactions will be discussed. We then highlight the impact of emulsion formulation on the mechanisms, taking into consideration the new trends in terms of emulsifiers as well as their own sensitivity to oxidation. Finally, novel antioxidant strategies that have emerged to meet the recent consumer's demand will be detailed. In an era defined by the pursuit of healthier, more natural, and sustainable food choices, a comprehensive understanding of lipid oxidation in emulsions is not only an academic quest, but also a crucial step towards meeting the evolving expectations of consumers and ensuring the quality and stability of lipid-rich food products.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"94 ","pages":"Article 101275"},"PeriodicalIF":13.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000080/pdfft?md5=f0d83c88b76139b37ef6d65fc4b4ad2f&pid=1-s2.0-S0163782724000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial phospholipid transport: Role of contact sites and lipid transport proteins","authors":"Vijay Aditya Mavuduru ,&nbsp;Lavanya Vadupu ,&nbsp;Krishna Kanta Ghosh ,&nbsp;Sabyasachi Chakrabortty ,&nbsp;Balázs Gulyás ,&nbsp;Parasuraman Padmanabhan ,&nbsp;Writoban Basu Ball","doi":"10.1016/j.plipres.2024.101268","DOIUrl":"10.1016/j.plipres.2024.101268","url":null,"abstract":"<div><p><span>One of the major constituents of mitochondrial membranes<span> is the phospholipids, which play a key role in maintaining the structure and the functions of the mitochondria. However, mitochondria do not synthesize most of the phospholipids </span></span><em>in situ</em><span><span><span>, necessitating the presence of phospholipid import pathways. Even for the phospholipids, which are synthesized within the inner mitochondrial membrane (IMM), the phospholipid precursors must be imported from outside the mitochondria. Therefore, the mitochondria heavily rely on the phospholipid transport pathways for its proper functioning. Since, mitochondria are not part of a vesicular trafficking network, the molecular mechanisms of how mitochondria receive its phospholipids remain a relevant question. One of the major ways that hydrophobic phospholipids can cross the aqueous barrier of inter or intraorganellar spaces is by apposing membranes, thereby decreasing the distance of transport, or by being sequestered by </span>lipid transport proteins (LTPs). Therefore, with the discovery of LTPs and membrane contact sites (MCSs), we are beginning to understand the molecular mechanisms of phospholipid transport pathways in the mitochondria. In this review, we will present a brief overview of the recent findings on the molecular architecture and the importance of the MCSs, both the intraorganellar and interorganellar contact sites, in facilitating the mitochondrial phospholipid transport. In addition, we will also discuss the role of LTPs for trafficking phospholipids through the </span>intermembrane space<span> (IMS) of the mitochondria. Mechanistic insights into different phospholipid transport pathways of mitochondria could be exploited to vary the composition of membrane phospholipids and gain a better understanding of their precise role in membrane homeostasis<span> and mitochondrial bioenergetics.</span></span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"94 ","pages":"Article 101268"},"PeriodicalIF":13.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139112232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of DHA on cognitive dysfunction in aging and Alzheimer's disease: The mediating roles of ApoE","authors":"Xin Zhang ,&nbsp;Tian Yuan ,&nbsp;Xuhui Chen ,&nbsp;Xuebo Liu ,&nbsp;Jun Hu ,&nbsp;Zhigang Liu","doi":"10.1016/j.plipres.2023.101256","DOIUrl":"10.1016/j.plipres.2023.101256","url":null,"abstract":"<div><p>The prevalence of Alzheimer's disease (AD) continues to rise due to the increasing aging population. Among the various genetic factors associated with AD, apolipoprotein E (ApoE), a lipid transporter, stands out as the primary genetic risk factor. Specifically, individuals carrying the ApoE4 allele exhibit a significantly higher risk. However, emerging research indicates that dietary factors play a prominent role in modifying the risk of AD. Docosahexaenoic acid (DHA), a prominent ω-3 fatty acid, has garnered considerable attention for its potential to ameliorate cognitive function. The intricate interplay between DHA and the ApoE genotype within the brain, which may influence DHA's utilization and functionality, warrants further investigation. This review meticulously examines experimental and clinical studies exploring the effects of DHA on cognitive decline. Special emphasis is placed on elucidating the role of ApoE gene polymorphism and the underlying mechanisms are discussed. These studies suggest that early DHA supplementation may confer benefits to cognitively normal older adults carrying the ApoE4 gene. However, once AD develops, ApoE4 non-carriers may experience greater benefits compared to ApoE4 carriers, although the overall effectiveness of DHA supplementation at this stage is limited. Potential mechanisms underlying these differential effects may include accelerated DHA catabolism in ApoE4 carriers, impaired transport across the blood-brain barrier (BBB), and compromised lipidation and circulatory function in ApoE4 carriers. Thus, the supplementation of DHA may represent a potential intervention strategy aimed at compensating for these deficiencies in ApoE4 carriers prior to the onset of AD.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101256"},"PeriodicalIF":13.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61564921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}