Progress in lipid research最新文献

{"title":"Plant terpenoid biosynthetic network and its multiple layers of regulation","authors":"Matthew E. Bergman ,&nbsp;Ruy W.J. Kortbeek ,&nbsp;Michael Gutensohn ,&nbsp;Natalia Dudareva","doi":"10.1016/j.plipres.2024.101287","DOIUrl":"10.1016/j.plipres.2024.101287","url":null,"abstract":"<div><p>Terpenoids constitute one of the largest and most chemically diverse classes of primary and secondary metabolites in nature with an exceptional breadth of functional roles in plants. Biosynthesis of all terpenoids begins with the universal five‑carbon building blocks, isopentenyl diphosphate (IPP) and its allylic isomer dimethylallyl diphosphate (DMAPP), which in plants are derived from two compartmentally separated but metabolically crosstalking routes, the mevalonic acid (MVA) and methylerythritol phosphate (MEP) pathways. Here, we review the current knowledge on the terpenoid precursor pathways and highlight the critical hidden constraints as well as multiple regulatory mechanisms that coordinate and homeostatically govern carbon flux through the terpenoid biosynthetic network in plants.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101287"},"PeriodicalIF":14.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging altered lipid metabolism in treating B cell malignancies","authors":"Jaewoong Lee ,&nbsp;Arya Mani ,&nbsp;Min-Jeong Shin ,&nbsp;Ronald M. Krauss","doi":"10.1016/j.plipres.2024.101288","DOIUrl":"10.1016/j.plipres.2024.101288","url":null,"abstract":"<div><p>B cell malignancies, comprising over 80 heterogeneous blood cancers, pose significant prognostic challenges due to intricate oncogenic signaling. Emerging evidence emphasizes the pivotal role of disrupted lipid metabolism in the development of these malignancies. Variations in lipid species, such as phospholipids, cholesterol, sphingolipids, and fatty acids, are widespread across B cell malignancies, contributing to uncontrolled cell proliferation and survival.</p><p>Phospholipids play a crucial role in initial signaling cascades leading to B cell activation and malignant transformation through constitutive B cell receptor (BCR) signaling. Dysregulated cholesterol and sphingolipid homeostasis support lipid raft integrity, crucial for propagating oncogenic signals. Sphingolipids impact malignant B cell stemness, proliferation, and survival, while glycosphingolipids in lipid rafts modulate BCR activation. Additionally, cancer cells enhance fatty acid-related processes to meet heightened metabolic demands. In obese individuals, the obesity-derived lipids and adipokines surrounding adipocytes rewire lipid metabolism in malignant B cells, evading cytotoxic therapies. Genetic drivers such as MYC translocations also intrinsically alter lipid metabolism in malignant B cells.</p><p>In summary, intrinsic and extrinsic factors converge to reprogram lipid metabolism, fostering aggressive phenotypes in B cell malignancies. Therefore, targeting altered lipid metabolism has translational potential for improving risk stratification and clinical management of diverse B cell malignancy subtypes.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101288"},"PeriodicalIF":14.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000213/pdfft?md5=03464b63a3a9a1b370e073b24162c6bc&pid=1-s2.0-S0163782724000213-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxylipin profiling for clinical research: Current status and future perspectives","authors":"Karol Parchem ,&nbsp;Sophia Letsiou ,&nbsp;Toni Petan ,&nbsp;Olga Oskolkova ,&nbsp;Isabel Medina ,&nbsp;Ondrej Kuda ,&nbsp;Valerie B. O'Donnell ,&nbsp;Anna Nicolaou ,&nbsp;Maria Fedorova ,&nbsp;Valery Bochkov ,&nbsp;Cécile Gladine","doi":"10.1016/j.plipres.2024.101276","DOIUrl":"10.1016/j.plipres.2024.101276","url":null,"abstract":"<div><p>Oxylipins are potent lipid mediators with increasing interest in clinical research. They are usually measured in systemic circulation and can provide a wealth of information regarding key biological processes such as inflammation, vascular tone, or blood coagulation. Although procedures still require harmonization to generate comparable oxylipin datasets, performing comprehensive profiling of circulating oxylipins in large studies is feasible and no longer restricted by technical barriers. However, it is essential to improve and facilitate the biological interpretation of complex oxylipin profiles to truly leverage their potential in clinical research. This requires regular updating of our knowledge about the metabolism and the mode of action of oxylipins, and consideration of all factors that may influence circulating oxylipin profiles independently of the studied disease or condition. This review aims to provide the readers with updated and necessary information regarding oxylipin metabolism, their different forms in systemic circulation, the current limitations in deducing oxylipin cellular effects from in vitro bioactivity studies, the biological and technical confounding factors needed to consider for a proper interpretation of oxylipin profiles.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"95 ","pages":"Article 101276"},"PeriodicalIF":13.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000092/pdfft?md5=619145ecf36daed6b2120ba73986df02&pid=1-s2.0-S0163782724000092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid oxidation in emulsions: New insights from the past two decades","authors":"Marie Hennebelle ,&nbsp;Pierre Villeneuve ,&nbsp;Erwann Durand ,&nbsp;Jérôme Lecomte ,&nbsp;John van Duynhoven ,&nbsp;Anne Meynier ,&nbsp;Betül Yesiltas ,&nbsp;Charlotte Jacobsen ,&nbsp;Claire Berton-Carabin","doi":"10.1016/j.plipres.2024.101275","DOIUrl":"10.1016/j.plipres.2024.101275","url":null,"abstract":"<div><p>Lipid oxidation constitutes the main source of degradation of lipid-rich foods, including food emulsions. The complexity of the reactions at play combined with the increased demand from consumers for less processed and more natural foods result in additional challenges in controlling this phenomenon. This review provides an overview of the insights acquired over the past two decades on the understanding of lipid oxidation in oil-in-water (O/W) emulsions. After introducing the general structure of O/W emulsions and the classical mechanisms of lipid oxidation, the contribution of less studied oxidation products and the spatiotemporal resolution of these reactions will be discussed. We then highlight the impact of emulsion formulation on the mechanisms, taking into consideration the new trends in terms of emulsifiers as well as their own sensitivity to oxidation. Finally, novel antioxidant strategies that have emerged to meet the recent consumer's demand will be detailed. In an era defined by the pursuit of healthier, more natural, and sustainable food choices, a comprehensive understanding of lipid oxidation in emulsions is not only an academic quest, but also a crucial step towards meeting the evolving expectations of consumers and ensuring the quality and stability of lipid-rich food products.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"94 ","pages":"Article 101275"},"PeriodicalIF":13.6,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782724000080/pdfft?md5=f0d83c88b76139b37ef6d65fc4b4ad2f&pid=1-s2.0-S0163782724000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139567981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial phospholipid transport: Role of contact sites and lipid transport proteins","authors":"Vijay Aditya Mavuduru ,&nbsp;Lavanya Vadupu ,&nbsp;Krishna Kanta Ghosh ,&nbsp;Sabyasachi Chakrabortty ,&nbsp;Balázs Gulyás ,&nbsp;Parasuraman Padmanabhan ,&nbsp;Writoban Basu Ball","doi":"10.1016/j.plipres.2024.101268","DOIUrl":"10.1016/j.plipres.2024.101268","url":null,"abstract":"<div><p><span>One of the major constituents of mitochondrial membranes<span> is the phospholipids, which play a key role in maintaining the structure and the functions of the mitochondria. However, mitochondria do not synthesize most of the phospholipids </span></span><em>in situ</em><span><span><span>, necessitating the presence of phospholipid import pathways. Even for the phospholipids, which are synthesized within the inner mitochondrial membrane (IMM), the phospholipid precursors must be imported from outside the mitochondria. Therefore, the mitochondria heavily rely on the phospholipid transport pathways for its proper functioning. Since, mitochondria are not part of a vesicular trafficking network, the molecular mechanisms of how mitochondria receive its phospholipids remain a relevant question. One of the major ways that hydrophobic phospholipids can cross the aqueous barrier of inter or intraorganellar spaces is by apposing membranes, thereby decreasing the distance of transport, or by being sequestered by </span>lipid transport proteins (LTPs). Therefore, with the discovery of LTPs and membrane contact sites (MCSs), we are beginning to understand the molecular mechanisms of phospholipid transport pathways in the mitochondria. In this review, we will present a brief overview of the recent findings on the molecular architecture and the importance of the MCSs, both the intraorganellar and interorganellar contact sites, in facilitating the mitochondrial phospholipid transport. In addition, we will also discuss the role of LTPs for trafficking phospholipids through the </span>intermembrane space<span> (IMS) of the mitochondria. Mechanistic insights into different phospholipid transport pathways of mitochondria could be exploited to vary the composition of membrane phospholipids and gain a better understanding of their precise role in membrane homeostasis<span> and mitochondrial bioenergetics.</span></span></span></p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"94 ","pages":"Article 101268"},"PeriodicalIF":13.6,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139112232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphatidic acid signaling and function in nuclei","authors":"Shuaibing Yao ,&nbsp;Sang-Chul Kim ,&nbsp;Jianwu Li ,&nbsp;Shan Tang ,&nbsp;Xuemin Wang","doi":"10.1016/j.plipres.2023.101267","DOIUrl":"10.1016/j.plipres.2023.101267","url":null,"abstract":"<div><p>Membrane lipidomes are dynamic and their changes generate lipid mediators affecting various biological processes. Phosphatidic acid (PA) has emerged as an important class of lipid mediators involved in a wide range of cellular and physiological responses in plants, animals, and microbes. The regulatory functions of PA have been studied primarily outside the nuclei, but an increasing number of recent studies indicates that some of the PA effects result from its action in nuclei. PA levels in nuclei are dynamic in response to stimuli. Changes in nuclear PA levels can result from activities of enzymes associated with nuclei and/or from movements of PA generated extranuclearly. PA has also been found to interact with proteins involved in nuclear functions, such as transcription factors and proteins undergoing nuclear translocation in response to stimuli. The nuclear action of PA affects various aspects of plant growth, development, and response to stress and environmental changes.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101267"},"PeriodicalIF":13.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000577/pdfft?md5=b8a95a7e0cf2d7931c42eb46a5f22a93&pid=1-s2.0-S0163782723000577-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis of phosphatidylglycerol in photosynthetic organisms","authors":"Koichi Kobayashi ,&nbsp;Haruhiko Jimbo ,&nbsp;Yuki Nakamura ,&nbsp;Hajime Wada","doi":"10.1016/j.plipres.2023.101266","DOIUrl":"10.1016/j.plipres.2023.101266","url":null,"abstract":"<div><p>Phosphatidylglycerol (PG) is a unique phospholipid class with its indispensable role in photosynthesis and growth in land plants, algae, and cyanobacteria. PG is the only major phospholipid in the thylakoid membrane of cyanobacteria and plant chloroplasts and a main lipid component in photosynthetic protein-cofactor complexes such as photosystem I and photosystem II. In plants and algae, PG is also essential as a substrate for the biosynthesis of cardiolipin, which is a unique lipid present only in mitochondrial membranes and crucial for the functions of mitochondria. PG biosynthesis pathways in plants include three membranous organelles, plastids, mitochondria, and the endoplasmic reticulum in a complex manner. While the molecular biology underlying the role of PG in photosynthetic functions is well established, many enzymes responsible for the PG biosynthesis are only recently cloned and functionally characterized in the model plant species including <em>Arabidopsis thaliana</em> and <em>Chlamydomonas reinhardtii</em> and cyanobacteria such as <em>Synechocystis</em> sp. PCC 6803. The characterization of those enzymes helps understand not only the metabolic flow for PG production but also the crosstalk of biosynthesis pathways between PG and other lipids. This review aims to summarize recent advances in the understanding of the PG biosynthesis pathway and functions of involved enzymes.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101266"},"PeriodicalIF":13.6,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000565/pdfft?md5=59eec7a8fe480a879401a444422a47bd&pid=1-s2.0-S0163782723000565-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders","authors":"Nuanyi Liang ,&nbsp;Brian A. Harsch ,&nbsp;Sitong Zhou ,&nbsp;Alison Borkowska ,&nbsp;Gregory C. Shearer ,&nbsp;Rima Kaddurah-Daouk ,&nbsp;John W. Newman ,&nbsp;Kamil Borkowski","doi":"10.1016/j.plipres.2023.101265","DOIUrl":"10.1016/j.plipres.2023.101265","url":null,"abstract":"<div><p>Lipoprotein metabolism is critical to inflammation. While the periphery and central nervous system (CNS) have separate yet connected lipoprotein systems, impaired lipoprotein metabolism is implicated in both cardiometabolic and neurological disorders. Despite the substantial investigation into the composition, structure and function of lipoproteins, the lipoprotein oxylipin profiles, their influence on lipoprotein functions, and their potential biological implications are unclear. Lipoproteins carry most of the circulating oxylipins. Importantly, lipoprotein-mediated oxylipin transport allows for endocrine signaling by these lipid mediators, long considered to have only autocrine and paracrine functions. Alterations in plasma lipoprotein oxylipin composition can directly impact inflammatory responses of lipoprotein metabolizing cells. Similar investigations of CNS lipoprotein oxylipins are non-existent to date. However, as APOE4 is associated with Alzheimer's disease-related microglia dysfunction and oxylipin dysregulation, ApoE4-dependent lipoprotein oxylipin modulation in neurological pathologies is suggested. Such investigations are crucial to bridge knowledge gaps linking oxylipin- and lipoprotein-related disorders in both periphery and CNS. Here, after providing a summary of existent literatures on lipoprotein oxylipin analysis methods, we emphasize the importance of lipoproteins in oxylipin transport and argue that understanding the compartmentalization and distribution of lipoprotein oxylipins may fundamentally alter our consideration of the roles of lipoprotein in cardiometabolic and neurological disorders.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101265"},"PeriodicalIF":13.6,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000553/pdfft?md5=be8e25586ceac1d086f14095d47c4e1e&pid=1-s2.0-S0163782723000553-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The heterogeneity and complexity of skin surface lipids in human skin health and disease","authors":"Dalibor Mijaljica,&nbsp;Joshua P. Townley,&nbsp;Fabrizio Spada,&nbsp;Ian P. Harrison","doi":"10.1016/j.plipres.2023.101264","DOIUrl":"10.1016/j.plipres.2023.101264","url":null,"abstract":"<div><p>The outermost epidermal layer of the skin, the <em>stratum corneum</em>, is not simply a barrier that safeguards skin integrity from external insults and invaders, it is also a delicately integrated interface composed of firm, essentially dead corneocytes and a distinctive lipid matrix. Together, the <em>stratum corneum</em> lipid matrix and sebum lipids derived from sebaceous glands give rise to a remarkably complex but quite unique blend of skin surface lipids that demonstrates tremendous heterogeneity and provides the skin with its indispensable protective coating. The <em>stratum corneum</em> lipid matrix is composed primarily of three major lipid classes: ceramides, non-esterified fatty acids and cholesterol, whereas sebum is a waxy mixture predominantly composed of acylglycerols, wax esters, non-esterified fatty acids, squalene, cholesterol and cholesterol esters. The balance of these skin surface lipids in terms of their relative abundance, composition, molecular organisation and dynamics, and their intricate interactions play a crucial role in the maintenance of healthy skin. For that reason, even minuscule alterations in skin surface lipid properties or overall lipid profile have been implicated in the aetiology of many common skin diseases including atopic dermatitis, psoriasis, xerosis, ichthyosis and acne. Novel lipid-based interventions aimed at correcting the skin surface lipid abnormalities have the potential to repair skin barrier integrity and the symptoms associated with such skin diseases, even though the exact mechanisms of lipid restoration remain elusive.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101264"},"PeriodicalIF":13.6,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0163782723000541/pdfft?md5=1010c40e6cd9758c917348dc99212284&pid=1-s2.0-S0163782723000541-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71493509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of DHA on cognitive dysfunction in aging and Alzheimer's disease: The mediating roles of ApoE","authors":"Xin Zhang ,&nbsp;Tian Yuan ,&nbsp;Xuhui Chen ,&nbsp;Xuebo Liu ,&nbsp;Jun Hu ,&nbsp;Zhigang Liu","doi":"10.1016/j.plipres.2023.101256","DOIUrl":"10.1016/j.plipres.2023.101256","url":null,"abstract":"<div><p>The prevalence of Alzheimer's disease (AD) continues to rise due to the increasing aging population. Among the various genetic factors associated with AD, apolipoprotein E (ApoE), a lipid transporter, stands out as the primary genetic risk factor. Specifically, individuals carrying the ApoE4 allele exhibit a significantly higher risk. However, emerging research indicates that dietary factors play a prominent role in modifying the risk of AD. Docosahexaenoic acid (DHA), a prominent ω-3 fatty acid, has garnered considerable attention for its potential to ameliorate cognitive function. The intricate interplay between DHA and the ApoE genotype within the brain, which may influence DHA's utilization and functionality, warrants further investigation. This review meticulously examines experimental and clinical studies exploring the effects of DHA on cognitive decline. Special emphasis is placed on elucidating the role of ApoE gene polymorphism and the underlying mechanisms are discussed. These studies suggest that early DHA supplementation may confer benefits to cognitively normal older adults carrying the ApoE4 gene. However, once AD develops, ApoE4 non-carriers may experience greater benefits compared to ApoE4 carriers, although the overall effectiveness of DHA supplementation at this stage is limited. Potential mechanisms underlying these differential effects may include accelerated DHA catabolism in ApoE4 carriers, impaired transport across the blood-brain barrier (BBB), and compromised lipidation and circulatory function in ApoE4 carriers. Thus, the supplementation of DHA may represent a potential intervention strategy aimed at compensating for these deficiencies in ApoE4 carriers prior to the onset of AD.</p></div>","PeriodicalId":20650,"journal":{"name":"Progress in lipid research","volume":"93 ","pages":"Article 101256"},"PeriodicalIF":13.6,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61564921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}