Oxylipin profiling for clinical research: Current status and future perspectives

IF 14 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Karol Parchem , Sophia Letsiou , Toni Petan , Olga Oskolkova , Isabel Medina , Ondrej Kuda , Valerie B. O'Donnell , Anna Nicolaou , Maria Fedorova , Valery Bochkov , Cécile Gladine
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引用次数: 0

Abstract

Oxylipins are potent lipid mediators with increasing interest in clinical research. They are usually measured in systemic circulation and can provide a wealth of information regarding key biological processes such as inflammation, vascular tone, or blood coagulation. Although procedures still require harmonization to generate comparable oxylipin datasets, performing comprehensive profiling of circulating oxylipins in large studies is feasible and no longer restricted by technical barriers. However, it is essential to improve and facilitate the biological interpretation of complex oxylipin profiles to truly leverage their potential in clinical research. This requires regular updating of our knowledge about the metabolism and the mode of action of oxylipins, and consideration of all factors that may influence circulating oxylipin profiles independently of the studied disease or condition. This review aims to provide the readers with updated and necessary information regarding oxylipin metabolism, their different forms in systemic circulation, the current limitations in deducing oxylipin cellular effects from in vitro bioactivity studies, the biological and technical confounding factors needed to consider for a proper interpretation of oxylipin profiles.

用于临床研究的氧脂分析:现状与未来展望。
氧脂是一种强效脂质介质,在临床研究中越来越受到关注。它们通常在全身循环中测量,可提供有关炎症、血管张力或血液凝固等关键生物过程的大量信息。尽管生成可比氧脂素数据集的程序仍需统一,但在大型研究中对循环氧脂素进行全面分析是可行的,而且不再受技术障碍的限制。然而,要真正发挥其在临床研究中的潜力,就必须改进和促进对复杂的氧脂素谱的生物学解释。这就要求我们定期更新有关氧化脂代谢和作用模式的知识,并考虑所有可能影响循环氧化脂谱的因素(与所研究的疾病或状况无关)。本综述旨在为读者提供最新的必要信息,内容涉及氧脂代谢、其在全身循环中的不同形式、目前从体外生物活性研究中推断氧脂对细胞作用的局限性、正确解释氧脂特征需要考虑的生物和技术干扰因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Progress in lipid research
Progress in lipid research 生物-生化与分子生物学
CiteScore
24.50
自引率
2.20%
发文量
37
审稿时长
14.6 weeks
期刊介绍: The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.
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