Progress in lipid research最新文献_第4页

Advances in research on microbial conjugated linoleic acid bioconversion 微生物共轭亚油酸生物转化研究进展。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-10-26 DOI: 10.1016/j.plipres.2023.101257

Chen Wu , Haiqin Chen , Yongchao Mei , Bo Yang , Jianxin Zhao , Catherine Stanton , Wei Chen

{"title":"Advances in research on microbial conjugated linoleic acid bioconversion","authors":"Chen Wu , Haiqin Chen , Yongchao Mei , Bo Yang , Jianxin Zhao , Catherine Stanton , Wei Chen","doi":"10.1016/j.plipres.2023.101257","DOIUrl":"10.1016/j.plipres.2023.101257","url":null,"abstract":"<div><p>Conjugated linoleic acid (CLA) is a functional food ingredient with prebiotic properties that provides health benefits for various human pathologies and disorders. However, limited natural CLA sources in animals and plants have led microorganisms like <em>Lactobacillus</em> and <em>Bifidobacterium</em> to emerge as new CLA sources. Microbial conversion of linoleic acid to CLA is mediated by linoleic acid isomerase and multicomponent enzymatic systems, with CLA production efficiency dependent on microbial species and strains. Additionally, complex factors like LA concentration, growth status, culture substrates, precursor type, prebiotic additives, and co-cultured microbe identity strongly influence CLA production and isomer composition. This review summarizes advances in the past decade regarding microbial CLA production, including bacteria and fungi. We highlight CLA production and potential regulatory mechanisms and discuss using microorganisms to enhance CLA content and nutritional value of fermented products. We also identify primary microbial CLA production bottlenecks and provide strategies to address these challenges and enhance production through functional gene and enzyme mining and downstream processing. This review aims to provide a reference for microbial CLA production and broaden the understanding of the potential probiotic role of microbial CLA producers.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101257"},"PeriodicalIF":13.6,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000474/pdfft?md5=a9e30a4fa83bcdb6a1b3eaa05560cfef&pid=1-s2.0-S0163782723000474-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications Omega-3长链多不饱和脂肪酸：代谢和健康意义

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-10-13 DOI: 10.1016/j.plipres.2023.101255

Imad Khan , Mudassar Hussain , Bangzhi Jiang , Lei Zheng , Yuechao Pan , Jijie Hu , Adil Khan , Azqa Ashraf , Xiaoqiang Zou

{"title":"Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications","authors":"Imad Khan , Mudassar Hussain , Bangzhi Jiang , Lei Zheng , Yuechao Pan , Jijie Hu , Adil Khan , Azqa Ashraf , Xiaoqiang Zou","doi":"10.1016/j.plipres.2023.101255","DOIUrl":"https://doi.org/10.1016/j.plipres.2023.101255","url":null,"abstract":"<div><p><span>Recently, omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have gained substantial interest due to their specific structure and biological functions. Humans cannot naturally produce these fatty acids (FAs), making it crucial to obtain them from our diet. This comprehensive review details n-3 LC-PUFAs and their role in promoting and maintaining optimal health. The article thoroughly analyses several sources of n-3 LC-PUFAs and their respective bioavailability, covering marine, microbial and plant-based sources. Furthermore, we provide an in-depth analysis of the biological impacts of n-3 LC-PUFAs on health conditions, with particular emphasis on cardiovascular disease (CVD), gastrointestinal (GI) cancer, diabetes, depression, arthritis, and cognition. In addition, we highlight the significance of fortification and supplementation of n-3 LC-PUFAs in both functional foods and dietary supplements. Additionally, we conducted a detailed analysis of the several kinds of n-3 LC-PUFAs supplements currently available in the market, including an assessment of their recommended intake, safety, and effectiveness. The </span>dietary guidelines associated with n-3 LC-PUFAs are also highlighted, focusing on the significance of maintaining a well-balanced intake of n-3 PUFAs to enhance health benefits. Lastly, we highlight future directions for further research in this area and their potential implications for public health.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101255"},"PeriodicalIF":13.6,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49814516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How fish consumption prevents the development of Major Depressive Disorder? A comprehensive review of the interplay between n-3 PUFAs, LTP and BDNF 鱼类消费如何预防严重抑郁症的发展？n-3 PUFA、LTP和BDNF之间相互作用的全面综述。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-10-09 DOI: 10.1016/j.plipres.2023.101254

Łukasz Kołodziej , Piotr Lech Czarny , Sylwia Ziółkowska , Katarzyna Białek , Janusz Szemraj , Piotr Gałecki , Kuan-Pin Su , Tomasz Śliwiński

{"title":"How fish consumption prevents the development of Major Depressive Disorder? A comprehensive review of the interplay between n-3 PUFAs, LTP and BDNF","authors":"Łukasz Kołodziej , Piotr Lech Czarny , Sylwia Ziółkowska , Katarzyna Białek , Janusz Szemraj , Piotr Gałecki , Kuan-Pin Su , Tomasz Śliwiński","doi":"10.1016/j.plipres.2023.101254","DOIUrl":"10.1016/j.plipres.2023.101254","url":null,"abstract":"<div><p>MDD (major depressive disorder) is a highly prevalent mental disorder with a complex etiology involving behavioral and neurochemical factors as well as environmental stress. The interindividual variability in response to stress stimuli may be explained by processes such as long-term potentiation (LTP) and long-term depression (LTD). LTP can be described as the strengthening of synaptic transmission, which translates into more efficient cognitive performance and is regulated by brain-derived neurotrophic factor (BDNF), a protein responsible for promoting neural growth. It is found in high concentrations in the hippocampus, a part of the limbic system which is far less active in people with MDD. Omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) not only contribute to structural and antioxidative functions but are essential for the maintenance of LTP and stable BDNF levels. This review explores the mechanisms and potential roles of omega-3 fatty acids in the prevention of MDD.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101254"},"PeriodicalIF":13.6,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41210683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The skin barrier: An extraordinary interface with an exceptional lipid organization 皮肤屏障：具有特殊脂质组织的特殊界面。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-09-04 DOI: 10.1016/j.plipres.2023.101252

Joke A. Bouwstra , Andreea Nădăban , Wim Bras , Clare McCabe , Annette Bunge , Gerrit S. Gooris

{"title":"The skin barrier: An extraordinary interface with an exceptional lipid organization","authors":"Joke A. Bouwstra , Andreea Nădăban , Wim Bras , Clare McCabe , Annette Bunge , Gerrit S. Gooris","doi":"10.1016/j.plipres.2023.101252","DOIUrl":"10.1016/j.plipres.2023.101252","url":null,"abstract":"<div><p>The barrier function of the skin is primarily located in the stratum corneum (SC), the outermost layer of the skin. The SC is composed of dead cells with highly organized lipid lamellae in the intercellular space. As the lipid matrix forms the only continuous pathway, the lipids play an important role in the permeation of compounds through the SC. The main lipid classes are ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs). Analysis of the SC lipid matrix is of crucial importance in understanding the skin barrier function, not only in healthy skin, but also in inflammatory skin diseases with an impaired skin barrier. In this review we provide i) a historical overview of the steps undertaken to obtain information on the lipid composition and organization in SC of healthy skin and inflammatory skin diseases, ii) information on the role CERs, CHOL and FFAs play in the lipid phase behavior of very complex lipid model systems and how this knowledge can be used to understand the deviation in lipid phase behavior in inflammatory skin diseases, iii) knowledge on the role of both, CER subclasses and chain length distribution, on lipid organization and lipid membrane permeability in complex and simple model systems with synthetic CERs, CHOL and FFAs, iv) similarity in lipid phase behavior in SC of different species and complex model systems, and vi) future directions in modulating lipid composition that is expected to improve the skin barrier in inflammatory skin diseases.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101252"},"PeriodicalIF":13.6,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10153430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The fats of the matter: Lipids in prebiotic chemistry and in origin of life studies 物质的脂肪:益生元化学中的脂质和生命起源的研究

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-09-01 DOI: 10.1016/j.plipres.2023.101253

Tania C.B. Santos, Anthony H. Futerman

{"title":"The fats of the matter: Lipids in prebiotic chemistry and in origin of life studies","authors":"Tania C.B. Santos, Anthony H. Futerman","doi":"10.1016/j.plipres.2023.101253","DOIUrl":"10.1016/j.plipres.2023.101253","url":null,"abstract":"<div><p>The unique biophysical and biochemical properties of lipids render them crucial in most models of the origin of life (OoL). Many studies have attempted to delineate the prebiotic pathways by which lipids were formed, how micelles and vesicles were generated, and how these micelles and vesicles became selectively permeable towards the chemical precursors required to initiate and support biochemistry and inheritance. Our analysis of a number of such studies highlights the extremely narrow and limited range of conditions by which an experiment is considered to have successfully modeled a role for lipids in an OoL experiment. This is in line with a recent proposal that bias is introduced into OoL studies by the extent and the kind of human intervention. It is self-evident that OoL studies can only be performed by human intervention, and we now discuss the possibility that some assumptions and simplifications inherent in such experimental approaches do not permit determination of mechanistic insight into the roles of lipids in the OoL. With these limitations in mind, we suggest that more nuanced experimental approaches than those currently pursued may be required to elucidate the generation and function of lipids, micelles and vesicles in the OoL.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101253"},"PeriodicalIF":13.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10283654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphingosine 1-phosphate signaling during infection and immunity 鞘氨醇1-磷酸在感染和免疫中的信号传导

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-08-24 DOI: 10.1016/j.plipres.2023.101251

Sabira Mohammed , Anu Bindu , Arun Viswanathan , Kuzhuvelil B. Harikumar

引用次数: 1

Triacylglycerol uptake and handling by macrophages: From fatty acids to lipoproteins 巨噬细胞对三酰甘油的摄取和处理:从脂肪酸到脂蛋白

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-08-22 DOI: 10.1016/j.plipres.2023.101250

Lei Deng , Sander Kersten , Rinke Stienstra

{"title":"Triacylglycerol uptake and handling by macrophages: From fatty acids to lipoproteins","authors":"Lei Deng , Sander Kersten , Rinke Stienstra","doi":"10.1016/j.plipres.2023.101250","DOIUrl":"10.1016/j.plipres.2023.101250","url":null,"abstract":"<div><p>Macrophages are essential innate immune cells and form our first line of immune defense. Also known as professional phagocytes, macrophages interact and take up various particles, including lipids. Defective lipid handling can drive excessive lipid accumulation leading to foam cell formation, a key feature of various cardiometabolic conditions such as atherosclerosis, non-alcoholic fatty liver disease, and obesity. At the same time, intracellular lipid storage and foam cell formation can also be viewed as a protective and anti-lipotoxic mechanism against a lipid-rich environment and associated elevated lipid uptake. Traditionally, foam cell formation has primarily been linked to cholesterol uptake via native and modified low-density lipoproteins. However, other lipids, including non-esterified fatty acids and triacylglycerol (TAG)-rich lipoproteins (very low-density lipoproteins and chylomicrons), can also interact with macrophages. Recent studies have identified multiple pathways mediating TAG uptake and processing by macrophages, including endocytosis and receptor/transporter-mediated internalization and transport. This review will present the current knowledge of how macrophages take up different lipids and lipoprotein particles and address how TAG-rich lipoproteins are processed intracellularly. Understanding how macrophages take up and process different lipid species such as TAG is necessary to design future therapeutic interventions to correct excessive lipid accumulation and associated co-morbidities.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101250"},"PeriodicalIF":13.6,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer FADS2在主要癌症热点11q13位点的功能改变了癌症中的脂肪酸代谢

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-08-18 DOI: 10.1016/j.plipres.2023.101242

Kumar S.D. Kothapalli , Hui Gyu Park , Niharika S.L. Kothapalli , J. Thomas Brenna

{"title":"FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer","authors":"Kumar S.D. Kothapalli , Hui Gyu Park , Niharika S.L. Kothapalli , J. Thomas Brenna","doi":"10.1016/j.plipres.2023.101242","DOIUrl":"10.1016/j.plipres.2023.101242","url":null,"abstract":"<div><p>Dysregulation of fatty acid metabolism and <em>de novo</em><span><span><span><span> lipogenesis is a key driver of several cancer types through highly </span>unsaturated fatty acid<span> (HUFA) signaling precursors such as arachidonic acid. The </span></span>human chromosome<span> 11q13 locus has long been established as the most frequently amplified in a variety of human cancers. The fatty acid desaturase genes (FADS1, FADS2 and FADS3) responsible for HUFA </span></span>biosynthesis<span> localize to the 11q12-13.1 region. FADS2 activity is promiscuous, catalyzing biosynthesis of several unsaturated fatty acids by Δ6, Δ8, and Δ4 desaturation. Our main aim here is to review known and putative consequences of FADS2 dysregulation due to effects on the 11q13 locus potentially driving various cancer types. FADS2 silencing causes synthesis of sciadonic acid (5Z,11Z,14Z-20:3) in MCF7 cells and breast cancer </span></span><em>in vivo</em><span>. 5Z,11Z,14Z-20:3 is structurally identical to arachidonic acid (5Z,8Z,11Z,14Z–20:4) except it lacks the internal Δ8 double bond required for prostaglandin<span><span> and leukotriene synthesis, among other eicosanoids<span><span>. Palmitic acid has </span>substrate specificity for both </span></span>SCD<span><span><span> and FADS2. Melanoma, prostate, liver and lung cancer cells insensitive to SCD inhibition show increased FADS2 activity and sapienic acid biosynthesis. Elevated serum mead acid levels found in hepatocellular carcinoma patients suggest an unsatisfied demand for arachidonic acid. FADS2 </span>circular RNAs are at high levels in colorectal and lung cancer tissues. FADS2 circular RNAs are associated with shorter overall survival in colorectal cancer patients. The evidence thusfar supports an effort for future research on the role of FADS2 as a </span>tumor suppressor in a range of neoplastic disorders.</span></span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"92 ","pages":"Article 101242"},"PeriodicalIF":13.6,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10068709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles 哺乳动物脂滴:结构、病理、免疫和抗毒理学作用

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101233

Nour Hammoudeh , Chadi Soukkarieh , Denis J. Murphy , Abdulsamie Hanano

{"title":"Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles","authors":"Nour Hammoudeh , Chadi Soukkarieh , Denis J. Murphy , Abdulsamie Hanano","doi":"10.1016/j.plipres.2023.101233","DOIUrl":"10.1016/j.plipres.2023.101233","url":null,"abstract":"<div><p><span>Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a </span>neutral lipid<span><span><span> core surrounded by a membrane made up of a phospholipid monolayer and a specific population of proteins that varies according to the location and function of each LD. Over the past decade, there have been significant advances in the understanding of LD biogenesis and functions. LDs are now recognized as dynamic organelles that participate in many aspects of cellular </span>homeostasis<span> plus other vital functions. LD biogenesis is a complex, highly-regulated process with assembly occurring on the endoplasmic reticulum although aspects of the underpinning molecular mechanisms remain elusive. For example, it is unclear how many enzymes<span> participate in the biosynthesis<span> of the neutral lipid components of LDs and how this process is coordinated in response to different metabolic cues to promote or suppress LD formation and turnover. In addition to enzymes involved in the biosynthesis of neutral lipids, various scaffolding proteins play roles in coordinating LD formation. Despite their lack of ultrastructural diversity, LDs in different mammalian cell types are involved in a wide range of biological functions. These include roles in membrane homeostasis, regulation of hypoxia, neoplastic inflammatory responses, cellular oxidative status, </span></span></span></span>lipid peroxidation, and protection against potentially toxic intracellular fatty acids and lipophilic xenobiotics. Herein, the roles of mammalian LDs and their associated proteins are reviewed with a particular focus on their roles in pathological, immunological and anti-toxicological processes.</span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101233"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10605667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Archaeal lipids 古代脂质。

IF 13.6 1区医学

Progress in lipid research Pub Date : 2023-07-01 DOI: 10.1016/j.plipres.2023.101237

Tomáš Řezanka , Lucie Kyselová , Denis J. Murphy

{"title":"Archaeal lipids","authors":"Tomáš Řezanka , Lucie Kyselová , Denis J. Murphy","doi":"10.1016/j.plipres.2023.101237","DOIUrl":"10.1016/j.plipres.2023.101237","url":null,"abstract":"<div><p>The major archaeal membrane glycerolipids are distinguished from those of bacteria and eukaryotes by the contrasting stereochemistry of their glycerol backbones, and by the use of ether-linked isoprenoid-based alkyl chains rather than ester-linked fatty acyl chains for their hydrophobic moieties. These fascinating compounds play important roles in the extremophile<span><span><span> lifestyles of many species, but are also present in the growing numbers of recently discovered mesophilic archaea<span>. The past decade has witnessed significant advances in our understanding of archaea in general and their lipids in particular. Much of the new information has come from the ability to screen large microbial populations via environmental </span></span>metagenomics, which has revolutionised our understanding of the extent of archaeal biodiversity that is coupled with a strict conservation of their membrane </span>lipid compositions<span>. Significant additional progress has come from new culturing and analytical techniques that are gradually enabling archaeal physiology and biochemistry to be studied in real time. These studies are beginning to shed light on the much-discussed and still-controversial process of eukaryogenesis, which probably involved both bacterial and archaeal progenitors. Puzzlingly, although eukaryotes retain many attributes of their putative archaeal ancestors, their lipid compositions only reflect their bacterial progenitors. Finally, elucidation of archaeal lipids and their metabolic pathways have revealed potentially interesting applications that have opened up new frontiers for biotechnological exploitation of these organisms. This review is concerned with the analysis, structure, function, evolution and biotechnology of archaeal lipids and their associated metabolic pathways.</span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"91 ","pages":"Article 101237"},"PeriodicalIF":13.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2