Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications

IF 14 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in lipid research Pub Date : 2023-10-13 DOI:10.1016/j.plipres.2023.101255

Imad Khan , Mudassar Hussain , Bangzhi Jiang , Lei Zheng , Yuechao Pan , Jijie Hu , Adil Khan , Azqa Ashraf , Xiaoqiang Zou

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引用次数: 0

Abstract

Recently, omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have gained substantial interest due to their specific structure and biological functions. Humans cannot naturally produce these fatty acids (FAs), making it crucial to obtain them from our diet. This comprehensive review details n-3 LC-PUFAs and their role in promoting and maintaining optimal health. The article thoroughly analyses several sources of n-3 LC-PUFAs and their respective bioavailability, covering marine, microbial and plant-based sources. Furthermore, we provide an in-depth analysis of the biological impacts of n-3 LC-PUFAs on health conditions, with particular emphasis on cardiovascular disease (CVD), gastrointestinal (GI) cancer, diabetes, depression, arthritis, and cognition. In addition, we highlight the significance of fortification and supplementation of n-3 LC-PUFAs in both functional foods and dietary supplements. Additionally, we conducted a detailed analysis of the several kinds of n-3 LC-PUFAs supplements currently available in the market, including an assessment of their recommended intake, safety, and effectiveness. The dietary guidelines associated with n-3 LC-PUFAs are also highlighted, focusing on the significance of maintaining a well-balanced intake of n-3 PUFAs to enhance health benefits. Lastly, we highlight future directions for further research in this area and their potential implications for public health.

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Omega-3长链多不饱和脂肪酸：代谢和健康意义

近年来，ω-3长链多不饱和脂肪酸（n-3LC-PUFA）由于其特殊的结构和生物功能而引起了人们的极大兴趣。人类无法自然产生这些脂肪酸，因此从我们的饮食中获取这些脂肪酸至关重要。这篇综合综述详细介绍了n-3 LC PUFA及其在促进和保持最佳健康方面的作用。本文全面分析了n-3LC-PUFA的几种来源及其各自的生物利用度，包括海洋、微生物和植物来源。此外，我们对n-3 LC-PUFA对健康状况的生物学影响进行了深入分析，特别强调心血管疾病（CVD）、胃肠道（GI）癌症、糖尿病、抑郁症、关节炎和认知。此外，我们强调了在功能性食品和膳食补充剂中强化和补充n-3LC-PUFA的重要性。此外，我们对目前市场上可用的几种n-3LC-PUFA补充剂进行了详细分析，包括对其推荐摄入量、安全性和有效性的评估。还强调了与n-3 LC PUFA相关的饮食指南，重点是保持n-3 PUFA的均衡摄入对提高健康益处的重要性。最后，我们强调了该领域未来进一步研究的方向及其对公共卫生的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in lipid research 生物-生化与分子生物学

CiteScore

24.50

自引率

2.20%

发文量

审稿时长

14.6 weeks

期刊介绍： The significance of lipids as a fundamental category of biological compounds has been widely acknowledged. The utilization of our understanding in the fields of biochemistry, chemistry, and physiology of lipids has continued to grow in biotechnology, the fats and oils industry, and medicine. Moreover, new aspects such as lipid biophysics, particularly related to membranes and lipoproteins, as well as basic research and applications of liposomes, have emerged. To keep up with these advancements, there is a need for a journal that can evaluate recent progress in specific areas and provide a historical perspective on current research. Progress in Lipid Research serves this purpose.