Progress in lipid research最新文献_第4页

FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer FADS2在主要癌症热点11q13位点的功能改变了癌症中的脂肪酸代谢

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-08-18 DOI: 10.1016/j.plipres.2023.101242

Kumar S.D. Kothapalli , Hui Gyu Park , Niharika S.L. Kothapalli , J. Thomas Brenna

{"title":"FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer","authors":"Kumar S.D. Kothapalli , Hui Gyu Park , Niharika S.L. Kothapalli , J. Thomas Brenna","doi":"10.1016/j.plipres.2023.101242","DOIUrl":"10.1016/j.plipres.2023.101242","url":null,"abstract":"<div>Dysregulation of fatty acid metabolism and de novo lipogenesis is a key driver of several cancer types through highly unsaturated fatty acid (HUFA) signaling precursors such as arachidonic acid. The human chromosome 11q13 locus has long been established as the most frequently amplified in a variety of human cancers. The fatty acid desaturase genes (FADS1, FADS2 and FADS3) responsible for HUFA biosynthesis localize to the 11q12-13.1 region. FADS2 activity is promiscuous, catalyzing biosynthesis of several unsaturated fatty acids by Δ6, Δ8, and Δ4 desaturation. Our main aim here is to review known and putative consequences of FADS2 dysregulation due to effects on the 11q13 locus potentially driving various cancer types. FADS2 silencing causes synthesis of sciadonic acid (5Z,11Z,14Z-20:3) in MCF7 cells and breast cancer in vivo. 5Z,11Z,14Z-20:3 is structurally identical to arachidonic acid (5Z,8Z,11Z,14Z–20:4) except it lacks the internal Δ8 double bond required for prostaglandin and leukotriene synthesis, among other eicosanoids. Palmitic acid has substrate specificity for both SCD and FADS2. Melanoma, prostate, liver and lung cancer cells insensitive to SCD inhibition show increased FADS2 activity and sapienic acid biosynthesis. Elevated serum mead acid levels found in hepatocellular carcinoma patients suggest an unsatisfied demand for arachidonic acid. FADS2 circular RNAs are at high levels in colorectal and lung cancer tissues. FADS2 circular RNAs are associated with shorter overall survival in colorectal cancer patients. The evidence thusfar supports an effort for future research on the role of FADS2 as a tumor suppressor in a range of neoplastic disorders.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101242"},"PeriodicalIF":13.6,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10068709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles 哺乳动物脂滴:结构、病理、免疫和抗毒理学作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101233

Nour Hammoudeh , Chadi Soukkarieh , Denis J. Murphy , Abdulsamie Hanano

{"title":"Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles","authors":"Nour Hammoudeh , Chadi Soukkarieh , Denis J. Murphy , Abdulsamie Hanano","doi":"10.1016/j.plipres.2023.101233","DOIUrl":"10.1016/j.plipres.2023.101233","url":null,"abstract":"<div>Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific population of proteins that varies according to the location and function of each LD. Over the past decade, there have been significant advances in the understanding of LD biogenesis and functions. LDs are now recognized as dynamic organelles that participate in many aspects of cellular homeostasis plus other vital functions. LD biogenesis is a complex, highly-regulated process with assembly occurring on the endoplasmic reticulum although aspects of the underpinning molecular mechanisms remain elusive. For example, it is unclear how many enzymes participate in the biosynthesis of the neutral lipid components of LDs and how this process is coordinated in response to different metabolic cues to promote or suppress LD formation and turnover. In addition to enzymes involved in the biosynthesis of neutral lipids, various scaffolding proteins play roles in coordinating LD formation. Despite their lack of ultrastructural diversity, LDs in different mammalian cell types are involved in a wide range of biological functions. These include roles in membrane homeostasis, regulation of hypoxia, neoplastic inflammatory responses, cellular oxidative status, lipid peroxidation, and protection against potentially toxic intracellular fatty acids and lipophilic xenobiotics. Herein, the roles of mammalian LDs and their associated proteins are reviewed with a particular focus on their roles in pathological, immunological and anti-toxicological processes.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101233"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10605667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Archaeal lipids 古代脂质。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101237

Tomáš Řezanka , Lucie Kyselová , Denis J. Murphy

{"title":"Archaeal lipids","authors":"Tomáš Řezanka , Lucie Kyselová , Denis J. Murphy","doi":"10.1016/j.plipres.2023.101237","DOIUrl":"10.1016/j.plipres.2023.101237","url":null,"abstract":"<div>The major archaeal membrane glycerolipids are distinguished from those of bacteria and eukaryotes by the contrasting stereochemistry of their glycerol backbones, and by the use of ether-linked isoprenoid-based alkyl chains rather than ester-linked fatty acyl chains for their hydrophobic moieties. These fascinating compounds play important roles in the extremophile lifestyles of many species, but are also present in the growing numbers of recently discovered mesophilic archaea. The past decade has witnessed significant advances in our understanding of archaea in general and their lipids in particular. Much of the new information has come from the ability to screen large microbial populations via environmental metagenomics, which has revolutionised our understanding of the extent of archaeal biodiversity that is coupled with a strict conservation of their membrane lipid compositions. Significant additional progress has come from new culturing and analytical techniques that are gradually enabling archaeal physiology and biochemistry to be studied in real time. These studies are beginning to shed light on the much-discussed and still-controversial process of eukaryogenesis, which probably involved both bacterial and archaeal progenitors. Puzzlingly, although eukaryotes retain many attributes of their putative archaeal ancestors, their lipid compositions only reflect their bacterial progenitors. Finally, elucidation of archaeal lipids and their metabolic pathways have revealed potentially interesting applications that have opened up new frontiers for biotechnological exploitation of these organisms. This review is concerned with the analysis, structure, function, evolution and biotechnology of archaeal lipids and their associated metabolic pathways.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101237"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The pathophysiological role of dihydroceramide desaturase in the nervous system 二氢神经酰胺去饱和酶在神经系统中的病理生理作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101236

Fei-Yang Tzou , Thorsten Hornemann , Jui-Yu Yeh , Shu-Yi Huang

{"title":"The pathophysiological role of dihydroceramide desaturase in the nervous system","authors":"Fei-Yang Tzou , Thorsten Hornemann , Jui-Yu Yeh , Shu-Yi Huang","doi":"10.1016/j.plipres.2023.101236","DOIUrl":"10.1016/j.plipres.2023.101236","url":null,"abstract":"<div>Dihydroceramide desaturase 1 (DEGS1) converts dihydroceramide (dhCer) to ceramide (Cer) by inserting a C4-C5 trans (∆4E) double bond into the sphingoid backbone. Low DEGS activity causes accumulation of dhCer and other dihydrosphingolipid species. Although dhCer and Cer are structurally very similar, their imbalances can have major consequences both in vitro and in vivo. Mutations in the human DEGS1 gene are known to cause severe neurological defects, such as hypomyelinating leukodystrophy. Likewise, inhibition of DEGS1 activity in fly and zebrafish models causes dhCer accumulation and subsequent neuronal dysfunction, suggesting that DEGS1 activity plays a conserved and critical role in the nervous system. Dihydrosphingolipids and their desaturated counterparts are known to control various essential processes, including autophagy, exosome biogenesis, ER stress, cell proliferation, and cell death. Furthermore, model membranes with either dihydrosphingolipids or sphingolipids exhibit different biophysical properties, including membrane permeability and packing, thermal stability, and lipid diffusion. However, the links between molecular properties, in vivo functional data, and clinical manifestations that underlie impaired DEGS1 function remain largely unresolved. In this review, we summarize the known biological and pathophysiological roles of dhCer and its derivative dihydrosphingolipid species in the nervous system, and we highlight several possible disease mechanisms that warrant further investigation.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101236"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10605673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases 鞘糖脂在肿瘤诊断和治疗中的病理生理作用和应用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101241

Xuefeng Jin , Guang-Yu Yang

{"title":"Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases","authors":"Xuefeng Jin , Guang-Yu Yang","doi":"10.1016/j.plipres.2023.101241","DOIUrl":"10.1016/j.plipres.2023.101241","url":null,"abstract":"<div>Glycosphingolipids (GSLs) are major amphiphilic glycolipids present on the surface of living cell membranes. They have important biological functions, including maintaining plasma membrane stability, regulating signal transduction, and mediating cell recognition and adhesion. Specific GSLs and related enzymes are abnormally expressed in many cancer diseases and affect the malignant characteristics of tumors. The regulatory roles of GSLs in signaling pathways suggest that they are involved in tumor pathogenesis. GSLs have therefore been widely studied as diagnostic markers of cancer diseases and important targets of immunotherapy. This review describes the tumor-related biological functions of GSLs and systematically introduces recent progress in using diverse GSLs and related enzymes to diagnose and treat tumor diseases. Development of drugs and biomarkers for personalized cancer therapy based on GSL structure is also discussed. These advances, combined with recent progress in the preparation of GSLs derivatives through synthetic biology technologies, suggest a strong future for the use of customized GSL libraries in treating human diseases.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101241"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10250739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lipidomics in pathogenesis, progression and treatment of nonalcoholic steatohepatitis (NASH): Recent advances 非酒精性脂肪性肝炎(NASH)的发病、进展和治疗中的脂质组学研究进展

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101238

Giovanni Musso , Francesca Saba , Maurizio Cassader , Roberto Gambino

{"title":"Lipidomics in pathogenesis, progression and treatment of nonalcoholic steatohepatitis (NASH): Recent advances","authors":"Giovanni Musso , Francesca Saba , Maurizio Cassader , Roberto Gambino","doi":"10.1016/j.plipres.2023.101238","DOIUrl":"10.1016/j.plipres.2023.101238","url":null,"abstract":"<div>Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting up to 30% of the general adult population. NAFLD encompasses a histological spectrum ranging from pure steatosis to non-alcoholic steatohepatitis (NASH). NASH can progress to cirrhosis and is becoming the most common indication for liver transplantation, as a result of increasing disease prevalence and of the absence of approved treatments. Lipidomic readouts of liver blood and urine samples from experimental models and from NASH patients disclosed an abnormal lipid composition and metabolism. Collectively, these changes impair organelle function and promote cell damage, necro-inflammation and fibrosis, a condition termed lipotoxicity. We will discuss the lipid species and metabolic pathways leading to NASH development and progression to cirrhosis, as well as and those species that can contribute to inflammation resolution and fibrosis regression. We will also focus on emerging lipid-based therapeutic opportunities, including specialized proresolving lipid molecules and macrovesicles contributing to cell-to-cell communication and NASH pathophysiology.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101238"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Systematic crosstalk in plasmalogen and diacyl lipid biosynthesis for their differential yet concerted molecular functions in the cell 在细胞中不同而一致的分子功能中，磷脂原和二酰基脂质生物合成的系统串扰

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101234

Tomohiro Kimura , Atsuko K. Kimura , Richard M. Epand

{"title":"Systematic crosstalk in plasmalogen and diacyl lipid biosynthesis for their differential yet concerted molecular functions in the cell","authors":"Tomohiro Kimura , Atsuko K. Kimura , Richard M. Epand","doi":"10.1016/j.plipres.2023.101234","DOIUrl":"10.1016/j.plipres.2023.101234","url":null,"abstract":"<div>Plasmalogen is a major phospholipid of mammalian cell membranes. Recently it is becoming evident that the sn-1 vinyl-ether linkage in plasmalogen, contrasting to the ester linkage in the counterpart diacyl glycerophospholipid, yields differential molecular characteristics for these lipids especially related to hydrocarbon-chain order, so as to concertedly regulate biological membrane processes. A role played by NMR in gaining information in this respect, ranging from molecular to tissue levels, draws particular attention. We note here that a broad range of enzymes in de novo synthesis pathway of plasmalogen commonly constitute that of diacyl glycerophospholipid. This fact forms the basis for systematic crosstalk that not only controls a quantitative balance between these lipids, but also senses a defect causing loss of lipid in either pathway for compensation by increase of the counterpart lipid. However, this inherent counterbalancing mechanism paradoxically amplifies imbalance in differential effects of these lipids in a diseased state on membrane processes. While sharing of enzymes has been recognized, it is now possible to overview the crosstalk with growing information for specific enzymes involved. The overview provides a fundamental clue to consider cell and tissue type-dependent schemes in regulating membrane processes by plasmalogen and diacyl glycerophospholipid in health and disease.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101234"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10249841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the new adipokine asprosin be a metabolic troublemaker for cardiovascular diseases? A state-of-the-art review 新的脂肪因子asprosin会成为心血管疾病的代谢麻烦制造者吗?最先进的评论

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101240

Zhengbin Zhang , Liwen Zhu , Ziqian Wang , Ning Hua , Shunying Hu , Yundai Chen

引用次数: 0

Lipid metabolism around the body clocks 围绕生物钟的脂质代谢

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101235

Volodymyr Petrenko , Flore Sinturel , Howard Riezman , Charna Dibner

{"title":"Lipid metabolism around the body clocks","authors":"Volodymyr Petrenko , Flore Sinturel , Howard Riezman , Charna Dibner","doi":"10.1016/j.plipres.2023.101235","DOIUrl":"10.1016/j.plipres.2023.101235","url":null,"abstract":"<div>Lipids play important roles in energy metabolism along with diverse aspects of biological membrane structure, signaling and other functions. Perturbations of lipid metabolism are responsible for the development of various pathologies comprising metabolic syndrome, obesity, and type 2 diabetes. Accumulating evidence suggests that circadian oscillators, operative in most cells of our body, coordinate temporal aspects of lipid homeostasis. In this review we summarize current knowledge on the circadian regulation of lipid digestion, absorption, transportation, biosynthesis, catabolism, and storage. Specifically, we focus on the molecular interactions between functional clockwork and biosynthetic pathways of major lipid classes comprising cholesterol, fatty acids, triacylglycerols, glycerophospholipids, glycosphingolipids, and sphingomyelins. A growing body of epidemiological studies associate a socially imposed circadian misalignment common in modern society with growing incidence of metabolic disorders, however the disruption of lipid metabolism rhythms in this connection has only been recently revealed. Here, we highlight recent studies that unravel the mechanistic link between intracellular molecular clocks, lipid homeostasis and development of metabolic diseases based on animal models of clock disruption and on innovative translational studies in humans. We also discuss the perspectives of manipulating circadian oscillators as a potentially powerful approach for preventing and managing metabolic disorders in human patients.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101235"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10623385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The imperative of arachidonic acid in early human development 花生四烯酸在人类早期发育中的重要性

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101222

Michael A. Crawford , Andrew J. Sinclair , Barbara Hall , Enitan Ogundipe , Yiqun Wang , Dimitrios Bitsanis , Ovrang B. Djahanbakhch , Laurence Harbige , Kebreab Ghebremeskel , Ivan Golfetto , Therishnee Moodley , Ahmed Hassam , AnnieBelle Sassine , Mark R. Johnson

{"title":"The imperative of arachidonic acid in early human development","authors":"Michael A. Crawford , Andrew J. Sinclair , Barbara Hall , Enitan Ogundipe , Yiqun Wang , Dimitrios Bitsanis , Ovrang B. Djahanbakhch , Laurence Harbige , Kebreab Ghebremeskel , Ivan Golfetto , Therishnee Moodley , Ahmed Hassam , AnnieBelle Sassine , Mark R. Johnson","doi":"10.1016/j.plipres.2023.101222","DOIUrl":"10.1016/j.plipres.2023.101222","url":null,"abstract":"<div>This review is about the role of arachidonic acid (ArA) in foetal and early growth and development. In 1975 and ‘76, we reported the preferential incorporation of ArA into the developing brain of rat pups, its conservation as a principal component in the brains of 32 mammalian species and the high proportion delivered by the human placenta for foetal nutrition, compared to its parent linoleic acid (LA). ArA is quantitatively the principal acyl component of membrane lipids from foetal red cells, mononuclear cells, astrocytes, endothelium, and placenta. Functionally, we present evidence that ArA, but not DHA, relaxes the foetal mesenteric arteries. The placenta biomagnifies ArA, doubling the proportion of the maternal level in cord blood. The proportions of ArA and its allies (di-homo-gamma-linolenic acid (DGLA), adrenic acid and ω6 docosapentaenoic acid) are similar or higher than the total of ω3 fatty acids in human milk, maintaining the abundant supply to the developing infant. Despite the evidence of the importance of ArA, the European Food Standard Agency, in 2014 rejected the joint FAO and WHO recommendation on the inclusion of ArA in infant formula, although they recommended DHA. The almost universal dominance of ArA in the membrane phosphoglycerides during human organogenesis and prenatal growth suggests that the importance of ArA and its allies in reproductive biology needs to be re-evaluated urgently.</div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101222"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10260260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3